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ONTOLOGY REPORT - ANNOTATIONS


Term:licoricidin
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Accession:CHEBI:69082 term browser browse the term
Definition:A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.
Synonyms:exact_synonym: 4-[(3R)-7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-chromen-3-yl]-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol
 related_synonym: 2',4',7'-trihydroxy-5-methoxy-3',6-diisopentenyl-isoflavan;   4-((R)-7-hydroxy-5-methoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-3-yl)-2-((E)-3-methyl-but-2-enyl)-benzene-1,3-diol;   Formula=C26H32O5;   InChI=1S/C26H32O5/c1-15(2)6-8-19-22(27)11-10-18(25(19)29)17-12-21-24(31-14-17)13-23(28)20(26(21)30-5)9-7-16(3)4/h6-7,10-11,13,17,27-29H,8-9,12,14H2,1-5H3/t17-/m0/s1;   InChIKey=GBRZTUJCDFSIHM-KRWDZBQOSA-N;   SMILES=COc1c(CC=C(C)C)c(O)cc2OC[C@H](Cc12)c1ccc(O)c(CC=C(C)C)c1O
 xref: CAS:30508-27-1;   KEGG:C16986;   LIPID_MAPS_instance:LMPK12080045
 xref_mesh: MESH:C401293
 xref: PMID:12127165;   PMID:20487583;   PMID:20722535;   PMID:21851508;   PMID:22074222;   Reaxys:5362788


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licoricidin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        antimicrobial agent 17260
          antibacterial agent 12988
            licoricidin 3
              licorisoflavan A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic molecule 19461
                              organic cyclic compound 19222
                                organic heterocyclic compound 18339
                                  oxacycle 17118
                                    benzopyran 9473
                                      1-benzopyran 9169
                                        isoflavonoid 2690
                                          isoflavans 220
                                            hydroxyisoflavans 55
                                              licoricidin 3
                                                licorisoflavan A 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.