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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trichlorfon
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Accession:CHEBI:6908 term browser browse the term
Definition:A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Synonyms:exact_synonym: dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
 related_synonym: 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester;   Chlorophos;   Formula=C4H8Cl3O4P;   InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3;   InChIKey=NFACJZMKEDPNKN-UHFFFAOYSA-N;   Methyl chlorophos;   Metrifonate;   SMILES=COP(=O)(OC)C(O)C(Cl)(Cl)Cl;   metrifonato;   metrifonatum
 xref: Beilstein:1709434;   CAS:52-68-6;   Drug_Central:1787;   KEGG:C07971;   KEGG:D00805;   LINCS:LSM-4995
 xref_mesh: MESH:D014236
 xref: PMID:19775726;   PMID:24122545;   PPDB:657;   Reaxys:1709434;   VSDB:657;   Wikipedia:Metrifonate


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trichlorfon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects activity
decreases activity
ISO
EXP
[Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]
Trichlorfon affects the activity of ACHE protein
[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein
Trichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE protein
CTD PMID:235931 PMID:1852719 PMID:4859365 PMID:8783813 PMID:9268605 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G App amyloid beta precursor protein increases secretion
affects metabolic processing
affects cleavage
ISO
EXP
Trichlorfon results in increased secretion of APP protein alternative form
Trichlorfon affects the metabolism of APP protein
Trichlorfon affects the cleavage of APP protein
CTD PMID:10773217 PMID:11099780 PMID:11526466 PMID:11822883 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein] CTD PMID:235931 PMID:11311445 PMID:18825528 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein] CTD PMID:19631781 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19631781 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19631781 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Trichlorfon results in decreased activity of CAT protein
Trichlorfon results in increased activity of CAT protein
CTD PMID:15386949 PMID:17697763 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein CTD PMID:12794734 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects expression EXP Trichlorfon affects the expression of CHRM4 mRNA; Trichlorfon affects the expression of CHRM4 protein CTD PMID:12093157 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO Trichlorfon results in decreased activity of CYP11A1 protein
Trichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 protein
CTD PMID:17350742 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Trichlorfon inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:17329077 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Trichlorfon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases activity ISO Trichlorfon results in increased activity of HNF4A protein CTD PMID:20143881 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Nefh neurofilament heavy chain decreases expression ISO Trichlorfon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Trichlorfon results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO Trichlorfon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Trichlorfon results in decreased expression of SERPINA3 protein CTD PMID:10599054 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Trichlorfon results in decreased expression of STAR mRNA
Trichlorfon results in decreased expression of STAR mRNA; Trichlorfon results in decreased expression of STAR protein
CTD PMID:17329077 PMID:17350742 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Syn1 synapsin I decreases expression ISO Trichlorfon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396
JBrowse link
G Syp synaptophysin decreases expression ISO Trichlorfon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Trichlorfon results in increased expression of TP53 protein CTD PMID:19631781 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        agrochemical 15039
          trichlorfon 21
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      chalcogen 19460
                        oxygen atom 19436
                          oxygen molecular entity 19436
                            hydroxides 19175
                              oxoacid 18488
                                pnictogen oxoacid 10688
                                  phosphorus oxoacid 9669
                                    phosphorus oxoacid derivative 9133
                                      phosphonic acid derivative 2336
                                        phosphonate 168
                                          organic phosphonate 168
                                            trichlorfon 21
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