The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] teriflunomide results in decreased activity of DHODH protein teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]] teriflunomide results in decreased expression of DHODH mRNA
teriflunomide results in increased expression of G6PC1 mRNA Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC1 mRNA]
Cytidine inhibits the reaction [teriflunomide results in increased expression of GYPA protein]; Uridine inhibits the reaction [teriflunomide results in increased expression of GYPA protein]
Ceramides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]
teriflunomide results in increased expression of PCK1 mRNA Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA]
Ceramides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein affects the localization of RELA protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]
teriflunomide inhibits the reaction [TNF protein affects the localization of RELA protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased activity of LCK protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; teriflunomide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]] teriflunomide inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]