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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Mibefradil
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Accession:CHEBI:6920 term browser browse the term
Definition:A tetralin that has formula C29H38FN3O3.
Synonyms:related_synonym: Formula=C29H38FN3O3;   InChI=1S/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1;   InChIKey=HBNPJJILLOYFJU-VMPREFPWSA-N;   Ro 40-5967;   SMILES=COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C;   mibefradil dihydrochloride;   posicor
 xref: CAS:116644-53-2;   Drug_Central:1797;   KEGG:C07222;   KEGG:D08217;   LINCS:LSM-2192
 xref_mesh: MESH:D020748


show annotations for term's descendants           Sort by:
Mibefradil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Mibefradil results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Mibefradil inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Mibefradil inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; Mibefradil inhibits the reaction [AGT protein results in increased uptake of Calcium] CTD PMID:18331727 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G affects response to substance
multiple interactions		 ISO
EXP		 CACNA1G protein affects the susceptibility to Mibefradil
Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]		 CTD PMID:12130671 PMID:17110049 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP
ISO		 Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]
Mibefradil inhibits the reaction [CACNA1H protein results in increased transport of Calcium]		 CTD PMID:9930755 PMID:17110049 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I multiple interactions EXP Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] CTD PMID:17110049 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Mibefradil inhibits the reaction [Potassium results in increased secretion of CALCA protein] CTD PMID:18178321 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Mibefradil inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA] CTD PMID:18331727 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Mibefradil results in decreased activity of CYP3A4 protein CTD PMID:15860655 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA] CTD PMID:8934362 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hexa hexosaminidase subunit alpha multiple interactions EXP Mibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]] CTD PMID:19546254 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP Mibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of [HEXB protein binds to HEXA protein]] CTD PMID:19546254 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Mibefradil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Mibefradil results in decreased activity of KCNH2 protein		 CTD PMID:21158687 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions EXP Mibefradil inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of LAMP1 protein] CTD PMID:19546254 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        pharmacological role 19030
          antagonist 17213
            calcium channel blocker 7155
              T-type calcium channel blocker 53
                Mibefradil 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                carbocyclic compound 18563
                                  carbopolycyclic compound 17167
                                    carbobicyclic compound 5871
                                      tetralins 819
                                        Mibefradil 13
paths to the root