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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methyl caffeate
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Accession:CHEBI:6856 term browser browse the term
Definition:An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.
Synonyms:exact_synonym: methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
 related_synonym: Caffeic acid, methyl ester;   Formula=C10H10O4;   InChI=1S/C10H10O4/c1-14-10(13)5-3-7-2-4-8(11)9(12)6-7/h2-6,11-12H,1H3/b5-3+;   InChIKey=OCNYGKNIVPVPPX-HWKANZROSA-N;   SMILES=COC(=O)\\C=C\\c1ccc(O)c(O)c1
 xref: CAS:3843-74-1;   KEGG:C10477;   KNApSAcK:C00002759
 xref_mesh: MESH:C042405
 xref: PMID:21963451;   Reaxys:2938303;   Wikipedia:Methyl_caffeate

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methyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of AKT1 protein CTD PMID:25481497 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO methyl caffeate results in increased expression of BAX protein CTD PMID:26415618 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO methyl caffeate binds to and results in decreased expression of BCL2 protein CTD PMID:26415618 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO methyl caffeate results in increased expression of BID protein CTD PMID:26415618 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Casp3 caspase 3 increases activity ISO methyl caffeate results in increased activity of CASP3 protein CTD PMID:26415618 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO methyl caffeate analog results in increased expression of CDKN1A protein CTD PMID:25481497 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO methyl caffeate analog results in decreased expression of KDR protein CTD PMID:25481497 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MAPK1 protein CTD PMID:25481497 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MAPK3 protein CTD PMID:25481497 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mdm2 MDM2 proto-oncogene affects binding ISO methyl caffeate binds to MDM2 protein CTD PMID:26415618 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:25481497 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased activity of MMP9 protein CTD PMID:25481497 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO methyl caffeate analog results in decreased phosphorylation of MTOR protein CTD PMID:25481497 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO methyl caffeate binds to and results in increased activity of PARP1 protein CTD PMID:26415618 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO methyl caffeate analog results in increased expression of TP53 protein CTD PMID:25481497 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO methyl caffeate analog results in decreased expression of and results in decreased secretion of VEGFA protein CTD PMID:25481497 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      application 19465
        fuel 10817
          methanol 3073
            methyl ester 3062
              methyl caffeate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        monocarboxylic acid 17483
                                          alpha,beta-unsaturated monocarboxylic acid 11383
                                            cinnamic acids 2378
                                              hydroxycinnamic acid 1254
                                                caffeic acid 550
                                                  alkyl caffeate ester 361
                                                    methyl caffeate 16
paths to the root