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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:linagliptin
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Accession:CHEBI:68610 term browser browse the term
Definition:A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes.
Synonyms:exact_synonym: 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
 related_synonym: (R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione;   BI 1356;   Formula=C25H28N8O2;   InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1;   InChIKey=LTXREWYXXSTFRX-QGZVFWFLSA-N;   SMILES=CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1;   Tradjenta
 xref: CAS:668270-12-0;   KEGG:D09566
 xref_mesh: MESH:D000069476
 xref: PDBeChem:356;   PMID:19476474;   PMID:19552619;   PMID:19732457;   PMID:19771584;   PMID:19777398;   PMID:19947894;   PMID:20086031;   PMID:20160157;   PMID:20497745;   PMID:20538719;   PMID:20637971;   PMID:20875371;   PMID:21053992;   PMID:21059094;   PMID:21084763;   PMID:21114605;   PMID:21205122;   PMID:21306414;   PMID:21340661;   PMID:21352464;   PMID:21410628;   PMID:21443284;   PMID:21543033;   PMID:21603986;   PMID:21642558;   PMID:21672124;   PMID:21680988;   PMID:21681003;   PMID:21701440;   PMID:21714581;   PMID:21723606;   PMID:21752782;   PMID:21781152;   PMID:21803422;   PMID:21883034;   PMID:21913883;   PMID:21916836;   PMID:22022857;   PMID:22143285;   PMID:22145698;   PMID:22149370;   PMID:22177783;   PMID:22198311;   PMID:22217485;   PMID:22234149;   PMID:22242621;   PMID:22268497;   PMID:22318932;   PMID:22340363;   PMID:22346314;   PMID:22356132;   PMID:22420306;   PMID:22440191;   PMID:22482239;   PMID:22493041;   PMID:22498683;   PMID:22541836;   PMID:22568694;   PMID:22587735;   PMID:22651241;   PMID:22691164;   PMID:22748821;   PMID:22761275;   PMID:22761701;   PMID:22804249;   PMID:22816729;   PMID:22879795;   PMID:22913735;   PMID:22926098;   PMID:22939034;   PMID:22974280;   PMID:22986920;   PMID:22997980;   PMID:23033241;   Patent:EP1852108;   Patent:EP246874;   Patent:US2007259900;   Patent:US2012165525;   Patent:WO2004018468;   Patent:WO2006048427;   Patent:WO2009022008;   Patent:WO2010072776;   Reaxys:11300181;   Wikipedia:Linagliptin


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linagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:39102946 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:32567747 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cst3 cystatin C multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in increased expression of CST3 protein] CTD PMID:39102946 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:156,790,079...156,793,937 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] CTD PMID:32567747 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity EXP Linagliptin results in decreased activity of DPP4 protein CTD PMID:22125632 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:67,370,804...67,452,422 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of DUSP1 mRNA] CTD PMID:35122774 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in decreased expression of FOXO3 protein] CTD PMID:39102946 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]] CTD PMID:28619389 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA] CTD PMID:32567747 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of IL10 protein]] CTD PMID:28619389 PMID:35122774 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of IL6 protein] CTD PMID:35122774 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]]; Linagliptin inhibits the reaction [Letrozole results in increased expression of INS1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of INS1 protein]] CTD PMID:28619389 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO
EXP 		Linagliptin inhibits the reaction [Cuprizone results in increased expression of JAK2 protein modified form]
Linagliptin inhibits the reaction [Acetic Acid results in increased phosphorylation of JAK2 protein] 		CTD PMID:29864483 PMID:35122774 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of LHB protein]] CTD PMID:28619389 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:39102946 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:39102946 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mbp myelin basic protein multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of MBP mRNA] CTD PMID:29864483 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of MTOR mRNA] CTD PMID:35122774 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]] CTD PMID:28619389 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of NR0B2 mRNA] CTD PMID:35122774 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of OLIG2 mRNA] CTD PMID:29864483 NCBI chr11:43,961,585...43,964,961
Ensembl chr11:43,958,940...43,968,634 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PINK1] CTD PMID:39102946 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Plp1 proteolipid protein 1 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA] CTD PMID:29864483 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:104,975,780...104,993,314 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP 		Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A protein]
Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of PPARGC1A mRNA]; Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A] 		CTD PMID:32567747 PMID:35122774 PMID:39102946 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PRKN] CTD PMID:39102946 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO 		indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole affects the localization of RELA protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of RELA protein] 		CTD PMID:28619389 PMID:29864483 PMID:35122774 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO
EXP 		Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA]
Linagliptin inhibits the reaction [Acetic Acid results in decreased expression of SIRT1 mRNA] 		CTD PMID:29864483 PMID:35122774 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA] CTD PMID:39102946 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Linagliptin inhibits the reaction [Acetic Acid results in increased expression of SOCS3 mRNA] CTD PMID:35122774 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Linagliptin inhibits the reaction [Cisplatin results in increased expression of SQSTM1] CTD PMID:39102946 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP 		Linagliptin inhibits the reaction [Cuprizone results in increased expression of STAT3 protein modified form]
Linagliptin inhibits the reaction [Acetic Acid results in increased phosphorylation of STAT3 protein] 		CTD PMID:29864483 PMID:35122774 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of TGFB1 protein]] CTD PMID:28619389 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO 		indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Linagliptin inhibits the reaction [Letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole results in increased expression of TNF protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of TNF protein] 		CTD PMID:28619389 PMID:29864483 PMID:35122774 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
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  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            hypoglycemic agent 4252
              linagliptin 33
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Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      imidazopyrimidine 7810
                                        purines 7809
                                          aminopurine 6764
                                            2-aminopurines 6322
                                              guanine 6294
                                                xanthine 6208
                                                  7H-xanthine 3141
                                                    linagliptin 33
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