Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bruceine D
go back to main search page
Accession:CHEBI:68931 term browser browse the term
Definition:A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.
Synonyms:exact_synonym: (1beta,11beta,12alpha,15beta)-1,11,12,14,15-pentahydroxy-13,20-epoxypicras-3-ene-2,16-dione
 related_synonym: Formula=C20H26O9;   InChI=1S/C20H26O9/c1-7-4-9(21)13(23)17(2)8(7)5-10-19-6-28-18(3,14(24)11(22)12(17)19)20(19,27)15(25)16(26)29-10/h4,8,10-15,22-25,27H,5-6H2,1-3H3/t8-,10+,11+,12+,13+,14-,15-,17-,18+,19+,20+/m0/s1;   InChIKey=JBDMZGKDLMGOFR-KQSRGDCESA-N;   SMILES=CC1=CC(=O)[C@@H](O)[C@@]2(C)[C@H]1C[C@H]1OC(=O)[C@H](O)[C@@]3(O)[C@]4(C)OC[C@]13[C@@H]2[C@@H](O)[C@@H]4O
 alt_id: CHEBI:3191
 xref: CAS:21499-66-1;   KEGG:C08752;   KNApSAcK:C00003702
 xref_mesh: MESH:C030412
 xref: PMID:22070654;   Reaxys:9674394


show annotations for term's descendants           Sort by:
bruceine D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions		 ISO bruceine D results in decreased expression of CTNNB1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of CTNNB1 protein]]; bruceine D affects the reaction [Oxygen deficiency affects the expression of CTNNB1 protein]; bruceine D inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]		 CTD PMID:34900531 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 decreases expression
affects binding
multiple interactions		 ISO bruceine D results in decreased expression of CTNNBIP1 protein
bruceine D binds to CTNNBIP1 protein
bruceine D inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]]; CTNNBIP1 protein affects the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]		 CTD PMID:34900531 NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression		 ISO bruceine D affects the reaction [Oxygen deficiency affects the expression of CYCS protein]
bruceine D results in decreased expression of CYCS protein		 CTD PMID:34900531 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO bruceine D inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; CTNNBIP1 protein affects the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Cycloheximide inhibits the reaction [bruceine D inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]
bruceine D results in decreased expression of HIF1A protein		 CTD PMID:34900531 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of HK2 protein]] CTD PMID:34900531 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression
multiple interactions		 ISO bruceine D results in decreased expression of LDHA protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of LDHA protein]]		 CTD PMID:34900531 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of PKM protein]] CTD PMID:34900531 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC16A3 protein]] CTD PMID:34900531 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
multiple interactions		 ISO bruceine D results in decreased expression of SLC2A1 protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A1 protein]]		 CTD PMID:34900531 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression
multiple interactions		 ISO bruceine D results in decreased expression of SLC2A3 protein
bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]; CTNNBIP1 protein affects the reaction [bruceine D affects the reaction [Oxygen deficiency affects the expression of SLC2A3 protein]]		 CTD PMID:34900531 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        biochemical role 19567
          metabolite 19552
            bruceine D 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic group 18957
                              organic divalent group 18938
                                organodiyl group 18938
                                  carbonyl group 18890
                                    carbonyl compound 18890
                                      ketone 17189
                                        oxyketone 8838
                                          alpha-oxyketone 8838
                                            alpha-hydroxy ketone 8838
                                              secondary alpha-hydroxy ketone 1036
                                                bruceine D 10
paths to the root