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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dexamethasone phosphate
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Accession:CHEBI:68637 term browser browse the term
Definition:A steroid phosphate that is the 21-O-phospho derivative of dexamethasone.
Synonyms:exact_synonym: (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate
 related_synonym: Betnelan phosphate;   Dexamethasone 21-orthophosphate;   Dexamethasone-21-dihydrogen-phosphate;   Formula=C22H30FO8P;   Hexadrol phosphate;   InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1;   InChIKey=VQODGRNSFPNSQE-CXSFZGCWSA-N;   Neodecadron;   SMILES=[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COP(O)(O)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
 xref: CAS:312-93-6;   Drug_Central:3920
 xref_mesh: MESH:C004180
 xref: PMID:19910302;   PMID:20003498;   PMID:20642832;   PMID:21629568;   PMID:22115712;   Reaxys:2230371
 cyclic_relationship: is_conjugate_acid_of CHEBI:68638



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dexamethasone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]; dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:25447644 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]; dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dexamethasone 21-phosphate results in increased cleavage of PARP1 protein CTD PMID:25447644 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]
dexamethasone 21-phosphate affects the localization of RELA protein
CTD PMID:17931716 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form
CTD PMID:25447644 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        xenobiotic 18547
          dexamethasone 4548
            dexamethasone phosphate 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      ketone 17049
                                        oxo steroid 10299
                                          3-oxo steroid 9904
                                            3-oxo-Delta(1) steroid 5188
                                              3-oxo-Delta(1),Delta(4)-steroid 5188
                                                dexamethasone 4548
                                                  dexamethasone phosphate 10
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