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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chetomin
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Accession:CHEBI:68741 term browser browse the term
Definition:An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Synonyms:exact_synonym: 3-(hydroxymethyl)-10b-(3-{[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl}-1H-indol-1-yl)-2-methyl-2,3,5a,6,10b,11-hexahydro-3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
 related_synonym: Formula=C31H30N6O6S4;   InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3;   InChIKey=ZRZWBWPDBOVIGQ-UHFFFAOYSA-N;   SMILES=CN1C(=O)C23CC4(C(Nc5ccccc45)N2C(=O)C1(CO)SS3)n1cc(CC23SSC(CO)(N(C)C2=O)C(=O)N3C)c2ccccc12
 xref: CAS:1403-36-7;   Chemspider:2592
 xref_mesh: MESH:C001598
 xref: PMID:14738397;   Reaxys:5722511


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chetomin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:21926265 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]]
chetomin results in decreased expression of HIF1A mRNA
CTD PMID:19744167 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] CTD PMID:19744167 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO chetomin inhibits the reaction [aristolochic acid I results in increased expression of VEGFA protein]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]] CTD PMID:19744167, PMID:21554934 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        immunomodulator 13689
          immunosuppressive agent 11936
            chetomin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteropolycyclic compound 17820
                                    organic heterobicyclic compound 16742
                                      benzopyrrole 9339
                                        indoles 9193
                                          chetomin 4
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