Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphodiesterase IV inhibitor
go back to main search page
Accession:CHEBI:68844 term browser browse the term
Definition:An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.
Synonyms:related_synonym: PDE4 inhibitor;   PDE4 inhibitors;   phosphodiesterase 4 inhibitor;   phosphodiesterase 4 inhibitors;   phosphodiesterase IV inhibitors;   type 4 phosphodiesterase inhibitor;   type 4 phosphodiesterase inhibitors
 xref: Wikipedia:Phosphodiesterase-4_inhibitor


show annotations for term's descendants           Sort by:
 
etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion
ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein
CTD PMID:16083514 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
piclamilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of piclamilast CTD PMID:12464242 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP piclamilast inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein
CTD PMID:18276108 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Pde3a phosphodiesterase 3A decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Pde3b phosphodiesterase 3B decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO Roflumilast results in decreased activity of PDE4A protein CTD PMID:15901792 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B decreases activity ISO Roflumilast results in decreased activity of PDE4B protein CTD PMID:15901792 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4c phosphodiesterase 4C decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr16:20,442,305...20,466,386
Ensembl chr16:20,442,609...20,460,959
Ensembl chr16:20,442,609...20,460,959
JBrowse link
G Pde4d phosphodiesterase 4D decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression
EXP RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein
CTD PMID:18276108 NCBI chr 7:139,232,263...139,254,668
Ensembl chr 7:139,232,251...139,254,551
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21913898 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,776,046...70,779,249
Ensembl chr 4:70,776,046...70,779,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            EC 3.* (hydrolase) inhibitor 17660
              EC 3.1.* (ester hydrolase) inhibitor 12877
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 1349
                  EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 31
                    phosphodiesterase IV inhibitor 31
                      SCH-351591 8
                      apremilast 0
                      crisaborole 0
                      etazolate 2
                      piclamilast 2
                      roflumilast 19
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.