CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Mezerein
Accession: CHEBI:6918
browse the term
Definition: A diterpenoid that has formula C38H38O10.
Synonyms: related_synonym: Formula=C38H38O10; InChI=1S/C38H38O10/c1-21(2)36-30(44-27(40)18-12-11-15-24-13-7-5-8-14-24)23(4)37-26-19-22(3)29(41)35(26,43)33(42)34(20-39)31(45-34)28(37)32(36)46-38(47-36,48-37)25-16-9-6-10-17-25/h5-19,23,26,28,30-33,39,42-43H,1,20H2,2-4H3/b15-11+,18-12+/t23-,26-,28+,30-,31+,32-,33-,34+,35-,36+,37+,38?/m1/s1; InChIKey=DLEDLHFNQDHEOJ-HBJWEEFJSA-N; SMILES=C[C@@H]1[C@@H](OC(=O)\\C=C\\C=C\\c2ccccc2)[C@@]2(OC3(O[C@@H]2[C@@H]2[C@@H]4O[C@]4(CO)[C@@H](O)[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]12O3)c1ccccc1)C(C)=C
xref: CAS:34807-41-5; KEGG:C09134; KNApSAcK:C00003454
xref_mesh: MESH:C011309
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Cat
catalase
multiple interactions decreases activity
ISO
Iron promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [mezerein results in decreased activity of CAT protein]
CTD
PMID:12065085
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccnb1
cyclin B1
increases expression
ISO
mezerein results in increased expression of CCNB1 mRNA
CTD
PMID:19000923
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Chek1
checkpoint kinase 1
increases expression
ISO
mezerein results in increased expression of CHEK1 mRNA
CTD
PMID:19000923
NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
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Dmp1
dentin matrix acidic phosphoprotein 1
increases expression
ISO
mezerein results in increased expression of DMP1 mRNA
CTD
PMID:19000923
NCBI chr14:6,889,851...6,923,961
Ensembl chr14:6,889,856...6,900,733
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Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
mezerein results in increased expression of FOSL1 mRNA
CTD
PMID:19000923
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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Hells
helicase, lymphoid specific
increases expression
ISO
mezerein results in increased expression of HELLS mRNA
CTD
PMID:19000923
NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183 Ensembl chr 1:257,766,691...257,949,183
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Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA
CTD
PMID:3115617
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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Il1a
interleukin 1 alpha
increases expression multiple interactions
ISO
mezerein results in increased expression of IL1A mRNA; mezerein results in increased expression of IL1A protein Plant Extracts inhibits the reaction [mezerein results in increased expression of IL1A mRNA]; Plant Extracts inhibits the reaction [mezerein results in increased expression of IL1A protein]
CTD
PMID:7665919 PMID:8435107
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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Il1rl1
interleukin 1 receptor-like 1
increases expression
ISO
mezerein results in increased expression of IL1RL1 mRNA
CTD
PMID:19000923
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
mezerein results in increased expression of JUN mRNA
CTD
PMID:19000923
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
mezerein results in increased expression of JUNB mRNA
CTD
PMID:19000923
NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
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Mcm3
minichromosome maintenance complex component 3
increases expression
ISO
mezerein results in increased expression of MCM3 mRNA
CTD
PMID:19000923
NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
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Nup54
nucleoporin 54
increases expression
ISO
mezerein results in increased expression of NUP54 mRNA
CTD
PMID:19000923
NCBI chr14:17,123,434...17,141,832
Ensembl chr14:17,123,360...17,141,767
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Odc1
ornithine decarboxylase 1
multiple interactions increases activity
ISO
Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Iron promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [mezerein results in increased activity of ODC1 protein]; Sodium Selenite inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [mezerein results in increased activity of ODC1 protein]
CTD
PMID:3098411 PMID:12065085
NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
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Orm1
orosomucoid 1
increases expression
ISO
mezerein results in increased expression of ORM1 mRNA
CTD
PMID:19000923
NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases activity
ISO
3-aminobenzamide inhibits the reaction [mezerein results in increased activity of PARP1 protein]
CTD
PMID:2120135 PMID:2126186
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Phex
phosphate regulating endopeptidase homolog, X-linked
increases expression
ISO
mezerein results in increased expression of PHEX mRNA
CTD
PMID:19000923
NCBI chr X:40,460,047...40,717,982
Ensembl chr X:40,460,047...40,717,982
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Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
increases expression
ISO
mezerein results in increased expression of PIK3R5 mRNA
CTD
PMID:19000923
NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
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Prkca
protein kinase C, alpha
multiple interactions
ISO
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCA protein
CTD
PMID:8892972
NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
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Prkcb
protein kinase C, beta
multiple interactions
ISO
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein; [bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCB protein alternative form
CTD
PMID:8892972
NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
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Prkcg
protein kinase C, gamma
multiple interactions
ISO
[bryostatin 1 co-treated with mezerein] results in decreased expression of PRKCG protein
CTD
PMID:8892972
NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
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Rad21
RAD21 cohesin complex component
increases expression
ISO
mezerein results in increased expression of RAD21 mRNA
CTD
PMID:19000923
NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
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Rad51ap1
RAD51 associated protein 1
increases expression
ISO
mezerein results in increased expression of RAD51AP1 mRNA
CTD
PMID:19000923
NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
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Rif1
replication timing regulatory factor 1
increases expression
ISO
mezerein results in increased expression of RIF1 mRNA
CTD
PMID:19000923
NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
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Scarb1
scavenger receptor class B, member 1
increases expression
ISO
mezerein results in increased expression of SCARB1 mRNA
CTD
PMID:19000923
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Slc2a1
solute carrier family 2 member 1
increases expression
ISO
mezerein results in increased expression of SLC2A1 mRNA
CTD
PMID:19000923
NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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Stmn1
stathmin 1
increases expression
ISO
mezerein results in increased expression of STMN1 mRNA
CTD
PMID:19000923
NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
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Tfrc
transferrin receptor
increases expression
ISO
mezerein results in increased expression of TFRC mRNA
CTD
PMID:19000923
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
mezerein results in increased expression of TGFB1 mRNA
CTD
PMID:8148055
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
mezerein results in increased expression of VEGFA mRNA
CTD
PMID:19000923
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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