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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chetomin
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Accession:CHEBI:68741 term browser browse the term
Definition:An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Synonyms:exact_synonym: 3-(hydroxymethyl)-10b-(3-{[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl}-1H-indol-1-yl)-2-methyl-2,3,5a,6,10b,11-hexahydro-3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
 related_synonym: Formula=C31H30N6O6S4;   InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3;   InChIKey=ZRZWBWPDBOVIGQ-UHFFFAOYSA-N;   SMILES=CN1C(=O)C23CC4(C(Nc5ccccc45)N2C(=O)C1(CO)SS3)n1cc(CC23SSC(CO)(N(C)C2=O)C(=O)N3C)c2ccccc12
 xref: CAS:1403-36-7;   Chemspider:2592
 xref_mesh: MESH:C001598
 xref: PMID:14738397;   Reaxys:5722511



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chetomin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:21926265 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]]
chetomin results in decreased expression of HIF1A mRNA
CTD PMID:19744167 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] CTD PMID:19744167 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO chetomin inhibits the reaction [aristolochic acid I results in increased expression of VEGFA protein]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]] CTD PMID:19744167 PMID:21554934 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        immunomodulator 15025
          immunosuppressive agent 13893
            chetomin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  organic heteropolycyclic compound 18254
                                    organic heterobicyclic compound 17226
                                      benzopyrrole 9603
                                        indoles 9275
                                          chetomin 4
paths to the root