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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metronidazole
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Accession:CHEBI:6909 term browser browse the term
Definition:A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Synonyms:exact_synonym: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
 related_synonym: 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;   1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole;   1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole;   1-(beta-oxyethyl)-2-methyl-5-nitroimidazole;   2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole;   2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole;   2-methyl-5-nitroimidazole-1-ethanol;   Formula=C6H9N3O3;   InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3;   InChIKey=VAOCPAMSLUNLGC-UHFFFAOYSA-N;   SMILES=Cc1ncc(n1CCO)[N+]([O-])=O;   metronidazol;   metronidazolum
 alt_id: CHEBI:39845;   CHEBI:63636
 xref: Beilstein:611683;   CAS:443-48-1;   DrugBank:DB00916;   Drug_Central:1790;   HMDB:HMDB0015052;   KEGG:D00409;   LINCS:LSM-5628
 xref_mesh: MESH:D008795
 xref: PDBeChem:2MN;   PMID:11906111;   PMID:14702395;   PMID:15739364;   PMID:16304169;   PMID:16901452;   PMID:18397330;   PMID:19485831;   PMID:22226009;   PMID:22252819;   Patent:US2944061;   Reaxys:611683;   VSDB:1826;   Wikipedia:Metronidazole
 cyclic_relationship: is_conjugate_base_of CHEBI:64682



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metronidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Metronidazole results in decreased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Metronidazole results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Metronidazole results in increased expression of ABCG8 mRNA CTD PMID:24657338 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of ACACA mRNA CTD PMID:34979169 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACAT2 protein CTD PMID:30545405 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Acat2l1 acetyl-CoA acetyltransferase 2-like 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACAT2L1 protein CTD PMID:30545405 NCBI chr 1:47,803,822...47,829,012
Ensembl chr 1:47,803,813...47,829,151
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of ADIPOQ mRNA CTD PMID:34979169 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahsg alpha-2-HS-glycoprotein multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of AHSG protein CTD PMID:30545405 NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ALDOA protein CTD PMID:30545405 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Aldob aldolase, fructose-bisphosphate B multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ALDOB protein CTD PMID:30545405 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Arg2 arginase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of ARG2 protein CTD PMID:30545405 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ARPC3 protein CTD PMID:30545405 NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of ASAH1 protein CTD PMID:30545405 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ATP1A1 protein CTD PMID:30545405 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ATP2A3 protein CTD PMID:30545405 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ATP5J2 protein CTD PMID:30545405 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ATP5H protein CTD PMID:30545405 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ATP5J protein CTD PMID:30545405 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of B3GALT5 protein CTD PMID:30545405 NCBI chr11:35,584,273...35,630,922
Ensembl chr11:35,585,220...35,630,917
JBrowse link
G Clca4 chloride channel accessory 4 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of CLCA4 protein CTD PMID:30545405 NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
JBrowse link
G Cldn7 claudin 7 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of CLDN7 protein CTD PMID:30545405 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CMBL protein CTD PMID:30545405 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cndp2 carnosine dipeptidase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of CNDP2 protein CTD PMID:30545405 NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of COX5A protein CTD PMID:30545405 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of COX6B1 protein CTD PMID:30545405 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of COX7A2 protein CTD PMID:30545405 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 protein]; [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] results in decreased expression of CSF2 protein CTD PMID:31442584 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctsa cathepsin A multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CTSA protein CTD PMID:30545405 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP1A2 mRNA CTD PMID:30545405 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2C11 mRNA CTD PMID:30545405 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA CTD PMID:30545405 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2E1 mRNA CTD PMID:30545405 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA
Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone]; Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus]; Metronidazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:15855244 PMID:15869686 PMID:19299527 PMID:30545405 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of EPCAM protein CTD PMID:30545405 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Ereg epiregulin increases expression ISO Metronidazole results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ETFA protein CTD PMID:30545405 NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969
JBrowse link
G Ezr ezrin multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of EZR protein CTD PMID:30545405 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [elemicin results in increased expression of FASN mRNA] CTD PMID:34979169 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GFPT2 protein CTD PMID:30545405 NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329
JBrowse link
G Gipc2 GIPC PDZ domain containing family, member 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GIPC2 protein CTD PMID:30545405 NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236
JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of GNG12 protein CTD PMID:30545405 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [elemicin results in increased activity of GPT protein] CTD PMID:34979169 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of GPX1 protein CTD PMID:30545405 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of GSTA3 mRNA CTD PMID:30545405 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of GSTM2 mRNA CTD PMID:30545405 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of HEXB protein CTD PMID:30545405 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of HNRNPH2 protein CTD PMID:30545405 NCBI chr  X:97,780,890...97,786,846
Ensembl chr  X:97,780,785...97,787,041
JBrowse link
G Hp haptoglobin multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of HP protein CTD PMID:30545405 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Il24 interleukin 24 increases expression ISO Metronidazole results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] results in decreased expression of IL6 protein; Dextran Sulfate inhibits the reaction [[Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] results in decreased expression of IL6 protein] CTD PMID:31442584 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of MAP1 protein CTD PMID:30545405 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Krt16 keratin 16 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of KRT16 protein CTD PMID:30545405 NCBI chr10:85,168,357...85,171,744
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Lep leptin multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lyz2 lysozyme 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of LYZ2 protein CTD PMID:30545405 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of MAPK3 protein CTD PMID:30545405 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mlxip MLX interacting protein multiple interactions ISO [Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [elemicin results in increased expression of MLXIP mRNA] CTD PMID:34979169 NCBI chr12:33,128,524...33,192,300
Ensembl chr12:33,128,520...33,192,374
JBrowse link
G Myh14 myosin heavy chain 14 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of MYH14 protein CTD PMID:30545405 NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of NDUFA13 protein CTD PMID:30545405 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of NDUFAB1 protein CTD PMID:30545405 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Metronidazole inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:12568917 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of NPC2 protein CTD PMID:30545405 NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
JBrowse link
G Pdxk pyridoxal kinase multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of PDXK protein CTD PMID:30545405 NCBI chr20:10,210,393...10,231,937
Ensembl chr20:10,210,289...10,232,110
JBrowse link
G Pfn1 profilin 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PFN1 protein CTD PMID:30545405 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgam1 phosphoglycerate mutase 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PGAM1 protein CTD PMID:30545405 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pmm2 phosphomannomutase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PMM2 protein CTD PMID:30545405 NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PPP1CA protein CTD PMID:30545405 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PPP1CB protein CTD PMID:30545405 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PPP1CC protein CTD PMID:30545405 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of PSMA3 protein CTD PMID:30545405 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
JBrowse link
G Ralb RAS like proto-oncogene B multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of RALB protein CTD PMID:30545405 NCBI chr13:30,588,036...30,624,199
Ensembl chr13:30,588,033...30,624,202
JBrowse link
G Ran RAN, member RAS oncogene family multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of RAN protein CTD PMID:30545405 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
JBrowse link
G Rida reactive intermediate imine deaminase A homolog multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of RIDA protein CTD PMID:30545405 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716
JBrowse link
G Rpl30 ribosomal protein L30 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of RPL30 protein CTD PMID:30545405 NCBI chr 7:65,648,470...65,651,363
Ensembl chr 7:65,645,991...65,651,363
Ensembl chr10:65,645,991...65,651,363
JBrowse link
G Rpn2 ribophorin II multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of RPN2 protein CTD PMID:30545405 NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
JBrowse link
G Rps23 ribosomal protein S23 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of RPS23 protein CTD PMID:30545405 NCBI chr 2:22,079,339...22,080,909
Ensembl chr 2:22,079,302...22,080,918
JBrowse link
G Rps27l ribosomal protein S27-like multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of RPS27L protein CTD PMID:30545405 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Metronidazole affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Metronidazole affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-DMb RT1 class II, locus DMb multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of RT1-DMB protein CTD PMID:30545405 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G S100a10 S100 calcium binding protein A10 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of S100A10 protein CTD PMID:30545405 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of S100A11 protein CTD PMID:30545405 NCBI chr 2:179,191,504...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G Scarb2 scavenger receptor class B, member 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of SCARB2 protein CTD PMID:30545405 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
JBrowse link
G Serpinb6a serpin family B member 6A multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SERPINB6 protein CTD PMID:30545405 NCBI chr17:30,871,428...30,989,703
Ensembl chr17:30,871,468...31,014,427
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SHMT2 protein CTD PMID:30545405 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SLC3A1 protein CTD PMID:30545405 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Metronidazole results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO Metronidazole results in increased expression of SLCO2B1 mRNA CTD PMID:24657338 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein CTD PMID:30545405 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TARS protein CTD PMID:30545405 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Tm9sf2 transmembrane 9 superfamily member 2 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TM9SF2 protein CTD PMID:30545405 NCBI chr15:99,201,556...99,254,054
Ensembl chr15:99,201,489...99,254,049
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TMED10 protein CTD PMID:30545405 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; [Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] results in decreased expression of TNF protein; Dextran Sulfate inhibits the reaction [[Ampicillin co-treated with Vancomycin co-treated with Neomycin co-treated with Metronidazole] results in decreased expression of TNF protein] CTD PMID:31442584 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tubal3 tubulin, alpha-like 3 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TUBAL3 protein CTD PMID:30545405 NCBI chr17:66,323,733...66,332,423
Ensembl chr17:66,323,733...66,335,355
JBrowse link
G Twf1 twinfilin actin-binding protein 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TWF1 protein CTD PMID:30545405 NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894
JBrowse link
G Txndc5 thioredoxin domain containing 5 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of TXNDC5 protein CTD PMID:30545405 NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of UQCRC1 protein CTD PMID:30545405 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of UQCRFS1 protein CTD PMID:30545405 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein multiple interactions EXP [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of UQCRH protein CTD PMID:30545405 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        antimicrobial agent 17818
          metronidazole 99
            metronidazole benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  heteroarene 16628
                                    monocyclic heteroarene 13606
                                      azole 12836
                                        diazole 8631
                                          imidazoles 7724
                                            metronidazole 99
                                              metronidazole benzoate 0
paths to the root