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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Methysticin
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Accession:CHEBI:6895 term browser browse the term
Definition:A 2-pyranone that has formula C15H14O5.
Synonyms:related_synonym: Formula=C15H14O5;   InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1;   InChIKey=GTEXBOVBADJOQH-FWEMWIAWSA-N;   SMILES=COC1=CC(=O)O[C@H](C1)\\C=C\\c1ccc2OCOc2c1
 xref: CAS:495-85-2;   KEGG:C09952;   KNApSAcK:C00003005
 xref_mesh: MESH:C076881


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Methysticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA] CTD PMID:21908763 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased expression of CYP1A1 mRNA]; [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA]; methysticin results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:21908763 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP methysticin results in decreased activity of CYP2C19 protein CTD PMID:16033948 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases activity EXP methysticin results in decreased activity of CYP2C9 protein CTD PMID:16033948 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methysticin results in increased expression of HMOX1 mRNA CTD PMID:28448946 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein] CTD PMID:28448946 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO methysticin affects the localization of NFE2L2 protein CTD PMID:28448946 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19808
      atom 19807
        nonmetal atom 19694
          oxygen atom 19432
            oxygen molecular entity 19432
              organooxygen compound 19001
                ether 16911
                  aromatic ether 16217
                    Methysticin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic ester 15892
                                        lactone 11245
                                          delta-lactone 3871
                                            2-pyranones 755
                                              Methysticin 11
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