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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indacaterol
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Accession:CHEBI:68575 term browser browse the term
Definition:A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease.
Synonyms:exact_synonym: 5-{(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one
 related_synonym: 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one;   Formula=C24H28N2O3;   InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1;   InChIKey=QZZUEBNBZAPZLX-QFIPXVFZSA-N;   QAB-149;   QAB149;   SMILES=CCc1cc2CC(Cc2cc1CC)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
 xref: CAS:312753-06-3;   DrugBank:DB05039;   Drug_Central:4183;   HMDB:HMDB0015608;   KEGG:D09318
 xref_mesh: MESH:C510790
 xref: PMID:21740451;   PMID:21883146;   PMID:22035851;   PMID:22079756;   PMID:22119310;   PMID:22122202;   PMID:22356291;   PMID:22383666;   PMID:22419862;   PMID:22452977;   PMID:22471750;   PMID:22483398;   PMID:22499359;   PMID:22544891;   PMID:22573707;   PMID:22578206;   PMID:22583463;   PMID:22611179;   PMID:22648561;   PMID:22682643;   PMID:22726538;   PMID:22732017;   PMID:22735463;   PMID:22848154;   PMID:22932315;   Patent:WO2005123684;   Patent:WO2006128675;   Patent:WO2010114472;   Reaxys:10392427;   Wikipedia:Indacaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:68574


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indacaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 increases activity ISO indacaterol results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            bronchodilator agent 4144
              indacaterol 1
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Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organonitrogen heterocyclic compound 18546
                                    quinolines 2714
                                      hydroxyquinoline 331
                                        monohydroxyquinoline 328
                                          indacaterol 1
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