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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:metoprolol
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Accession:CHEBI:6904 term browser browse the term
Definition:A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Synonyms:exact_synonym: 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol
 related_synonym: (RS)-Metoprolol;   1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol;   Formula=C15H25NO3;   InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3;   InChIKey=IUBSYMUCCVWXPE-UHFFFAOYSA-N;   SMILES=COCCc1ccc(OCC(O)CNC(C)C)cc1
 xref: CAS:37350-58-6;   CAS:51384-51-1;   DrugBank:DB00264;   Drug_Central:1786;   HMDB:HMDB0001932;   KEGG:C07202;   KEGG:D02358;   LINCS:LSM-1259
 xref_mesh: MESH:D008790
 xref: PMID:15140634;   PMID:15797646;   PMID:23314750;   PMID:24025984;   Reaxys:1117585;   Wikipedia:Metoprolol


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metoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects response to substance ISO ACE gene polymorphism affects the susceptibility to Metoprolol CTD PMID:20819590 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions ISO [ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol CTD PMID:17496726 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
affects response to substance
increases expression
affects binding
multiple interactions
decreases methylation 		ISO
EXP 		Metoprolol results in decreased activity of ADRB1 protein
ADRB1 gene affects the susceptibility to Metoprolol; ADRB1 gene polymorphism affects the susceptibility to Metoprolol; ADRB1 protein polymorphism affects the susceptibility to Metoprolol
Metoprolol results in increased expression of ADRB1 mRNA
Metoprolol binds to ADRB1 protein
Metoprolol binds to and results in increased activity of ADRB1 protein; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein]
Metoprolol results in decreased methylation of ADRB1 promoter
Metoprolol results in increased expression of ADRB1 mRNA; Metoprolol results in increased expression of ADRB1 protein
[ADRB1 gene polymorphism co-treated with ADRA2C gene polymorphism] affects the susceptibility to Metoprolol; [Metoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; Metoprolol binds to and results in decreased activity of ADRB1 protein; Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein] 		CTD PMID:1312942 PMID:1389726 PMID:9593075 PMID:10372227 PMID:11562432 More... NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects binding
increases expression
affects response to substance
multiple interactions 		EXP
ISO 		Metoprolol binds to ADRB2 protein
Metoprolol results in increased expression of ADRB2 mRNA
ADRB2 gene polymorphism affects the susceptibility to Metoprolol
Metoprolol results in increased expression of ADRB2 protein
Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein]
[Metoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Metoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Metoprolol binds to and results in decreased activity of ADRB2 protein; Metoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein] 		CTD PMID:9593075 PMID:14730417 PMID:17671401 PMID:17925438 PMID:18703049 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases expression 		EXP
ISO 		Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB3 protein]
Metoprolol results in increased expression of ADRB3 protein
Metoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] 		CTD PMID:14730417 PMID:18703049 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Metoprolol results in increased phosphorylation of AKT1 protein CTD PMID:18703049 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance ISO ARRB2 protein affects the susceptibility to Metoprolol CTD PMID:22888001 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Metoprolol results in increased expression of ATP2A2 mRNA CTD PMID:16162791 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Metoprolol inhibits the reaction [Isoproterenol results in increased expression of BCL2L1 protein] CTD PMID:12738230 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Metoprolol results in increased cleavage of CASP3 protein CTD PMID:19106745 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Metoprolol results in increased cleavage of CASP9 protein CTD PMID:19106745 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP
ISO 		Metoprolol results in increased expression of CCN2 mRNA CTD PMID:22888001 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO
EXP 		Metoprolol results in increased expression of COL1A1 mRNA CTD PMID:22888001 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Metoprolol results in increased expression of COL3A1 mRNA CTD PMID:30809271 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Metoprolol results in increased expression of CPT1A protein CTD PMID:19233164 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions
decreases expression 		EXP Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter]
Metoprolol results in decreased expression of CPT1B protein 		CTD PMID:19233164 NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Cyb5a cytochrome b5 type A affects metabolic processing ISO CYB5A affects the metabolism of Metoprolol CTD PMID:20430864 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance
affects metabolic processing
multiple interactions
increases metabolic processing 		ISO CYP2D6 gene affects the susceptibility to Metoprolol; CYP2D6 gene polymorphism affects the susceptibility to Metoprolol
CYP2D6 protein affects the metabolism of Metoprolol; CYP2D6 protein polymorphism affects the metabolism of Metoprolol
[Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; [Paroxetine results in decreased activity of CYP2D6 protein] which results in increased susceptibility to Metoprolol; [Terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol]; Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]; YM 758 inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] 		CTD PMID:10470702 PMID:10848718 PMID:11823760 PMID:12172215 PMID:12464242 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation 		ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol] CTD PMID:30087611 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ece1 endothelin converting enzyme 1 decreases expression ISO Metoprolol results in decreased expression of ECE1 mRNA CTD PMID:9607404 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA] CTD PMID:11435416 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 decreases expression EXP Metoprolol results in decreased expression of FOXO3 protein CTD PMID:18703049 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein] CTD PMID:1378361 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gata4 GATA binding protein 4 decreases phosphorylation EXP Metoprolol results in decreased phosphorylation of GATA4 protein CTD PMID:21472269 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
affects localization 		EXP Metoprolol results in increased expression of GJA1 protein
[Isoproterenol co-treated with Metoprolol] results in increased expression of GJA1 protein
Metoprolol affects the localization of GJA1 protein 		CTD PMID:17445419 PMID:20215810 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 affects response to substance ISO GRK4 gene SNP affects the susceptibility to Metoprolol CTD PMID:19119263 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 affects response to substance ISO GRK5 protein affects the susceptibility to Metoprolol CTD PMID:22888001 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Xamoterol results in increased expression of HMOX1 protein] CTD PMID:15179140 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1a interleukin 1 alpha increases expression
increases secretion 		ISO Metoprolol results in increased expression of IL1A mRNA
Metoprolol results in increased secretion of IL1A protein 		CTD PMID:17467819 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA] CTD PMID:11406463 PMID:12619890 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jph2 junctophilin 2 increases expression ISO Metoprolol results in increased expression of JPH2 protein CTD PMID:22375019 NCBI chr 3:151,994,768...152,058,941
Ensembl chr 3:151,994,778...152,058,904 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity 		ISO Metoprolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein]
Metoprolol results in decreased activity of KCNH2 protein 		CTD PMID:15679475 PMID:16314852 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions EXP Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter] CTD PMID:19233164 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mir190a microRNA 190a multiple interactions ISO Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases secretion 		ISO
EXP 		Metoprolol results in decreased expression of MMP2 mRNA; Metoprolol results in decreased expression of MMP2 protein
Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Metoprolol results in decreased secretion of MMP2 protein 		CTD PMID:15326086 PMID:20424515 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases secretion 		ISO Metoprolol results in decreased expression of MMP9 mRNA; Metoprolol results in decreased expression of MMP9 protein
Metoprolol results in decreased secretion of MMP9 protein 		CTD PMID:20424515 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Metoprolol results in decreased expression of MYC protein CTD PMID:21472269 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Metoprolol promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:17592507 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases phosphorylation EXP Metoprolol results in increased phosphorylation of NFATC4 protein CTD PMID:21472269 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Metoprolol inhibits the reaction [[Ramipril co-treated with Sodium Chloride deficiency] results in increased expression of NOS1 protein]; Metoprolol inhibits the reaction [Ramipril promotes the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA]]; Metoprolol inhibits the reaction [Sodium Chloride deficiency results in increased expression of NOS1 mRNA] CTD PMID:11832429 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Metoprolol inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:18703049 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP Metoprolol results in decreased expression of NOS3 protein CTD PMID:18703049 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression 		EXP Metoprolol promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Metoprolol results in decreased expression of NPPA mRNA 		CTD PMID:17592507 PMID:20353484 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Metoprolol results in decreased expression of NPPB mRNA; Metoprolol results in decreased expression of NPPB protein CTD PMID:11181074 PMID:20353484 PMID:30310171 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases metabolic processing ISO NR1I3 gene mutant form results in decreased metabolism of Metoprolol CTD PMID:27434302 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] CTD PMID:10353628 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Penk proenkephalin multiple interactions EXP Metoprolol inhibits the reaction [Isoproterenol results in increased expression of PENK mRNA] CTD PMID:1363325 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein] CTD PMID:19233164 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein]; Metoprolol inhibits the reaction [PPARGC1A protein binds to CPT1B promoter]; Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein] CTD PMID:19233164 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression EXP Metoprolol results in decreased expression of PPP3CA protein CTD PMID:30310171 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Prdx3 peroxiredoxin 3 increases expression EXP Metoprolol results in increased expression of PRDX3 protein CTD PMID:30310171 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression 		EXP
ISO 		Metoprolol inhibits the reaction [Isoflurane results in increased expression of PTGS2 mRNA]; Metoprolol inhibits the reaction [Oxygen deficiency results in increased expression of PTGS2 mRNA]
Metoprolol results in decreased expression of PTGS2 mRNA; Metoprolol results in decreased expression of PTGS2 protein
Metoprolol results in increased expression of PTGS2 mRNA 		CTD PMID:17467819 PMID:20424515 PMID:21615343 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ren renin decreases expression ISO
EXP 		Metoprolol results in decreased expression of REN protein
Metoprolol results in decreased expression of REN mRNA 		CTD PMID:2454358 PMID:8203557 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases expression EXP Metoprolol results in increased expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases activity 		ISO Metoprolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
Metoprolol results in increased activity of RYR2 protein 		CTD PMID:12743001 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Sgcd sarcoglycan, delta affects response to substance ISO SGCD affects the susceptibility to Metoprolol CTD PMID:20675662 NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Metoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Spn sialophorin decreases response to substance ISO SPN protein results in decreased susceptibility to Metoprolol CTD PMID:18711009 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Metoprolol results in increased expression of TGFB1 mRNA CTD PMID:22888001 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression EXP Metoprolol results in decreased expression of THBS1 mRNA CTD PMID:20353484 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs4 thrombospondin 4 decreases expression EXP Metoprolol results in decreased expression of THBS4 mRNA CTD PMID:20353484 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:15326086 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Metoprolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]] CTD PMID:15081246 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Usf2 upstream transcription factor 2, c-fos interacting multiple interactions
increases expression 		EXP Metoprolol promotes the reaction [USF2 protein binds to PPARGC1A protein]
Metoprolol results in increased expression of USF2 protein 		CTD PMID:19233164 NCBI chr 1:86,174,703...86,185,942
Ensembl chr 1:86,174,703...86,185,617 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Metoprolol results in decreased expression of VEGFA mRNA; Metoprolol results in decreased expression of VEGFA protein CTD PMID:20424515 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        xenobiotic 19508
          metoprolol 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              pnictogen hydride 18558
                                nitrogen hydride 18469
                                  azane 18229
                                    ammonia 18228
                                      organic amino compound 18228
                                        amino alcohol 1082
                                          propanolamine 190
                                            metoprolol 71
paths to the root