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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indacaterol
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Accession:CHEBI:68575 term browser browse the term
Definition:A monohydroxyquinoline that consists of 5-[(1R)-2-amino-1-hydroxyethyl]-8-hydroxyquinolin-2-one having a 5,6-diethylindan-2-yl group attached to the amino function. Used as the maleate salt for treatment of chronic obstructive pulmonary disease.
Synonyms:exact_synonym: 5-{(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one
 related_synonym: 5-(2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one;   Formula=C24H28N2O3;   InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1;   InChIKey=QZZUEBNBZAPZLX-QFIPXVFZSA-N;   QAB-149;   QAB149;   SMILES=CCc1cc2CC(Cc2cc1CC)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
 xref: CAS:312753-06-3;   DrugBank:DB05039;   Drug_Central:4183;   HMDB:HMDB0015608;   KEGG:D09318
 xref_mesh: MESH:C510790
 xref: PMID:21740451;   PMID:21883146;   PMID:22035851;   PMID:22079756;   PMID:22119310;   PMID:22122202;   PMID:22356291;   PMID:22383666;   PMID:22419862;   PMID:22452977;   PMID:22471750;   PMID:22483398;   PMID:22499359;   PMID:22544891;   PMID:22573707;   PMID:22578206;   PMID:22583463;   PMID:22611179;   PMID:22648561;   PMID:22682643;   PMID:22726538;   PMID:22732017;   PMID:22735463;   PMID:22848154;   PMID:22932315;   Patent:WO2005123684;   Patent:WO2006128675;   Patent:WO2010114472;   Reaxys:10392427;   Wikipedia:Indacaterol
 cyclic_relationship: is_conjugate_base_of CHEBI:68574


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indacaterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 increases activity ISO indacaterol results in increased activity of ADRB2 protein CTD PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      application 19760
        pharmaceutical 19633
          drug 19633
            bronchodilator agent 3792
              indacaterol 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic molecule 19835
                              organic cyclic compound 19589
                                organic heterocyclic compound 18857
                                  organonitrogen heterocyclic compound 17955
                                    quinolines 2626
                                      hydroxyquinoline 321
                                        monohydroxyquinoline 318
                                          indacaterol 1
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