Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3,7-trimethyluric acid
go back to main search page
Accession:CHEBI:691622 term browser browse the term
Definition:An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8, and the nitrogens at positions 1, 3, and 7 are substituted by methyl groups. It is a metabolite of caffeine.
Synonyms:related_synonym: 1,3,7-trimethylurate;   7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione;   8-oxy-caffeine;   Formula=C8H10N4O3;   InChI=1S/C8H10N4O3/c1-10-4-5(9-7(10)14)11(2)8(15)12(3)6(4)13/h1-3H3,(H,9,14);   InChIKey=BYXCFUMGEBZDDI-UHFFFAOYSA-N;   SMILES=Cn1c2[nH]c(=O)n(C)c2c(=O)n(C)c1=O
 xref: CAS:5415-44-1;   HMDB:HMDB0002123;   KEGG:C16361
 xref_mesh: MESH:C039222
 xref: PMID:15537072;   PMID:17981969;   Reaxys:20503
 cyclic_relationship: is_conjugate_acid_of CHEBI:132940

show annotations for term's descendants           Sort by:
1,3,7-trimethyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid CTD PMID:31132250 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            xenobiotic metabolite 14041
              human xenobiotic metabolite 13294
                1,3,7-trimethyluric acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      imidazopyrimidine 5437
                                        purines 5435
                                          oxopurine 4024
                                            1,3,7-trimethyluric acid 1
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.