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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:teriflunomide
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Accession:CHEBI:68540 term browser browse the term
Definition:An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Synonyms:exact_synonym: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
 related_synonym: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide;   A 77-1726;   A 771726;   Aubagio;   Formula=C12H9F3N2O2;   HMR 1726;   HMR1726;   InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-;   InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N;   SMILES=C\\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F;   teriflunomida;   teriflunomidum
 alt_id: MESH:C072876
 xref: CAS:163451-81-8;   Drug_Central:4634;   KEGG:D10172
 xref_mesh: MESH:C072876
 xref: PDBeChem:A26;   PMID:20880295;   PMID:21349677;   PMID:21367665;   PMID:21425264;   PMID:21625416;   PMID:21991951;   PMID:22012334;   PMID:22052286;   PMID:22052362;   PMID:22148963;   PMID:22229697;   PMID:22278631;   PMID:22307384;   PMID:22398660;   PMID:22426573;   PMID:22612746;   PMID:22622860;   PMID:22673950;   PMID:22723573;   PMID:22766059;   PMID:22784880;   PMID:22796174;   PMID:22960763;   PMID:22965070;   Reaxys:6655982;   Wikipedia:Teriflunomide

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teriflunomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO A 771726 results in decreased phosphorylation of AKT1 protein CTD PMID:19174558 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO A 771726 results in decreased expression of BCL2L1 mRNA CTD PMID:29427785 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO A 771726 results in increased expression of BNIP3 mRNA CTD PMID:29427785 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO A 771726 results in increased expression of CCNA2 protein CTD PMID:12181422 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO A 771726 results in decreased expression of CCND2 protein CTD PMID:19174558 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207 		JBrowse link
G Ccne1 cyclin E1 decreases expression
increases expression		 ISO A 771726 results in decreased expression of CCNE1 protein
A 771726 results in increased expression of CCNE1 protein		 CTD PMID:12181422, PMID:19174558 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO A 771726 results in decreased expression of CDC25A protein CTD PMID:19174558 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO A 771726 results in increased expression of CDKN1A protein CTD PMID:12181422 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Chdh choline dehydrogenase decreases expression ISO A 771726 results in decreased expression of CHDH mRNA CTD PMID:29427785 NCBI chr16:6,078,083...6,109,386
Ensembl chr16:6,078,122...6,109,382 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO A 771726 results in decreased expression of CXCR1 mRNA CTD PMID:10076546 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO A 771726 results in decreased expression of CYP24A1 mRNA CTD PMID:29427785 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression		 ISO teriflunomide results in increased activity of CYP2B6 protein
teriflunomide results in increased expression of CYP2B6 mRNA		 CTD PMID:30364229 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Ddx28 DEAD-box helicase 28 decreases expression ISO A 771726 results in decreased expression of DDX28 mRNA CTD PMID:29427785 NCBI chr19:37,988,423...37,990,353
Ensembl chr19:37,988,423...37,990,353 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
decreases expression		 ISO
EXP		 A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
A 771726 results in decreased activity of DHODH protein
A 771726 results in decreased expression of DHODH mRNA
A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]; A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; A 771726 inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; A 771726 inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; A 771726 inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]		 CTD PMID:9776318, PMID:9802339, PMID:11248707, PMID:29427785 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO teriflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:30364229 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO teriflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:30364229 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO A 771726 results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:19174558 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial decreases expression ISO A 771726 results in decreased expression of FARS2 mRNA CTD PMID:29427785 NCBI chr17:29,006,981...29,438,906
Ensembl chr17:29,006,988...29,438,668 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions		 ISO teriflunomide results in decreased expression of FASN mRNA
[Colforsin co-treated with teriflunomide] results in increased expression of FASN mRNA		 CTD PMID:30364229 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit increases expression
multiple interactions		 ISO teriflunomide results in increased expression of G6PC mRNA
Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC mRNA]		 CTD PMID:30364229 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO A 771726 results in decreased expression of HSPA1L mRNA CTD PMID:29427785 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO A 771726 results in increased expression of IL10RA mRNA; A 771726 results in increased expression of IL10RA protein CTD PMID:10076546 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO A 771726 inhibits the reaction [TNF protein results in increased activity of LCK protein] CTD PMID:9973483 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO A 771726 inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:9973483 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Mtfr2 mitochondrial fission regulator 2 decreases expression ISO A 771726 results in decreased expression of MTFR2 mRNA CTD PMID:29427785 NCBI chr 1:15,834,779...15,850,424
Ensembl chr 1:15,782,477...15,860,624 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO A 771726 inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; A 771726 inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Ceramides inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:9973483 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO A 771726 inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:9973483 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
affects localization		 ISO teriflunomide results in increased expression of NR1I3 mRNA
teriflunomide affects the localization of NR1I3 protein mutant form		 CTD PMID:30364229 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO Mifepristone inhibits the reaction [teriflunomide results in increased activity of NR3C1 protein] CTD PMID:30364229 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Oat ornithine aminotransferase increases expression ISO A 771726 results in increased expression of OAT mRNA CTD PMID:29427785 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions		 ISO teriflunomide results in increased expression of PCK1 mRNA
Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA]		 CTD PMID:30364229 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO A 771726 results in decreased expression of RB1 protein CTD PMID:19174558 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO A 771726 inhibits the reaction [TNF protein affects the localization of RELA protein]; A 771726 inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; A 771726 inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Ceramides inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [A 771726 results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:9973483 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO A 771726 results in decreased phosphorylation of RPS6KB1 protein CTD PMID:19174558 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression ISO A 771726 results in increased expression of SLC25A25 mRNA CTD PMID:29427785 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression ISO A 771726 results in decreased expression of TFB1M mRNA CTD PMID:29427785 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP A 771726 inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein] CTD PMID:15586409 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 A 771726 inhibits the reaction [TNF protein affects the localization of RELA protein]; A 771726 inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; A 771726 inhibits the reaction [TNF protein results in increased activity of LCK protein]; A 771726 inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; A 771726 inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; A 771726 inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]
A 771726 inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]		 CTD PMID:9973483, PMID:15586409 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO A 771726 results in increased expression of TP53 mRNA; A 771726 results in increased expression of TP53 protein CTD PMID:10076546 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tuba1a tubulin, alpha 1A affects expression ISO teriflunomide affects the expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        aetiopathogenetic role 18936
          hepatotoxic agent 14564
            teriflunomide 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                alpha,beta-unsaturated carboxylic acid amide 4754
                                                  enamide 4754
                                                    teriflunomide 40
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