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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Mezerein
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Accession:CHEBI:6918 term browser browse the term
Definition:A diterpenoid that has formula C38H38O10.
Synonyms:related_synonym: Formula=C38H38O10;   InChI=1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3/b15-11+,18-12+/t23-,26-,28+,30-,31+,32-,33-,34+,35-,36+,37+,38?/m1/s1;   InChIKey=DLEDLHFNQDHEOJ-HBJWEEFJSA-N;   SMILES=C[C@@H]1[C@@H](OC(=O)\\C=C\\C=C\\c2ccccc2)[C@@]2(OC3(O[C@@H]2[C@@H]2[C@@H]4O[C@]4(CO)[C@@H](O)[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]12O3)c1ccccc1)C(C)=C
 xref: CAS:34807-41-5;   KEGG:C09134;   KNApSAcK:C00003454
 xref_mesh: MESH:C011309

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Mezerein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity		 ISO Iron promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [mezerein results in decreased activity of CAT protein] CTD PMID:12065085 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO mezerein results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO mezerein results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO mezerein results in increased expression of DMP1 mRNA CTD PMID:19000923 NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO mezerein results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO mezerein results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA CTD PMID:3115617 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions		 ISO mezerein results in increased expression of IL1A mRNA; mezerein results in increased expression of IL1A protein
Plant Extracts inhibits the reaction [mezerein results in increased expression of IL1A mRNA]; Plant Extracts inhibits the reaction [mezerein results in increased expression of IL1A protein]		 CTD PMID:7665919 PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO mezerein results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO mezerein results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO mezerein results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO mezerein results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Nup54 nucleoporin 54 increases expression ISO mezerein results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:17,123,434...17,141,832
Ensembl chr14:17,123,360...17,141,767 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 ISO Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Iron promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [mezerein results in increased activity of ODC1 protein]; Sodium Selenite inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [mezerein results in increased activity of ODC1 protein] CTD PMID:3098411 PMID:12065085 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO mezerein results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity		 ISO 3-aminobenzamide inhibits the reaction [mezerein results in increased activity of PARP1 protein] CTD PMID:2120135 PMID:2126186 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO mezerein results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO mezerein results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein CTD PMID:8892972 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form CTD PMID:8892972 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein CTD PMID:8892972 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636 		JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO mezerein results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO mezerein results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO mezerein results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO mezerein results in increased expression of SCARB1 mRNA CTD PMID:19000923 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO mezerein results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO mezerein results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Tfrc transferrin receptor increases expression ISO mezerein results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO mezerein results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO mezerein results in increased expression of VEGFA mRNA CTD PMID:19000923 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          carbon atom 19625
            organic molecular entity 19625
              isoprenoid 9623
                terpenoid 9607
                  diterpenoid 8446
                    Mezerein 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            organic hydride 18291
                              organic fundamental parent 18291
                                hydrocarbon 18015
                                  terpene 9623
                                    diterpene 8446
                                      diterpenoid 8446
                                        Mezerein 30
paths to the root