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ONTOLOGY REPORT - ANNOTATIONS


Term:metoprolol
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Accession:CHEBI:6904 term browser browse the term
Definition:A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Synonyms:exact_synonym: 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol
 related_synonym: (RS)-Metoprolol;   1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;   Formula=C15H25NO3;   InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3;   InChIKey=IUBSYMUCCVWXPE-UHFFFAOYSA-N;   SMILES=COCCc1ccc(OCC(O)CNC(C)C)cc1
 xref: CAS:37350-58-6 "ChemIDplus";   CAS:37350-58-6 "KEGG COMPOUND";   CAS:51384-51-1 "ChemIDplus";   CAS:51384-51-1 "KEGG COMPOUND";   DrugBank:DB00264;   Drug_Central:1786 "DrugCentral";   HMDB:HMDB0001932;   KEGG:C07202;   KEGG:D02358;   LINCS:LSM-1259
 xref_mesh: MESH:D008790
 xref: PMID:15140634 "Europe PMC";   PMID:15797646 "Europe PMC";   PMID:24025984 "Europe PMC";   Reaxys:1117585 "Reaxys";   Wikipedia:Metoprolol


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metoprolol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6480464
G Adra2c adrenergic receptor, alpha 2c JBrowse link 5 35,278,566 35,281,763 RGD:6480464
G Adrb1 adrenergic receptor, beta 1 JBrowse link 19 56,722,117 56,725,150 RGD:6480464
G Adrb2 adrenergic receptor, beta 2 JBrowse link 18 62,177,713 62,179,981 RGD:6480464
G Adrb3 adrenergic receptor, beta 3 JBrowse link 8 27,225,776 27,230,845 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Arrb1 arrestin, beta 1 JBrowse link 7 99,535,147 99,606,772 RGD:6480464
G Arrb2 arrestin, beta 2 JBrowse link 11 70,432,485 70,440,828 RGD:6480464
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 JBrowse link 5 122,453,513 122,502,225 RGD:6480464
G Bcl2l1 BCL2-like 1 JBrowse link 2 152,758,732 152,833,803 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 10 24,595,442 24,598,683 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Col3a1 collagen, type III, alpha 1 JBrowse link 1 45,311,538 45,349,706 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1a, liver JBrowse link 19 3,322,326 3,385,735 RGD:6480464
G Cpt1b carnitine palmitoyltransferase 1b, muscle JBrowse link 15 89,416,405 89,425,862 RGD:6480464
G Cyb5a cytochrome b5 type A (microsomal) JBrowse link 18 84,851,338 84,879,871 RGD:6480464
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 JBrowse link 15 82,370,527 82,380,260 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Ece1 endothelin converting enzyme 1 JBrowse link 4 137,862,237 137,965,229 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Fkbp1b FK506 binding protein 1b JBrowse link 12 4,833,174 4,841,736 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Foxo3 forkhead box O3 JBrowse link 10 42,181,845 42,276,839 RGD:6480464
G G6pdx glucose-6-phosphate dehydrogenase X-linked JBrowse link X 74,409,483 74,428,880 RGD:6480464
G Gata4 GATA binding protein 4 JBrowse link 14 63,198,914 63,271,712 RGD:6480464
G Gja1 gap junction protein, alpha 1 JBrowse link 10 56,377,300 56,390,419 RGD:6480464
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 5 34,660,250 34,755,305 RGD:6480464
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 19 60,889,560 61,095,968 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Jph2 junctophilin 2 JBrowse link 2 163,336,242 163,398,049 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Jund jun D proto-oncogene JBrowse link 8 70,697,739 70,700,616 RGD:6480464
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 JBrowse link 5 24,319,589 24,351,684 RGD:6480464
G Mef2a myocyte enhancer factor 2A JBrowse link 7 67,231,163 67,376,456 RGD:6480464
G Mir190a microRNA 190a JBrowse link 9 67,236,660 67,236,726 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 8 92,827,290 92,853,421 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta JBrowse link 14 54,970,684 54,994,626 RGD:6480464
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 JBrowse link 14 55,824,795 55,833,943 RGD:6480464
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Nppa natriuretic peptide type A JBrowse link 4 148,000,722 148,002,074 RGD:6480464
G Nppb natriuretic peptide type B JBrowse link 4 147,985,786 147,987,205 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 1 171,213,934 171,218,845 RGD:6480464
G Odc1 ornithine decarboxylase, structural 1 JBrowse link 12 17,544,808 17,551,502 RGD:6480464
G Penk preproenkephalin JBrowse link 4 4,133,536 4,138,815 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha JBrowse link 5 51,454,249 52,115,853 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Ren1 renin 1 structural JBrowse link 1 133,350,674 133,360,320 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:6480464
G Ryr2 ryanodine receptor 2, cardiac JBrowse link 13 11,553,099 12,106,945 RGD:6480464
G Sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) JBrowse link 11 46,971,077 47,989,451 RGD:6480464
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 JBrowse link 17 12,648,874 12,675,838 RGD:6480464
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 JBrowse link 17 12,584,189 12,628,489 RGD:6480464
G Spn sialophorin JBrowse link 7 127,123,637 127,145,552 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 2 118,111,876 118,127,133 RGD:6480464
G Thbs4 thrombospondin 4 JBrowse link 13 92,751,586 92,794,818 RGD:6480464
G Timp2 tissue inhibitor of metalloproteinase 2 JBrowse link 11 118,301,061 118,355,411 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Usf2 upstream transcription factor 2 JBrowse link 7 30,945,248 30,956,951 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20752
    role 20730
      biological role 20729
        xenobiotic 18727
          metoprolol 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 20752
    subatomic particle 20745
      composite particle 20745
        hadron 20745
          baryon 20745
            nucleon 20745
              atomic nucleus 20745
                atom 20745
                  main group element atom 20665
                    main group molecular entity 20665
                      s-block molecular entity 20156
                        hydrogen molecular entity 20064
                          hydrides 18920
                            inorganic hydride 17486
                              pnictogen hydride 17434
                                nitrogen hydride 17236
                                  azane 17097
                                    ammonia 17094
                                      organic amino compound 17093
                                        amino alcohol 869
                                          propanolamine 165
                                            metoprolol 69
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.