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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:deferiprone
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Accession:CHEBI:68554 term browser browse the term
Definition:A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.
Synonyms:exact_synonym: 3-hydroxy-1,2-dimethylpyridin-4(1H)-one
 related_synonym: 1,2-Dimethyl-3-hydroxypyrid-4-one;   3-Hydroxy-1,2-dimethyl-4(1H)-pyridone;   Ferriprox;   Formula=C7H9NO2;   InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3;   InChIKey=TZXKOCQBRNJULO-UHFFFAOYSA-N;   SMILES=Cc1c(O)c(=O)ccn1C
 xref: Beilstein:1447108;   CAS:30652-11-0;   Drug_Central:4188;   KEGG:D07416;   LINCS:LSM-36972
 xref_mesh: MESH:C044919
 xref: PMID:21853518;   PMID:22025507;   PMID:22034002;   PMID:22130677;   PMID:22171759;   PMID:22180427;   PMID:22277065;   PMID:22354281;   PMID:22406440;   PMID:22454828;   PMID:22457166;   PMID:22459459;   PMID:22468647;   PMID:22565013;   PMID:22572843;   PMID:22579919;   PMID:22621771;   PMID:22622672;   PMID:22664119;   PMID:22759897;   PMID:22850524;   PMID:22943064;   PMID:22978744;   Reaxys:1447108;   Wikipedia:Deferiprone



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deferiprone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein] CTD PMID:17172471 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:33285147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein] CTD PMID:33285147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
deferiprone inhibits the reaction [[Lipopolysaccharides co-treated with Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]
CTD PMID:14576080 PMID:25813056 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP
ISO
deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]
CTD PMID:17172471 PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP
ISO
Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]
CTD PMID:32937103 PMID:33285147 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fxn frataxin increases expression ISO deferiprone results in increased expression of FXN mRNA; deferiprone results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; deferiprone inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]
CTD PMID:17172471 PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]
Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]
CTD PMID:17172471 PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33285147 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP deferiprone inhibits the reaction [Doxorubicin results in decreased activity of SOD1 protein] CTD PMID:17007740 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tf transferrin increases expression
decreases uptake
ISO deferiprone results in increased expression of TF mRNA; deferiprone results in increased expression of TF protein
deferiprone results in decreased uptake of TF protein
CTD PMID:9763218 PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deferiprone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20083
    role 20034
      chemical role 19571
        ligand 5849
          chelator 5838
            iron chelator 1232
              deferiprone 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 20083
    subatomic particle 20081
      composite particle 20081
        hadron 20081
          baryon 20081
            nucleon 20081
              atomic nucleus 20081
                atom 20081
                  main group element atom 19982
                    p-block element atom 19982
                      carbon group element atom 19909
                        carbon atom 19902
                          organic molecular entity 19902
                            organic molecule 19849
                              organic cyclic compound 19604
                                organic heterocyclic compound 18824
                                  organic heteromonocyclic compound 17173
                                    pyridines 9189
                                      pyridone 140
                                        4-pyridones 35
                                          deferiprone 19
paths to the root