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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enzalutamide
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Accession:CHEBI:68534 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with methylamine. Used for the treatment of of metastatic castration-resistant prostate cancer.
Synonyms:exact_synonym: 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
 related_synonym: Formula=C21H16F4N4O2S;   InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30);   InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N;   MDV 3100;   MDV3100;   SMILES=CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F;   XTANDI
 xref: CAS:915087-33-1;   Drug_Central:4628;   LINCS:LSM-6254
 xref_mesh: MESH:C540278
 xref: PMID:21986558;   PMID:22101903;   PMID:22113551;   PMID:22162475;   PMID:22229405;   PMID:22258371;   PMID:22258374;   PMID:22266222;   PMID:22310230;   PMID:22373838;   PMID:22393799;   PMID:22411952;   PMID:22429837;   PMID:22472508;   PMID:22516457;   PMID:22710436;   PMID:22815001;   PMID:22845410;   PMID:22852027;   PMID:22894553;   PMID:22956944;   PMID:22985411;   PMID:22987974;   Patent:US2007254933;   Patent:WO2006124118;   Patent:WO2011106570;   Reaxys:11718700;   Wikipedia:Enzalutamide



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enzalutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression ISO enzalutamide results in decreased expression of AADAT mRNA CTD PMID:29581250 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO enzalutamide results in decreased expression of ABCC4 mRNA CTD PMID:29581250 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO enzalutamide results in decreased expression of ACSM1 mRNA CTD PMID:29581250 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 affects expression ISO enzalutamide affects the expression of ADAM10 mRNA CTD PMID:30940724 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects expression ISO enzalutamide affects the expression of ADAM17 mRNA CTD PMID:30940724 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent decreases expression ISO enzalutamide results in decreased expression of ADPRM mRNA CTD PMID:29581250 NCBI chr10:51,732,073...51,744,635
Ensembl chr10:51,731,993...51,744,635
JBrowse link
G Aff3 AF4/FMR2 family, member 3 decreases expression ISO enzalutamide results in decreased expression of AFF3 mRNA CTD PMID:29581250 NCBI chr 9:40,399,109...40,856,716
Ensembl chr 9:40,404,375...40,857,247
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO enzalutamide results in decreased expression of ALDH1A3 mRNA CTD PMID:29581250 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Alpk2 alpha-kinase 2 decreases expression ISO enzalutamide results in decreased expression of ALPK2 mRNA CTD PMID:29581250 NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
JBrowse link
G Anxa4 annexin A4 affects expression ISO enzalutamide affects the expression of ANXA4 mRNA CTD PMID:30940724 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1A mRNA CTD PMID:30940724 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit affects expression ISO enzalutamide affects the expression of APH1B mRNA CTD PMID:30940724 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G App amyloid beta precursor protein affects expression ISO enzalutamide affects the expression of APP mRNA CTD PMID:30940724 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
decreases response to substance
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; [enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR mRNA alternative form; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of AR protein alternative form; [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of AR protein; enzalutamide binds to and results in decreased localization of and results in decreased activity of AR protein; enzalutamide inhibits the reaction [Dihydrotestosterone affects the localization of AR protein]; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]
enzalutamide results in decreased activity of AR protein
AR alternative form results in decreased susceptibility to enzalutamide; AR protein alternative form results in decreased susceptibility to enzalutamide; AR protein results in decreased susceptibility to enzalutamide
enzalutamide results in decreased expression of AR protein; enzalutamide results in decreased expression of AR protein alternative form
CTD PMID:19359544 PMID:24740322 PMID:24759320 PMID:25908785 PMID:25970160 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding decreases expression ISO enzalutamide results in decreased expression of AZGP1 mRNA CTD PMID:29581250 NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein] CTD PMID:25970160 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO enzalutamide results in decreased expression of BMPR1B mRNA CTD PMID:29581250 NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of CASP3 protein]
enzalutamide results in decreased expression of CASP3 protein
CTD PMID:32184358 PMID:32805266 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO enzalutamide results in decreased expression of CASP8 protein CTD PMID:32805266 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO enzalutamide results in decreased expression of CCNB1 protein CTD PMID:32805266 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cd46 CD46 molecule increases expression ISO enzalutamide results in increased expression of CD46 protein CTD PMID:30185663 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of CDC25C protein CTD PMID:32184358 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B affects expression ISO enzalutamide affects the expression of CDKN1B mRNA CTD PMID:30940724 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression ISO enzalutamide affects the expression of CEBPA mRNA CTD PMID:30940724 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Crebbp CREB binding protein affects expression ISO enzalutamide affects the expression of CREBBP mRNA CTD PMID:30940724 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 decreases expression ISO enzalutamide results in decreased expression of CRISP3 mRNA CTD PMID:29581250 NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
JBrowse link
G Crym crystallin, mu multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA] CTD PMID:29581250 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of CSGALNACT1 mRNA CTD PMID:29581250 NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression ISO enzalutamide results in decreased expression of DPP4 mRNA CTD PMID:29581250 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 affects expression ISO enzalutamide affects the expression of DTX2 mRNA CTD PMID:30940724 NCBI chr12:20,643,289...20,682,908
Ensembl chr12:20,643,297...20,682,885
JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 affects expression ISO enzalutamide affects the expression of DTX3 mRNA CTD PMID:30940724 NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 affects expression ISO enzalutamide affects the expression of DTX4 mRNA CTD PMID:30940724 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818
JBrowse link
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 decreases expression ISO enzalutamide results in decreased expression of EDEM3 mRNA CTD PMID:29581250 NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523
JBrowse link
G Eed embryonic ectoderm development multiple interactions
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of EED protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of EED protein] CTD PMID:32805266 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
JBrowse link
G Efcab12 EF-hand calcium binding domain 12 decreases expression ISO enzalutamide results in decreased expression of EFCAB12 mRNA CTD PMID:29581250 NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 decreases expression ISO enzalutamide results in decreased expression of ELL2 mRNA CTD PMID:29581250 NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 decreases expression ISO enzalutamide results in decreased expression of ELOVL7 mRNA CTD PMID:29581250 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845
JBrowse link
G Ep300 E1A binding protein p300 affects expression ISO enzalutamide affects the expression of EP300 mRNA CTD PMID:30940724 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ephb4 EPH receptor B4 affects response to substance
multiple interactions
ISO EPHB4 protein affects the susceptibility to enzalutamide
enzalutamide promotes the reaction [EPHB4 protein affects the expression of KLK3 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD PMID:32184358 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Epn1 Epsin 1 affects expression ISO enzalutamide affects the expression of EPN1 mRNA CTD PMID:30940724 NCBI chr 1:68,742,491...68,760,507
Ensembl chr 1:68,742,789...68,758,874
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of EZH2 protein
[enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]
CTD PMID:32805266 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions
decreases expression
ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of FKBP5 mRNA; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of FKBP5 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of FKBP5 mRNA] CTD PMID:32184358 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Foxa1 forkhead box A1 affects expression ISO enzalutamide affects the expression of FOXA1 mRNA CTD PMID:30940724 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Galnt11 polypeptide N-acetylgalactosaminyltransferase 11 affects expression ISO enzalutamide affects the expression of GALNT11 mRNA CTD PMID:30940724 NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140
JBrowse link
G Gmds GDP-mannose 4, 6-dehydratase affects expression ISO enzalutamide affects the expression of GMDS mRNA CTD PMID:30940724 NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO enzalutamide results in decreased expression of GNMT mRNA CTD PMID:29581250 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects expression ISO enzalutamide affects the expression of GOT1 mRNA CTD PMID:30940724 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 decreases expression ISO enzalutamide results in decreased expression of GREB1 mRNA CTD PMID:29581250 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Hes1 hes family bHLH transcription factor 1 affects expression ISO enzalutamide affects the expression of HES1 mRNA CTD PMID:30940724 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hnf1b HNF1 homeobox B affects expression ISO enzalutamide affects the expression of HNF1B mRNA CTD PMID:30940724 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
JBrowse link
G Ift172 intraflagellar transport 172 affects expression ISO enzalutamide affects the expression of IFT172 mRNA CTD PMID:30940724 NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860
JBrowse link
G Ift74 intraflagellar transport 74 affects expression ISO enzalutamide affects the expression of IFT74 mRNA CTD PMID:30940724 NCBI chr 5:109,460,372...109,563,839
Ensembl chr 5:109,474,255...109,563,833
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO enzalutamide results in decreased expression of IGF1 mRNA CTD PMID:29581250 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO enzalutamide results in decreased expression of IGF1R mRNA CTD PMID:29581250 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases response to substance
ISO Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 decreases expression ISO enzalutamide results in decreased expression of IQGAP2 mRNA CTD PMID:29581250 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
JBrowse link
G Itch itchy E3 ubiquitin protein ligase affects expression ISO enzalutamide affects the expression of ITCH mRNA CTD PMID:30940724 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 affects expression ISO enzalutamide affects the expression of ITGB1BP1 mRNA CTD PMID:30940724 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Jag1 jagged canonical Notch ligand 1 affects expression ISO enzalutamide affects the expression of JAG1 mRNA CTD PMID:30940724 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Jag2 jagged canonical Notch ligand 2 affects expression ISO enzalutamide affects the expression of JAG2 mRNA CTD PMID:30940724 NCBI chr 6:131,983,056...132,005,359
Ensembl chr 6:131,983,056...132,005,818
JBrowse link
G Kat2b lysine acetyltransferase 2B affects expression ISO enzalutamide affects the expression of KAT2B mRNA CTD PMID:30940724 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of CRYM mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of KLK3 protein]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA]; KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA] CTD PMID:29581250 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
JBrowse link
G Kif5c kinesin family member 5C decreases expression ISO enzalutamide results in decreased expression of KIF5C mRNA CTD PMID:29581250 NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
JBrowse link
G Krt19 keratin 19 affects expression ISO enzalutamide affects the expression of KRT19 mRNA CTD PMID:30940724 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO enzalutamide results in decreased expression of LCK mRNA CTD PMID:29581250 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of LCP1 mRNA] CTD PMID:29581250 NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G LOC498222 similar to specifically androgen-regulated protein decreases expression ISO enzalutamide results in decreased expression of C1ORF116 mRNA CTD PMID:29581250 NCBI chr13:42,187,442...42,201,432
Ensembl chr13:42,188,609...42,201,426
JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO enzalutamide results in decreased expression of MAF mRNA CTD PMID:29581250 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 affects expression ISO enzalutamide affects the expression of MAML1 mRNA CTD PMID:30940724 NCBI chr10:34,588,639...34,624,298
Ensembl chr10:34,588,646...34,623,338
JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 affects expression ISO enzalutamide affects the expression of MAML3 mRNA CTD PMID:30940724 NCBI chr 2:135,722,585...136,136,975
Ensembl chr 2:135,721,021...136,137,814
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [enzalutamide co-treated with GSK-2816126] results in increased expression of MAP1LC3B protein modified form CTD PMID:32805266 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MAP2 mRNA] CTD PMID:29581250 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mdk midkine affects expression ISO enzalutamide affects the expression of MDK mRNA CTD PMID:30940724 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 affects expression ISO enzalutamide affects the expression of MIB1 mRNA CTD PMID:30940724 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689
JBrowse link
G Mib2 MIB E3 ubiquitin protein ligase 2 affects expression ISO enzalutamide affects the expression of MIB2 mRNA CTD PMID:30940724 NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MKI67 protein] CTD PMID:32184358 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 decreases expression ISO enzalutamide results in decreased expression of BRP44 mRNA CTD PMID:29581250 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664
JBrowse link
G Msmb microseminoprotein, beta decreases expression ISO enzalutamide results in decreased expression of MSMB mRNA CTD PMID:33932781 NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
affects expression
ISO enzalutamide results in decreased expression of MYC protein
[enzalutamide co-treated with NVP-BHG712] results in decreased expression of MYC protein; enzalutamide inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to MYC enhancer]]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC mRNA]; enzalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of MYC protein]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of MYC protein]
enzalutamide affects the expression of MYC mRNA
CTD PMID:24759320 PMID:25970160 PMID:30940724 PMID:32184358 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myo1b myosin Ib multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of MYO1B mRNA] CTD PMID:29581250 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
JBrowse link
G Ncstn nicastrin affects expression ISO enzalutamide affects the expression of NCSTN mRNA CTD PMID:30940724 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Neurl1b neuralized E3 ubiquitin protein ligase 1B affects expression ISO enzalutamide affects the expression of NEURL1B mRNA CTD PMID:30940724 NCBI chr10:16,758,097...16,784,943
Ensembl chr10:16,757,208...16,785,119
JBrowse link
G Nkap NFKB activating protein affects expression ISO enzalutamide affects the expression of NKAP mRNA CTD PMID:30940724 NCBI chr  X:116,373,031...116,392,677
Ensembl chr  X:116,372,839...116,394,945
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of NKX3-1 mRNA
enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of NKX3-1 mRNA]; NVP-BHG712 promotes the reaction [enzalutamide results in decreased expression of NKX3-1 mRNA]
CTD PMID:29581250 PMID:32184358 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nle1 notchless homolog 1 affects expression ISO enzalutamide affects the expression of NLE1 mRNA CTD PMID:30940724 NCBI chr10:67,834,059...67,844,771
Ensembl chr10:67,834,062...67,842,658
JBrowse link
G Notch1 notch receptor 1 affects response to substance
affects expression
multiple interactions
ISO NOTCH1 protein affects the susceptibility to enzalutamide
enzalutamide affects the expression of NOTCH1 mRNA
[NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein
CTD PMID:30940724 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Notch2 notch receptor 2 affects expression ISO enzalutamide affects the expression of NOTCH2 mRNA CTD PMID:30940724 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
JBrowse link
G Notch3 notch receptor 3 affects expression ISO enzalutamide affects the expression of NOTCH3 mRNA CTD PMID:30940724 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases cleavage
multiple interactions
ISO enzalutamide results in decreased cleavage of PARP1 protein
[enzalutamide co-treated with GSK-2816126] results in increased cleavage of PARP1 protein; [nirogacestat results in increased susceptibility to enzalutamide] which results in increased cleavage of PARP1 protein; [NOTCH1 protein affects the susceptibility to enzalutamide] which affects the cleavage of PARP1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in increased cleavage of PARP1 protein]; EPHB4 protein affects the reaction [enzalutamide results in decreased cleavage of PARP1 protein]
CTD PMID:30940724 PMID:32184358 PMID:32805266 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Perp p53 apoptosis effector related to PMP22 affects expression ISO enzalutamide affects the expression of PERP mRNA CTD PMID:30940724 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression ISO enzalutamide results in decreased expression of PLA2G5 mRNA CTD PMID:29581250 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 mRNA; [enzalutamide co-treated with NVP-BHG712] results in decreased expression of PLK1 protein; enzalutamide promotes the reaction [NVP-BHG712 results in decreased expression of PLK1 mRNA] CTD PMID:32184358 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO enzalutamide results in decreased expression of PLOD2 mRNA CTD PMID:29581250 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
JBrowse link
G Pofut1 protein O-fucosyltransferase 1 affects expression ISO enzalutamide affects the expression of POFUT1 mRNA CTD PMID:30940724 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786
JBrowse link
G Psen1 presenilin 1 affects expression ISO enzalutamide affects the expression of PSEN1 mRNA CTD PMID:30940724 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 affects expression ISO enzalutamide affects the expression of PSEN2 mRNA CTD PMID:30940724 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit affects expression ISO enzalutamide affects the expression of PSENEN mRNA CTD PMID:30940724 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO enzalutamide results in decreased expression of PTGER4 mRNA CTD PMID:29581250 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Rbm15 RNA binding motif protein 15 affects expression ISO enzalutamide affects the expression of RBM15 mRNA CTD PMID:30940724 NCBI chr 2:194,945,717...194,954,523
Ensembl chr 2:194,945,974...194,954,703
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region affects expression ISO enzalutamide affects the expression of RBPJ mRNA CTD PMID:30940724 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO enzalutamide results in decreased expression of RGS2 mRNA CTD PMID:29581250 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rhou ras homolog family member U decreases expression ISO enzalutamide results in decreased expression of RHOU mRNA CTD PMID:29581250 NCBI chr19:51,641,408...51,651,249
Ensembl chr19:51,641,227...51,650,552
JBrowse link
G Rps19 ribosomal protein S19 affects expression ISO enzalutamide affects the expression of RPS19 mRNA CTD PMID:30940724 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
JBrowse link
G Rps27a ribosomal protein S27a affects expression ISO enzalutamide affects the expression of RPS27A mRNA CTD PMID:30940724 NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 affects expression ISO enzalutamide affects the expression of S1PR3 mRNA CTD PMID:30940724 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase affects expression ISO enzalutamide affects the expression of SEL1L mRNA CTD PMID:30940724 NCBI chr 6:110,735,450...110,779,695
Ensembl chr 6:110,735,450...110,779,648
JBrowse link
G Selenop selenoprotein P decreases expression ISO enzalutamide results in decreased expression of SELENOP mRNA CTD PMID:29581250 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases expression
ISO KDM1A protein promotes the reaction [enzalutamide results in decreased expression of SLC22A3 mRNA] CTD PMID:29581250 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Snw1 SNW domain containing 1 affects expression ISO enzalutamide affects the expression of SNW1 mRNA CTD PMID:30940724 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO enzalutamide results in decreased expression of SOCS2 mRNA CTD PMID:29581250 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO enzalutamide affects the expression of SOX9 mRNA CTD PMID:30940724 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Spen spen family transcriptional repressor affects expression ISO enzalutamide affects the expression of SPEN mRNA CTD PMID:30940724 NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811
JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 decreases expression ISO enzalutamide results in decreased expression of SPOCK1 mRNA CTD PMID:29581250 NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935
JBrowse link
G St6galnac1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 decreases expression ISO enzalutamide results in decreased expression of ST6GALNAC1 mRNA CTD PMID:29581250 NCBI chr10:101,972,656...101,983,053
Ensembl chr10:101,972,668...101,983,053
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases response to substance
ISO enzalutamide promotes the reaction [Niclosamide results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Niclosamide inhibits the reaction [STAT3 protein results in decreased susceptibility to enzalutamide] CTD PMID:25970160 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Susd5 sushi domain containing 5 affects expression ISO enzalutamide affects the expression of SUSD5 mRNA CTD PMID:30940724 NCBI chr 8:113,996,771...114,036,133
Ensembl chr 8:113,997,362...114,035,861
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
decreases expression
ISO [enzalutamide co-treated with GSK-2816126] inhibits the reaction [AR protein binds to [EZH2 protein binds to SUZ12 protein binds to EED protein]]; enzalutamide promotes the reaction [GSK-2816126 results in decreased expression of SUZ12 protein]; GSK-2816126 promotes the reaction [enzalutamide results in decreased expression of SUZ12 protein] CTD PMID:32805266 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO enzalutamide results in decreased expression of TENM1 mRNA CTD PMID:29581250 NCBI chr  X:121,400,466...122,289,877
Ensembl chr  X:121,403,649...122,290,207
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression
multiple interactions
ISO enzalutamide results in decreased expression of TMCC3 mRNA
KDM1A protein promotes the reaction [enzalutamide results in decreased expression of TMCC3 mRNA]
CTD PMID:29581250 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tpd52 tumor protein D52 decreases expression ISO enzalutamide results in decreased expression of TPD52 mRNA CTD PMID:29581250 NCBI chr 2:92,735,246...92,816,079
Ensembl chr 2:92,735,620...92,816,622
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO enzalutamide results in decreased expression of TRPM8 mRNA CTD PMID:29581250 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO enzalutamide affects the expression of UBA52 mRNA CTD PMID:30940724 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
JBrowse link
G Ubb ubiquitin B affects expression ISO enzalutamide affects the expression of UBB mRNA CTD PMID:30940724 NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ubc ubiquitin C affects expression ISO enzalutamide affects the expression of UBC mRNA CTD PMID:30940724 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [enzalutamide co-treated with NVP-BHG712] results in decreased expression of UBE2C mRNA CTD PMID:32184358 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Wdr12 WD repeat domain 12 affects expression ISO enzalutamide affects the expression of WDR12 mRNA CTD PMID:30940724 NCBI chr 9:61,475,498...61,502,584
Ensembl chr 9:61,475,517...61,502,469
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 decreases expression ISO enzalutamide results in decreased expression of WWTR1 mRNA CTD PMID:29581250 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      group 19990
        pseudohalo group 3909
          cyano group 3905
            nitrile 3909
              enzalutamide 127
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                monocarboxylic acid amide 15534
                                                  arenecarboxamide 7310
                                                    benzamides 7314
                                                      enzalutamide 127
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