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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylphenidate
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Accession:CHEBI:6887 term browser browse the term
Definition:A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
Synonyms:exact_synonym: rac-methyl (2R)-phenyl[(2R)-piperidin-2-yl]acetate
 related_synonym: Daytrana;   Formula=C14H19NO2;   dl-threo-methylphenidate;   methyl rac-threo-alpha-phenyl-alpha-2-piperidinylacetate;   methyl rac-threo-phenidylacetate;   methylphenidan;   methylphenidatum;   metilfenidato;   rac-threo-alpha-phenyl-2-piperidineacetic acid methyl ester;   rac-threo-methyl alpha-phenyl-alpha-(2-piperidyl)acetate;   threo-(+-)-methylphenidate
 xref: Beilstein:200061;   CAS:113-45-1;   CAS:20748-11-2;   DrugBank:DB00422;   HMDB:HMDB0014566;   KEGG:C07196;   KEGG:D04999
 xref_mesh: MESH:D008774
 xref: PMID:10786896;   PMID:11160455;   PMID:11862378;   PMID:16953648;   PMID:17201613;   PMID:18670250;   PMID:18978488;   PMID:22098932;   PMID:23104969;   PMID:23813595;   PMID:23975034;   PMID:25433180;   PMID:25449360;   PMID:25553710;   Patent:US2507631;   Patent:US2957880;   Reaxys:200061;   Wikipedia:Methylphenidate
 cyclic_relationship: is_conjugate_base_of CHEBI:51856


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methylphenidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B decreases expression ISO Methylphenidate results in decreased expression of AKR1B3 mRNA CTD PMID:22470460 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression ISO Methylphenidate results in increased expression of AP2B1 mRNA CTD PMID:22470460 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression ISO Methylphenidate results in decreased expression of ARAP1 mRNA CTD PMID:22470460 NCBI chr 1:166,459,062...166,525,200
Ensembl chr 1:166,478,005...166,525,255
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP Methylphenidate affects the expression of ARC mRNA CTD PMID:19222557 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression ISO Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 NCBI chr 8:117,387,004...117,446,085
Ensembl chr 8:117,387,010...117,446,019
JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression ISO Methylphenidate results in decreased expression of ARMC9 mRNA CTD PMID:22470460 NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750
JBrowse link
G B4galt4 beta-1,4-galactosyltransferase 4 decreases expression ISO Methylphenidate results in decreased expression of B4GALT4 mRNA CTD PMID:22470460 NCBI chr11:64,558,006...64,584,054
Ensembl chr11:64,557,977...64,583,994
JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression ISO Methylphenidate results in decreased expression of BCL9 mRNA CTD PMID:22470460 NCBI chr 2:199,334,644...199,420,083
Ensembl chr 2:199,334,664...199,354,793
JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression
multiple interactions
decreases expression
EXP
ISO
Methylphenidate affects the expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]
Methylphenidate results in decreased expression of BDNF mRNA
CTD PMID:19222557, PMID:22470460, PMID:24394491 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G C2 complement C2 increases expression ISO Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G Cald1 caldesmon 1 increases expression ISO Methylphenidate results in increased expression of CALD1 mRNA CTD PMID:22470460 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO Methylphenidate results in increased expression of CBR3 mRNA CTD PMID:22470460 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ccdc166 coiled-coil domain containing 166 decreases expression ISO Methylphenidate results in decreased expression of CCDC166 mRNA CTD PMID:22470460 NCBI chr 7:117,039,890...117,041,693
Ensembl chr 7:117,039,892...117,041,693
JBrowse link
G Ccdc91 coiled-coil domain containing 91 decreases expression ISO Methylphenidate results in decreased expression of CCDC91 mRNA CTD PMID:22470460 NCBI chr 4:181,873,465...182,043,593
Ensembl chr 4:181,874,861...182,043,593
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Methylphenidate results in increased expression of CDK5R1 mRNA CTD PMID:22470460 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
increases metabolic processing
ISO [CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate
CTD PMID:15082749, PMID:18485328, PMID:20097249, PMID:25445008 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Methylphenidate results in increased expression of CHD2 mRNA CTD PMID:22470460 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167
JBrowse link
G Chga chromogranin A decreases expression ISO Methylphenidate results in decreased expression of CHGA mRNA CTD PMID:22470460 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Chid1 chitinase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of CHID1 mRNA CTD PMID:22470460 NCBI chr 1:214,476,418...214,511,569
Ensembl chr 1:214,476,387...214,511,529
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression ISO Methylphenidate results in decreased expression of CHRNA6 mRNA CTD PMID:22470460 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718
JBrowse link
G Chst8 carbohydrate sulfotransferase 8 decreases expression ISO Methylphenidate results in decreased expression of CHST8 mRNA CTD PMID:22470460 NCBI chr 1:90,542,095...90,685,257
Ensembl chr 1:90,542,096...90,685,257
JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Methylphenidate results in increased expression of CLPX mRNA CTD PMID:22470460 NCBI chr 8:70,789,137...70,843,133
Ensembl chr 8:70,789,256...70,843,123
JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 increases expression ISO Methylphenidate results in increased expression of CNNM1 mRNA CTD PMID:22470460 NCBI chr 1:263,184,361...263,243,912
Ensembl chr 1:263,186,235...263,242,468
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like decreases expression ISO Methylphenidate results in decreased expression of CNOT6L mRNA CTD PMID:22470460 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Methylphenidate results in increased expression of CNR1 mRNA CTD PMID:22470460 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of COMTD1 mRNA CTD PMID:22470460 NCBI chr15:2,631,529...2,634,640
Ensembl chr15:2,631,529...2,634,640
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases expression
EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein
Methylphenidate results in decreased expression of CREB mRNA
CTD PMID:21753012 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression ISO Methylphenidate results in decreased expression of D2HGDH mRNA CTD PMID:22470460 NCBI chr 9:100,956,570...100,974,393
Ensembl chr 9:100,956,477...100,974,551
JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Methylphenidate results in increased expression of DAB2 mRNA CTD PMID:22470460 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dapk3 death-associated protein kinase 3 decreases expression ISO Methylphenidate results in decreased expression of DAPK3 mRNA CTD PMID:22470460 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805
JBrowse link
G Dhx35 DEAH-box helicase 35 decreases expression ISO Methylphenidate results in decreased expression of DHX35 mRNA CTD PMID:22470460 NCBI chr 3:155,297,545...155,354,857
Ensembl chr 3:155,297,566...155,356,462
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate CTD PMID:11454915 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
affects expression
EXP
ISO
[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of DRD2 mRNA
Methylphenidate affects the expression of DRD2 protein
CTD PMID:11454915, PMID:17599397, PMID:22470460 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd4 dopamine receptor D4 affects response to substance ISO DRD4 promoter mutant form affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA] CTD PMID:16549270, PMID:19931852, PMID:20020108, PMID:21753012 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 decreases expression ISO Methylphenidate results in decreased expression of ENTPD5 mRNA CTD PMID:22470460 NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 decreases expression ISO Methylphenidate results in decreased expression of EPB41L1 mRNA CTD PMID:22470460 NCBI chr 3:152,492,725...152,622,047
Ensembl chr 3:152,552,822...152,619,722
JBrowse link
G Epha10 EPH receptor A10 decreases expression ISO Methylphenidate results in decreased expression of EPHA10 mRNA CTD PMID:22470460 NCBI chr 5:142,875,171...142,910,537
Ensembl chr 5:142,875,773...142,908,395
JBrowse link
G Exog exo/endonuclease G decreases expression ISO Methylphenidate results in decreased expression of EXOG mRNA CTD PMID:22470460 NCBI chr 8:128,133,398...128,153,110
Ensembl chr 8:128,133,431...128,153,110
JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 decreases expression ISO Methylphenidate results in decreased expression of FANK1 mRNA CTD PMID:22470460 NCBI chr 1:205,842,469...205,954,152
Ensembl chr 1:205,842,489...205,950,371
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression ISO Methylphenidate results in increased expression of FCGR2B mRNA CTD PMID:22470460 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
ISO
EXP
[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]
Methylphenidate results in increased expression of FOS protein
Methylphenidate results in decreased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein
CTD PMID:12112414, PMID:12699766, PMID:15916815, PMID:19931852, PMID:21753012 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylphenidate results in increased expression of FOSB protein CTD PMID:15916815 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 decreases expression ISO Methylphenidate results in decreased expression of GALNT10 mRNA CTD PMID:22470460 NCBI chr10:43,067,316...43,208,992
Ensembl chr10:43,067,299...43,210,427
JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression ISO Methylphenidate results in decreased expression of GCH1 mRNA CTD PMID:22470460 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression ISO Methylphenidate results in decreased expression of GDNF mRNA CTD PMID:22470460 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Ghdc GH3 domain containing decreases expression ISO Methylphenidate results in decreased expression of GHDC mRNA CTD PMID:22470460 NCBI chr10:88,672,834...88,677,055
Ensembl chr10:88,672,843...88,677,055
JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression ISO Methylphenidate results in decreased expression of GRIK3 mRNA CTD PMID:22470460 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
JBrowse link
G Gucy2c guanylate cyclase 2C decreases expression ISO Methylphenidate results in decreased expression of GUCY2C mRNA CTD PMID:22470460 NCBI chr 4:170,659,993...170,740,274
Ensembl chr 4:170,659,998...170,740,274
JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Methylphenidate results in decreased expression of HBP1 mRNA CTD PMID:22470460 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions
EXP Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]
CTD PMID:16549270 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression ISO Methylphenidate results in decreased expression of HSPB6 mRNA CTD PMID:22470460 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
JBrowse link
G Il6 interleukin 6 increases expression ISO Methylphenidate results in increased expression of IL6 mRNA CTD PMID:22470460 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 increases expression ISO Methylphenidate results in increased expression of IP6K1 mRNA CTD PMID:22470460 NCBI chr 8:116,781,957...116,826,152
Ensembl chr 8:116,804,451...116,823,540
JBrowse link
G Jak3 Janus kinase 3 decreases expression ISO Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Kifc3 kinesin family member C3 decreases expression ISO Methylphenidate results in decreased expression of KIFC3 mRNA CTD PMID:22470460 NCBI chr19:10,305,405...10,339,186
Ensembl chr19:10,320,604...10,339,178
JBrowse link
G Lad1 ladinin 1 decreases expression ISO Methylphenidate results in decreased expression of LAD1 mRNA CTD PMID:22470460 NCBI chr13:52,645,257...52,659,619
Ensembl chr13:52,645,257...52,659,619
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Methylphenidate results in decreased expression of LAMA3 mRNA CTD PMID:22470460 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression ISO Methylphenidate results in decreased expression of LARGE1 mRNA CTD PMID:22470460 NCBI chr19:12,481,563...12,945,320
Ensembl chr19:12,481,540...12,942,963
JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO Methylphenidate results in increased expression of LASP1 mRNA CTD PMID:22470460 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression ISO Methylphenidate results in decreased expression of LGALS3BP mRNA CTD PMID:22470460 NCBI chr10:107,415,334...107,424,672
Ensembl chr10:107,415,326...107,424,710
JBrowse link
G Lhfpl5 LHFPL tetraspan subfamily member 5 decreases expression ISO Methylphenidate results in decreased expression of LHFPL5 mRNA CTD PMID:22470460 NCBI chr20:5,815,837...5,826,137
Ensembl chr20:5,815,837...5,826,137
JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression ISO Methylphenidate results in decreased expression of LRRC27 mRNA CTD PMID:22470460 NCBI chr 1:211,543,751...211,575,823
Ensembl chr 1:211,543,751...211,575,820
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression ISO Methylphenidate results in decreased expression of MAP1LC3B mRNA CTD PMID:22470460 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
EXP Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein
CTD PMID:21753012 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Methylphenidate results in increased expression of MAPK8 mRNA CTD PMID:22470460 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mlc1 modulator of VRAC current 1 decreases expression ISO Methylphenidate results in decreased expression of MLC1 mRNA CTD PMID:22470460 NCBI chr 7:129,949,984...129,970,314
Ensembl chr 7:129,949,967...129,970,550
JBrowse link
G Morn2 MORN repeat containing 2 decreases expression ISO Methylphenidate results in decreased expression of MORN2 mRNA CTD PMID:22470460 NCBI chr 6:2,969,290...2,974,419
Ensembl chr 6:2,969,333...2,974,418
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
affects expression
EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate affects the expression of MTOR mRNA
CTD PMID:21753012 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mvp major vault protein decreases expression ISO Methylphenidate results in decreased expression of MVP mRNA CTD PMID:22470460 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
JBrowse link
G Nabp1 nucleic acid binding protein 1 increases expression ISO Methylphenidate results in increased expression of NABP1 mRNA CTD PMID:22470460 NCBI chr 9:55,049,893...55,057,784
Ensembl chr 9:55,050,203...55,057,658
JBrowse link
G Nacad NAC alpha domain containing decreases expression ISO Methylphenidate results in decreased expression of NACAD mRNA CTD PMID:22470460 NCBI chr14:86,860,607...86,868,605
Ensembl chr14:86,860,608...86,868,598
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 decreases expression ISO Methylphenidate results in decreased expression of NCOR2 mRNA CTD PMID:22470460 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Methylphenidate results in increased expression of NETO2 mRNA CTD PMID:22470460 NCBI chr19:22,450,579...22,486,530
Ensembl chr19:22,450,030...22,486,531
JBrowse link
G Nol3 nucleolar protein 3 decreases expression ISO Methylphenidate results in decreased expression of NOL3 mRNA CTD PMID:22470460 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649
JBrowse link
G Nsun4 NOP2/Sun RNA methyltransferase 4 increases expression ISO Methylphenidate results in increased expression of NSUN4 mRNA CTD PMID:22470460 NCBI chr 5:134,885,377...134,905,492
Ensembl chr 5:134,886,497...134,905,588
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 increases expression ISO Methylphenidate results in increased expression of PARP3 mRNA CTD PMID:22470460 NCBI chr 8:115,173,440...115,179,543
Ensembl chr 8:115,173,453...115,179,191
JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 increases expression ISO Methylphenidate results in increased expression of PEAR1 mRNA CTD PMID:22470460 NCBI chr 2:187,114,219...187,134,209
Ensembl chr 2:187,114,217...187,133,993
JBrowse link
G Peds1 plasmanylethanolamine desaturase 1 decreases expression ISO Methylphenidate results in decreased expression of TMEM189 mRNA CTD PMID:22470460 NCBI chr 3:164,376,621...164,388,213
Ensembl chr 3:164,376,630...164,388,492
JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression ISO Methylphenidate results in decreased expression of PISD mRNA CTD PMID:22470460 NCBI chr14:83,298,630...83,347,697
Ensembl chr14:83,298,674...83,346,738
JBrowse link
G Pkn1 protein kinase N1 decreases expression ISO Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 NCBI chr19:24,803,524...24,832,305
Ensembl chr19:24,803,524...24,831,500
JBrowse link
G Pnma8b PNMA family member 8B increases expression ISO Methylphenidate results in increased expression of PNMAL2 mRNA CTD PMID:22470460 NCBI chr 1:78,876,205...78,878,779
Ensembl chr 1:78,876,205...78,878,779
JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression ISO Methylphenidate results in increased expression of PRKG2 mRNA CTD PMID:22470460 NCBI chr14:12,217,121...12,313,616
Ensembl chr14:12,218,553...12,315,229
JBrowse link
G Prlr prolactin receptor decreases expression ISO Methylphenidate results in decreased expression of PRLR mRNA CTD PMID:22470460 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Prpf39 pre-mRNA processing factor 39 increases expression ISO Methylphenidate results in increased expression of PRPF39 mRNA CTD PMID:22470460 NCBI chr 6:86,785,793...86,810,806
Ensembl chr 6:86,785,771...86,810,316
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 decreases expression ISO Methylphenidate results in decreased expression of PTDSS2 mRNA CTD PMID:22470460 NCBI chr 1:214,122,981...214,148,011
Ensembl chr 1:214,123,044...214,149,729
JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 increases expression ISO Methylphenidate results in increased expression of PTPN21 mRNA CTD PMID:22470460 NCBI chr 6:122,656,500...122,721,496
Ensembl chr 6:122,656,500...122,721,496
JBrowse link
G Pus7l pseudouridine synthase 7 like decreases expression ISO Methylphenidate results in decreased expression of PUS7L mRNA CTD PMID:22470460 NCBI chr 7:135,765,307...135,803,818
Ensembl chr 7:135,765,303...135,800,481
JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression ISO Methylphenidate results in increased expression of RAB38 mRNA CTD PMID:22470460 NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO Methylphenidate results in decreased expression of RACGAP1 mRNA CTD PMID:22470460 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases expression ISO Methylphenidate results in increased expression of RBFOX1 mRNA CTD PMID:22470460 NCBI chr10:8,312,961...10,437,778
Ensembl chr10:8,312,961...8,654,892
JBrowse link
G Rcc2 regulator of chromosome condensation 2 decreases expression ISO Methylphenidate results in decreased expression of RCC2 mRNA CTD PMID:22470460 NCBI chr 5:159,220,531...159,236,313
Ensembl chr 5:159,220,979...159,234,320
JBrowse link
G Ret ret proto-oncogene decreases expression ISO Methylphenidate results in decreased expression of RET mRNA CTD PMID:22470460 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a decreases expression ISO Methylphenidate results in decreased expression of RGMA mRNA CTD PMID:22470460 NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514
JBrowse link
G Rgs20 regulator of G-protein signaling 20 decreases expression ISO Methylphenidate results in decreased expression of RGS20 mRNA CTD PMID:22470460 NCBI chr 5:14,367,498...14,494,048
Ensembl chr 5:14,415,606...14,494,756
JBrowse link
G Rhbdd2 rhomboid domain containing 2 decreases expression ISO Methylphenidate results in decreased expression of RHBDD2 mRNA CTD PMID:22470460 NCBI chr12:24,091,132...24,102,081
Ensembl chr12:24,092,004...24,102,084
JBrowse link
G Sdc3 syndecan 3 decreases expression ISO Methylphenidate results in decreased expression of SDC3 mRNA CTD PMID:22470460 NCBI chr 5:148,923,098...148,956,404
Ensembl chr 5:148,923,098...148,956,404
JBrowse link
G Siae sialic acid acetylesterase decreases expression ISO Methylphenidate results in decreased expression of SIAE mRNA CTD PMID:22470460 NCBI chr 8:40,078,269...40,113,514
Ensembl chr 8:40,078,269...40,113,514
JBrowse link
G Slc10a4 solute carrier family 10, member 4 decreases expression ISO Methylphenidate results in decreased expression of SLC10A4 mRNA CTD PMID:22470460 NCBI chr14:37,764,839...37,770,059
Ensembl chr14:37,764,839...37,770,059
JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression ISO Methylphenidate results in decreased expression of SLC18A2 mRNA CTD PMID:22470460 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases expression ISO Methylphenidate results in increased expression of SLC2A12 mRNA CTD PMID:22470460 NCBI chr 1:24,003,625...24,056,373
Ensembl chr 1:24,003,625...24,056,373
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases response to substance
affects response to substance
ISO [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methylphenidate results in decreased expression of SLC6A3 mRNA
Methylphenidate results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate
CTD PMID:12112414, PMID:12699766, PMID:15059031, PMID:16139732, PMID:17234900, PMID:18614672, PMID:19462300, PMID:22470460, PMID:31009648 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sncaip synuclein, alpha interacting protein increases expression ISO Methylphenidate results in increased expression of SNCAIP mRNA CTD PMID:22470460 NCBI chr18:47,739,284...47,877,679
Ensembl chr18:47,739,140...47,877,676
JBrowse link
G Sncg synuclein, gamma decreases expression ISO Methylphenidate results in decreased expression of SNCG mRNA CTD PMID:22470460 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707
JBrowse link
G Snx22 sorting nexin 22 decreases expression ISO Methylphenidate results in decreased expression of SNX22 mRNA CTD PMID:22470460 NCBI chr 8:71,725,405...71,728,729
Ensembl chr 8:71,725,771...71,728,685
JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression ISO Methylphenidate results in decreased expression of SORCS3 mRNA CTD PMID:22470460 NCBI chr 1:267,986,305...268,620,331
Ensembl chr 1:268,189,277...268,620,331
JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression ISO Methylphenidate results in increased expression of SOX11 mRNA CTD PMID:22470460 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression ISO Methylphenidate results in decreased expression of STAT5A mRNA CTD PMID:22470460 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stox2 storkhead box 2 increases expression ISO Methylphenidate results in increased expression of STOX2 mRNA CTD PMID:22470460 NCBI chr16:47,994,555...48,233,588
Ensembl chr16:48,120,864...48,228,891
JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component decreases expression ISO Methylphenidate results in decreased expression of SUDS3 mRNA CTD PMID:22470460 NCBI chr12:45,199,012...45,221,507
Ensembl chr12:45,199,577...45,221,512
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Methylphenidate results in decreased expression of TMEM185B mRNA CTD PMID:22470460 NCBI chr13:35,554,621...35,557,952
Ensembl chr13:35,554,964...35,556,016
JBrowse link
G Tmem30a transmembrane protein 30A decreases expression ISO Methylphenidate results in decreased expression of TMEM30A mRNA CTD PMID:22470460 NCBI chr 8:87,222,107...87,245,953
Ensembl chr 8:87,223,948...87,245,951
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Methylphenidate results in increased expression of TNF mRNA CTD PMID:22470460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Traf5 TNF receptor-associated factor 5 decreases expression ISO Methylphenidate results in decreased expression of TRAF5 mRNA CTD PMID:22470460 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209
JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Methylphenidate results in increased expression of TRIM25 mRNA CTD PMID:22470460 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
G Tspan17 tetraspanin 17 decreases expression ISO Methylphenidate results in decreased expression of TSPAN17 mRNA CTD PMID:22470460 NCBI chr17:10,356,980...10,364,614
Ensembl chr17:10,356,936...10,364,570
JBrowse link
G Ttf1 transcription termination factor 1 increases expression ISO Methylphenidate results in increased expression of TTF1 mRNA CTD PMID:22470460 NCBI chr 3:7,635,630...7,660,153
Ensembl chr 3:7,635,933...7,660,673
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 decreases expression ISO Methylphenidate results in decreased expression of TWSG1 mRNA CTD PMID:22470460 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622
JBrowse link
G Ube3d ubiquitin protein ligase E3D decreases expression ISO Methylphenidate results in decreased expression of UBE2CBP mRNA CTD PMID:22470460 NCBI chr 8:93,948,689...94,120,477
Ensembl chr 8:93,948,767...94,120,458
JBrowse link
G Ubxn10 UBX domain protein 10 decreases expression ISO Methylphenidate results in decreased expression of UBXN10 mRNA CTD PMID:22470460 NCBI chr 5:157,158,129...157,165,767
Ensembl chr 5:157,159,936...157,165,767
JBrowse link
G Uck2 uridine-cytidine kinase 2 decreases expression ISO Methylphenidate results in decreased expression of UCK2 mRNA CTD PMID:22470460 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976
JBrowse link
G Vash1 vasohibin 1 increases expression ISO Methylphenidate results in increased expression of VASH1 mRNA CTD PMID:22470460 NCBI chr 6:110,624,377...110,640,942
Ensembl chr 6:110,624,856...110,637,382
JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) decreases expression ISO Methylphenidate results in decreased expression of WARS2 mRNA CTD PMID:22470460 NCBI chr 2:201,170,363...201,256,115
Ensembl chr 2:201,172,312...201,255,703
JBrowse link
G Zfp14 ZFP14 zinc finger protein decreases expression ISO Methylphenidate results in decreased expression of ZFP14 mRNA CTD PMID:22470460 NCBI chr 1:88,350,361...88,367,370
Ensembl chr 1:88,350,361...88,361,851
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      chemical substance 11928
        mixture 10845
          racemate 9741
            methylphenidate 127
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        amino acid 14072
                                          non-proteinogenic amino acid 1773
                                            beta-amino acid 183
                                              beta-amino acid ester 127
                                                methyl phenyl(piperidin-2-yl)acetate 127
                                                  methyl (S)-phenyl[(S)-piperidin-2-yl]acetate 127
                                                    methylphenidate 127
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.