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ONTOLOGY REPORT - ANNOTATIONS


Term:azilsartan
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Accession:CHEBI:68850 term browser browse the term
Definition:A benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) for treatment of hypertension.
Synonyms:exact_synonym: 2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
 related_synonym: Formula=C25H20N4O5;   InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32);   InChIKey=KGSXMPPBFPAXLY-UHFFFAOYSA-N;   SMILES=CCOc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1;   TAK-536
 xref: CAS:147403-03-0 "ChemIDplus";   CAS:147403-03-0 "KEGG DRUG";   KEGG:D08864
 xref_mesh: MESH:C521273
 xref: PMID:21749604 "Europe PMC";   PMID:21983318 "Europe PMC";   PMID:21986624 "Europe PMC";   PMID:22278628 "Europe PMC";   PMID:22365278 "Europe PMC";   PMID:22399858 "Europe PMC";   PMID:22661897 "Europe PMC";   PMID:22728984 "Europe PMC";   PMID:22745562 "Europe PMC";   PMID:22975662 "Europe PMC";   PMID:23012812 "Europe PMC";   PMID:23034464 "Europe PMC";   PMID:23051655 "Europe PMC";   Patent:EP1787647;   Patent:US2005187269;   Patent:WO2012107814;   Reaxys:7673311 "Reaxys";   Wikipedia:Azilsartan


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azilsartan term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            cardiovascular drug 7550
              antihypertensive agent 1637
                azilsartan 3
                  azilsartan medoxomil 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          benzimidazolecarboxylic acid 71
                                            azilsartan 3
                                              azilsartan medoxomil 0
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