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ONTOLOGY REPORT - ANNOTATIONS


Term:deferiprone
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Accession:CHEBI:68554 term browser browse the term
Definition:A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Synonyms:exact_synonym: 3-hydroxy-1,2-dimethylpyridin-4(1H)-one
 related_synonym: 1,2-Dimethyl-3-hydroxypyrid-4-one;   3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;   Ferriprox;   Formula=C7H9NO2;   InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3;   InChIKey=TZXKOCQBRNJULO-UHFFFAOYSA-N;   SMILES=Cc1c(O)c(=O)ccn1C
 xref: Beilstein:1447108;   CAS:30652-11-0;   Drug_Central:4188;   KEGG:D07416;   LINCS:LSM-36972
 xref_mesh: MESH:C044919
 xref: PMID:21853518;   PMID:22025507;   PMID:22034002;   PMID:22130677;   PMID:22171759;   PMID:22180427;   PMID:22277065;   PMID:22354281;   PMID:22406440;   PMID:22454828;   PMID:22457166;   PMID:22459459;   PMID:22468647;   PMID:22565013;   PMID:22572843;   PMID:22579919;   PMID:22621771;   PMID:22622672;   PMID:22664119;   PMID:22759897;   PMID:22850524;   PMID:22943064;   PMID:22978744;   Reaxys:1447108;   Wikipedia:Deferiprone


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deferiprone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:6480464
G Fxn frataxin JBrowse link 1 242,123,975 242,152,834 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      chemical role 19251
        ligand 5750
          chelator 5727
            iron chelator 1181
              deferiprone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic molecule 19461
                              organic cyclic compound 19222
                                organic heterocyclic compound 18339
                                  organic heteromonocyclic compound 16403
                                    pyridines 8373
                                      pyridone 117
                                        4-pyridones 28
                                          deferiprone 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.