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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ezogabine
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Accession:CHEBI:68584 term browser browse the term
Definition:A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Synonyms:related_synonym: D-23129;   Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate;   Formula=C16H18FN3O2;   InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21);   InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N;   N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester;   Potiga;   SMILES=CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N;   ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate;   retigabine
 xref: CAS:150812-12-7;   Drug_Central:4181;   KEGG:C13826;   KEGG:D09569
 xref_mesh: MESH:C101866
 xref: PMID:22991134;   Patent:US2002015730;   Patent:US2002111379;   Patent:US2002183395;   Patent:US2012053238;   Patent:US5384330;   Patent:US6348486;   Patent:WO2007090409;   Patent:WO2011012659;   Reaxys:8072099;   Wikipedia:Ezogabine


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ezogabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit affects activity ISO ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ezogabine inhibits the reaction [Sarin results in increased expression of IL1B protein] CTD PMID:32209366 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO ezogabine inhibits the reaction [Sarin results in increased expression of IL6 protein] CTD PMID:32209366 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 affects activity ISO ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 multiple interactions
affects activity		 EXP
ISO		 ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
ezogabine affects the activity of KCNQ2 protein		 CTD PMID:15634793 PMID:26627826 NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093 		JBrowse link
G Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 affects activity
decreases response to substance		 ISO ezogabine affects the activity of KCNQ3 protein
KCNQ3 protein mutant form results in decreased susceptibility to ezogabine		 CTD PMID:26627826 NCBI chr15:65,858,223...66,158,485
Ensembl chr15:65,858,236...66,158,491 		JBrowse link
G Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 multiple interactions
increases activity		 ISO [ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium CTD PMID:16904708 PMID:21782781 NCBI chr 4:120,553,331...120,605,809
Ensembl chr 4:120,553,335...120,605,809 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO ezogabine results in decreased expression of SAE1 protein CTD PMID:34509475 NCBI chr 7:16,054,161...16,121,821
Ensembl chr 7:16,054,159...16,121,731 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha affects activity ISO ezogabine affects the activity of SCN5A protein CTD PMID:28641963 NCBI chr 9:119,312,470...119,408,096
Ensembl chr 9:119,312,474...119,408,082 		JBrowse link
G Tspo translocator protein multiple interactions ISO ezogabine inhibits the reaction [Sarin results in increased expression of TSPO protein] CTD PMID:32209366 NCBI chr15:83,447,774...83,458,404
Ensembl chr15:83,447,793...83,458,404 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biophysical role 14206
          membrane transport modulator 14020
            potassium channel modulator 441
              ezogabine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            inorganic hydride 18672
                              pnictogen hydride 18652
                                nitrogen hydride 18519
                                  azane 18426
                                    ammonia 18425
                                      organic amino compound 18425
                                        polyamine 8959
                                          triamine 30
                                            benzenetriamine 10
                                              benzene-1,2,4-triamine 10
                                                ezogabine 10
paths to the root