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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rivaroxaban
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Accession:CHEBI:68579 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery.
Synonyms:exact_synonym: 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
 related_synonym: BAY 59-7939;   BAY59-7939;   Formula=C19H18ClN3O5S;   InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1;   InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N;   SMILES=O1CC(N(CC1)C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(C=4SC(=CC4)Cl)=O)=O;   Xarelto
 xref: CAS:366789-02-8;   DrugBank:DB06228;   Drug_Central:4182;   KEGG:D07086;   LINCS:LSM-5499
 xref_mesh: MESH:D000069552
 xref: PDBeChem:RIV;   PMCID:PMC7292653;   PMID:22042412;   PMID:22173426;   PMID:22187012;   PMID:22242932;   PMID:22272729;   PMID:22372178;   PMID:22387577;   PMID:22422332;   PMID:22533680;   PMID:22534269;   PMID:22534775;   PMID:22542983;   PMID:22651881;   PMID:22664783;   PMID:22701330;   PMID:22740145;   PMID:22777255;   PMID:22800431;   PMID:22811404;   PMID:22871192;   PMID:22884545;   PMID:22932305;   PMID:22958812;   PMID:23006523;   PMID:23014816;   PMID:30653475;   PMID:31784708;   PMID:32002769;   PMID:32023227;   PMID:32223113;   PMID:32223511;   PMID:32252075;   PMID:32265542;   PMID:32279215;   PMID:32296145;   PMID:32382756;   PMID:32519800;   PMID:32548552;   PMID:32548556;   Patent:EP1685841;   Patent:US2005182055;   Patent:US2007026065;   Patent:US2009036504;   Patent:US2010151011;   Patent:US2011034453;   Patent:US2011112083;   Patent:US2011152266;   Patent:US2011288294;   Patent:US7816355;   Patent:WO2004060887;   Patent:WO2005068456;   Patent:WO2008140220;   Patent:WO2011080341;   Patent:WO2012035057;   Patent:WO2012051692;   Reaxys:10206739;   Wikipedia:Rivaroxaban


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rivaroxaban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30719803 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alb albumin multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] CTD PMID:30719803 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G F10 coagulation factor X decreases activity ISO Rivaroxaban results in decreased activity of F10 protein CTD PMID:16084352 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of F3 protein] CTD PMID:30719803 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30719803 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] CTD PMID:30719803 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30719803 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Rivaroxaban inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] CTD PMID:30719803 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pharmaceutical 19321
          drug 19321
            hematologic agent 4398
              anticoagulant 4180
                rivaroxaban 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        carboacyl group 17441
                                          univalent carboacyl group 17441
                                            carbamoyl group 17248
                                              carboxamide 17248
                                                lactam 8308
                                                  rivaroxaban 8
paths to the root