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ONTOLOGY REPORT - ANNOTATIONS


Term:ezogabine
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Accession:CHEBI:68584 term browser browse the term
Definition:A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Synonyms:related_synonym: D-23129;   Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate;   Formula=C16H18FN3O2;   InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21);   InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N;   N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester;   Potiga;   SMILES=CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N;   ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate;   retigabine
 xref: CAS:150812-12-7 "ChemIDplus";   CAS:150812-12-7 "KEGG COMPOUND";   Drug_Central:4181 "DrugCentral";   KEGG:C13826;   KEGG:D09569
 xref_mesh: MESH:C101866
 xref: PMID:22991134 "Europe PMC";   Patent:US2002015730;   Patent:US2002111379;   Patent:US2002183395;   Patent:US2012053238;   Patent:US5384330;   Patent:US6348486;   Patent:WO2007090409;   Patent:WO2011012659;   Reaxys:8072099 "Reaxys";   Wikipedia:Ezogabine


show annotations for term's descendants       view all columns           Sort by:
 
ezogabine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 JBrowse link 3 176,585,897 176,645,029 RGD:6480464
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 JBrowse link 7 106,714,479 107,009,639 RGD:6480464
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 JBrowse link 5 139,625,783 139,677,300 RGD:6480464
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biophysical role 12131
          membrane transport modulator 11895
            potassium channel modulator 340
              ezogabine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        polyamine 8074
                                          triamine 27
                                            benzenetriamine 6
                                              benzene-1,2,4-triamine 6
                                                ezogabine 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.