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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dexamethasone phosphate
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Accession:CHEBI:68637 term browser browse the term
Definition:A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Synonyms:exact_synonym: (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
 related_synonym: Betnelan phosphate;   Dexamethasone 21-orthophosphate;   Dexamethasone-21-dihydrogen-phosphate;   Formula=C22H30FO8P;   Hexadrol phosphate;   InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=VQODGRNSFPNSQE-CXSFZGCWSA-N;   Neodecadron;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COP(O)(O)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
 xref: CAS:312-93-6;   Drug_Central:3920
 xref_mesh: MESH:C004180
 xref: PMID:19910302;   PMID:20003498;   PMID:20642832;   PMID:21629568;   PMID:22115712;   Reaxys:2230371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68638


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dexamethasone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]; dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:25447644 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]; dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dexamethasone 21-phosphate results in increased cleavage of PARP1 protein CTD PMID:25447644 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]
dexamethasone 21-phosphate affects the localization of RELA protein
CTD PMID:17931716 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form
CTD PMID:25447644 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        xenobiotic 18398
          dexamethasone 4503
            dexamethasone phosphate 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      ketone 16828
                                        oxo steroid 9719
                                          3-oxo steroid 9276
                                            3-oxo-Delta(1) steroid 5141
                                              3-oxo-Delta(1),Delta(4)-steroid 5141
                                                dexamethasone 4503
                                                  dexamethasone phosphate 10
paths to the root