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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mexiletine
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Accession:CHEBI:6916 term browser browse the term
Definition:An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Synonyms:related_synonym: (+-)-1-(2,6-dimethylphenoxy)propan-2-amine;   (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane;   1-(2',6'-dimethylphenoxy)-2-aminopropane;   1-(2,6-dimethylphenoxy)-2-propanamine;   1-methyl-2-(2,6-xylyloxy)ethanamine;   Formula=C11H17NO;   InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3;   InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N;   SMILES=CC(N)COc1c(C)cccc1C;   mexiletina;   mexiletinum
 alt_id: CHEBI:115958
 xref: CAS:31828-71-4;   DrugBank:DB00379;   Drug_Central:1794;   HMDB:HMDB0014523;   KEGG:C07220;   KEGG:D08215;   LINCS:LSM-1700
 xref_mesh: MESH:D008801
 xref: PMID:10883344;   PMID:11009230;   Patent:FR1551055;   Patent:US3954872;   Reaxys:2092205;   Wikipedia:Mexiletine


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mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1A interleukin 1 alpha multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Mexiletine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 multiple interactions EXP Mexiletine inhibits the reaction [decamethrin results in increased activity of SCN10A protein] CTD PMID:16325806 NCBI chr 3:38,696,807...38,816,217
Ensembl chr 3:38,696,802...38,816,286 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 affects binding EXP Mexiletine binds to SCN5A protein CTD PMID:22848561 NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,687 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 increases response to substance EXP SCN9A mRNA SNP results in increased susceptibility to Mexiletine CTD PMID:19162012 NCBI chr 2:166,195,185...166,375,987
Ensembl chr 2:166,195,185...166,376,001 		JBrowse link
G TMPRSS2 transmembrane serine protease 2 increases expression EXP Mexiletine results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr21:41,464,305...41,508,158
Ensembl chr21:41,464,300...41,531,116 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Mexiletine CTD PMID:19362101 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            cardiovascular drug 8765
              anti-arrhythmia drug 1505
                mexiletine 8
                  mexiletine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        primary amino compound 9935
                                          mexiletine 8
                                            mexiletine hydrochloride 0
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