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ONTOLOGY REPORT - ANNOTATIONS


Term:teriflunomide
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Accession:CHEBI:68540 term browser browse the term
Definition:An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Synonyms:exact_synonym: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
 related_synonym: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide;   A 77-1726;   A 771726;   Aubagio;   Formula=C12H9F3N2O2;   HMR 1726;   HMR1726;   InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-;   InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N;   SMILES=C\\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F;   teriflunomida;   teriflunomidum
 alt_id: MESH:C072876
 xref: CAS:163451-81-8 "ChemIDplus";   CAS:163451-81-8 "KEGG DRUG";   Drug_Central:4634 "DrugCentral";   KEGG:D10172
 xref_mesh: MESH:C072876
 xref: PDBeChem:A26;   PMID:20880295 "Europe PMC";   PMID:21349677 "Europe PMC";   PMID:21367665 "Europe PMC";   PMID:21425264 "Europe PMC";   PMID:21625416 "Europe PMC";   PMID:21991951 "Europe PMC";   PMID:22012334 "Europe PMC";   PMID:22052286 "Europe PMC";   PMID:22052362 "Europe PMC";   PMID:22148963 "Europe PMC";   PMID:22229697 "Europe PMC";   PMID:22278631 "Europe PMC";   PMID:22307384 "Europe PMC";   PMID:22398660 "Europe PMC";   PMID:22426573 "Europe PMC";   PMID:22612746 "Europe PMC";   PMID:22622860 "Europe PMC";   PMID:22673950 "Europe PMC";   PMID:22723573 "Europe PMC";   PMID:22766059 "Europe PMC";   PMID:22784880 "Europe PMC";   PMID:22796174 "Europe PMC";   PMID:22960763 "Europe PMC";   PMID:22965070 "Europe PMC";   Reaxys:6655982 "Reaxys";   Wikipedia:Teriflunomide


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teriflunomide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnd2 cyclin D2 JBrowse link 4 159,674,885 159,697,207 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Cdc25a cell division cycle 25A JBrowse link 8 117,953,223 117,971,552 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Chdh choline dehydrogenase JBrowse link 16 6,078,083 6,109,386 RGD:6480464
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:6480464
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 JBrowse link 3 168,097,484 168,111,920 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Ddx28 DEAD-box helicase 28 JBrowse link 19 37,988,423 37,990,353 RGD:6480464
G Dhodh dihydroorotate dehydrogenase (quinone) JBrowse link 19 42,066,103 42,087,906 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial JBrowse link 17 29,006,981 29,438,906 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G G6pc glucose-6-phosphatase, catalytic subunit JBrowse link 10 89,286,009 89,296,213 RGD:6480464
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:6480464
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6480464
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6480464
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6480464
G Mtfr2 mitochondrial fission regulator 2 JBrowse link 1 15,834,779 15,850,424 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Oat ornithine aminotransferase JBrowse link 1 204,562,289 204,582,070 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1 JBrowse link 3 171,213,936 171,219,885 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Slc25a25 solute carrier family 25 member 25 JBrowse link 3 11,442,396 11,476,186 RGD:6480464
G Tfb1m transcription factor B1, mitochondrial JBrowse link 1 44,433,116 44,474,674 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          hepatotoxic agent 14277
            teriflunomide 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                alpha,beta-unsaturated carboxylic acid amide 4750
                                                  enamide 4750
                                                    teriflunomide 40
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.