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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Methysticin
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Accession:CHEBI:6895 term browser browse the term
Definition:A 2-pyranone that has formula C15H14O5.
Synonyms:related_synonym: Formula=C15H14O5;   InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1;   InChIKey=GTEXBOVBADJOQH-FWEMWIAWSA-N;   SMILES=COC1=CC(=O)O[C@H](C1)\\C=C\\c1ccc2OCOc2c1
 xref: CAS:495-85-2;   KEGG:C09952;   KNApSAcK:C00003005
 xref_mesh: MESH:C076881


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Methysticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA] CTD PMID:21908763 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions 		ISO methysticin results in decreased activity of CES1 protein
methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate] 		CTD PMID:35278473 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression 		ISO 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased expression of CYP1A1 mRNA]; [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA]; methysticin results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:21908763 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity EXP methysticin results in decreased activity of CYP2C19 protein CTD PMID:16033948 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases activity EXP methysticin results in decreased activity of CYP2C9 protein CTD PMID:16033948 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:247,966,346...248,022,388 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methysticin results in increased expression of HMOX1 mRNA CTD PMID:28448946 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein] CTD PMID:28448946 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO methysticin affects the localization of NFE2L2 protein CTD PMID:28448946 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          oxygen atom 20457
            oxygen molecular entity 20457
              organooxygen compound 19806
                ether 17649
                  aromatic ether 16793
                    Methysticin 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  ester 17805
                                    carboxylic ester 17260
                                      lactone 13419
                                        delta-lactone 4379
                                          2-pyranones 775
                                            Methysticin 12
paths to the root