CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: methyl caffeate
Accession: CHEBI:6856
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Definition: An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.
Synonyms: exact_synonym: methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
related_synonym: Caffeic acid, methyl ester; Formula=C10H10O4; InChI=1S/C10H10O4/c1-14-10(13)5-3-7-2-4-8(11)9(12)6-7/h2-6,11-12H,1H3/b5-3+; InChIKey=OCNYGKNIVPVPPX-HWKANZROSA-N; SMILES=COC(=O)\\C=C\\c1ccc(O)c(O)c1
xref: CAS:3843-74-1; KEGG:C10477; KNApSAcK:C00002759
xref_mesh: MESH:C042405
xref: PMID:21963451; Reaxys:2938303; Wikipedia:Methyl_caffeate
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
methyl caffeate analog results in decreased phosphorylation of AKT1 protein
CTD
PMID:25481497
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
methyl caffeate results in increased expression of BAX protein
CTD
PMID:26415618
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
methyl caffeate binds to and results in decreased expression of BCL2 protein
CTD
PMID:26415618
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bid
BH3 interacting domain death agonist
increases expression
ISO
methyl caffeate results in increased expression of BID protein
CTD
PMID:26415618
NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
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Casp3
caspase 3
increases activity
ISO
methyl caffeate results in increased activity of CASP3 protein
CTD
PMID:26415618
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
methyl caffeate analog results in increased expression of CDKN1A protein
CTD
PMID:25481497
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Kdr
kinase insert domain receptor
decreases expression
ISO
methyl caffeate analog results in decreased expression of KDR protein
CTD
PMID:25481497
NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
methyl caffeate analog results in decreased phosphorylation of MAPK1 protein
CTD
PMID:25481497
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
methyl caffeate analog results in decreased phosphorylation of MAPK3 protein
CTD
PMID:25481497
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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Mdm2
MDM2 proto-oncogene
affects binding
ISO
methyl caffeate binds to MDM2 protein
CTD
PMID:26415618
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
methyl caffeate analog results in decreased expression of and results in decreased activity of MMP2 protein
CTD
PMID:25481497
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
methyl caffeate analog results in decreased expression of and results in decreased activity of MMP9 protein
CTD
PMID:25481497
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
methyl caffeate analog results in decreased phosphorylation of MTOR protein
CTD
PMID:25481497
NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
methyl caffeate binds to and results in increased activity of PARP1 protein
CTD
PMID:26415618
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Tp53
tumor protein p53
increases expression
ISO
methyl caffeate analog results in increased expression of TP53 protein
CTD
PMID:25481497
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
methyl caffeate analog results in decreased expression of and results in decreased secretion of VEGFA protein
CTD
PMID:25481497
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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