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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.21.6 (coagulation factor Xa) inhibitor
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Accession:CHEBI:68581 term browser browse the term
Definition:An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of coagulation factor Xa (EC 3.4.21.6).
Synonyms:related_synonym: EC 3.4.21.6 inhibitor;   EC 3.4.21.6 inhibitors;   Stuart factor inhibitor;   Stuart factor inhibitors;   activated Stuart-Prower factor inhibitor;   activated Stuart-Prower factor inhibitors;   activated blood-coagulation factor X inhibitor;   activated blood-coagulation factor X inhibitors;   activated factor X inhibitor;   activated factor X inhibitors;   autoprothrombin C inhibitor;   autoprothrombin C inhibitors;   coagulation factor Xa (EC 3.4.21.6) inhibitors;   coagulation factor Xa inhibitor;   coagulation factor Xa inhibitors;   factor Xa inhibitor;   factor Xa inhibitors;   plasma thromboplastin inhibitor;   plasma thromboplastin inhibitors;   prothrombase inhibitor;   prothrombase inhibitors;   prothrombinase inhibitor;   prothrombinase inhibitors;   thrombokinase inhibitor;   thrombokinase inhibitors;   thromboplastin inhibitor;   thromboplastin inhibitors
 xref: Wikipedia:Factor_Xa_inhibitor


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rivaroxaban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30719803 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:30719803 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G F10 coagulation factor X decreases activity ISO Rivaroxaban results in decreased activity of F10 protein CTD PMID:16084352 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of F3 protein] CTD PMID:30719803 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30719803 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] CTD PMID:30719803 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30719803 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:30719803 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          enzyme inhibitor 18227
            EC 3.* (hydrolase) inhibitor 17691
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3243
                EC 3.4.21.* (serine endopeptidase) inhibitor 1597
                  EC 3.4.21.6 (coagulation factor Xa) inhibitor 8
                    Glu-Gly-Arg-chloromethylketone 0
                    apixaban 0
                    betrixaban 0
                    edoxaban 0
                    edoxaban tosylate + 0
                    edoxaban tosylate hydrate 0
                    eribaxaban 0
                    rivaroxaban 8
paths to the root