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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ezogabine
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Accession:CHEBI:68584 term browser browse the term
Definition:A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Synonyms:related_synonym: D-23129;   Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate;   Formula=C16H18FN3O2;   InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21);   InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N;   N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester;   Potiga;   SMILES=CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N;   ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate;   retigabine
 xref: CAS:150812-12-7;   Drug_Central:4181;   KEGG:C13826;   KEGG:D09569
 xref_mesh: MESH:C101866
 xref: PMID:22991134;   Patent:US2002015730;   Patent:US2002111379;   Patent:US2002183395;   Patent:US2012053238;   Patent:US5384330;   Patent:US6348486;   Patent:WO2007090409;   Patent:WO2011012659;   Reaxys:8072099;   Wikipedia:Ezogabine



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ezogabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects activity ISO ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ezogabine inhibits the reaction [Sarin results in increased expression of IL1B protein] CTD PMID:32209366 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ezogabine inhibits the reaction [Sarin results in increased expression of IL6 protein] CTD PMID:32209366 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions
affects activity
ISO ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
ezogabine affects the activity of KCNQ2 protein
CTD PMID:15634793 PMID:26627826 NCBI chr 3:188,572,345...188,631,391
Ensembl chr 3:168,195,357...168,275,071
JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 decreases response to substance
affects activity
ISO KCNQ3 protein mutant form results in decreased susceptibility to ezogabine
ezogabine affects the activity of KCNQ3 protein
CTD PMID:26627826 NCBI chr 7:99,614,089...99,914,736
Ensembl chr 7:97,730,465...98,025,653
JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 multiple interactions
increases activity
ISO [ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium CTD PMID:16904708 PMID:21782781 NCBI chr 5:139,560,366...139,612,212
Ensembl chr 5:134,275,934...134,326,932
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO ezogabine results in decreased expression of SAE1 protein CTD PMID:34509475 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects activity ISO ezogabine affects the activity of SCN5A protein CTD PMID:28641963 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Tspo translocator protein multiple interactions EXP ezogabine inhibits the reaction [Sarin results in increased expression of TSPO protein] CTD PMID:32209366 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        biophysical role 14074
          membrane transport modulator 13911
            potassium channel modulator 424
              ezogabine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    main group molecular entity 19836
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19162
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        polyamine 9030
                                          triamine 32
                                            benzenetriamine 10
                                              benzene-1,2,4-triamine 10
                                                ezogabine 10
paths to the root