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G |
Ace |
angiotensin I converting enzyme |
affects response to substance |
ISO |
ACE gene polymorphism affects the susceptibility to Metoprolol |
CTD |
PMID:20819590 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Adra2c |
adrenoceptor alpha 2C |
multiple interactions |
ISO |
[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol |
CTD |
PMID:17496726 |
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NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
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G |
Adrb1 |
adrenoceptor beta 1 |
decreases activity affects binding multiple interactions increases expression decreases methylation affects response to substance |
ISO EXP |
Metoprolol results in decreased activity of ADRB1 protein Metoprolol binds to ADRB1 protein [ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol; [Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; Metoprolol binds to and results in decreased activity of ADRB1 protein; Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein] Metoprolol results in increased expression of ADRB1 mRNA; Metoprolol results in increased expression of ADRB1 protein Metoprolol results in decreased methylation of ADRB1 promoter Metoprolol binds to and results in increased activity of ADRB1 protein; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein] ADRB1 gene affects the susceptibility to Metoprolol; ADRB1 gene polymorphism affects the susceptibility to Metoprolol; ADRB1 protein polymorphism affects the susceptibility to Metoprolol |
CTD |
PMID:1312942 PMID:1389726 PMID:9593075 PMID:10372227 PMID:11562432 PMID:12844134 PMID:14730417 PMID:15060759 PMID:15864115 PMID:17200720 PMID:17496726 PMID:18703049 PMID:19094446 PMID:20590644 PMID:20675662 PMID:20821015 PMID:21311897 PMID:22165287 PMID:22192668 More...
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NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
affects binding multiple interactions increases expression affects response to substance |
EXP ISO |
Metoprolol binds to ADRB2 protein [Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Metoprolol binds to and results in decreased activity of ADRB2 protein; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein] Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein] Metoprolol results in increased expression of ADRB2 protein ADRB2 gene polymorphism affects the susceptibility to Metoprolol Metoprolol results in increased expression of ADRB2 mRNA |
CTD |
PMID:9593075 PMID:14730417 PMID:17671401 PMID:17925438 PMID:18703049 PMID:20675662 More...
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions increases expression |
EXP ISO |
Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB3 protein] Metoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] Metoprolol results in increased expression of ADRB3 protein |
CTD |
PMID:14730417 PMID:18703049 |
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NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
EXP |
Metoprolol results in increased phosphorylation of AKT1 protein |
CTD |
PMID:18703049 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] |
CTD |
PMID:24334028 |
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NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Arrb2 |
arrestin, beta 2 |
affects response to substance |
ISO |
ARRB2 protein affects the susceptibility to Metoprolol |
CTD |
PMID:22888001 |
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NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
increases expression |
EXP |
Metoprolol results in increased expression of ATP2A2 mRNA |
CTD |
PMID:16162791 |
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NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein] |
CTD |
PMID:12738230 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
increases cleavage |
ISO |
Metoprolol results in increased cleavage of CASP3 protein |
CTD |
PMID:19106745 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases cleavage |
ISO |
Metoprolol results in increased cleavage of CASP9 protein |
CTD |
PMID:19106745 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
EXP ISO |
Metoprolol results in increased expression of CCN2 mRNA |
CTD |
PMID:22888001 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression |
ISO EXP |
Metoprolol results in increased expression of COL1A1 mRNA |
CTD |
PMID:22888001 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
increases expression |
ISO |
Metoprolol results in increased expression of COL3A1 mRNA |
CTD |
PMID:30809271 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
EXP |
Metoprolol results in increased expression of CPT1A protein |
CTD |
PMID:19233164 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
multiple interactions decreases expression |
EXP |
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter] Metoprolol results in decreased expression of CPT1B protein |
CTD |
PMID:19233164 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cyb5a |
cytochrome b5 type A |
affects metabolic processing |
ISO |
CYB5A affects the metabolism of Metoprolol |
CTD |
PMID:20430864 |
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NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects response to substance increases metabolic processing multiple interactions affects metabolic processing |
ISO |
CYP2D6 gene affects the susceptibility to Metoprolol; CYP2D6 gene polymorphism affects the susceptibility to Metoprolol CYP2D6 protein results in increased metabolism of Metoprolol [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; [Terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]; Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CYP2D6 protein affects the metabolism of Metoprolol; CYP2D6 protein polymorphism affects the metabolism of Metoprolol |
CTD |
PMID:10470702 PMID:10848718 PMID:11823760 PMID:12172215 PMID:12464242 PMID:15286053 PMID:15327588 PMID:15541258 PMID:18648788 PMID:18784654 PMID:18979093 PMID:19094446 PMID:19230594 PMID:24894748 More...
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases hydroxylation |
ISO |
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol] |
CTD |
PMID:30087611 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Ece1 |
endothelin converting enzyme 1 |
decreases expression |
ISO |
Metoprolol results in decreased expression of ECE1 mRNA |
CTD |
PMID:9607404 |
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NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA] |
CTD |
PMID:11435416 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fkbp1b |
FKBP prolyl isomerase 1B |
multiple interactions |
ISO |
Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein] |
CTD |
PMID:12743001 |
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NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] |
CTD |
PMID:15179140 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxo3 |
forkhead box O3 |
decreases expression |
EXP |
Metoprolol results in decreased expression of FOXO3 protein |
CTD |
PMID:18703049 |
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NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein] |
CTD |
PMID:1378361 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gata4 |
GATA binding protein 4 |
decreases phosphorylation |
EXP |
Metoprolol results in decreased phosphorylation of GATA4 protein |
CTD |
PMID:21472269 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression affects localization multiple interactions |
EXP |
Metoprolol results in increased expression of GJA1 protein Metoprolol affects the localization of GJA1 protein [Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein |
CTD |
PMID:17445419 PMID:20215810 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Grk4 |
G protein-coupled receptor kinase 4 |
affects response to substance |
ISO |
GRK4 gene SNP affects the susceptibility to Metoprolol |
CTD |
PMID:19119263 |
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NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
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G |
Grk5 |
G protein-coupled receptor kinase 5 |
affects response to substance |
ISO |
GRK5 protein affects the susceptibility to Metoprolol |
CTD |
PMID:22888001 |
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NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Xamoterol results in increased expression of HMOX1 protein] |
CTD |
PMID:15179140 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il1a |
interleukin 1 alpha |
increases expression increases secretion |
ISO |
Metoprolol results in increased expression of IL1A mRNA Metoprolol results in increased secretion of IL1A protein |
CTD |
PMID:17467819 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA] |
CTD |
PMID:11406463 PMID:12619890 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jph2 |
junctophilin 2 |
increases expression |
ISO |
Metoprolol results in increased expression of JPH2 protein |
CTD |
PMID:22375019 |
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NCBI chr 3:151,994,768...152,058,941
Ensembl chr 3:151,994,778...152,058,904
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] |
CTD |
PMID:15179140 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] |
CTD |
PMID:15179140 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
Metoprolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein] Metoprolol results in decreased activity of KCNH2 protein |
CTD |
PMID:15679475 PMID:16314852 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Mef2a |
myocyte enhancer factor 2a |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter] |
CTD |
PMID:19233164 |
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NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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G |
Mir190 |
microRNA 190 |
multiple interactions |
ISO |
Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] |
CTD |
PMID:24334028 |
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NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression decreases secretion multiple interactions |
ISO EXP |
Metoprolol results in decreased expression of MMP2 mRNA; Metoprolol results in decreased expression of MMP2 protein Metoprolol results in decreased secretion of MMP2 protein Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] |
CTD |
PMID:15326086 PMID:20424515 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression decreases secretion |
ISO |
Metoprolol results in decreased expression of MMP9 mRNA; Metoprolol results in decreased expression of MMP9 protein Metoprolol results in decreased secretion of MMP9 protein |
CTD |
PMID:20424515 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
EXP |
Metoprolol results in decreased expression of MYC protein |
CTD |
PMID:21472269 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions |
EXP |
Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA] |
CTD |
PMID:17592507 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Nfatc4 |
nuclear factor of activated T-cells 4 |
increases phosphorylation |
EXP |
Metoprolol results in increased phosphorylation of NFATC4 protein |
CTD |
PMID:21472269 |
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NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Metoprolol inhibits the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] |
CTD |
PMID:11832429 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] |
CTD |
PMID:18703049 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
Metoprolol results in decreased expression of NOS3 protein |
CTD |
PMID:18703049 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nppa |
natriuretic peptide A |
multiple interactions decreases expression |
EXP |
Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] Metoprolol results in decreased expression of NPPA mRNA |
CTD |
PMID:17592507 PMID:20353484 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
decreases expression |
EXP |
Metoprolol results in decreased expression of NPPB mRNA; Metoprolol results in decreased expression of NPPB protein |
CTD |
PMID:11181074 PMID:20353484 PMID:30310171 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
decreases metabolic processing |
ISO |
NR1I3 gene mutant form results in decreased metabolism of Metoprolol |
CTD |
PMID:27434302 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
ISO |
Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] |
CTD |
PMID:10353628 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Penk |
proenkephalin |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] |
CTD |
PMID:1363325 |
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NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein] |
CTD |
PMID:19233164 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter]; Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein] |
CTD |
PMID:19233164 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
decreases expression |
EXP |
Metoprolol results in decreased expression of PPP3CA protein |
CTD |
PMID:30310171 |
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NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G |
Prdx3 |
peroxiredoxin 3 |
increases expression |
EXP |
Metoprolol results in increased expression of PRDX3 protein |
CTD |
PMID:30310171 |
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NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression decreases expression |
EXP ISO |
Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]; Metoprolol inhibits the reaction [Oxygen deficiency results in increased expression of PTGS2 mRNA] Metoprolol results in increased expression of PTGS2 mRNA Metoprolol results in decreased expression of PTGS2 mRNA; Metoprolol results in decreased expression of PTGS2 protein |
CTD |
PMID:17467819 PMID:20424515 PMID:21615343 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ren |
renin |
decreases expression |
ISO EXP |
Metoprolol results in decreased expression of REN protein Metoprolol results in decreased expression of REN mRNA |
CTD |
PMID:2454358 PMID:8203557 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases expression |
EXP |
Metoprolol results in increased expression of RPS6KB1 mRNA |
CTD |
PMID:28099878 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Ryr2 |
ryanodine receptor 2 |
multiple interactions increases activity |
ISO |
Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein] Metoprolol results in increased activity of RYR2 protein |
CTD |
PMID:12743001 |
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NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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G |
Sgcd |
sarcoglycan, delta |
affects response to substance |
ISO |
SGCD affects the susceptibility to Metoprolol |
CTD |
PMID:20675662 |
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NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Metoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] |
CTD |
PMID:19740083 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Spn |
sialophorin |
decreases response to substance |
ISO |
SPN protein results in decreased susceptibility to Metoprolol |
CTD |
PMID:18711009 |
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NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
EXP |
Metoprolol results in increased expression of TGFB1 mRNA |
CTD |
PMID:22888001 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thbs1 |
thrombospondin 1 |
decreases expression |
EXP |
Metoprolol results in decreased expression of THBS1 mRNA |
CTD |
PMID:20353484 |
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NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Thbs4 |
thrombospondin 4 |
decreases expression |
EXP |
Metoprolol results in decreased expression of THBS4 mRNA |
CTD |
PMID:20353484 |
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NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] |
CTD |
PMID:15326086 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Metoprolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]] |
CTD |
PMID:15081246 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Usf2 |
upstream transcription factor 2, c-fos interacting |
multiple interactions increases expression |
EXP |
Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein] Metoprolol results in increased expression of USF2 protein |
CTD |
PMID:19233164 |
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NCBI chr 1:86,174,703...86,185,942
Ensembl chr 1:86,174,703...86,185,617
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Metoprolol results in decreased expression of VEGFA mRNA; Metoprolol results in decreased expression of VEGFA protein |
CTD |
PMID:20424515 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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