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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enzalutamide
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Accession:CHEBI:68534 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.
Synonyms:exact_synonym: 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
 related_synonym: Formula=C21H16F4N4O2S;   InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30);   InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N;   MDV 3100;   MDV3100;   SMILES=CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F;   XTANDI
 xref: CAS:915087-33-1;   Drug_Central:4628;   LINCS:LSM-6254
 xref_mesh: MESH:C540278
 xref: PMID:21986558;   PMID:22101903;   PMID:22113551;   PMID:22162475;   PMID:22229405;   PMID:22258371;   PMID:22258374;   PMID:22266222;   PMID:22310230;   PMID:22373838;   PMID:22393799;   PMID:22411952;   PMID:22429837;   PMID:22472508;   PMID:22516457;   PMID:22710436;   PMID:22815001;   PMID:22845410;   PMID:22852027;   PMID:22894553;   PMID:22956944;   PMID:22985411;   PMID:22987974;   Patent:US2007254933;   Patent:WO2006124118;   Patent:WO2011106570;   Reaxys:11718700;   Wikipedia:Enzalutamide


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enzalutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression ISO enzalutamide results in decreased expression of AADAT mRNA CTD PMID:29581250 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO enzalutamide results in decreased expression of ABCC4 mRNA CTD PMID:29581250 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO enzalutamide results in decreased expression of ACSM1 mRNA CTD PMID:29581250 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 affects expression ISO enzalutamide affects the expression of ADAM10 mRNA CTD PMID:30940724 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects expression ISO enzalutamide affects the expression of ADAM17 mRNA CTD PMID:30940724 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent decreases expression ISO enzalutamide results in decreased expression of ADPRM mRNA CTD PMID:29581250 NCBI chr10:53,583,275...53,595,821
Ensembl chr10:53,583,276...53,595,827
JBrowse link
G Aff3 AF4/FMR2 family, member 3 decreases expression ISO enzalutamide results in decreased expression of AFF3 mRNA CTD PMID:29581250 NCBI chr 9:44,837,979...45,291,964
Ensembl chr 9:44,839,960...45,292,047
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO enzalutamide results in decreased expression of ALDH1A3 mRNA CTD PMID:29581250 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Alpk2 alpha-kinase 2 decreases expression ISO enzalutamide results in decreased expression of ALPK2 mRNA CTD PMID:29581250 NCBI chr18:60,960,009...61,072,116
Ensembl chr18:60,960,662...61,057,365
JBrowse link
G Anxa4 annexin A4 affects expression ISO enzalutamide affects the expression of ANXA4 mRNA CTD PMID:30940724 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1A mRNA CTD PMID:30940724 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1B mRNA CTD PMID:30940724 NCBI chr 8:72,508,008...72,598,921
Ensembl chr 8:72,476,425...72,629,265
JBrowse link
G App amyloid beta precursor protein affects expression ISO enzalutamide affects the expression of APP mRNA CTD PMID:30940724 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
decreases response to substance
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA alternative form; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein alternative form; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of AR protein; enzalutamide binds to and results in decreased localization of and results in decreased activity of AR protein; enzalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]
enzalutamide results in decreased activity of AR protein
AR alternative form results in decreased susceptibility to enzalutamide; AR protein alternative form results in decreased susceptibility to enzalutamide; AR protein results in decreased susceptibility to enzalutamide
enzalutamide results in decreased expression of AR protein; enzalutamide results in decreased expression of AR protein alternative form
CTD PMID:19359544 PMID:24740322 PMID:24759320 PMID:25908785 PMID:25970160 PMID:28757136 PMID:30940724 PMID:32184358 PMID:32805266 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding decreases expression ISO enzalutamide results in decreased expression of AZGP1 mRNA CTD PMID:29581250 NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein] CTD PMID:25970160 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO enzalutamide results in decreased expression of BMPR1B mRNA CTD PMID:29581250 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of CASP3 protein]
enzalutamide results in decreased expression of CASP3 protein
CTD PMID:32184358 PMID:32805266 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 decreases expression ISO enzalutamide results in decreased expression of CASP8 protein CTD PMID:32805266 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO enzalutamide results in decreased expression of CCNB1 protein CTD PMID:32805266 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cd46 CD46 molecule increases expression ISO enzalutamide results in increased expression of CD46 protein CTD PMID:30185663 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C protein CTD PMID:32184358 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO enzalutamide affects the expression of CDKN1B mRNA CTD PMID:30940724 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO enzalutamide affects the expression of CEBPA mRNA CTD PMID:30940724 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Crebbp CREB binding protein affects expression ISO enzalutamide affects the expression of CREBBP mRNA CTD PMID:30940724 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 decreases expression ISO enzalutamide results in decreased expression of CRISP3 mRNA CTD PMID:29581250 NCBI chr 9:24,047,405...24,088,066
Ensembl chr 9:24,066,303...24,088,064
JBrowse link
G Crym crystallin, mu multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA] CTD PMID:29581250 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of CSGALNACT1 mRNA CTD PMID:29581250 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO enzalutamide results in decreased expression of DPP4 mRNA CTD PMID:29581250 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 affects expression ISO enzalutamide affects the expression of DTX2 mRNA CTD PMID:30940724 NCBI chr12:23,687,958...23,727,594
Ensembl chr12:23,687,966...23,727,564
JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 affects expression ISO enzalutamide affects the expression of DTX3 mRNA CTD PMID:30940724 NCBI chr 7:70,476,737...70,482,852
Ensembl chr 7:70,476,729...70,481,796
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 affects expression ISO enzalutamide affects the expression of DTX4 mRNA CTD PMID:30940724 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 decreases expression ISO enzalutamide results in decreased expression of EDEM3 mRNA CTD PMID:29581250 NCBI chr13:69,135,095...69,197,708
Ensembl chr13:69,135,128...69,199,511
JBrowse link
G Eed embryonic ectoderm development multiple interactions
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of EED protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of EED protein] CTD PMID:32805266 NCBI chr 1:154,189,252...154,216,340
Ensembl chr 1:154,189,260...154,216,340
JBrowse link
G Efcab12 EF-hand calcium binding domain 12 decreases expression ISO enzalutamide results in decreased expression of EFCAB12 mRNA CTD PMID:29581250 NCBI chr 4:147,720,813...147,743,342
Ensembl chr 4:147,721,045...147,742,114
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 decreases expression ISO enzalutamide results in decreased expression of ELL2 mRNA CTD PMID:29581250 NCBI chr 2:2,456,189...2,525,590
Ensembl chr 2:2,456,735...2,524,237
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 decreases expression ISO enzalutamide results in decreased expression of ELOVL7 mRNA CTD PMID:29581250 NCBI chr 2:40,373,211...40,386,643
Ensembl chr 2:40,373,211...40,386,669
JBrowse link
G Ep300 E1A binding protein p300 affects expression ISO enzalutamide affects the expression of EP300 mRNA CTD PMID:30940724 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ephb4 EPH receptor B4 affects response to substance
multiple interactions
ISO EPHB4 protein affects the susceptibility to enzalutamide
enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD PMID:32184358 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
JBrowse link
G Epn1 Epsin 1 affects expression ISO enzalutamide affects the expression of EPN1 mRNA CTD PMID:30940724 NCBI chr 1:72,294,153...72,310,217
Ensembl chr 1:72,294,153...72,311,856
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of EZH2 protein
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]
CTD PMID:32805266 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression
ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of FKBP5 mRNA; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of FKBP5 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of FKBP5 mRNA] CTD PMID:32184358 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Foxa1 forkhead box A1 affects expression ISO enzalutamide affects the expression of FOXA1 mRNA CTD PMID:30940724 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 affects expression ISO enzalutamide affects the expression of GALNT11 mRNA CTD PMID:30940724 NCBI chr 4:6,297,255...6,330,765
Ensembl chr 4:6,297,258...6,330,765
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase affects expression ISO enzalutamide affects the expression of GMDS mRNA CTD PMID:30940724 NCBI chr17:33,408,722...33,938,086
Ensembl chr17:33,408,722...33,938,085
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO enzalutamide results in decreased expression of GNMT mRNA CTD PMID:29581250 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression ISO enzalutamide affects the expression of GOT1 mRNA CTD PMID:30940724 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO enzalutamide results in decreased expression of GREB1 mRNA CTD PMID:29581250 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Hes1 hes family bHLH transcription factor 1 affects expression ISO enzalutamide affects the expression of HES1 mRNA CTD PMID:30940724 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hnf1b HNF1 homeobox B affects expression ISO enzalutamide affects the expression of HNF1B mRNA CTD PMID:30940724 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Ift172 intraflagellar transport 172 affects expression ISO enzalutamide affects the expression of IFT172 mRNA CTD PMID:30940724 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Ift74 intraflagellar transport 74 affects expression ISO enzalutamide affects the expression of IFT74 mRNA CTD PMID:30940724 NCBI chr 5:113,579,065...113,682,485
Ensembl chr 5:113,592,919...113,682,484
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO enzalutamide results in decreased expression of IGF1 mRNA CTD PMID:29581250 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO enzalutamide results in decreased expression of IGF1R mRNA CTD PMID:29581250 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases response to substance
ISO Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 decreases expression ISO enzalutamide results in decreased expression of IQGAP2 mRNA CTD PMID:29581250 NCBI chr 2:26,161,628...26,439,067
Ensembl chr 2:26,167,199...26,438,790
JBrowse link
G Itch itchy E3 ubiquitin protein ligase affects expression ISO enzalutamide affects the expression of ITCH mRNA CTD PMID:30940724 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 affects expression ISO enzalutamide affects the expression of ITGB1BP1 mRNA CTD PMID:30940724 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Jag1 jagged canonical Notch ligand 1 affects expression ISO enzalutamide affects the expression of JAG1 mRNA CTD PMID:30940724 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jag2 jagged canonical Notch ligand 2 affects expression ISO enzalutamide affects the expression of JAG2 mRNA CTD PMID:30940724 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Kat2b lysine acetyltransferase 2B affects expression ISO enzalutamide affects the expression of KAT2B mRNA CTD PMID:30940724 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA] CTD PMID:29581250 NCBI chr 5:154,909,003...154,965,171
Ensembl chr 5:154,909,003...154,965,171
JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO enzalutamide results in decreased expression of KIF5C mRNA CTD PMID:29581250 NCBI chr 3:35,014,157...35,257,417
Ensembl chr 3:35,014,538...35,257,407
JBrowse link
G Krt19 keratin 19 affects expression ISO enzalutamide affects the expression of KRT19 mRNA CTD PMID:30940724 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO enzalutamide results in decreased expression of LCK mRNA CTD PMID:29581250 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA] CTD PMID:29581250 NCBI chr15:57,170,566...57,277,811
Ensembl chr15:57,221,292...57,277,811
JBrowse link
G LOC498222 similar to specifically androgen-regulated protein decreases expression ISO enzalutamide results in decreased expression of C1ORF116 mRNA CTD PMID:29581250 NCBI chr13:47,452,436...47,467,432
Ensembl chr13:47,454,591...47,467,432
JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO enzalutamide results in decreased expression of MAF mRNA CTD PMID:29581250 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 affects expression ISO enzalutamide affects the expression of MAML1 mRNA CTD PMID:30940724 NCBI chr10:35,765,196...35,801,375
Ensembl chr10:35,765,719...35,800,120
JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 affects expression ISO enzalutamide affects the expression of MAML3 mRNA CTD PMID:30940724 NCBI chr 2:140,734,138...141,276,886 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [enzalutamide co-treated with GSK-2816126] results in increased expression of MAP1LC3B protein modified form CTD PMID:32805266 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA] CTD PMID:29581250 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mdk midkine affects expression ISO enzalutamide affects the expression of MDK mRNA CTD PMID:30940724 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 affects expression ISO enzalutamide affects the expression of MIB1 mRNA CTD PMID:30940724 NCBI chr18:1,970,914...2,094,920
Ensembl chr18:1,970,914...2,094,920
JBrowse link
G Mib2 MIB E3 ubiquitin protein ligase 2 affects expression ISO enzalutamide affects the expression of MIB2 mRNA CTD PMID:30940724 NCBI chr 5:173,082,943...173,099,353
Ensembl chr 5:173,082,943...173,098,816
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MKI67 protein] CTD PMID:32184358 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 decreases expression ISO enzalutamide results in decreased expression of BRP44 mRNA CTD PMID:29581250 NCBI chr13:83,680,527...83,700,491
Ensembl chr13:83,681,322...83,700,213
JBrowse link
G Msmb microseminoprotein, beta decreases expression ISO enzalutamide results in decreased expression of MSMB mRNA CTD PMID:33932781 NCBI chr16:8,280,275...8,300,853
Ensembl chr16:8,280,275...8,300,852
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
affects expression
ISO enzalutamide results in decreased expression of MYC protein
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of MYC protein; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MYC protein]
enzalutamide affects the expression of MYC mRNA
CTD PMID:24759320 PMID:25970160 PMID:30940724 PMID:32184358 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myo1b myosin Ib multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA] CTD PMID:29581250 NCBI chr 9:54,706,005...54,766,054
Ensembl chr 9:54,558,202...54,766,054
JBrowse link
G Ncstn nicastrin affects expression ISO enzalutamide affects the expression of NCSTN mRNA CTD PMID:30940724 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Neurl1b neuralized E3 ubiquitin protein ligase 1B affects expression ISO enzalutamide affects the expression of NEURL1B mRNA CTD PMID:30940724 NCBI chr10:17,048,251...17,075,139
Ensembl chr10:17,048,251...17,075,139
JBrowse link
G Nkap NFKB activating protein affects expression ISO enzalutamide affects the expression of NKAP mRNA CTD PMID:30940724 NCBI chr  X:123,751,196...123,770,595
Ensembl chr  X:123,751,089...123,770,595
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of NKX3-1 mRNA
enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of NKX3-1 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of NKX3-1 mRNA]
CTD PMID:29581250 PMID:32184358 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nle1 notchless homolog 1 affects expression ISO enzalutamide affects the expression of NLE1 mRNA CTD PMID:30940724 NCBI chr10:70,250,959...70,261,880
Ensembl chr10:70,250,959...70,259,553
JBrowse link
G Notch1 notch receptor 1 affects response to substance
affects expression
multiple interactions
ISO NOTCH1 protein affects the susceptibility to enzalutamide
enzalutamide affects the expression of NOTCH1 mRNA
[NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein
CTD PMID:30940724 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch2 notch receptor 2 affects expression ISO enzalutamide affects the expression of NOTCH2 mRNA CTD PMID:30940724 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Notch3 notch receptor 3 affects expression ISO enzalutamide affects the expression of NOTCH3 mRNA CTD PMID:30940724 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases cleavage
multiple interactions
ISO enzalutamide results in decreased cleavage of PARP1 protein
[enzalutamide co-treated with GSK-2816126] results in increased cleavage of PARP1 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in increased cleavage of PARP1 protein; [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of PARP1 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD PMID:30940724 PMID:32184358 PMID:32805266 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Perp p53 apoptosis effector related to PMP22 affects expression ISO enzalutamide affects the expression of PERP mRNA CTD PMID:30940724 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO enzalutamide results in decreased expression of PLA2G5 mRNA CTD PMID:29581250 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of PLK1 mRNA] CTD PMID:32184358 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO enzalutamide results in decreased expression of PLOD2 mRNA CTD PMID:29581250 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Pofut1 protein O-fucosyltransferase 1 affects expression ISO enzalutamide affects the expression of POFUT1 mRNA CTD PMID:30940724 NCBI chr 3:148,722,864...148,749,743
Ensembl chr 3:148,722,955...148,747,208
JBrowse link
G Psen1 presenilin 1 affects expression ISO enzalutamide affects the expression of PSEN1 mRNA CTD PMID:30940724 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 affects expression ISO enzalutamide affects the expression of PSEN2 mRNA CTD PMID:30940724 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit affects expression ISO enzalutamide affects the expression of PSENEN mRNA CTD PMID:30940724 NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO enzalutamide results in decreased expression of PTGER4 mRNA CTD PMID:29581250 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Rbm15 RNA binding motif protein 15 affects expression ISO enzalutamide affects the expression of RBM15 mRNA CTD PMID:30940724 NCBI chr 2:210,079,678...210,090,200
Ensembl chr 2:210,081,770...210,088,949
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region affects expression ISO enzalutamide affects the expression of RBPJ mRNA CTD PMID:30940724 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO enzalutamide results in decreased expression of RGS2 mRNA CTD PMID:29581250 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhou ras homolog family member U decreases expression ISO enzalutamide results in decreased expression of RHOU mRNA CTD PMID:29581250 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
JBrowse link
G Rps19 ribosomal protein S19 affects expression ISO enzalutamide affects the expression of RPS19 mRNA CTD PMID:30940724 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
JBrowse link
G Rps27a ribosomal protein S27a affects expression ISO enzalutamide affects the expression of RPS27A mRNA CTD PMID:30940724 NCBI chr14:113,966,163...113,968,440
Ensembl chr14:113,966,611...113,968,268
Ensembl chr 5:113,966,611...113,968,268
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 affects expression ISO enzalutamide affects the expression of S1PR3 mRNA CTD PMID:30940724 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase affects expression ISO enzalutamide affects the expression of SEL1L mRNA CTD PMID:30940724 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859
JBrowse link
G Selenop selenoprotein P decreases expression ISO enzalutamide results in decreased expression of SELENOP mRNA CTD PMID:29581250 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA] CTD PMID:29581250 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Snw1 SNW domain containing 1 affects expression ISO enzalutamide affects the expression of SNW1 mRNA CTD PMID:30940724 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO enzalutamide results in decreased expression of SOCS2 mRNA CTD PMID:29581250 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO enzalutamide affects the expression of SOX9 mRNA CTD PMID:30940724 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Spen spen family transcriptional repressor affects expression ISO enzalutamide affects the expression of SPEN mRNA CTD PMID:30940724 NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965
JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 decreases expression ISO enzalutamide results in decreased expression of SPOCK1 mRNA CTD PMID:29581250 NCBI chr17:7,675,531...7,797,863
Ensembl chr17:7,675,531...7,797,863
JBrowse link
G St6galnac1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of ST6GALNAC1 mRNA CTD PMID:29581250 NCBI chr10:105,713,305...105,723,700
Ensembl chr10:105,713,317...105,723,700
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases response to substance
ISO enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Susd5 sushi domain containing 5 affects expression ISO enzalutamide affects the expression of SUSD5 mRNA CTD PMID:30940724 NCBI chr 8:122,331,489...122,370,684
Ensembl chr 8:122,331,583...122,368,368
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of SUZ12 protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of SUZ12 protein] CTD PMID:32805266 NCBI chr10:67,325,101...67,371,588
Ensembl chr10:67,325,347...67,369,668
JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO enzalutamide results in decreased expression of TENM1 mRNA CTD PMID:29581250 NCBI chr  X:129,034,755...129,336,023
NCBI chr  X:128,923,951...128,951,520
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of TMCC3 mRNA
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA]
CTD PMID:29581250 NCBI chr 7:35,266,953...35,543,770
Ensembl chr 7:35,309,265...35,543,759
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO enzalutamide results in decreased expression of TMPRSS2 mRNA CTD PMID:29581250 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tpd52 tumor protein D52 decreases expression ISO enzalutamide results in decreased expression of TPD52 mRNA CTD PMID:29581250 NCBI chr 2:94,959,732...95,041,277
Ensembl chr 2:95,008,311...95,040,514
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO enzalutamide results in decreased expression of TRPM8 mRNA CTD PMID:29581250 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO enzalutamide affects the expression of UBA52 mRNA CTD PMID:30940724 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ubb ubiquitin B affects expression ISO enzalutamide affects the expression of UBB mRNA CTD PMID:30940724 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881
JBrowse link
G Ubc ubiquitin C affects expression ISO enzalutamide affects the expression of UBC mRNA CTD PMID:30940724 NCBI chr12:36,638,457...36,642,734
Ensembl chr12:36,638,457...36,642,734
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of UBE2C mRNA CTD PMID:32184358 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Wdr12 WD repeat domain 12 affects expression ISO enzalutamide affects the expression of WDR12 mRNA CTD PMID:30940724 NCBI chr 9:66,851,499...66,878,534
Ensembl chr 9:66,851,940...66,877,972
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO enzalutamide results in decreased expression of WWTR1 mRNA CTD PMID:29581250 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19775
    chemical entity 19775
      group 19695
        pseudohalo group 3228
          cyano group 3228
            nitrile 3228
              enzalutamide 128
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    subatomic particle 19774
      composite particle 19774
        hadron 19774
          baryon 19774
            nucleon 19774
              atomic nucleus 19774
                atom 19774
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19584
                        carbon atom 19574
                          organic molecular entity 19574
                            organic group 18622
                              organic divalent group 18613
                                organodiyl group 18613
                                  carbonyl group 18530
                                    carbonyl compound 18530
                                      carboxylic acid 18207
                                        carboacyl group 17440
                                          univalent carboacyl group 17440
                                            carbamoyl group 17249
                                              carboxamide 17249
                                                monocarboxylic acid amide 14874
                                                  arenecarboxamide 6595
                                                    benzamides 6595
                                                      enzalutamide 128
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