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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Methysticin
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Accession:CHEBI:6895 term browser browse the term
Definition:A 2-pyranone that has formula C15H14O5.
Synonyms:related_synonym: Formula=C15H14O5;   InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1;   InChIKey=GTEXBOVBADJOQH-FWEMWIAWSA-N;   SMILES=COC1=CC(=O)O[C@H](C1)\\C=C\\c1ccc2OCOc2c1
 xref: CAS:495-85-2;   KEGG:C09952;   KNApSAcK:C00003005
 xref_mesh: MESH:C076881

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Methysticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA] CTD PMID:21908763 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased activity of CYP1A1 protein]; 3',4'-dimethoxyflavone inhibits the reaction [methysticin results in increased expression of CYP1A1 mRNA]; [methysticin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein affects the susceptibility to [methysticin results in increased activity of CYP1A1 protein]; AHR protein affects the susceptibility to [methysticin results in increased expression of CYP1A1 mRNA]; methysticin results in increased expression of and results in increased activity of CYP1A1 protein CTD PMID:21908763 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP methysticin results in decreased activity of CYP2C19 protein CTD PMID:16033948 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases activity EXP methysticin results in decreased activity of CYP2C9 protein CTD PMID:16033948 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO methysticin results in increased expression of GCLC mRNA CTD PMID:28448946 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO methysticin results in increased expression of HMOX1 mRNA CTD PMID:28448946 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein] CTD PMID:28448946 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO methysticin affects the localization of NFE2L2 protein CTD PMID:28448946 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein]; methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              organooxygen compound 18777
                ether 15937
                  aromatic ether 15393
                    Methysticin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        lactone 5978
                                          delta-lactone 3798
                                            2-pyranones 738
                                              Methysticin 11
paths to the root

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