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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:teriflunomide
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Accession:CHEBI:68540 term browser browse the term
Definition:An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.
Synonyms:exact_synonym: (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
 related_synonym: (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide;   A 77-1726;   A 771726;   Aubagio;   Formula=C12H9F3N2O2;   HMR 1726;   HMR1726;   InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-;   InChIKey=UTNUDOFZCWSZMS-YFHOEESVSA-N;   SMILES=C\\C(O)=C(/C#N)C(=O)Nc1ccc(cc1)C(F)(F)F;   teriflunomida;   teriflunomidum
 alt_id: MESH:C072876
 xref: CAS:163451-81-8;   Drug_Central:4634;   KEGG:D10172
 xref_mesh: MESH:C072876
 xref: PDBeChem:A26;   PMID:20880295;   PMID:21349677;   PMID:21367665;   PMID:21425264;   PMID:21625416;   PMID:21991951;   PMID:22012334;   PMID:22052286;   PMID:22052362;   PMID:22148963;   PMID:22229697;   PMID:22278631;   PMID:22307384;   PMID:22398660;   PMID:22426573;   PMID:22612746;   PMID:22622860;   PMID:22673950;   PMID:22723573;   PMID:22766059;   PMID:22784880;   PMID:22796174;   PMID:22960763;   PMID:22965070;   Reaxys:6655982;   Wikipedia:Teriflunomide

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teriflunomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO teriflunomide results in decreased phosphorylation of AKT1 protein CTD PMID:19174558 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO teriflunomide results in decreased expression of BCL2L1 mRNA CTD PMID:29427785 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO teriflunomide results in increased expression of BNIP3 mRNA CTD PMID:29427785 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO teriflunomide results in increased expression of CCNA2 protein CTD PMID:12181422 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO teriflunomide results in decreased expression of CCND2 protein CTD PMID:19174558 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression		 ISO teriflunomide results in increased expression of CCNE1 protein
teriflunomide results in decreased expression of CCNE1 protein		 CTD PMID:12181422 PMID:19174558 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO teriflunomide results in decreased expression of CDC25A protein CTD PMID:19174558 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO teriflunomide results in increased expression of CDKN1A protein CTD PMID:12181422 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chdh choline dehydrogenase decreases expression ISO teriflunomide results in decreased expression of CHDH mRNA CTD PMID:29427785 NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO teriflunomide results in decreased expression of CXCR1 mRNA CTD PMID:10076546 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO teriflunomide results in decreased expression of CYP24A1 mRNA CTD PMID:29427785 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression		 ISO teriflunomide results in increased activity of CYP2B6 protein
teriflunomide results in increased expression of CYP2B6 mRNA		 CTD PMID:30364229 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression ISO teriflunomide results in increased expression of CYP2C9 mRNA CTD PMID:30364229 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases activity		 ISO teriflunomide results in increased expression of CYP3A4 mRNA
teriflunomide results in increased activity of CYP3A4 protein		 CTD PMID:30364229 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddx28 DEAD-box helicase 28 decreases expression ISO teriflunomide results in decreased expression of DDX28 mRNA CTD PMID:29427785 NCBI chr19:33,909,799...33,911,729
Ensembl chr19:33,909,801...33,911,742 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases expression
decreases activity		 ISO
EXP		 teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
teriflunomide results in decreased expression of DHODH mRNA
teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [DHODH protein results in increased metabolism of Ubiquinone]; teriflunomide inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]; teriflunomide inhibits the reaction [Ubiquinone affects the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]]
teriflunomide results in decreased activity of DHODH protein		 CTD PMID:9776318 PMID:9802339 PMID:11248707 PMID:29427785 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO teriflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:30364229 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO teriflunomide inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:30364229 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO teriflunomide results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:19174558 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial decreases expression ISO teriflunomide results in decreased expression of FARS2 mRNA CTD PMID:29427785 NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337 		JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions		 ISO teriflunomide results in decreased expression of FASN mRNA
[Colforsin co-treated with teriflunomide] results in increased expression of FASN mRNA		 CTD PMID:30364229 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions		 ISO teriflunomide results in increased expression of G6PC1 mRNA
Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC1 mRNA]		 CTD PMID:30364229 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gypa glycophorin A multiple interactions
increases expression		 ISO Cytidine inhibits the reaction [teriflunomide results in increased expression of GYPA protein]; Uridine inhibits the reaction [teriflunomide results in increased expression of GYPA protein] CTD PMID:12181422 NCBI chr19:27,450,311...27,465,940 JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO teriflunomide results in decreased expression of HSPA1L mRNA CTD PMID:29427785 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO teriflunomide results in increased expression of IL10RA mRNA; teriflunomide results in increased expression of IL10RA protein CTD PMID:10076546 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO teriflunomide inhibits the reaction [TNF protein results in increased activity of LCK protein] CTD PMID:9973483 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO teriflunomide inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] CTD PMID:9973483 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mtfr2 mitochondrial fission regulator 2 decreases expression ISO teriflunomide results in decreased expression of MTFR2 mRNA CTD PMID:29427785 NCBI chr 1:15,123,232...15,138,632 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ceramides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:9973483 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO teriflunomide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:9973483 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
affects localization		 ISO teriflunomide results in increased expression of NR1I3 mRNA
teriflunomide affects the localization of NR1I3 protein mutant form		 CTD PMID:30364229 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO Mifepristone inhibits the reaction [teriflunomide results in increased activity of NR3C1 protein] CTD PMID:30364229 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oat ornithine aminotransferase increases expression ISO teriflunomide results in increased expression of OAT mRNA CTD PMID:29427785 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions		 ISO teriflunomide results in increased expression of PCK1 mRNA
Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA]		 CTD PMID:30364229 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO teriflunomide results in decreased expression of RB1 protein CTD PMID:19174558 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ceramides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Hydrogen Peroxide inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Lipopolysaccharides inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; Okadaic Acid inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein affects the localization of RELA protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [teriflunomide results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:9973483 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO teriflunomide results in decreased phosphorylation of RPS6KB1 protein CTD PMID:19174558 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 increases expression ISO teriflunomide results in increased expression of SLC25A25 mRNA CTD PMID:29427785 NCBI chr 3:15,708,702...15,742,195
Ensembl chr 3:15,708,703...15,742,216 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression ISO teriflunomide results in decreased expression of TFB1M mRNA CTD PMID:29427785 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP teriflunomide inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein] CTD PMID:15586409 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 teriflunomide inhibits the reaction [TNF protein affects the localization of RELA protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; teriflunomide inhibits the reaction [TNF protein results in increased activity of LCK protein]; teriflunomide inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; teriflunomide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; teriflunomide inhibits the reaction [TNF protein results in increased expression of [NFKB1 protein binds to RELA protein]]
teriflunomide inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]		 CTD PMID:9973483 PMID:15586409 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO teriflunomide results in increased expression of TP53 mRNA; teriflunomide results in increased expression of TP53 protein CTD PMID:10076546 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1a tubulin, alpha 1A affects expression ISO teriflunomide affects the expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:130,113,214...130,116,880 JBrowse link
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        aetiopathogenetic role 19035
          hepatotoxic agent 15122
            teriflunomide 43
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                alpha,beta-unsaturated carboxylic acid amide 6706
                                                  enamide 6706
                                                    teriflunomide 43
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