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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:licocoumarone
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Accession:CHEBI:69098 term browser browse the term
Definition:A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by a hydroxy group at position 6, a methoxy group at position 4, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.
Synonyms:exact_synonym: 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl]benzene-1,3-diol
 related_synonym: 2-(2',4'-dihydroxyphenyl)-6-hydroxy-5-isopentenyl-4-methoxybenzofuran;   Formula=C20H20O5;   InChI=1S/C20H20O5/c1-11(2)4-6-14-17(23)10-19-15(20(14)24-3)9-18(25-19)13-7-5-12(21)8-16(13)22/h4-5,7-10,21-23H,6H2,1-3H3;   InChIKey=CNPMAFLUEHEXRE-UHFFFAOYSA-N;   SMILES=COc1c(CC=C(C)C)c(O)cc2oc(cc12)-c1ccc(O)cc1O
 xref: HMDB:HMDB0038755;   LIPID_MAPS_instance:LMPK12160045
 xref_mesh: MESH:C000617177
 xref: PMID:10993226;   PMID:12392103;   PMID:1913999;   PMID:1941536;   PMID:20724155;   PMID:22074222;   PMID:2632045;   Reaxys:4821696


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licocoumarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions ISO licocoumarone binds to and results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO licocoumarone results in decreased expression of MET protein CTD PMID:31838052 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      biological role 19722
        antimicrobial agent 17897
          antibacterial agent 14709
            licocoumarone 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic molecule 19602
                              organic cyclic compound 19412
                                organic heterocyclic compound 18771
                                  organic heteropolycyclic compound 18259
                                    organic heterobicyclic compound 17228
                                      mancude organic heterobicyclic parent 8239
                                        benzofuran 20
                                          1-benzofuran 20
                                            licocoumarone 2
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