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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:asperentin
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Accession:CHEBI:68792 term browser browse the term
Definition:A member of the class of isocoumarins that is 6,8-dihydroxy-3,4-dihydro-1H-isochromen-1-one substituted by a [6-methyltetrahydro-2H-pyran-2-yl]methyl group at position 3. It has been isolated from the fungus Chaetomium globosum and Aspergillus flavus.
Synonyms:exact_synonym: 6,8-dihydroxy-3-{[(2R,6S)-6-methyltetrahydro-2H-pyran-2-yl]methyl}-3,4-dihydro-1H-isochromen-1-one
 related_synonym: 3,4-dihydro-6,8-dihydroxy-3-(tetrahydro-6-methyl-H-pyran-2-yl)methylisocoumarin;   Formula=C16H20O5;   InChI=1S/C16H20O5/c1-9-3-2-4-12(20-9)8-13-6-10-5-11(17)7-14(18)15(10)16(19)21-13/h5,7,9,12-13,17-18H,2-4,6,8H2,1H3/t9-,12+,13?/m0/s1;   InChIKey=WOMKDMUZNBFXKG-XAWKZAOJSA-N;   SMILES=[H][C@@]1(CCC[C@H](C)O1)CC1Cc2cc(O)cc(O)c2C(=O)O1;   cladosporin
 xref: CAS:35818-31-6;   Chemspider:34206
 xref_mesh: MESH:C000488
 xref: PMID:17125234;   PMID:22663064;   PMID:22704625;   PMID:23413753;   PMID:4629903;   PMID:5169000;   Reaxys:5086911


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asperentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO cladosporin results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO cladosporin results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 2:237,727,782...237,751,327
Ensembl chr 2:237,727,764...237,751,378
JBrowse link
G Blvrb biliverdin reductase B increases expression ISO cladosporin results in increased expression of BLVRB mRNA CTD PMID:21356202 NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 increases expression ISO cladosporin results in increased expression of CCL12 mRNA CTD PMID:21356202 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO cladosporin results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
decreases expression
ISO cladosporin results in increased expression of CCL20 mRNA
cladosporin results in decreased expression of CCL20 mRNA
CTD PMID:19818335, PMID:21356202 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO cladosporin results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr12:2,429,492...2,438,928
Ensembl chr12:2,429,509...2,438,817
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO cladosporin results in decreased expression of CCL3 mRNA CTD PMID:19818335, PMID:21356202 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO cladosporin results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO cladosporin results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO cladosporin results in increased expression of CCR1 mRNA CTD PMID:19818335 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO cladosporin results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO cladosporin results in increased expression of CCR2 mRNA CTD PMID:19818335
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO cladosporin results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO cladosporin results in increased expression of CCR4 mRNA CTD PMID:19818335 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO cladosporin results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO cladosporin results in increased expression of CCR7 mRNA CTD PMID:19818335 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression ISO cladosporin results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130
JBrowse link
G Cd40lg CD40 ligand increases expression ISO cladosporin results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO cladosporin results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression
increases expression
ISO cladosporin results in decreased expression of CXCL10 mRNA
cladosporin results in increased expression of CXCL10 protein
CTD PMID:19818335, PMID:21356202 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 decreases expression ISO cladosporin results in decreased expression of CXCL11 mRNA CTD PMID:19818335 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO cladosporin results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO cladosporin results in increased expression of CXCL13 mRNA CTD PMID:19818335 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO cladosporin results in increased expression of CXCL2 mRNA; cladosporin results in increased expression of CXCL2 protein CTD PMID:19818335, PMID:21356202 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
increases expression
ISO cladosporin results in decreased expression of CXCL1 mRNA
cladosporin results in increased expression of CXCL1 mRNA
CTD PMID:19818335, PMID:21356202 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO cladosporin results in decreased expression of CXCR2 mRNA
cladosporin results in increased expression of CXCR2 mRNA
CTD PMID:19818335 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO cladosporin results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO cladosporin results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 8:48,835,688...48,852,032
Ensembl chr 8:48,836,957...48,850,671
JBrowse link
G Ifng interferon gamma increases expression ISO cladosporin results in increased expression of IFNG mRNA CTD PMID:19818335 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression ISO cladosporin results in increased expression of IL10 mRNA CTD PMID:19818335 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO cladosporin results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO cladosporin results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il15 interleukin 15 increases expression ISO cladosporin results in increased expression of IL15 mRNA CTD PMID:19818335 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il16 interleukin 16 increases expression ISO cladosporin results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il18 interleukin 18 increases expression ISO cladosporin results in increased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
ISO cladosporin results in increased expression of IL1B mRNA
cladosporin results in decreased expression of IL1B mRNA
CTD PMID:19818335, PMID:21356202 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO cladosporin results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO cladosporin results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
JBrowse link
G Il4 interleukin 4 increases expression ISO cladosporin results in increased expression of IL4 mRNA CTD PMID:19818335 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5ra interleukin 5 receptor subunit alpha increases expression ISO cladosporin results in increased expression of IL5RA mRNA CTD PMID:19818335 NCBI chr 4:138,796,165...138,834,164
Ensembl chr 4:138,795,327...138,830,117
JBrowse link
G Il6 interleukin 6 increases expression ISO cladosporin results in increased expression of IL6 mRNA CTD PMID:21356202 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO cladosporin results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO cladosporin results in decreased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO cladosporin results in increased expression of ITGAM mRNA CTD PMID:19818335 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G LOC103694381 lymphotoxin-beta increases expression ISO cladosporin results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr20:4,861,343...4,863,513
Ensembl chr20:4,861,335...4,863,198
JBrowse link
G Lta lymphotoxin alpha increases expression ISO cladosporin results in increased expression of LTA mRNA CTD PMID:19818335 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO cladosporin results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO cladosporin results in increased expression of SPP1 mRNA CTD PMID:19818335 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression
ISO cladosporin results in decreased expression of TNF mRNA
cladosporin results in increased expression of TNF mRNA
CTD PMID:19818335, PMID:21356202 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO cladosporin results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antifungal agent 14872
            asperentin 51
              5'-hydroxy-asperentin-8-O-methylether 0
              5'-hydroxyasperentin 0
              asperentin-8-methyl ether 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          delta-lactone 3799
                                            isocoumarins 1314
                                              asperentin 51
                                                5'-hydroxy-asperentin-8-O-methylether 0
                                                5'-hydroxyasperentin 0
                                                asperentin-8-methyl ether 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.