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ONTOLOGY REPORT - ANNOTATIONS


Term:abiraterone
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Accession:CHEBI:68642 term browser browse the term
Definition:A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer.
Synonyms:exact_synonym: 17-(pyridin-3-yl)androsta-5,16-dien-3beta-ol
 related_synonym: (3beta)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol;   17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;   Formula=C24H31NO;   InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1;   InChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N;   SMILES=[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=CC[C@@]21[H])c1cccnc1
 xref: CAS:154229-19-3 "ChemIDplus"
 xref_mesh: MESH:C089740
 xref: PDBeChem:AER;   PMID:21093995 "Europe PMC";   PMID:21239011 "Europe PMC";   PMID:21242338 "Europe PMC";   PMID:21326154 "Europe PMC";   PMID:21612468 "Europe PMC";   PMID:21729712 "Europe PMC";   PMID:21743442 "Europe PMC";   PMID:21807635 "Europe PMC";   PMID:21808270 "Europe PMC";   PMID:21857690 "Europe PMC";   PMID:21864180 "Europe PMC";   PMID:21864181 "Europe PMC";   PMID:21864182 "Europe PMC";   PMID:21878199 "Europe PMC";   PMID:22002259 "Europe PMC";   PMID:22170708 "Europe PMC";   PMID:22266943 "Europe PMC";   PMID:22331349 "Europe PMC";   PMID:22373884 "Europe PMC";   PMID:22402426 "Europe PMC";   PMID:22411952 "Europe PMC";   PMID:22451619 "Europe PMC";   PMID:22500680 "Europe PMC";   PMID:22611169 "Europe PMC";   PMID:22753664 "Europe PMC";   PMID:22763809 "Europe PMC";   PMID:22822591 "Europe PMC";   PMID:22915660 "Europe PMC";   PMID:23024987 "Europe PMC";   Patent:EP1336602;   Patent:US2011034428;   Patent:US5604213;   Patent:WO2012083112;   Reaxys:7309269 "Reaxys";   Wikipedia:Abiraterone


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abiraterone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 JBrowse link 8 85,838,594 85,841,816 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              abiraterone 6
                abiraterone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic polycyclic compound 16028
                                  steroid 12767
                                    hydroxy steroid 12357
                                      3-hydroxy steroid 9982
                                        sterol 408
                                          3beta-sterol 402
                                            abiraterone 6
                                              abiraterone acetate 0
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