Term: | sch 210972 |
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Accession: | CHEBI:68749
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Definition: | A member of the class of pyrrolidin-2-ones isolated from the fungal fermentation broth of Chaetomium globosum and shown to exhibit inhibitory activity against chemokine receptor CCR-5. |
Synonyms: | exact_synonym: | (2S)-3-{(2S,4Z)-4-[{(1R,2S,4aR,6S,8R,8aS)-2-[(2E)-but-2-en-2-yl]-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl}(hydroxy)methylidene]-3,5-dioxopyrrolidin-2-yl}-2-hydroxy-2-methylpropanoic acid |
| related_synonym: | Formula=C25H35NO6; InChI=1S/C25H35NO6/c1-6-13(3)16-8-7-15-10-12(2)9-14(4)18(15)19(16)22(28)20-21(27)17(26-23(20)29)11-25(5,32)24(30)31/h6-8,12,14-19,28,32H,9-11H2,1-5H3,(H,26,29)(H,30,31)/b13-6+,22-20-/t12-,14+,15-,16+,17-,18-,19-,25-/m0/s1; InChIKey=AVZATKWNGXCSDN-IIRHHVPJSA-N; SMILES=[H][C@]12C[C@@H](C)C[C@@H](C)[C@]1([H])[C@@H](\\C(O)=C1\\C(=O)N[C@@H](C[C@](C)(O)C(O)=O)C1=O)[C@]([H])(C=C2)C(\\C)=C\\C; sch210972 |
| xref: | PMID:16872138; PMID:17827664; PMID:19413111; PMID:25450623; PMID:25885659; PMID:26360642; PMID:28387469 |
| cyclic_relationship: | is_conjugate_acid_of CHEBI:167897 |
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