Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:latrunculin A
go back to main search page
Accession:CHEBI:69136 term browser browse the term
Definition:A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.
Synonyms:related_synonym: (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one;   Formula=C22H31NO5S;   InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1;   InChIKey=DDVBPZROPPMBLW-IZGXTMSKSA-N;   LAT-A;   LatA;   NSC 613011;   SMILES=[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/C=C/CC\\C(C)=C/C(=O)O2)O1
 alt_id: CHEBI:43626
 xref: CAS:76343-93-6
 xref_mesh: MESH:C037067
 xref: PDBeChem:LAR;   PMID:10859320;   PMID:12087066;   PMID:17897856;   PMID:19528469;   PMID:20677927;   PMID:22492972;   PMID:22498812;   PMID:3200109;   PMID:3556584;   PMID:9250716;   Reaxys:4239363


show annotations for term's descendants           Sort by:
 
latrunculin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta decreases response to substance ISO ACTB protein mutant form results in decreased susceptibility to latrunculin A CTD PMID:16685646 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Casp3 caspase 3 increases activity ISO latrunculin A results in increased activity of CASP3 protein CTD PMID:16723733 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdh1 cadherin 1 decreases uptake ISO latrunculin A results in decreased uptake of CDH1 protein modified form CTD PMID:20547569 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ctnna1 catenin alpha 1 multiple interactions EXP latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]]; latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Diaph1 diaphanous-related formin 1 affects localization ISO latrunculin A affects the localization of DIAPH1 protein CTD PMID:22918941 NCBI chr18:30,972,907...31,071,371
Ensembl chr18:30,972,907...31,071,371
JBrowse link
G Fscn1 fascin actin-bundling protein 1 multiple interactions EXP latrunculin A affects the reaction [FSCN1 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G Fscn2 fascin actin-bundling protein 2, retinal multiple interactions EXP latrunculin A affects the reaction [FSCN2 protein inhibits the reaction [CTNNA1 protein affects the susceptibility to Cisplatin]] CTD PMID:27989596 NCBI chr10:109,528,307...109,540,675
Ensembl chr10:109,533,487...109,540,026
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO latrunculin A inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgb1 integrin subunit beta 1 decreases activity ISO latrunculin A results in decreased activity of ITGB1 protein CTD PMID:16723733 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Prlr prolactin receptor decreases uptake ISO latrunculin A results in decreased uptake of PRLR protein CTD PMID:20547569 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            latrunculin A 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          macrocyclic lactone 1731
                                            macrolide 1598
                                              latrunculin A 10
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.