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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:abiraterone
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Accession:CHEBI:68642 term browser browse the term
Definition:A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.
Synonyms:exact_synonym: 17-(pyridin-3-yl)androsta-5,16-dien-3beta-ol
 related_synonym: (3beta)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol;   17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;   Formula=C24H31NO;   InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1;   InChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=CC[C@@]21[H])c1cccnc1
 xref: CAS:154229-19-3
 xref_mesh: MESH:C089740
 xref: PDBeChem:AER;   PMID:21093995;   PMID:21239011;   PMID:21242338;   PMID:21326154;   PMID:21612468;   PMID:21729712;   PMID:21743442;   PMID:21807635;   PMID:21808270;   PMID:21857690;   PMID:21864180;   PMID:21864181;   PMID:21864182;   PMID:21878199;   PMID:22002259;   PMID:22170708;   PMID:22266943;   PMID:22331349;   PMID:22373884;   PMID:22402426;   PMID:22411952;   PMID:22451619;   PMID:22500680;   PMID:22611169;   PMID:22753664;   PMID:22763809;   PMID:22822591;   PMID:22915660;   PMID:23024987;   Patent:EP1336602;   Patent:US2011034428;   Patent:US5604213;   Patent:WO2012083112;   Reaxys:7309269;   Wikipedia:Abiraterone



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abiraterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor decreases response to substance ISO AR alternative form results in decreased susceptibility to abiraterone CTD PMID:25908785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cd46 CD46 molecule increases expression
decreases response to substance
ISO abiraterone results in increased expression of CD46 protein
CD46 protein results in decreased susceptibility to abiraterone
CTD PMID:30185663 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
multiple interactions
EXP
ISO
abiraterone results in decreased activity of CYP17A1 protein
abiraterone analog results in decreased activity of CYP17A1 protein; abiraterone results in decreased activity of CYP17A1 protein
[[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone] which results in increased chemical synthesis of 17-alpha-Hydroxypregnenolone; [[abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone] which results in increased chemical synthesis of 17-alpha-Hydroxyprogesterone; [abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Pregnenolone; [abiraterone results in decreased activity of CYP17A1 protein] which results in decreased hydroxylation of Progesterone
CTD PMID:17194026 PMID:25993309 PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 decreases expression ISO abiraterone results in decreased expression of EEF1A1 mRNA CTD PMID:27015953 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO abiraterone results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO abiraterone results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
JBrowse link

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  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            antineoplastic agent 17627
              abiraterone 6
                abiraterone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic polycyclic compound 17178
                                  steroid 14369
                                    hydroxy steroid 14085
                                      3-hydroxy steroid 12140
                                        sterol 455
                                          3beta-sterol 449
                                            abiraterone 6
                                              abiraterone acetate 0
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