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ONTOLOGY REPORT - ANNOTATIONS


Term:teriflunomide
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Accession:CHEBI:68540 term browser browse the term
Definition:An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Synonyms:exact_synonym: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
 related_synonym: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide;   A 77-1726;   A 771726;   Aubagio;   Formula=C12H9F3N2O2;   HMR 1726;   HMR1726;   InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-;   InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N;   SMILES=C\\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F;   teriflunomida;   teriflunomidum
 alt_id: MESH:C072876
 xref: CAS:163451-81-8 "ChemIDplus";   CAS:163451-81-8 "KEGG DRUG";   Drug_Central:4634 "DrugCentral";   KEGG:D10172
 xref_mesh: MESH:C072876
 xref: PDBeChem:A26;   PMID:20880295 "Europe PMC";   PMID:21349677 "Europe PMC";   PMID:21367665 "Europe PMC";   PMID:21425264 "Europe PMC";   PMID:21625416 "Europe PMC";   PMID:21991951 "Europe PMC";   PMID:22012334 "Europe PMC";   PMID:22052286 "Europe PMC";   PMID:22052362 "Europe PMC";   PMID:22148963 "Europe PMC";   PMID:22229697 "Europe PMC";   PMID:22278631 "Europe PMC";   PMID:22307384 "Europe PMC";   PMID:22398660 "Europe PMC";   PMID:22426573 "Europe PMC";   PMID:22612746 "Europe PMC";   PMID:22622860 "Europe PMC";   PMID:22673950 "Europe PMC";   PMID:22723573 "Europe PMC";   PMID:22766059 "Europe PMC";   PMID:22784880 "Europe PMC";   PMID:22796174 "Europe PMC";   PMID:22960763 "Europe PMC";   PMID:22965070 "Europe PMC";   Reaxys:6655982 "Reaxys";   Wikipedia:Teriflunomide


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teriflunomide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Bcl2l1 BCL2-like 1 JBrowse link 2 152,758,732 152,833,803 RGD:6480464
G Bnip3 BCL2/adenovirus E1B interacting protein 3 JBrowse link 7 138,890,836 138,909,506 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 3 36,564,865 36,573,038 RGD:6480464
G Ccnd2 cyclin D2 JBrowse link 6 127,125,162 127,152,188 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 7 38,097,984 38,107,490 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 9 109,875,518 109,893,895 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Chdh choline dehydrogenase JBrowse link 14 30,008,901 30,040,468 RGD:6480464
G Cxcr1 chemokine (C-X-C motif) receptor 1 JBrowse link 1 74,191,785 74,194,708 RGD:6480464
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 JBrowse link 2 170,482,957 170,497,145 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 JBrowse link 19 39,061,006 39,093,948 RGD:6480464
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 JBrowse link 19 39,113,898 39,186,756 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Ddx28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 JBrowse link 8 106,009,616 106,011,486 RGD:6480464
G Dhodh dihydroorotate dehydrogenase JBrowse link 8 109,593,244 109,608,699 RGD:6480464
G Egf epidermal growth factor JBrowse link 3 129,677,574 129,755,322 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 27,260,327 27,275,656 RGD:6480464
G Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) JBrowse link 13 36,117,428 36,537,595 RGD:6480464
G Fasn fatty acid synthase JBrowse link 11 120,805,958 120,825,166 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic JBrowse link 11 101,367,716 101,377,903 RGD:6480464
G Gypa glycophorin A JBrowse link 8 80,494,045 80,510,785 RGD:6480464
G Hspa1l heat shock protein 1-like JBrowse link 17 34,972,703 34,979,228 RGD:6480464
G Il10ra interleukin 10 receptor, alpha JBrowse link 9 45,253,837 45,269,149 RGD:6480464
G Lck lymphocyte protein tyrosine kinase JBrowse link 4 129,548,344 129,573,641 RGD:6480464
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link 9 64,185,769 64,253,605 RGD:6480464
G Mtfr2 mitochondrial fission regulator 2 JBrowse link 10 20,344,653 20,361,669 RGD:6480464
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 1 171,213,934 171,218,845 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 39,410,545 39,519,421 RGD:6480464
G Oat ornithine aminotransferase JBrowse link 7 132,557,475 132,576,398 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic JBrowse link 2 173,153,073 173,159,274 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 14 73,192,858 73,325,951 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:6480464
G Slc25a25 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 JBrowse link 2 32,414,487 32,451,470 RGD:6480464
G Tfb1m transcription factor B1, mitochondrial JBrowse link 17 3,519,250 3,557,796 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 15 98,949,847 98,953,501 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21025
    role 21006
      biological role 21004
        aetiopathogenetic role 19844
          hepatotoxic agent 14393
            teriflunomide 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 21025
    subatomic particle 21019
      composite particle 21019
        hadron 21019
          baryon 21019
            nucleon 21019
              atomic nucleus 21019
                atom 21019
                  main group element atom 20860
                    p-block element atom 20860
                      carbon group element atom 20601
                        carbon atom 20578
                          organic molecular entity 20578
                            organic group 19174
                              organic divalent group 19164
                                organodiyl group 19164
                                  carbonyl group 19134
                                    carbonyl compound 19134
                                      carboxylic acid 18814
                                        carboacyl group 17452
                                          univalent carboacyl group 17452
                                            carbamoyl group 17153
                                              carboxamide 17153
                                                alpha,beta-unsaturated carboxylic acid amide 4604
                                                  enamide 4604
                                                    teriflunomide 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.