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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ezogabine
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Accession:CHEBI:68584 term browser browse the term
Definition:A substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults.
Synonyms:related_synonym: D-23129;   Ethyl 2-amino-4-((p-fluorobenzyl)amino)carbanilate;   Formula=C16H18FN3O2;   InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21);   InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N;   N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester;   Potiga;   SMILES=CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N;   ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate;   retigabine
 xref: CAS:150812-12-7;   Drug_Central:4181;   KEGG:C13826;   KEGG:D09569
 xref_mesh: MESH:C101866
 xref: PMID:22991134;   Patent:US2002015730;   Patent:US2002111379;   Patent:US2002183395;   Patent:US2012053238;   Patent:US5384330;   Patent:US6348486;   Patent:WO2007090409;   Patent:WO2011012659;   Reaxys:8072099;   Wikipedia:Ezogabine


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ezogabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C affects activity ISO ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 multiple interactions
affects activity
ISO ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
ezogabine affects the activity of KCNQ2 protein
CTD PMID:15634793, PMID:26627826 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 decreases response to substance
affects activity
ISO KCNQ3 protein mutant form results in decreased susceptibility to ezogabine
ezogabine affects the activity of KCNQ3 protein
CTD PMID:26627826 NCBI chr 7:106,714,479...107,009,639
Ensembl chr 7:106,717,229...107,009,330
JBrowse link
G Kcnq4 potassium voltage-gated channel subfamily Q member 4 multiple interactions
increases activity
ISO [ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium CTD PMID:16904708, PMID:21782781 NCBI chr 5:139,625,783...139,677,300
Ensembl chr 5:139,627,576...139,677,300
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects activity ISO ezogabine affects the activity of SCN5A protein CTD PMID:28641963 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biophysical role 12283
          membrane transport modulator 12064
            potassium channel modulator 359
              ezogabine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        polyamine 8105
                                          triamine 26
                                            benzenetriamine 6
                                              benzene-1,2,4-triamine 6
                                                ezogabine 6
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