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ONTOLOGY REPORT - ANNOTATIONS


Term:teriflunomide
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Accession:CHEBI:68540 term browser browse the term
Definition:An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Synonyms:exact_synonym: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
 related_synonym: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide;   A 77-1726;   A 771726;   Aubagio;   Formula=C12H9F3N2O2;   HMR 1726;   HMR1726;   InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-;   InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N;   SMILES=C\\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F;   teriflunomida;   teriflunomidum
 alt_id: MESH:C072876
 xref: CAS:163451-81-8 "ChemIDplus";   CAS:163451-81-8 "KEGG DRUG";   Drug_Central:4634 "DrugCentral";   KEGG:D10172
 xref_mesh: MESH:C072876
 xref: PDBeChem:A26;   PMID:20880295 "Europe PMC";   PMID:21349677 "Europe PMC";   PMID:21367665 "Europe PMC";   PMID:21425264 "Europe PMC";   PMID:21625416 "Europe PMC";   PMID:21991951 "Europe PMC";   PMID:22012334 "Europe PMC";   PMID:22052286 "Europe PMC";   PMID:22052362 "Europe PMC";   PMID:22148963 "Europe PMC";   PMID:22229697 "Europe PMC";   PMID:22278631 "Europe PMC";   PMID:22307384 "Europe PMC";   PMID:22398660 "Europe PMC";   PMID:22426573 "Europe PMC";   PMID:22612746 "Europe PMC";   PMID:22622860 "Europe PMC";   PMID:22673950 "Europe PMC";   PMID:22723573 "Europe PMC";   PMID:22766059 "Europe PMC";   PMID:22784880 "Europe PMC";   PMID:22796174 "Europe PMC";   PMID:22960763 "Europe PMC";   PMID:22965070 "Europe PMC";   Reaxys:6655982 "Reaxys";   Wikipedia:Teriflunomide


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teriflunomide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6480464
G BCL2L1 BCL2 like 1 JBrowse link 20 31,664,452 31,723,963 RGD:6480464
G BNIP3 BCL2 interacting protein 3 JBrowse link 10 131,967,683 131,982,013 RGD:6480464
G CCNA2 cyclin A2 JBrowse link 4 121,816,444 121,823,883 RGD:6480464
G CCND2 cyclin D2 JBrowse link 12 4,273,762 4,305,353 RGD:6480464
G CCNE1 cyclin E1 JBrowse link 19 29,811,991 29,824,312 RGD:6480464
G CDC25A cell division cycle 25A JBrowse link 3 48,157,146 48,188,417 RGD:6480464
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6480464
G CHDH choline dehydrogenase JBrowse link 3 53,812,335 53,846,464 RGD:6480464
G CXCR1 C-X-C motif chemokine receptor 1 JBrowse link 2 218,162,841 218,166,962 RGD:6480464
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 JBrowse link 20 54,145,731 54,174,032 RGD:6480464
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 JBrowse link 19 40,991,282 41,018,398 RGD:6480464
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 JBrowse link 10 94,938,658 94,990,091 RGD:6480464
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 JBrowse link 7 99,756,967 99,784,184 RGD:6480464
G DDX28 DEAD-box helicase 28 JBrowse link 16 68,020,916 68,023,232 RGD:6480464
G DHODH dihydroorotate dehydrogenase (quinone) JBrowse link 16 72,008,744 72,027,659 RGD:6480464
G EGF epidermal growth factor JBrowse link 4 109,912,883 110,013,766 RGD:6480464
G EGFR epidermal growth factor receptor JBrowse link 7 55,019,017 55,211,628 RGD:6480464
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 38,030,534 38,060,365 RGD:6480464
G FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial JBrowse link 6 5,261,007 5,771,583 RGD:6480464
G FASN fatty acid synthase JBrowse link 17 82,078,338 82,098,303 RGD:6480464
G G6PC glucose-6-phosphatase catalytic subunit JBrowse link 17 42,900,799 42,914,438 RGD:6480464
G GYPA glycophorin A (MNS blood group) JBrowse link 4 144,109,303 144,140,854 RGD:6480464
G HSPA1L heat shock protein family A (Hsp70) member 1 like JBrowse link 6 31,809,619 31,815,283 RGD:6480464
G IL10RA interleukin 10 receptor subunit alpha JBrowse link 11 117,986,394 118,003,037 RGD:6480464
G LCK LCK proto-oncogene, Src family tyrosine kinase JBrowse link 1 32,251,265 32,286,167 RGD:6480464
G MAP2K1 mitogen-activated protein kinase kinase 1 JBrowse link 15 66,386,912 66,491,544 RGD:6480464
G MTFR2 mitochondrial fission regulator 2 JBrowse link 6 136,231,030 136,253,659 RGD:6480464
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 4 102,501,266 102,617,302 RGD:6480464
G NFKBIA NFKB inhibitor alpha JBrowse link 14 35,401,513 35,404,749 RGD:6480464
G NR1I3 nuclear receptor subfamily 1 group I member 3 JBrowse link 1 161,229,666 161,238,623 RGD:6480464
G NR3C1 nuclear receptor subfamily 3 group C member 1 JBrowse link 5 143,277,931 143,435,512 RGD:6480464
G OAT ornithine aminotransferase JBrowse link 10 124,397,303 124,418,976 RGD:6480464
G PCK1 phosphoenolpyruvate carboxykinase 1 JBrowse link 20 57,561,110 57,568,121 RGD:6480464
G RB1 RB transcriptional corepressor 1 JBrowse link 13 48,303,747 48,481,890 RGD:6480464
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:6480464
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:6480464
G SLC25A25 solute carrier family 25 member 25 JBrowse link 9 128,068,200 128,109,258 RGD:6480464
G TFB1M transcription factor B1, mitochondrial JBrowse link 6 155,229,871 155,314,497 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6480464
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:6480464
G TUBA1A tubulin alpha 1a JBrowse link 12 49,184,795 49,189,324 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23758
    role 23647
      biological role 23610
        aetiopathogenetic role 22205
          hepatotoxic agent 14696
            teriflunomide 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 23758
    subatomic particle 23707
      composite particle 23707
        hadron 23707
          baryon 23707
            nucleon 23707
              atomic nucleus 23707
                atom 23707
                  main group element atom 23527
                    p-block element atom 23527
                      carbon group element atom 23238
                        carbon atom 23215
                          organic molecular entity 23215
                            organic group 21900
                              organic divalent group 21872
                                organodiyl group 21872
                                  carbonyl group 21843
                                    carbonyl compound 21843
                                      carboxylic acid 20891
                                        carboacyl group 18987
                                          univalent carboacyl group 18987
                                            carbamoyl group 18375
                                              carboxamide 18375
                                                alpha,beta-unsaturated carboxylic acid amide 4635
                                                  enamide 4635
                                                    teriflunomide 43
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.