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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chaetoglobosin A
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Accession:CHEBI:68798 term browser browse the term
Definition:A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
Synonyms:exact_synonym: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16bR)-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trione
 related_synonym: Formula=C32H36N2O5;   InChI=1S/C32H36N2O5/c1-17-8-7-10-22-29-31(4,39-29)19(3)27-24(15-20-16-33-23-11-6-5-9-21(20)23)34-30(38)32(22,27)26(36)13-12-25(35)28(37)18(2)14-17/h5-7,9-14,16-17,19,22,24,27-29,33,37H,8,15H2,1-4H3,(H,34,38)/b10-7+,13-12+,18-14+/t17-,19-,22-,24-,27-,28+,29?,31+,32+/m0/s1;   InChIKey=OUMWCYMRLMEZJH-VOXRAUTJSA-N;   SMILES=[H][C@@]12O[C@]1(C)[C@@H](C)[C@@]1([H])[C@H](CC3=CNC4=CC=CC=C34)NC(=O)[C@@]11[C@H]2\\C=C\\C[C@H](C)\\C=C(C)\\[C@@H](O)C(=O)\\C=C\\C1=O
 xref: CAS:50335-03-0;   KNApSAcK:C00011307;   LIPID_MAPS_instance:LMPK11000003
 xref_mesh: MESH:C019290
 xref: PMID:12483566;   PMID:19246197;   PMID:23214998;   PMID:23611317;   PMID:436014;   Reaxys:5787518;   Wikipedia:Chaetoglobosin_A



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chaetoglobosin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of AKT1 protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]
CTD PMID:18040759 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP chaetoglobosins inhibits the reaction [Dieldrin results in decreased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein] CTD PMID:18040759 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
EXP chaetoglobosins results in increased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]
CTD PMID:18040759 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:33285210 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:33285210 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:33285210 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of IRF7 mRNA] CTD PMID:33285210 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK1 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
chaetoglobosins results in increased phosphorylation of MAPK3 protein
chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:18040759 PMID:33285210 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA] CTD PMID:33285210 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:33285210 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:33285210 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation EXP chaetoglobosins results in decreased phosphorylation of RAF1 protein CTD PMID:18040759 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33285210 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:33285210 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; chaetoglobosins inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; chaetoglobosins results in increased expression of and results in increased secretion of TNF protein CTD PMID:28535995 PMID:33285210 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19808
      molecular entity 19807
        main group molecular entity 19704
          gas molecular entity 17922
            oxirane 9749
              epoxide 9748
                chaetoglobosin A 16
                  chaetoglobosin P 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        oxyketone 8657
                                          alpha-oxyketone 8657
                                            alpha-hydroxy ketone 8657
                                              secondary alpha-hydroxy ketone 892
                                                chaetoglobosin A 16
                                                  chaetoglobosin P 0
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