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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trichlorfon
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Accession:CHEBI:6908 term browser browse the term
Definition:A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Synonyms:exact_synonym: dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
 related_synonym: 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester;   Chlorophos;   Formula=C4H8Cl3O4P;   InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3;   InChIKey=NFACJZMKEDPNKN-UHFFFAOYSA-N;   Methyl chlorophos;   Metrifonate;   SMILES=COP(=O)(OC)C(O)C(Cl)(Cl)Cl;   metrifonato;   metrifonatum
 xref: Beilstein:1709434;   CAS:52-68-6;   Drug_Central:1787;   KEGG:C07971;   KEGG:D00805;   LINCS:LSM-4995
 xref_mesh: MESH:D014236
 xref: PMID:19775726;   PMID:24122545;   PPDB:657;   Reaxys:1709434;   VSDB:657;   Wikipedia:Metrifonate


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trichlorfon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects activity
decreases activity
ISO
EXP
[Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]
Trichlorfon affects the activity of ACHE protein
[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein
Trichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE protein
CTD PMID:235931, PMID:1852719, PMID:4859365, PMID:8783813, PMID:9268605, PMID:9515941, PMID:10718203, PMID:10791297, PMID:11311445, PMID:11526466, PMID:11822883, PMID:12111444, PMID:12794734, PMID:15386949, PMID:15569517, PMID:16822217, PMID:18070496, PMID:18804659, PMID:19631781, PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G App amyloid beta precursor protein increases secretion
affects metabolic processing
affects cleavage
ISO
EXP
Trichlorfon results in increased secretion of APP protein alternative form
Trichlorfon affects the metabolism of APP protein
Trichlorfon affects the cleavage of APP protein
CTD PMID:10773217, PMID:11099780, PMID:11526466, PMID:11822883 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein] CTD PMID:235931, PMID:11311445, PMID:18825528 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein] CTD PMID:19631781 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19631781 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19631781 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Trichlorfon results in decreased activity of CAT protein
Trichlorfon results in increased activity of CAT protein
CTD PMID:15386949, PMID:17697763 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein CTD PMID:12794734 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects expression EXP Trichlorfon affects the expression of CHRM4 mRNA; Trichlorfon affects the expression of CHRM4 protein CTD PMID:12093157 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression
ISO Trichlorfon results in decreased activity of CYP11A1 protein
Trichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 protein
CTD PMID:17350742 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Trichlorfon inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:17329077 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Trichlorfon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases activity ISO Trichlorfon results in increased activity of HNF4A protein CTD PMID:20143881 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Nefh neurofilament heavy decreases expression ISO Trichlorfon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Trichlorfon results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO Trichlorfon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Serpina3m serpin family A member 3M decreases expression ISO Trichlorfon results in decreased expression of SERPINA3 protein CTD PMID:10599054 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Trichlorfon results in decreased expression of STAR mRNA
Trichlorfon results in decreased expression of STAR mRNA; Trichlorfon results in decreased expression of STAR protein
CTD PMID:17329077, PMID:17350742 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Syn1 synapsin I decreases expression ISO Trichlorfon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syp synaptophysin decreases expression ISO Trichlorfon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Trichlorfon results in increased expression of TP53 protein CTD PMID:19631781 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        agrochemical 14458
          trichlorfon 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      chalcogen 19382
                        oxygen atom 19343
                          oxygen molecular entity 19343
                            hydroxides 19091
                              oxoacid 18211
                                pnictogen oxoacid 10155
                                  phosphorus oxoacid 9041
                                    phosphorus oxoacid derivative 8525
                                      phosphonic acid derivative 2332
                                        phosphonate 165
                                          organic phosphonate 165
                                            trichlorfon 21
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