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G
|
Ace
|
angiotensin I converting enzyme
|
affects response to substance
|
ISO
|
ACE gene polymorphism affects the susceptibility to Metoprolol
|
CTD |
PMID:20819590 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G
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Adra2c
|
adrenoceptor alpha 2C
|
multiple interactions
|
ISO
|
[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol
|
CTD |
PMID:17496726 |
|
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
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|
G
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Adrb1
|
adrenoceptor beta 1
|
decreases activity affects response to substance increases expression affects binding multiple interactions decreases methylation
|
ISO EXP
|
Metoprolol results in decreased activity of ADRB1 protein ADRB1 gene affects the susceptibility to Metoprolol; ADRB1 gene polymorphism affects the susceptibility to Metoprolol; ADRB1 protein polymorphism affects the susceptibility to Metoprolol Metoprolol results in increased expression of ADRB1 mRNA Metoprolol binds to ADRB1 protein Metoprolol binds to and results in increased activity of ADRB1 protein; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein] Metoprolol results in decreased methylation of ADRB1 promoter Metoprolol results in increased expression of ADRB1 mRNA; Metoprolol results in increased expression of ADRB1 protein [ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol; [Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; Metoprolol binds to and results in decreased activity of ADRB1 protein; Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
|
CTD |
PMID:1312942 PMID:1389726 PMID:9593075 PMID:10372227 PMID:11562432 PMID:12844134 PMID:14730417 PMID:15060759 PMID:15864115 PMID:17200720 PMID:17496726 PMID:18703049 PMID:19094446 PMID:20590644 PMID:20675662 PMID:20821015 PMID:21311897 PMID:22165287 PMID:22192668 More...
|
|
NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
|
|
G
|
Adrb2
|
adrenoceptor beta 2
|
affects binding increases expression affects response to substance multiple interactions
|
EXP ISO
|
Metoprolol binds to ADRB2 protein Metoprolol results in increased expression of ADRB2 mRNA ADRB2 gene polymorphism affects the susceptibility to Metoprolol Metoprolol results in increased expression of ADRB2 protein Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein] [Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Metoprolol binds to and results in decreased activity of ADRB2 protein; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
|
CTD |
PMID:9593075 PMID:14730417 PMID:17671401 PMID:17925438 PMID:18703049 PMID:20675662 More...
|
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
|
|
G
|
Adrb3
|
adrenoceptor beta 3
|
multiple interactions increases expression
|
EXP ISO
|
Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB3 protein] Metoprolol results in increased expression of ADRB3 protein Metoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
|
CTD |
PMID:14730417 PMID:18703049 |
|
NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases phosphorylation
|
EXP
|
Metoprolol results in increased phosphorylation of AKT1 protein
|
CTD |
PMID:18703049 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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|
G
|
Arrb1
|
arrestin, beta 1
|
multiple interactions
|
ISO
|
Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
|
CTD |
PMID:24334028 |
|
NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061
|
|
G
|
Arrb2
|
arrestin, beta 2
|
affects response to substance
|
ISO
|
ARRB2 protein affects the susceptibility to Metoprolol
|
CTD |
PMID:22888001 |
|
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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|
G
|
Atp2a2
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
|
increases expression
|
EXP
|
Metoprolol results in increased expression of ATP2A2 mRNA
|
CTD |
PMID:16162791 |
|
NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein]
|
CTD |
PMID:12738230 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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|
G
|
Casp3
|
caspase 3
|
increases cleavage
|
ISO
|
Metoprolol results in increased cleavage of CASP3 protein
|
CTD |
PMID:19106745 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp9
|
caspase 9
|
increases cleavage
|
ISO
|
Metoprolol results in increased cleavage of CASP9 protein
|
CTD |
PMID:19106745 |
|
Ensembl chr 5:154,109,046...154,126,626
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|
G
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Ccn2
|
cellular communication network factor 2
|
increases expression
|
EXP ISO
|
Metoprolol results in increased expression of CCN2 mRNA
|
CTD |
PMID:22888001 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
increases expression
|
ISO EXP
|
Metoprolol results in increased expression of COL1A1 mRNA
|
CTD |
PMID:22888001 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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|
G
|
Col3a1
|
collagen type III alpha 1 chain
|
increases expression
|
ISO
|
Metoprolol results in increased expression of COL3A1 mRNA
|
CTD |
PMID:30809271 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
increases expression
|
EXP
|
Metoprolol results in increased expression of CPT1A protein
|
CTD |
PMID:19233164 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
|
|
G
|
Cpt1b
|
carnitine palmitoyltransferase 1B
|
multiple interactions decreases expression
|
EXP
|
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter] Metoprolol results in decreased expression of CPT1B protein
|
CTD |
PMID:19233164 |
|
NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:120,491,354...120,500,404
|
|
G
|
Cyb5a
|
cytochrome b5 type A
|
affects metabolic processing
|
ISO
|
CYB5A affects the metabolism of Metoprolol
|
CTD |
PMID:20430864 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
affects response to substance affects metabolic processing multiple interactions increases metabolic processing
|
ISO
|
CYP2D6 gene affects the susceptibility to Metoprolol; CYP2D6 gene polymorphism affects the susceptibility to Metoprolol CYP2D6 protein affects the metabolism of Metoprolol; CYP2D6 protein polymorphism affects the metabolism of Metoprolol [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; [Terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]; Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]
|
CTD |
PMID:10470702 PMID:10848718 PMID:11823760 PMID:12172215 PMID:12464242 PMID:15286053 PMID:15327588 PMID:15541258 PMID:18648788 PMID:18784654 PMID:18979093 PMID:19094446 PMID:19230594 PMID:24894748 More...
|
|
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions increases hydroxylation
|
ISO
|
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]
|
CTD |
PMID:30087611 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
Ece1
|
endothelin converting enzyme 1
|
decreases expression
|
ISO
|
Metoprolol results in decreased expression of ECE1 mRNA
|
CTD |
PMID:9607404 |
|
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
|
|
G
|
Edn1
|
endothelin 1
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]
|
CTD |
PMID:11435416 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G
|
Fkbp1b
|
FKBP prolyl isomerase 1B
|
multiple interactions
|
ISO
|
Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
|
CTD |
PMID:12743001 |
|
NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]
|
CTD |
PMID:15179140 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G
|
Foxo3
|
forkhead box O3
|
decreases expression
|
EXP
|
Metoprolol results in decreased expression of FOXO3 protein
|
CTD |
PMID:18703049 |
|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
|
|
G
|
G6pd
|
glucose-6-phosphate dehydrogenase
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]
|
CTD |
PMID:1378361 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G
|
Gata4
|
GATA binding protein 4
|
decreases phosphorylation
|
EXP
|
Metoprolol results in decreased phosphorylation of GATA4 protein
|
CTD |
PMID:21472269 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
|
|
G
|
Gja1
|
gap junction protein, alpha 1
|
increases expression multiple interactions affects localization
|
EXP
|
Metoprolol results in increased expression of GJA1 protein [Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein Metoprolol affects the localization of GJA1 protein
|
CTD |
PMID:17445419 PMID:20215810 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
|
|
G
|
Grk4
|
G protein-coupled receptor kinase 4
|
affects response to substance
|
ISO
|
GRK4 gene SNP affects the susceptibility to Metoprolol
|
CTD |
PMID:19119263 |
|
NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
|
|
G
|
Grk5
|
G protein-coupled receptor kinase 5
|
affects response to substance
|
ISO
|
GRK5 protein affects the susceptibility to Metoprolol
|
CTD |
PMID:22888001 |
|
NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Xamoterol results in increased expression of HMOX1 protein]
|
CTD |
PMID:15179140 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Il1a
|
interleukin 1 alpha
|
increases expression increases secretion
|
ISO
|
Metoprolol results in increased expression of IL1A mRNA Metoprolol results in increased secretion of IL1A protein
|
CTD |
PMID:17467819 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
|
CTD |
PMID:11406463 PMID:12619890 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G
|
Jph2
|
junctophilin 2
|
increases expression
|
ISO
|
Metoprolol results in increased expression of JPH2 protein
|
CTD |
PMID:22375019 |
|
NCBI chr 3:151,994,768...152,058,941
Ensembl chr 3:151,994,778...152,058,904
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]
|
CTD |
PMID:15179140 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
|
|
G
|
Jund
|
JunD proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]
|
CTD |
PMID:15179140 |
|
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
|
|
G
|
Kcnh2
|
potassium voltage-gated channel subfamily H member 2
|
multiple interactions decreases activity
|
ISO
|
Metoprolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein] Metoprolol results in decreased activity of KCNH2 protein
|
CTD |
PMID:15679475 PMID:16314852 |
|
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
|
|
G
|
Mef2a
|
myocyte enhancer factor 2a
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter]
|
CTD |
PMID:19233164 |
|
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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|
G
|
Mir190a
|
microRNA 190a
|
multiple interactions
|
ISO
|
Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
|
CTD |
PMID:24334028 |
|
NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
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|
G
|
Mmp2
|
matrix metallopeptidase 2
|
decreases expression multiple interactions decreases secretion
|
ISO EXP
|
Metoprolol results in decreased expression of MMP2 mRNA; Metoprolol results in decreased expression of MMP2 protein Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] Metoprolol results in decreased secretion of MMP2 protein
|
CTD |
PMID:15326086 PMID:20424515 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases expression decreases secretion
|
ISO
|
Metoprolol results in decreased expression of MMP9 mRNA; Metoprolol results in decreased expression of MMP9 protein Metoprolol results in decreased secretion of MMP9 protein
|
CTD |
PMID:20424515 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Myc
|
MYC proto-oncogene, bHLH transcription factor
|
decreases expression
|
EXP
|
Metoprolol results in decreased expression of MYC protein
|
CTD |
PMID:21472269 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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|
G
|
Myh7
|
myosin heavy chain 7
|
multiple interactions
|
EXP
|
Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA]
|
CTD |
PMID:17592507 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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|
G
|
Nfatc4
|
nuclear factor of activated T-cells 4
|
increases phosphorylation
|
EXP
|
Metoprolol results in increased phosphorylation of NFATC4 protein
|
CTD |
PMID:21472269 |
|
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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|
G
|
Nos1
|
nitric oxide synthase 1
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Metoprolol inhibits the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]
|
CTD |
PMID:11832429 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]
|
CTD |
PMID:18703049 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
decreases expression
|
EXP
|
Metoprolol results in decreased expression of NOS3 protein
|
CTD |
PMID:18703049 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G
|
Nppa
|
natriuretic peptide A
|
multiple interactions decreases expression
|
EXP
|
Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] Metoprolol results in decreased expression of NPPA mRNA
|
CTD |
PMID:17592507 PMID:20353484 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
|
|
G
|
Nppb
|
natriuretic peptide B
|
decreases expression
|
EXP
|
Metoprolol results in decreased expression of NPPB mRNA; Metoprolol results in decreased expression of NPPB protein
|
CTD |
PMID:11181074 PMID:20353484 PMID:30310171 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
|
|
G
|
Nr1i3
|
nuclear receptor subfamily 1, group I, member 3
|
decreases metabolic processing
|
ISO
|
NR1I3 gene mutant form results in decreased metabolism of Metoprolol
|
CTD |
PMID:27434302 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G
|
Odc1
|
ornithine decarboxylase 1
|
multiple interactions
|
ISO
|
Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
|
CTD |
PMID:10353628 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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|
G
|
Penk
|
proenkephalin
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA]
|
CTD |
PMID:1363325 |
|
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
EXP
|
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]
|
CTD |
PMID:19233164 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
EXP
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Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter]; Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein]
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CTD |
PMID:19233164 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G
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Ppp3ca
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protein phosphatase 3 catalytic subunit alpha
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decreases expression
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EXP
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Metoprolol results in decreased expression of PPP3CA protein
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CTD |
PMID:30310171 |
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NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G
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Prdx3
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peroxiredoxin 3
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increases expression
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EXP
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Metoprolol results in increased expression of PRDX3 protein
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CTD |
PMID:30310171 |
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NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions decreases expression increases expression
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EXP ISO
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Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]; Metoprolol inhibits the reaction [Oxygen deficiency results in increased expression of PTGS2 mRNA] Metoprolol results in decreased expression of PTGS2 mRNA; Metoprolol results in decreased expression of PTGS2 protein Metoprolol results in increased expression of PTGS2 mRNA
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CTD |
PMID:17467819 PMID:20424515 PMID:21615343 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G
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Ren
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renin
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decreases expression
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ISO EXP
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Metoprolol results in decreased expression of REN protein Metoprolol results in decreased expression of REN mRNA
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CTD |
PMID:2454358 PMID:8203557 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G
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Rps6kb1
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ribosomal protein S6 kinase B1
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increases expression
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EXP
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Metoprolol results in increased expression of RPS6KB1 mRNA
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CTD |
PMID:28099878 |
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NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G
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Ryr2
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ryanodine receptor 2
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multiple interactions increases activity
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ISO
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Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein] Metoprolol results in increased activity of RYR2 protein
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CTD |
PMID:12743001 |
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NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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G
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Sgcd
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sarcoglycan, delta
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affects response to substance
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ISO
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SGCD affects the susceptibility to Metoprolol
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CTD |
PMID:20675662 |
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NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840
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G
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Slc22a1
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solute carrier family 22 member 1
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multiple interactions
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ISO
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Metoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
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CTD |
PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G
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Slc22a2
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solute carrier family 22 member 2
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multiple interactions
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ISO
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Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]
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CTD |
PMID:19740083 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G
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Spn
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sialophorin
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decreases response to substance
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ISO
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SPN protein results in decreased susceptibility to Metoprolol
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CTD |
PMID:18711009 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G
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Tgfb1
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transforming growth factor, beta 1
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increases expression
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EXP
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Metoprolol results in increased expression of TGFB1 mRNA
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CTD |
PMID:22888001 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G
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Thbs1
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thrombospondin 1
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decreases expression
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EXP
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Metoprolol results in decreased expression of THBS1 mRNA
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CTD |
PMID:20353484 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G
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Thbs4
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thrombospondin 4
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decreases expression
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EXP
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Metoprolol results in decreased expression of THBS4 mRNA
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CTD |
PMID:20353484 |
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NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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G
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Timp2
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TIMP metallopeptidase inhibitor 2
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multiple interactions
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EXP
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Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]
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CTD |
PMID:15326086 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G
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Tnf
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tumor necrosis factor
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multiple interactions
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EXP
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Metoprolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
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CTD |
PMID:15081246 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G
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Usf2
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upstream transcription factor 2, c-fos interacting
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multiple interactions increases expression
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EXP
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Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein] Metoprolol results in increased expression of USF2 protein
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CTD |
PMID:19233164 |
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NCBI chr 1:86,174,703...86,185,942
Ensembl chr 1:86,174,703...86,185,617
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G
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Vegfa
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vascular endothelial growth factor A
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decreases expression
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ISO
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Metoprolol results in decreased expression of VEGFA mRNA; Metoprolol results in decreased expression of VEGFA protein
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CTD |
PMID:20424515 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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