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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutathione depleting agent
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Accession:CHEBI:68509 term browser browse the term
Definition:A compound which causes a reduction in the levels of glutathione in cells.
Synonyms:related_synonym: glutathione depleting agents;   glutathione depletion agent;   glutathione depletion agents;   glutathione depletor;   glutathione depletors


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diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression EXP diethyl maleate results in increased expression of ABCC2 mRNA CTD PMID:25270620 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abhd4 abhydrolase domain containing 4 increases expression EXP diethyl maleate results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:54,254,129...54,269,169
Ensembl chr14:54,254,188...54,270,637
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression EXP diethyl maleate results in decreased expression of ACACA mRNA CTD PMID:25270620 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]] CTD PMID:17134953 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045
JBrowse link
G Acy3 aspartoacylase (aminoacylase) 3 decreases expression ISO diethyl maleate results in decreased expression of ACY3 mRNA CTD PMID:21161181 NCBI chr19:3,986,570...3,990,007
Ensembl chr19:3,986,570...3,990,007
JBrowse link
G Adm adrenomedullin increases expression ISO diethyl maleate results in increased expression of ADM mRNA CTD PMID:33545341 NCBI chr 7:110,627,657...110,629,820
Ensembl chr 7:110,627,661...110,629,820
JBrowse link
G Adora3 adenosine A3 receptor decreases expression ISO diethyl maleate results in decreased expression of ADORA3 mRNA CTD PMID:21161181 NCBI chr 3:105,904,421...105,908,928
Ensembl chr 3:105,870,858...105,908,926
JBrowse link
G Aen apoptosis enhancing nuclease increases expression ISO diethyl maleate results in increased expression of AEN mRNA CTD PMID:33545341 NCBI chr 7:78,895,927...78,911,209
Ensembl chr 7:78,895,854...78,911,209
JBrowse link
G Afp alpha fetoprotein increases expression EXP diethyl maleate results in increased expression of AFP mRNA CTD PMID:25270620 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 increases expression EXP diethyl maleate results in increased expression of AHCYL1 mRNA CTD PMID:25270620 NCBI chr 3:107,663,120...107,696,560
Ensembl chr 3:107,663,118...107,696,560
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) increases expression ISO diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 NCBI chr 4:116,636,510...116,651,674
Ensembl chr 4:116,636,510...116,651,680
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) increases expression ISO diethyl maleate results in increased expression of AKR1B10 mRNA CTD PMID:33545341 NCBI chr 6:34,384,247...34,396,949
Ensembl chr 6:34,384,218...34,396,950
JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 increases expression EXP diethyl maleate results in increased expression of AKR1C19 mRNA CTD PMID:25270620 NCBI chr13:4,233,503...4,248,361
Ensembl chr13:4,228,700...4,252,843
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO diethyl maleate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects reduction EXP diethyl maleate affects the reduction of ALDH1A1 protein CTD PMID:19843705 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression ISO diethyl maleate results in decreased expression of ALDH1B1 mRNA CTD PMID:21161181 NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases reduction
increases expression
decreases expression
EXP
ISO
diethyl maleate results in decreased reduction of ALDH2 protein
diethyl maleate results in increased expression of ALDH2 protein
diethyl maleate results in decreased expression of ALDH2 protein
CTD PMID:19843705 PMID:21161181 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Aldob aldolase B, fructose-bisphosphate decreases expression ISO diethyl maleate results in decreased expression of ALDOB protein CTD PMID:21161181 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO diethyl maleate results in decreased expression of AMIGO2 mRNA CTD PMID:21161181 NCBI chr15:97,244,074...97,247,287
Ensembl chr15:97,244,125...97,247,287
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO diethyl maleate results in decreased expression of ANGPTL2 mRNA CTD PMID:21161181 NCBI chr 2:33,215,951...33,247,725
Ensembl chr 2:33,216,069...33,247,717
JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO diethyl maleate results in increased expression of ANGPTL4 mRNA CTD PMID:33545341 NCBI chr17:33,774,900...33,781,575
Ensembl chr17:33,773,750...33,781,830
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression ISO diethyl maleate results in decreased expression of ANKRD46 mRNA CTD PMID:21161181 NCBI chr15:36,477,668...36,496,791
Ensembl chr15:36,477,668...36,496,820
JBrowse link
G Anln anillin, actin binding protein increases expression ISO diethyl maleate results in increased expression of ANLN mRNA CTD PMID:21161181 NCBI chr 9:22,331,214...22,389,211
Ensembl chr 9:22,332,012...22,389,188
JBrowse link
G Anxa3 annexin A3 decreases expression ISO diethyl maleate results in decreased expression of ANXA3 mRNA CTD PMID:21161181 NCBI chr 5:96,793,385...96,845,968
Ensembl chr 5:96,793,339...96,845,966
JBrowse link
G Ap3m2 adaptor-related protein complex 3, mu 2 subunit decreases expression ISO diethyl maleate results in decreased expression of AP3M2 mRNA CTD PMID:21161181 NCBI chr 8:22,787,354...22,807,292
Ensembl chr 8:22,787,354...22,805,622
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Aplp1 amyloid beta (A4) precursor-like protein 1 decreases expression EXP diethyl maleate results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 7:30,434,980...30,445,582
Ensembl chr 7:30,434,982...30,445,535
JBrowse link
G Apol6 apolipoprotein L 6 decreases expression ISO diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr15:77,045,050...77,057,108
Ensembl chr15:77,044,729...77,057,106
JBrowse link
G Apol9a apolipoprotein L 9a decreases expression ISO diethyl maleate results in decreased expression of APOL9A mRNA CTD PMID:21161181 NCBI chr15:77,403,789...77,411,080
Ensembl chr15:77,403,789...77,411,135
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 increases expression ISO diethyl maleate results in increased expression of ARHGAP9 mRNA CTD PMID:33545341 NCBI chr10:127,321,913...127,329,947
Ensembl chr10:127,321,964...127,329,943
JBrowse link
G Arrdc2 arrestin domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of ARRDC2 mRNA CTD PMID:21161181 NCBI chr 8:70,835,129...70,839,720
Ensembl chr 8:70,835,129...70,839,720
JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression EXP diethyl maleate results in decreased expression of ARRDC4 mRNA CTD PMID:25270620 NCBI chr 7:68,736,994...68,749,238
Ensembl chr 7:68,736,995...68,749,241
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone increases expression ISO diethyl maleate results in increased expression of ASF1B mRNA CTD PMID:21161181 NCBI chr 8:83,955,694...83,970,195
Ensembl chr 8:83,955,507...83,970,197
JBrowse link
G Asxl1 ASXL transcriptional regulator 1 decreases expression EXP diethyl maleate results in decreased expression of ASXL1 mRNA CTD PMID:25270620 NCBI chr 2:153,345,830...153,404,007
Ensembl chr 2:153,345,829...153,404,007
JBrowse link
G Atm ataxia telangiectasia mutated increases expression ISO diethyl maleate results in increased expression of ATM mRNA CTD PMID:11875189 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit increases expression ISO diethyl maleate results in increased expression of ATP5F1B protein CTD PMID:21161181 NCBI chr10:128,083,307...128,090,388
Ensembl chr10:128,083,273...128,090,391
JBrowse link
G Aurka aurora kinase A increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of AURKA mRNA
diethyl maleate results in decreased expression of AURKA mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 2:172,356,190...172,370,886
Ensembl chr 2:172,356,190...172,370,535
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression ISO diethyl maleate results in increased expression of BBC3 mRNA CTD PMID:33545341 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
EXP
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA
diethyl maleate results in increased expression of BCL2 mRNA
CTD PMID:22564015 PMID:33545341 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression ISO diethyl maleate results in decreased expression of BCL2A1 mRNA CTD PMID:21161181 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 decreases expression EXP diethyl maleate results in decreased expression of BCL3 mRNA CTD PMID:25270620 NCBI chr 7:19,808,462...19,822,824
Ensembl chr 7:19,808,462...19,822,770
JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B decreases expression ISO diethyl maleate results in decreased expression of BCL6B mRNA CTD PMID:21161181 NCBI chr11:70,224,127...70,229,798
Ensembl chr11:70,224,128...70,229,798
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 decreases expression ISO diethyl maleate results in decreased expression of BHLHE41 mRNA CTD PMID:21161181 NCBI chr 6:145,858,243...145,865,420
Ensembl chr 6:145,858,243...145,865,558
JBrowse link
G Bhmt betaine-homocysteine methyltransferase decreases expression ISO diethyl maleate results in decreased expression of BHMT mRNA CTD PMID:21161181 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions EXP diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] CTD PMID:12774022 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Blvrb biliverdin reductase B (flavin reductase (NADPH)) increases expression EXP diethyl maleate results in increased expression of BLVRB mRNA CTD PMID:25270620 NCBI chr 7:27,447,978...27,465,981
Ensembl chr 7:27,447,978...27,466,144
JBrowse link
G Bmf BCL2 modifying factor decreases expression ISO diethyl maleate results in decreased expression of BMF mRNA CTD PMID:21161181 NCBI chr 2:118,528,757...118,549,686
Ensembl chr 2:118,528,757...118,549,687
JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 increases expression ISO diethyl maleate results in increased expression of BRIP1 mRNA CTD PMID:21161181 NCBI chr11:86,058,136...86,201,215
Ensembl chr11:86,058,138...86,201,193
JBrowse link
G Btbd2 BTB (POZ) domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of BTBD2 mRNA CTD PMID:21161181 NCBI chr10:80,642,623...80,656,494
Ensembl chr10:80,642,617...80,657,071
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
decreases expression
multiple interactions
EXP diethyl maleate results in increased expression of BTG2 mRNA
diethyl maleate results in decreased expression of BTG2 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD PMID:22003191 PMID:25270620 NCBI chr 1:134,074,865...134,079,155
Ensembl chr 1:134,075,170...134,079,120
JBrowse link
G C6 complement component 6 decreases expression ISO diethyl maleate results in decreased expression of C6 mRNA CTD PMID:21161181 NCBI chr15:4,727,067...4,804,045
Ensembl chr15:4,727,175...4,814,967
JBrowse link
G Casp2 caspase 2 increases expression ISO diethyl maleate results in increased expression of CASP2 mRNA CTD PMID:11875189 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO diethyl maleate results in increased expression of CASP3 mRNA
diethyl maleate results in increased cleavage of CASP3 protein
CTD PMID:11875189 PMID:21105742 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 increases expression ISO diethyl maleate results in increased expression of CASP9 mRNA CTD PMID:11875189 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase decreases expression ISO diethyl maleate results in decreased expression of CAT protein CTD PMID:21161181 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression EXP diethyl maleate results in increased expression of CBR1 mRNA CTD PMID:25270620 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression
multiple interactions
ISO
EXP
diethyl maleate results in increased expression of CBR3 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD PMID:20806931 PMID:25270620 NCBI chr16:93,683,219...93,690,991
Ensembl chr16:93,683,215...93,690,990
JBrowse link
G Cbx4 chromobox 4 increases expression ISO diethyl maleate results in increased expression of CBX4 mRNA CTD PMID:33545341 NCBI chr11:119,077,571...119,086,237
Ensembl chr11:119,077,573...119,086,221
JBrowse link
G Ccdc50 coiled-coil domain containing 50 decreases expression EXP diethyl maleate results in decreased expression of CCDC50 mRNA CTD PMID:25270620 NCBI chr16:27,387,065...27,452,218
Ensembl chr16:27,388,869...27,452,218
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO diethyl maleate results in decreased expression of CCNA1 mRNA CTD PMID:11875189 NCBI chr 3:55,045,469...55,057,634
Ensembl chr 3:55,045,469...55,055,501
JBrowse link
G Ccna2 cyclin A2 increases expression ISO diethyl maleate results in increased expression of CCNA2 mRNA CTD PMID:21161181 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
diethyl maleate results in decreased expression of CCND1 mRNA
diethyl maleate results in increased expression of CCND1 mRNA
CTD PMID:11875189 PMID:21161181 PMID:25270620 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccne2 cyclin E2 increases expression ISO diethyl maleate results in increased expression of CCNE2 mRNA CTD PMID:21161181 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Ccnk cyclin K decreases expression ISO diethyl maleate results in decreased expression of CCNK mRNA CTD PMID:11875189 NCBI chr12:108,179,308...108,203,359
Ensembl chr12:108,179,579...108,203,359
JBrowse link
G Cd80 CD80 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein
diethyl maleate results in increased expression of CD80 protein
CTD PMID:31958493 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein] CTD PMID:24136171 PMID:31958493 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO diethyl maleate results in increased expression of CDC25A mRNA CTD PMID:21161181 NCBI chr 9:109,875,518...109,893,895
Ensembl chr 9:109,875,579...109,893,895
JBrowse link
G Cdca2 cell division cycle associated 2 increases expression ISO diethyl maleate results in increased expression of CDCA2 mRNA CTD PMID:21161181 NCBI chr14:67,673,180...67,715,841
Ensembl chr14:67,676,331...67,715,841
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO diethyl maleate results in increased expression of CDCA3 mRNA CTD PMID:21161181 NCBI chr 6:124,829,530...124,833,701
Ensembl chr 6:124,829,547...124,833,701
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO diethyl maleate results in increased expression of CDCA8 mRNA CTD PMID:21161181 NCBI chr 4:124,918,465...124,936,917
Ensembl chr 4:124,918,465...124,939,311
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO diethyl maleate results in decreased expression of CDH11 mRNA CTD PMID:21161181 NCBI chr 8:102,632,095...102,785,493
Ensembl chr 8:102,632,095...102,785,642
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression
multiple interactions
ISO diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD PMID:11875189 PMID:27982581 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 increases expression EXP diethyl maleate results in increased expression of CDS2 mRNA CTD PMID:25270620 NCBI chr 2:132,253,338...132,312,050
Ensembl chr 2:132,263,148...132,312,050
JBrowse link
G Ces1d carboxylesterase 1D increases reduction
decreases expression
EXP
ISO
diethyl maleate results in increased reduction of CES1D protein
diethyl maleate results in decreased expression of CES1D protein
CTD PMID:19843705 PMID:21161181 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces2a carboxylesterase 2A increases reduction EXP diethyl maleate results in increased reduction of CES2A protein CTD PMID:19843705 NCBI chr 8:104,734,003...104,741,634
Ensembl chr 8:104,734,003...104,741,634
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO diethyl maleate results in decreased expression of CFLAR mRNA CTD PMID:21161181 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 increases expression ISO diethyl maleate results in increased expression of CHRNA4 mRNA CTD PMID:33545341 NCBI chr 2:181,022,311...181,043,579
Ensembl chr 2:181,018,380...181,043,546
JBrowse link
G Cidec cell death-inducing DFFA-like effector c decreases expression ISO diethyl maleate results in decreased expression of CIDEC mRNA CTD PMID:21161181 NCBI chr 6:113,424,634...113,435,760
Ensembl chr 6:113,424,634...113,435,760
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression ISO diethyl maleate results in decreased expression of CITED2 mRNA CTD PMID:21161181 NCBI chr10:17,723,228...17,725,674
Ensembl chr10:17,723,218...17,725,674
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression ISO diethyl maleate results in decreased expression of CITED4 mRNA CTD PMID:21161181 NCBI chr 4:120,666,563...120,667,820
Ensembl chr 4:120,666,572...120,667,820
JBrowse link
G Ckb creatine kinase, brain decreases reduction EXP diethyl maleate results in decreased reduction of CKB protein CTD PMID:19843705 NCBI chr12:111,669,355...111,672,338
Ensembl chr12:111,669,361...111,672,338
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO diethyl maleate results in increased expression of CKS2 mRNA CTD PMID:33545341 NCBI chr13:51,645,232...51,650,662
Ensembl chr13:51,645,232...51,650,660
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO diethyl maleate results in increased expression of CLK1 mRNA CTD PMID:33545341 NCBI chr 1:58,411,988...58,424,088
Ensembl chr 1:58,410,189...58,424,066
JBrowse link
G Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial decreases expression ISO diethyl maleate results in decreased expression of CMPK2 mRNA CTD PMID:21161181 NCBI chr12:26,469,117...26,479,837
Ensembl chr12:26,469,204...26,479,837
JBrowse link
G Cntn1 contactin 1 increases expression ISO diethyl maleate results in increased expression of CNTN1 mRNA CTD PMID:33545341 NCBI chr15:92,051,152...92,341,967
Ensembl chr15:92,051,165...92,341,967
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO diethyl maleate results in decreased expression of COL1A1 mRNA CTD PMID:21161181 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col3a1 collagen, type III, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of COL3A1 mRNA CTD PMID:25270620 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP diethyl maleate results in increased expression of COMMD3 mRNA CTD PMID:25270620 NCBI chr 2:18,672,435...18,676,231
Ensembl chr 2:18,672,384...18,676,231
JBrowse link
G Comt catechol-O-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of COMT mRNA CTD PMID:21161181 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Cp ceruloplasmin decreases expression EXP diethyl maleate results in decreased expression of CP mRNA CTD PMID:25270620 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Cpsf4l cleavage and polyadenylation specific factor 4-like increases expression ISO diethyl maleate results in increased expression of CPSF4L mRNA CTD PMID:33545341 NCBI chr11:113,698,171...113,710,167
Ensembl chr11:113,698,172...113,710,017
JBrowse link
G Crym crystallin, mu decreases expression ISO diethyl maleate results in decreased expression of CRYM mRNA CTD PMID:21161181 NCBI chr 7:120,186,380...120,201,989
Ensembl chr 7:120,186,380...120,202,111
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression ISO diethyl maleate results in decreased expression of CSRP1 mRNA CTD PMID:21161181 NCBI chr 1:135,720,063...135,752,229
Ensembl chr 1:135,720,061...135,752,232
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 decreases reduction EXP diethyl maleate results in decreased reduction of CSRP3 protein CTD PMID:19843705 NCBI chr 7:48,830,398...48,848,051
Ensembl chr 7:48,830,398...48,848,033
JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 decreases expression ISO diethyl maleate results in decreased expression of CXCL10 mRNA CTD PMID:21161181 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 decreases expression ISO diethyl maleate results in decreased expression of CXCL12 mRNA CTD PMID:21161181 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression
multiple interactions
increases secretion
increases stability
ISO diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein
bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein]
diethyl maleate results in increased secretion of CXCL8 protein
diethyl maleate results in increased stability of CXCL8 mRNA
CTD PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 More... NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 decreases expression ISO diethyl maleate results in decreased expression of CXCL9 mRNA CTD PMID:21161181 NCBI chr 5:92,321,331...92,328,079
Ensembl chr 5:92,321,347...92,328,079
JBrowse link
G Cyb5a cytochrome b5 type A (microsomal) increases expression EXP diethyl maleate results in increased expression of CYB5A mRNA CTD PMID:25270620 NCBI chr18:84,851,338...84,879,871
Ensembl chr18:84,838,704...84,879,871
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO diethyl maleate results in decreased expression of CYP26B1 mRNA CTD PMID:21161181 NCBI chr 6:84,571,414...84,593,908
Ensembl chr 6:84,571,414...84,593,908
JBrowse link
G D17H6S56E-5 DNA segment, Chr 17, human D6S56E 5 decreases expression EXP diethyl maleate results in decreased expression of D17H6S56E-5 mRNA CTD PMID:25270620 NCBI chr17:34,996,678...35,000,774 JBrowse link
G Dbp D site albumin promoter binding protein decreases expression ISO diethyl maleate results in decreased expression of DBP mRNA CTD PMID:21161181 NCBI chr 7:45,705,100...45,710,203
Ensembl chr 7:45,705,088...45,710,203
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO diethyl maleate results in increased expression of DDIT3 mRNA CTD PMID:33545341 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO diethyl maleate results in increased expression of DDIT4 mRNA CTD PMID:33545341 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like increases expression EXP diethyl maleate results in increased expression of DDIT4L mRNA CTD PMID:25270620 NCBI chr 3:137,623,672...137,628,332
Ensembl chr 3:137,621,612...137,628,333
JBrowse link
G Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 decreases expression ISO diethyl maleate results in decreased expression of DHX58 mRNA CTD PMID:21161181 NCBI chr11:100,694,884...100,704,271
Ensembl chr11:100,694,884...100,704,271
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO diethyl maleate results in increased expression of DNAJB1 mRNA CTD PMID:33545341 NCBI chr 8:83,608,175...83,612,653
Ensembl chr 8:83,608,193...83,612,653
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO diethyl maleate results in increased expression of DNAJB4 mRNA CTD PMID:33545341 NCBI chr 3:152,181,580...152,210,432
Ensembl chr 3:152,178,511...152,210,302
JBrowse link
G Dnmbp dynamin binding protein decreases expression ISO diethyl maleate results in decreased expression of DNMBP mRNA CTD PMID:21161181 NCBI chr19:43,846,815...43,940,232
Ensembl chr19:43,846,821...43,940,191
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases reduction EXP diethyl maleate results in decreased reduction of DPYSL2 protein CTD PMID:19843705 NCBI chr14:66,802,864...66,911,041
Ensembl chr14:66,802,864...66,868,688
JBrowse link
G Dtx3l deltex 3-like, E3 ubiquitin ligase decreases expression ISO diethyl maleate results in decreased expression of DTX3L mRNA CTD PMID:21161181 NCBI chr16:35,926,515...35,939,027
Ensembl chr16:35,926,511...35,939,151
JBrowse link
G Dus3l dihydrouridine synthase 3-like (S. cerevisiae) decreases expression EXP diethyl maleate results in decreased expression of DUS3L mRNA CTD PMID:25270620 NCBI chr17:56,764,751...56,770,093
Ensembl chr17:56,764,757...56,770,093
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO diethyl maleate results in increased expression of DUSP6 mRNA CTD PMID:33545341 NCBI chr10:99,263,231...99,267,489
Ensembl chr10:99,263,231...99,267,489
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase decreases expression ISO diethyl maleate results in decreased expression of EEF2K mRNA CTD PMID:21161181 NCBI chr 7:120,842,642...120,907,219
Ensembl chr 7:120,842,831...120,907,450
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO diethyl maleate results in decreased expression of EIF2AK2 mRNA CTD PMID:21161181 NCBI chr17:78,850,504...78,882,572
Ensembl chr17:78,852,564...78,882,573
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression EXP diethyl maleate results in increased expression of ENTPD5 mRNA CTD PMID:25270620 NCBI chr12:84,373,875...84,409,029
Ensembl chr12:84,373,857...84,409,029
JBrowse link
G Eras ES cell-expressed Ras decreases expression EXP diethyl maleate results in decreased expression of ERAS mRNA CTD PMID:25270620 NCBI chr  X:7,924,276...7,928,607
Ensembl chr  X:7,924,276...7,928,607
JBrowse link
G Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like increases expression ISO diethyl maleate results in increased expression of ERCC6L mRNA CTD PMID:21161181 NCBI chr  X:102,142,820...102,157,091
Ensembl chr  X:102,141,716...102,157,091
JBrowse link
G Exo1 exonuclease 1 increases expression ISO diethyl maleate results in increased expression of EXO1 mRNA CTD PMID:21161181 NCBI chr 1:175,880,768...175,911,396
Ensembl chr 1:175,880,581...175,913,489
JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO diethyl maleate results in increased expression of FABP1 protein CTD PMID:21161181 NCBI chr 6:71,199,879...71,205,034
Ensembl chr 6:71,199,827...71,205,023
JBrowse link
G Fabp7 fatty acid binding protein 7, brain decreases expression ISO diethyl maleate results in decreased expression of FABP7 mRNA CTD PMID:21161181 NCBI chr10:57,784,923...57,788,450
Ensembl chr10:57,784,881...57,788,450
JBrowse link
G Fam126b family with sequence similarity 126, member B decreases expression ISO diethyl maleate results in decreased expression of FAM126B mRNA CTD PMID:21161181 NCBI chr 1:58,522,806...58,586,333
Ensembl chr 1:58,522,806...58,586,323
JBrowse link
G Fam83d family with sequence similarity 83, member D increases expression ISO diethyl maleate results in increased expression of FAM83D mRNA CTD PMID:33545341 NCBI chr 2:158,768,099...158,786,637
Ensembl chr 2:158,768,093...158,786,637
JBrowse link
G Fasn fatty acid synthase decreases expression ISO diethyl maleate results in decreased expression of FASN mRNA CTD PMID:21161181 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO diethyl maleate results in decreased expression of FBN1 mRNA CTD PMID:21161181 NCBI chr 2:125,300,594...125,506,485
Ensembl chr 2:125,300,594...125,507,993
JBrowse link
G Fbp1 fructose bisphosphatase 1 decreases expression ISO diethyl maleate results in decreased expression of FBP1 protein CTD PMID:21161181 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fgf17 fibroblast growth factor 17 decreases expression EXP diethyl maleate results in decreased expression of FGF17 mRNA CTD PMID:25270620 NCBI chr14:70,636,203...70,642,268
Ensembl chr14:70,636,203...70,642,268
JBrowse link
G Fgg fibrinogen gamma chain decreases expression EXP diethyl maleate results in decreased expression of FGG mRNA CTD PMID:25270620 NCBI chr 3:83,007,724...83,015,056
Ensembl chr 3:83,007,724...83,015,049
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression ISO diethyl maleate results in decreased expression of FGR mRNA CTD PMID:21161181 NCBI chr 4:132,974,095...133,001,893
Ensembl chr 4:132,974,095...133,001,910
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression EXP diethyl maleate results in decreased expression of FNDC3B mRNA CTD PMID:25270620 NCBI chr 3:27,416,135...27,711,307
Ensembl chr 3:27,416,162...27,711,307
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression EXP
ISO
diethyl maleate results in increased expression of FOS mRNA CTD PMID:10915739 PMID:33545341 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO diethyl maleate results in increased expression of FOXO3 mRNA CTD PMID:33545341 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Fstl3 follistatin-like 3 increases expression ISO diethyl maleate results in increased expression of FSTL3 mRNA CTD PMID:33545341 NCBI chr10:79,777,274...79,782,630
Ensembl chr10:79,777,272...79,782,630
JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression EXP diethyl maleate results in decreased expression of G6PC mRNA CTD PMID:25270620 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
increases expression
ISO diethyl maleate results in increased activity of G6PD protein
diethyl maleate results in increased expression of G6PD mRNA
CTD PMID:3099627 PMID:33545341 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gab1 growth factor receptor bound protein 2-associated protein 1 decreases expression EXP diethyl maleate results in decreased expression of GAB1 mRNA CTD PMID:25270620 NCBI chr 8:80,764,431...80,880,519
Ensembl chr 8:80,764,438...80,880,519
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO diethyl maleate results in increased expression of GADD45A mRNA CTD PMID:33545341 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO diethyl maleate results in increased expression of GADD45G mRNA CTD PMID:33545341 NCBI chr13:51,846,675...51,848,475
Ensembl chr13:51,846,678...51,848,468
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases reduction EXP diethyl maleate results in increased reduction of GAPDH protein CTD PMID:19843705 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gba2 glucosidase beta 2 decreases expression EXP diethyl maleate results in decreased expression of GBA2 mRNA CTD PMID:25270620 NCBI chr 4:43,566,928...43,578,886
Ensembl chr 4:43,566,928...43,578,873
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO diethyl maleate results in decreased expression of GBP2 mRNA CTD PMID:21161181 NCBI chr 3:142,620,663...142,638,008
Ensembl chr 3:142,620,602...142,638,008
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
EXP
ISO
diethyl maleate results in increased activity of GCLC protein
diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 More... NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO
EXP
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein CTD PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO diethyl maleate results in increased expression of GCNT3 mRNA CTD PMID:33545341 NCBI chr 9:70,031,495...70,039,890
Ensembl chr 9:70,031,496...70,038,088
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO diethyl maleate results in increased expression of GDF15 mRNA CTD PMID:33545341 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression ISO diethyl maleate results in increased expression of GDF9 mRNA CTD PMID:33545341 NCBI chr11:53,430,774...53,437,904
Ensembl chr11:53,431,023...53,437,904
JBrowse link
G Gfod1 glucose-fructose oxidoreductase domain containing 1 increases expression ISO diethyl maleate results in increased expression of GFOD1 mRNA CTD PMID:33545341 NCBI chr13:43,195,240...43,304,172
Ensembl chr13:43,195,245...43,304,172
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) decreases expression EXP diethyl maleate results in decreased expression of GLUL mRNA CTD PMID:25270620 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial decreases expression ISO diethyl maleate results in decreased expression of GOT2 protein CTD PMID:21161181 NCBI chr 8:95,864,133...95,888,401
Ensembl chr 8:95,864,134...95,888,547
JBrowse link
G Gpihbp1 GPI-anchored HDL-binding protein 1 decreases expression EXP diethyl maleate results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr15:75,596,630...75,598,213
Ensembl chr15:75,596,628...75,599,481
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) decreases expression ISO diethyl maleate results in decreased expression of GRIA3 mRNA CTD PMID:21161181 NCBI chr  X:41,400,819...41,678,601
Ensembl chr  X:41,400,854...41,678,601
JBrowse link
G Gsn gelsolin decreases reduction EXP diethyl maleate results in decreased reduction of GSN protein CTD PMID:19843705 NCBI chr 2:35,256,359...35,307,902
Ensembl chr 2:35,256,380...35,307,892
JBrowse link
G Gsr glutathione reductase increases expression EXP diethyl maleate results in increased expression of GSR mRNA CTD PMID:25270620 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gss glutathione synthetase increases expression ISO diethyl maleate results in increased expression of GSS mRNA CTD PMID:10978506 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO diethyl maleate results in increased expression of GSTA5 protein CTD PMID:9794803 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP diethyl maleate results in increased expression of GSTA2 mRNA CTD PMID:25270620 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression ISO diethyl maleate results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 1:21,240,565...21,265,575
Ensembl chr 1:21,240,589...21,265,661
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases expression ISO diethyl maleate results in decreased expression of GSTM1 protein CTD PMID:21161181 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression EXP diethyl maleate results in increased expression of GSTO1 mRNA CTD PMID:25270620 NCBI chr19:47,854,973...47,864,790
Ensembl chr19:47,854,970...47,864,790
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO diethyl maleate results in increased expression of GSTP1 protein CTD PMID:9794803 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO diethyl maleate results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G Gtse1 G two S phase expressed protein 1 increases expression ISO diethyl maleate results in increased expression of GTSE1 mRNA CTD PMID:21161181 NCBI chr15:85,859,691...85,876,573
Ensembl chr15:85,859,745...85,876,573
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 decreases expression ISO diethyl maleate results in decreased expression of RT1-S3 mRNA CTD PMID:21161181 NCBI chr17:36,029,977...36,032,701
Ensembl chr17:36,029,773...36,032,855
JBrowse link
G H2az2 H2A.Z histone variant 2 increases expression ISO diethyl maleate results in increased expression of H2AZ2 mRNA CTD PMID:33545341 NCBI chr11:6,427,226...6,444,511
Ensembl chr11:6,427,229...6,444,443
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) increases expression EXP diethyl maleate results in increased expression of H6PD mRNA CTD PMID:25270620 NCBI chr 4:149,979,474...150,009,023
Ensembl chr 4:149,979,475...150,009,023
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO diethyl maleate results in increased expression of HAMP mRNA CTD PMID:33545341 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Helb helicase (DNA) B decreases expression EXP diethyl maleate results in decreased expression of HELB mRNA CTD PMID:25270620 NCBI chr10:120,083,608...120,113,010
Ensembl chr10:120,083,608...120,112,987
JBrowse link
G Hes6 hairy and enhancer of split 6 decreases expression ISO diethyl maleate results in decreased expression of HES6 mRNA CTD PMID:21161181 NCBI chr 1:91,411,483...91,414,038
Ensembl chr 1:91,411,483...91,414,038
JBrowse link
G Hjurp Holliday junction recognition protein increases expression ISO diethyl maleate results in increased expression of HJURP mRNA CTD PMID:21161181 NCBI chr 1:88,258,856...88,277,644
Ensembl chr 1:88,262,471...88,277,633
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO
EXP
diethyl maleate results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases reduction EXP diethyl maleate results in decreased reduction of HNRNPH1 protein CTD PMID:19843705 NCBI chr11:50,375,257...50,386,528
Ensembl chr11:50,376,990...50,386,528
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 increases expression ISO diethyl maleate results in increased expression of HSD17B10 mRNA CTD PMID:33545341 NCBI chr  X:152,001,896...152,004,442
Ensembl chr  X:152,001,845...152,004,442
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases expression ISO diethyl maleate results in decreased expression of HSD17B2 mRNA CTD PMID:21161181 NCBI chr 8:117,700,982...117,759,030
Ensembl chr 8:117,701,904...117,759,027
JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO diethyl maleate results in increased expression of HSPA1B mRNA CTD PMID:33545341 NCBI chr17:34,956,429...34,959,238
Ensembl chr17:34,956,436...34,959,238
JBrowse link
G Hspa1l heat shock protein 1-like increases expression ISO diethyl maleate results in increased expression of HSPA1L mRNA CTD PMID:33545341 NCBI chr17:34,972,703...34,979,228
Ensembl chr17:34,972,703...34,979,285
JBrowse link
G Hspa5 heat shock protein 5 decreases reduction EXP diethyl maleate results in decreased reduction of HSPA5 protein CTD PMID:19843705 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa8 heat shock protein 8 increases reduction EXP diethyl maleate results in increased reduction of HSPA8 protein CTD PMID:19843705 NCBI chr 9:40,801,276...40,805,202
Ensembl chr 9:40,800,984...40,810,087
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression EXP diethyl maleate results in increased expression of HTATIP2 mRNA CTD PMID:25270620 NCBI chr 7:49,759,045...49,774,000
Ensembl chr 7:49,759,115...49,773,975
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP diethyl maleate results in decreased expression of ICAM1 mRNA CTD PMID:25270620 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression EXP diethyl maleate results in decreased expression of ID3 mRNA CTD PMID:25270620 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Id4 inhibitor of DNA binding 4 decreases expression EXP diethyl maleate results in decreased expression of ID4 mRNA CTD PMID:25270620 NCBI chr13:48,261,116...48,266,028
Ensembl chr13:48,261,228...48,266,026
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO diethyl maleate results in decreased expression of IFIT3 mRNA CTD PMID:21161181 NCBI chr19:34,583,119...34,588,982
Ensembl chr19:34,583,531...34,588,731
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO diethyl maleate results in increased expression of IFRD1 mRNA CTD PMID:33545341 NCBI chr12:40,203,129...40,223,189
Ensembl chr12:40,201,567...40,248,504
JBrowse link
G Ikbke inhibitor of kappaB kinase epsilon decreases expression EXP diethyl maleate results in decreased expression of IKBKE mRNA CTD PMID:25270620 NCBI chr 1:131,254,600...131,279,601
Ensembl chr 1:131,254,343...131,279,606
JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma increases expression EXP diethyl maleate results in increased expression of IKBKG mRNA CTD PMID:25270620 NCBI chr  X:74,393,233...74,456,792
Ensembl chr  X:74,393,290...74,453,854
JBrowse link
G Il10 interleukin 10 increases secretion ISO diethyl maleate results in increased secretion of IL10 protein CTD PMID:31958493 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il18 interleukin 18 increases expression ISO diethyl maleate results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein CTD PMID:31958493 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Inhbb inhibin beta-B decreases expression EXP diethyl maleate results in decreased expression of INHBB mRNA CTD PMID:25270620 NCBI chr 1:119,415,463...119,422,248
Ensembl chr 1:119,415,465...119,422,248
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression ISO diethyl maleate results in decreased expression of INMT mRNA CTD PMID:21161181 NCBI chr 6:55,170,627...55,174,990
Ensembl chr 6:55,170,626...55,175,043
JBrowse link
G Ints7 integrator complex subunit 7 decreases expression EXP diethyl maleate results in decreased expression of INTS7 mRNA CTD PMID:25270620 NCBI chr 1:191,575,540...191,623,690
Ensembl chr 1:191,575,636...191,623,688
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO diethyl maleate results in decreased expression of IRF7 mRNA CTD PMID:21161181 NCBI chr 7:141,263,183...141,266,499
Ensembl chr 7:141,262,706...141,266,481
JBrowse link
G Irf9 interferon regulatory factor 9 decreases expression ISO diethyl maleate results in decreased expression of IRF9 mRNA CTD PMID:21161181 NCBI chr14:55,603,985...55,610,030
Ensembl chr14:55,603,571...55,610,030
JBrowse link
G Irgm1 immunity-related GTPase family M member 1 decreases expression ISO diethyl maleate results in decreased expression of IRGM mRNA CTD PMID:21161181 NCBI chr11:48,865,245...48,871,420
Ensembl chr11:48,861,968...48,871,683
JBrowse link
G Itgal integrin alpha L decreases expression ISO diethyl maleate results in decreased expression of ITGAL mRNA CTD PMID:21161181 NCBI chr 7:127,296,139...127,335,137
Ensembl chr 7:127,296,260...127,335,138
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression EXP diethyl maleate results in decreased expression of ITIH3 mRNA CTD PMID:25270620 NCBI chr14:30,908,572...30,923,787
Ensembl chr14:30,908,572...30,923,760
JBrowse link
G Itih4 inter alpha-trypsin inhibitor, heavy chain 4 decreases expression EXP diethyl maleate results in decreased expression of ITIH4 mRNA CTD PMID:25270620 NCBI chr14:30,886,476...30,901,986
Ensembl chr14:30,886,476...30,902,353
JBrowse link
G Jam3 junction adhesion molecule 3 decreases expression ISO diethyl maleate results in decreased expression of JAM3 mRNA CTD PMID:21161181 NCBI chr 9:27,097,384...27,155,421
Ensembl chr 9:27,097,384...27,155,421
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
increases phosphorylation
EXP pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
diethyl maleate results in increased expression of JUN mRNA
CTD PMID:10915739 PMID:12774022 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 decreases expression EXP diethyl maleate results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 7:100,176,507...100,184,869
Ensembl chr 7:100,176,502...100,184,869
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein CTD PMID:27358234 PMID:33545341 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 increases expression ISO diethyl maleate results in increased expression of KHDRBS3 mRNA CTD PMID:33545341 NCBI chr15:68,928,392...69,101,794
Ensembl chr15:68,928,420...69,101,211
JBrowse link
G Kifc5b kinesin family member C5B increases expression ISO diethyl maleate results in increased expression of KIFC1 mRNA CTD PMID:21161181 NCBI chr17:26,917,091...26,932,579
Ensembl chr17:26,917,091...26,932,583
JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression ISO
EXP
diethyl maleate results in decreased expression of KLF10 mRNA CTD PMID:21161181 PMID:25270620 NCBI chr15:38,291,464...38,300,711
Ensembl chr15:38,291,463...38,300,706
JBrowse link
G Krt75 keratin 75 increases reduction EXP diethyl maleate results in increased reduction of KRT75 protein CTD PMID:19843705 NCBI chr15:101,563,343...101,573,904
Ensembl chr15:101,563,345...101,573,904
JBrowse link
G Lama1 laminin, alpha 1 decreases expression EXP diethyl maleate results in decreased expression of LAMA1 mRNA CTD PMID:25270620 NCBI chr17:67,697,127...67,822,645
Ensembl chr17:67,697,259...67,822,647
JBrowse link
G Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 decreases expression EXP diethyl maleate results in decreased expression of LANCL2 mRNA CTD PMID:25270620 NCBI chr 6:57,702,455...57,739,449
Ensembl chr 6:57,702,540...57,739,439
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO diethyl maleate results in decreased expression of LDLR mRNA CTD PMID:21161181 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lepr leptin receptor decreases expression ISO diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein decreases expression ISO diethyl maleate results in decreased expression of LGALS3BP mRNA CTD PMID:21161181 NCBI chr11:118,392,747...118,401,959
Ensembl chr11:118,392,751...118,402,092
JBrowse link
G Lmnb1 lamin B1 increases expression ISO diethyl maleate results in increased expression of LMNB1 mRNA CTD PMID:21161181 NCBI chr18:56,707,813...56,753,424
Ensembl chr18:56,707,813...56,753,424
JBrowse link
G Lmo7 LIM domain only 7 decreases expression ISO diethyl maleate results in decreased expression of LMO7 mRNA CTD PMID:21161181 NCBI chr14:101,729,928...101,934,708
Ensembl chr14:101,729,957...101,934,710
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 decreases expression ISO diethyl maleate results in decreased expression of LRIG3 mRNA CTD PMID:21161181 NCBI chr10:125,966,219...126,015,359
Ensembl chr10:125,966,168...126,015,359
JBrowse link
G Lrrn4 leucine rich repeat neuronal 4 increases expression ISO diethyl maleate results in increased expression of LRRN4 mRNA CTD PMID:21161181 NCBI chr 2:132,866,686...132,894,010
Ensembl chr 2:132,868,305...132,880,891
JBrowse link
G Lrtm2 leucine-rich repeats and transmembrane domains 2 decreases expression ISO diethyl maleate results in decreased expression of LRTM2 mRNA CTD PMID:21161181 NCBI chr 6:119,315,133...119,332,270
Ensembl chr 6:119,315,133...119,330,766
JBrowse link
G Ltc4s leukotriene C4 synthase decreases expression ISO diethyl maleate results in decreased expression of LTC4S mRNA CTD PMID:21161181 NCBI chr11:50,236,461...50,238,532
Ensembl chr11:50,236,461...50,238,616
JBrowse link
G Lum lumican decreases expression ISO diethyl maleate results in decreased expression of LUM mRNA CTD PMID:21161181 NCBI chr10:97,565,501...97,572,703
Ensembl chr10:97,565,128...97,572,703
JBrowse link
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) increases expression ISO diethyl maleate results in increased expression of MAFF mRNA CTD PMID:20491607 PMID:33545341 NCBI chr15:79,346,621...79,359,078
Ensembl chr15:79,346,621...79,359,076
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) increases expression ISO diethyl maleate results in increased expression of MAFG mRNA CTD PMID:33545341 NCBI chr11:120,625,117...120,634,955
Ensembl chr11:120,625,117...120,633,600
JBrowse link
G Maoa monoamine oxidase A increases expression EXP diethyl maleate results in increased expression of MAOA mRNA CTD PMID:25270620 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Mapk1ip1l mitogen-activated protein kinase 1 interacting protein 1-like increases expression ISO diethyl maleate results in increased expression of MAPK1IP1L mRNA CTD PMID:33545341 NCBI chr14:47,298,274...47,323,206
Ensembl chr14:47,298,266...47,323,204
JBrowse link
G Marveld1 MARVEL (membrane-associating) domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of MARVELD1 mRNA CTD PMID:21161181 NCBI chr19:42,147,389...42,151,703
Ensembl chr19:42,147,400...42,151,703
JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 increases expression ISO diethyl maleate results in increased expression of MBOAT7 mRNA CTD PMID:33545341 NCBI chr 7:3,677,789...3,693,189
Ensembl chr 7:3,677,789...3,693,523
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression ISO diethyl maleate results in increased expression of MCM10 mRNA CTD PMID:21161181 NCBI chr 2:4,990,724...5,012,791
Ensembl chr 2:4,989,714...5,012,791
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO diethyl maleate results in increased expression of MCM4 mRNA CTD PMID:21161181 NCBI chr16:15,623,897...15,637,400
Ensembl chr16:15,623,897...15,637,400
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic increases expression EXP diethyl maleate results in increased expression of ME1 mRNA CTD PMID:25270620 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mfap4 microfibrillar-associated protein 4 decreases expression ISO diethyl maleate results in decreased expression of MFAP4 mRNA CTD PMID:21161181 NCBI chr11:61,485,431...61,488,708
Ensembl chr11:61,485,431...61,488,900
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO diethyl maleate results in decreased activity of MGMT protein CTD PMID:16950796 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO diethyl maleate results in increased expression of MKI67 mRNA CTD PMID:21161181 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mknk2 MAP kinase-interacting serine/threonine kinase 2 decreases expression ISO diethyl maleate results in decreased expression of MKNK2 mRNA CTD PMID:21161181 NCBI chr10:80,665,318...80,676,293
Ensembl chr10:80,665,327...80,678,112
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression EXP diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO diethyl maleate results in increased expression of MMP1 mRNA CTD PMID:33545341 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO diethyl maleate results in decreased expression of MMP2 mRNA CTD PMID:21161181 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO diethyl maleate results in increased expression of MMP3 mRNA CTD PMID:33545341 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Msn moesin increases reduction EXP diethyl maleate results in increased reduction of MSN protein CTD PMID:19843705 NCBI chr  X:96,096,045...96,168,553
Ensembl chr  X:96,096,042...96,168,552
JBrowse link
G Mt2 metallothionein 2 increases expression ISO diethyl maleate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mx1 MX dynamin-like GTPase 1 decreases expression ISO diethyl maleate results in decreased expression of MX1 mRNA CTD PMID:21161181 NCBI chr16:97,447,035...97,462,906
Ensembl chr16:97,447,035...97,462,907
JBrowse link
G Mx2 MX dynamin-like GTPase 2 decreases expression ISO diethyl maleate results in decreased expression of MX2 mRNA CTD PMID:21161181 NCBI chr16:97,536,081...97,560,901
Ensembl chr16:97,535,308...97,560,900
JBrowse link
G Mybl2 myeloblastosis oncogene-like 2 increases expression ISO diethyl maleate results in increased expression of MYBL2 mRNA CTD PMID:21161181 NCBI chr 2:163,054,327...163,084,688
Ensembl chr 2:163,054,687...163,084,688
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived decreases expression EXP diethyl maleate results in decreased expression of MYCN mRNA CTD PMID:25270620 NCBI chr12:12,936,093...12,941,836
Ensembl chr12:12,936,093...12,941,914
JBrowse link
G Nat8 N-acetyltransferase 8 (GCN5-related) decreases expression ISO diethyl maleate results in decreased expression of NAT8 mRNA CTD PMID:21161181 NCBI chr 6:85,830,387...85,836,857
Ensembl chr 6:85,830,388...85,832,082
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression ISO diethyl maleate results in increased expression of NCAPH mRNA CTD PMID:21161181 NCBI chr 2:127,103,809...127,133,954
Ensembl chr 2:127,103,809...127,133,954
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression ISO diethyl maleate results in increased expression of NDRG1 mRNA CTD PMID:33545341 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
increases activity
increases expression
multiple interactions
decreases response to substance
EXP
ISO
diethyl maleate affects the localization of NFE2L2 protein
diethyl maleate results in increased activity of NFE2L2 protein
diethyl maleate results in increased expression of NFE2L2 protein
diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
NFE2L2 results in decreased susceptibility to diethyl maleate
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:27358234 More... NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] CTD PMID:12774022 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]
Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD PMID:7532384 PMID:9918918 PMID:12774022 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Notch1 notch 1 increases expression ISO diethyl maleate results in increased expression of NOTCH1 mRNA CTD PMID:33545341 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO
EXP
diethyl maleate results in increased expression of NQO1 mRNA CTD PMID:20491607 PMID:25270620 PMID:33545341 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO diethyl maleate results in decreased expression of NR0B2 mRNA CTD PMID:21161181 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO diethyl maleate results in decreased expression of NR1D1 mRNA CTD PMID:21161181 NCBI chr11:98,767,932...98,775,377
Ensembl chr11:98,767,932...98,775,333
JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO diethyl maleate results in decreased expression of NREP mRNA CTD PMID:21161181 NCBI chr18:33,437,019...33,464,365
Ensembl chr18:33,437,019...33,464,029
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP diethyl maleate results in decreased expression of NSMF mRNA CTD PMID:25270620 NCBI chr 2:25,054,361...25,062,881
Ensembl chr 2:25,054,355...25,062,881
JBrowse link
G Ntf3 neurotrophin 3 decreases expression ISO diethyl maleate results in decreased expression of NTF3 mRNA CTD PMID:21161181 NCBI chr 6:126,101,412...126,166,772
Ensembl chr 6:126,101,412...126,166,910
JBrowse link
G Nup153 nucleoporin 153 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein CTD PMID:20041180 NCBI chr13:46,679,902...46,727,849
Ensembl chr13:46,679,905...46,727,940
JBrowse link
G Nup88 nucleoporin 88 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein CTD PMID:20041180 NCBI chr11:70,943,058...70,969,973
Ensembl chr11:70,943,058...70,969,973
JBrowse link
G Oaf out at first homolog decreases expression ISO diethyl maleate results in decreased expression of OAF mRNA CTD PMID:21161181 NCBI chr 9:43,221,278...43,239,816
Ensembl chr 9:43,221,235...43,239,911
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions EXP [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression ISO diethyl maleate results in increased expression of ORC1 mRNA CTD PMID:21161181 NCBI chr 4:108,575,705...108,616,030
Ensembl chr 4:108,579,423...108,614,833
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO diethyl maleate results in increased expression of OSGIN1 mRNA CTD PMID:33545341 NCBI chr 8:119,425,882...119,446,257
Ensembl chr 8:119,434,124...119,446,256
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 decreases expression ISO diethyl maleate results in decreased expression of P2RX7 mRNA CTD PMID:21161181 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO diethyl maleate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression ISO diethyl maleate results in decreased expression of PBLD protein CTD PMID:21161181 NCBI chr10:63,060,625...63,077,964
Ensembl chr10:63,060,162...63,077,962
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diethyl maleate results in decreased expression of PCNA mRNA CTD PMID:11875189 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO diethyl maleate results in decreased expression of PDLIM2 mRNA CTD PMID:21161181 NCBI chr14:70,162,621...70,177,672
Ensembl chr14:70,164,218...70,177,681
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 increases expression EXP diethyl maleate results in increased expression of PDRG1 mRNA CTD PMID:25270620 NCBI chr 2:153,008,890...153,016,019
Ensembl chr 2:153,008,890...153,015,427
JBrowse link
G Per2 period circadian clock 2 decreases expression ISO diethyl maleate results in decreased expression of PER2 mRNA CTD PMID:21161181 NCBI chr 1:91,415,977...91,459,351
Ensembl chr 1:91,415,982...91,459,324
JBrowse link
G Per3 period circadian clock 3 decreases expression ISO diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 NCBI chr 4:150,997,018...151,044,707
Ensembl chr 4:151,003,652...151,044,665
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO diethyl maleate results in increased activity of PGD protein CTD PMID:3099627 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 increases expression EXP diethyl maleate results in increased expression of PGRMC1 mRNA CTD PMID:25270620 NCBI chr  X:36,598,193...36,606,079
Ensembl chr  X:36,598,206...36,606,079
JBrowse link
G Pir pirin increases expression EXP diethyl maleate results in increased expression of PIR mRNA CTD PMID:25270620 NCBI chr  X:164,269,431...164,373,013
Ensembl chr  X:164,269,371...164,373,011
JBrowse link
G Pklr pyruvate kinase liver and red blood cell decreases expression ISO diethyl maleate results in decreased expression of PKLR mRNA CTD PMID:21161181 NCBI chr 3:89,136,122...89,146,815
Ensembl chr 3:89,136,142...89,146,784
JBrowse link
G Plat plasminogen activator, tissue increases expression
decreases expression
ISO
EXP
diethyl maleate results in increased expression of PLAT mRNA
diethyl maleate results in decreased expression of PLAT mRNA
CTD PMID:21161181 PMID:25270620 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Plek pleckstrin decreases expression ISO diethyl maleate results in decreased expression of PLEK mRNA CTD PMID:21161181 NCBI chr11:16,971,206...17,008,718
Ensembl chr11:16,971,206...17,052,381
JBrowse link
G Plekhm1 pleckstrin homology domain containing, family M (with RUN domain) member 1 increases expression ISO diethyl maleate results in increased expression of PLEKHM1 mRNA CTD PMID:33545341 NCBI chr11:103,364,275...103,412,705
Ensembl chr11:103,364,275...103,412,687
JBrowse link
G Plin2 perilipin 2 increases expression ISO diethyl maleate results in increased expression of PLIN2 mRNA CTD PMID:33545341 NCBI chr 4:86,626,910...86,670,217
Ensembl chr 4:86,648,386...86,670,060
JBrowse link
G Plk1 polo like kinase 1 increases expression ISO diethyl maleate results in increased expression of PLK1 mRNA CTD PMID:33545341 NCBI chr 7:122,159,435...122,169,884
Ensembl chr 7:122,159,439...122,169,873
JBrowse link
G Plk3 polo like kinase 3 increases expression ISO diethyl maleate results in increased expression of PLK3 mRNA CTD PMID:33545341 NCBI chr 4:117,128,655...117,133,963
Ensembl chr 4:117,128,655...117,133,963
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 increases expression ISO diethyl maleate results in increased expression of POU5F1 mRNA CTD PMID:33545341 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases activity
ISO diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein] CTD PMID:17134953 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta decreases expression ISO diethyl maleate results in decreased expression of PPARGC1B mRNA CTD PMID:21161181 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression ISO diethyl maleate results in decreased expression of PPP1R3B mRNA CTD PMID:21161181 NCBI chr 8:35,375,694...35,388,139
Ensembl chr 8:35,375,739...35,388,139
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C decreases expression ISO diethyl maleate results in decreased expression of PPP1R3C mRNA CTD PMID:21161181 NCBI chr19:36,731,731...36,736,604
Ensembl chr19:36,731,731...36,736,653
JBrowse link
G Prdm14 PR domain containing 14 decreases expression EXP diethyl maleate results in decreased expression of PRDM14 mRNA CTD PMID:25270620 NCBI chr 1:13,113,428...13,127,163
Ensembl chr 1:13,113,457...13,127,163
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO
diethyl maleate results in increased expression of PRDX1 mRNA CTD PMID:9506838 NCBI chr 4:116,685,599...116,700,000
Ensembl chr 4:116,685,544...116,700,822
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit decreases expression EXP diethyl maleate results in decreased expression of PRKAB1 mRNA CTD PMID:25270620 NCBI chr 5:116,013,586...116,024,503
Ensembl chr 5:116,013,586...116,024,508
JBrowse link
G Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit increases expression ISO diethyl maleate results in increased expression of PRKAG2 mRNA CTD PMID:33545341 NCBI chr 5:24,862,735...25,106,282
Ensembl chr 5:24,862,744...25,100,642
JBrowse link
G Prkcb protein kinase C, beta affects expression ISO diethyl maleate affects the expression of PRKCB protein CTD PMID:31958493 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein CTD PMID:11118818 NCBI chr14:30,595,353...30,626,414
Ensembl chr14:30,595,354...30,626,210
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein CTD PMID:11118818 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919
JBrowse link
G Prss8 protease, serine 8 (prostasin) decreases expression ISO diethyl maleate results in decreased expression of PRSS8 mRNA CTD PMID:21161181 NCBI chr 7:127,925,717...127,930,149
Ensembl chr 7:127,925,716...127,930,104
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression EXP diethyl maleate results in increased expression of PTGR1 mRNA CTD PMID:25270620 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression EXP diethyl maleate results in increased expression of PTPN14 mRNA CTD PMID:25270620 NCBI chr 1:189,728,216...189,876,695
Ensembl chr 1:189,728,268...189,876,695
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression EXP diethyl maleate results in decreased expression of PUS1 mRNA CTD PMID:25270620 NCBI chr 5:110,773,667...110,780,649
Ensembl chr 5:110,773,667...110,780,659
JBrowse link
G Pxn paxillin increases expression ISO diethyl maleate results in increased expression of PXN mRNA CTD PMID:33545341 NCBI chr 5:115,491,970...115,555,987
Ensembl chr 5:115,506,676...115,555,987
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases expression ISO diethyl maleate results in decreased expression of RAB27A mRNA CTD PMID:21161181 NCBI chr 9:73,044,810...73,097,623
Ensembl chr 9:73,044,854...73,097,629
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] CTD PMID:20116392 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rho rhodopsin increases expression ISO diethyl maleate results in increased expression of RHO mRNA CTD PMID:33545341 NCBI chr 6:115,926,754...115,940,038
Ensembl chr 6:115,931,748...115,940,036
JBrowse link
G Rnf114 ring finger protein 114 decreases expression EXP diethyl maleate results in decreased expression of RNF114 mRNA CTD PMID:25270620 NCBI chr 2:167,492,645...167,516,173
Ensembl chr 2:167,492,645...167,516,173
JBrowse link
G Rnf14 ring finger protein 14 increases expression EXP diethyl maleate results in increased expression of RNF14 mRNA CTD PMID:25270620 NCBI chr18:38,277,460...38,317,852
Ensembl chr18:38,284,537...38,317,849
JBrowse link
G Rrm2 ribonucleotide reductase M2 increases expression ISO diethyl maleate results in increased expression of RRM2 mRNA CTD PMID:21161181 PMID:33545341 NCBI chr12:24,708,254...24,714,146
Ensembl chr12:24,708,241...24,714,146
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO diethyl maleate results in decreased expression of RSAD2 mRNA CTD PMID:21161181 NCBI chr12:26,442,743...26,456,452
Ensembl chr12:26,442,746...26,456,452
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) decreases expression ISO diethyl maleate results in decreased expression of S100A9 mRNA CTD PMID:21161181 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721
JBrowse link
G Sash3 SAM and SH3 domain containing 3 decreases expression ISO diethyl maleate results in decreased expression of SASH3 mRNA CTD PMID:21161181 NCBI chr  X:48,146,436...48,161,565
Ensembl chr  X:48,146,436...48,161,565
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO diethyl maleate results in decreased expression of SCD1 mRNA CTD PMID:21161181 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Sds serine dehydratase decreases expression ISO diethyl maleate results in decreased expression of SDS mRNA CTD PMID:21161181 NCBI chr 5:120,476,547...120,483,932
Ensembl chr 5:120,476,526...120,483,932
JBrowse link
G Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b decreases expression EXP diethyl maleate results in decreased expression of SERPINB6B mRNA CTD PMID:25270620 NCBI chr13:32,956,811...32,979,067
Ensembl chr13:32,965,209...32,979,067
JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 decreases expression EXP diethyl maleate results in decreased expression of SERPIND1 mRNA CTD PMID:25270620 NCBI chr16:17,331,371...17,343,574
Ensembl chr16:17,331,371...17,343,575
JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO diethyl maleate results in increased expression of SERTAD1 mRNA CTD PMID:33545341 NCBI chr 7:27,486,953...27,490,316
Ensembl chr 7:27,486,910...27,490,316
JBrowse link
G Sez6 seizure related gene 6 decreases expression ISO diethyl maleate results in decreased expression of SEZ6 mRNA CTD PMID:21161181 NCBI chr11:77,930,587...77,979,052
Ensembl chr11:77,930,800...77,979,048
JBrowse link
G Sfxn1 sideroflexin 1 decreases expression EXP diethyl maleate results in decreased expression of SFXN1 mRNA CTD PMID:25270620 NCBI chr13:54,071,656...54,108,346
Ensembl chr13:54,071,869...54,108,342
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 (BTK-associated) increases expression ISO diethyl maleate results in increased expression of SH3BP5 mRNA CTD PMID:33545341 NCBI chr14:31,372,614...31,436,100
Ensembl chr14:31,359,880...31,436,078
JBrowse link
G Six4 sine oculis-related homeobox 4 increases expression EXP diethyl maleate results in increased expression of SIX4 mRNA CTD PMID:25270620 NCBI chr12:73,099,609...73,114,031
Ensembl chr12:73,099,609...73,113,456
JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 decreases expression EXP diethyl maleate results in decreased expression of SLC16A6 mRNA CTD PMID:25270620 NCBI chr11:109,450,855...109,473,598
Ensembl chr11:109,450,855...109,473,598
JBrowse link
G Slc1a4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 increases expression EXP diethyl maleate results in increased expression of SLC1A4 mRNA CTD PMID:25270620 NCBI chr11:20,302,180...20,332,713
Ensembl chr11:20,302,180...20,332,713
JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 decreases expression ISO diethyl maleate results in decreased expression of SLC2A2 mRNA CTD PMID:21161181 NCBI chr 3:28,697,903...28,728,361
Ensembl chr 3:28,697,903...28,731,359
JBrowse link
G Slc2a5 solute carrier family 2 (facilitated glucose transporter), member 5 decreases expression ISO diethyl maleate results in decreased expression of SLC2A5 mRNA CTD PMID:21161181 NCBI chr 4:150,119,344...150,144,168
Ensembl chr 4:150,119,283...150,144,169
JBrowse link
G Slc39a14 solute carrier family 39 (zinc transporter), member 14 decreases expression EXP diethyl maleate results in decreased expression of SLC39A14 mRNA CTD PMID:25270620 NCBI chr14:70,303,467...70,351,452
Ensembl chr14:70,303,469...70,351,425
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 increases expression ISO diethyl maleate results in increased expression of SLC3A2 mRNA CTD PMID:33545341 NCBI chr19:8,706,882...8,723,369
Ensembl chr19:8,706,882...8,723,369
JBrowse link
G Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 multiple interactions ISO diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA] CTD PMID:21303654 NCBI chr 1:45,908,070...45,926,532
Ensembl chr 1:45,908,068...45,926,523
JBrowse link
G Slc44a4 solute carrier family 44, member 4 decreases expression ISO diethyl maleate results in decreased expression of SLC44A4 mRNA CTD PMID:21161181 NCBI chr17:34,914,224...34,930,436
Ensembl chr17:34,914,466...34,930,436
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions
increases expression
EXP
ISO
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA] CTD PMID:12235164 PMID:33545341 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
G Slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 decreases expression ISO diethyl maleate results in decreased expression of SLC9A3R1 mRNA CTD PMID:21161181 NCBI chr11:115,163,341...115,181,178
Ensembl chr11:115,163,341...115,181,181
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO diethyl maleate results in decreased expression of SLCO2A1 mRNA CTD PMID:21161181 NCBI chr 9:103,007,061...103,096,002
Ensembl chr 9:102,988,712...103,096,002
JBrowse link
G Slfn3 schlafen 3 decreases expression ISO diethyl maleate results in decreased expression of SLFN3 mRNA CTD PMID:21161181 NCBI chr11:83,191,330...83,215,154
Ensembl chr11:83,191,330...83,215,154
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression ISO diethyl maleate results in increased expression of SMC4 mRNA CTD PMID:21161181 NCBI chr 3:69,004,738...69,034,623
Ensembl chr 3:69,004,738...69,034,623
JBrowse link
G Smtn smoothelin increases expression ISO diethyl maleate results in increased expression of SMTN mRNA CTD PMID:21161181 NCBI chr11:3,517,522...3,539,292
Ensembl chr11:3,517,523...3,540,612
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression EXP diethyl maleate results in decreased expression of SOCS3 mRNA CTD PMID:25270620 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing decreases expression ISO diethyl maleate results in decreased expression of SORL1 mRNA CTD PMID:21161181 NCBI chr 9:41,964,709...42,124,297
Ensembl chr 9:41,964,720...42,124,297
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 increases expression ISO diethyl maleate results in increased expression of SOX9 mRNA CTD PMID:21161181 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Sp5 trans-acting transcription factor 5 decreases expression EXP diethyl maleate results in decreased expression of SP5 mRNA CTD PMID:25270620 NCBI chr 2:70,474,923...70,477,726
Ensembl chr 2:70,474,923...70,477,729
JBrowse link
G Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) increases expression ISO diethyl maleate results in increased expression of SPC25 mRNA CTD PMID:21161181 NCBI chr 2:69,193,895...69,206,213
Ensembl chr 2:69,193,895...69,206,194
JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 increases expression EXP diethyl maleate results in increased expression of SPTA1 mRNA CTD PMID:25270620 NCBI chr 1:174,172,739...174,248,449
Ensembl chr 1:174,172,776...174,248,450
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases cleavage ISO diethyl maleate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 2:29,965,560...30,031,451
Ensembl chr 2:29,965,560...30,031,451
JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 increases expression EXP diethyl maleate results in increased expression of SPTBN4 mRNA CTD PMID:25270620 NCBI chr 7:27,356,383...27,447,704
Ensembl chr 7:27,356,383...27,447,686
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO diethyl maleate results in increased expression of SPTLC1 mRNA CTD PMID:33545341 NCBI chr13:53,332,748...53,377,417
Ensembl chr13:53,332,748...53,377,397
JBrowse link
G Sqstm1 sequestosome 1 increases expression EXP
ISO
diethyl maleate results in increased expression of SQSTM1 mRNA CTD PMID:25270620 PMID:33545341 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO diethyl maleate results in decreased expression of SREBF1 mRNA CTD PMID:21161181 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) multiple interactions
decreases expression
increases expression
EXP
ISO
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
diethyl maleate results in decreased expression of SRXN1 mRNA
NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein
CTD PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 NCBI chr 2:152,105,524...152,111,376
Ensembl chr 2:152,105,516...152,111,376
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO diethyl maleate results in decreased expression of STAT1 mRNA CTD PMID:21161181 NCBI chr 1:52,119,438...52,161,865
Ensembl chr 1:52,119,440...52,161,865
JBrowse link
G Steap4 STEAP family member 4 decreases expression EXP diethyl maleate results in decreased expression of STEAP4 mRNA CTD PMID:25270620 NCBI chr 5:7,960,472...7,982,213
Ensembl chr 5:7,960,457...7,982,213
JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO diethyl maleate results in decreased expression of SULF2 mRNA CTD PMID:21161181 NCBI chr 2:166,073,899...166,155,683
Ensembl chr 2:166,073,089...166,155,663
JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 decreases expression ISO diethyl maleate results in decreased expression of SULT1A1 protein CTD PMID:21161181 NCBI chr 7:126,672,865...126,690,443
Ensembl chr 7:126,672,865...126,676,432
JBrowse link
G Tagln transgelin decreases expression ISO diethyl maleate results in decreased expression of TAGLN mRNA CTD PMID:21161181 NCBI chr 9:45,929,628...45,936,058
Ensembl chr 9:45,929,619...45,936,058
JBrowse link
G Tatdn2 TatD DNase domain containing 2 increases expression ISO diethyl maleate results in increased expression of TATDN2 mRNA CTD PMID:33545341 NCBI chr 6:113,697,050...113,711,082
Ensembl chr 6:113,697,050...113,711,069
JBrowse link
G Tbcel tubulin folding cofactor E-like increases expression EXP diethyl maleate results in increased expression of TBCEL mRNA CTD PMID:25270620 NCBI chr 9:42,412,316...42,472,238
Ensembl chr 9:42,412,316...42,507,809
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases expression ISO diethyl maleate results in increased expression of TENT4A mRNA CTD PMID:33545341 NCBI chr13:69,497,952...69,534,236
Ensembl chr13:69,497,959...69,534,617
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A decreases expression ISO diethyl maleate results in decreased expression of TENT5A mRNA CTD PMID:21161181 NCBI chr 9:85,320,439...85,327,150
Ensembl chr 9:85,320,439...85,327,348
JBrowse link
G Tesmin testis expressed metallothionein like affects localization EXP diethyl maleate affects the localization of TESMIN protein CTD PMID:12606435 NCBI chr19:3,388,857...3,407,823
Ensembl chr19:3,388,857...3,407,823
JBrowse link
G Tfeb transcription factor EB decreases expression EXP diethyl maleate results in decreased expression of TFEB mRNA CTD PMID:25270620 NCBI chr17:47,737,037...47,792,416
Ensembl chr17:47,737,030...47,792,419
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide increases expression ISO diethyl maleate results in increased expression of TGM2 mRNA CTD PMID:21161181 NCBI chr 2:158,116,405...158,146,392
Ensembl chr 2:158,116,402...158,146,436
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO diethyl maleate results in increased expression of THBS1 mRNA CTD PMID:21161181 NCBI chr 2:118,111,876...118,127,133
Ensembl chr 2:118,111,876...118,127,133
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO diethyl maleate results in decreased expression of THRSP mRNA CTD PMID:21161181 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link
G Tm4sf1 transmembrane 4 superfamily member 1 increases expression ISO diethyl maleate results in increased expression of TM4SF1 mRNA CTD PMID:21161181 NCBI chr 3:57,285,611...57,387,736
Ensembl chr 3:57,285,611...57,301,988
JBrowse link
G Tmem209 transmembrane protein 209 increases expression EXP diethyl maleate results in increased expression of TMEM209 mRNA CTD PMID:25270620 NCBI chr 6:30,481,022...30,509,787
Ensembl chr 6:30,479,053...30,509,783
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) decreases expression ISO diethyl maleate results in decreased expression of TNFRSF14 mRNA CTD PMID:21161181 NCBI chr 4:154,918,487...154,928,620
Ensembl chr 4:154,921,933...154,928,563
JBrowse link
G Tpm2 tropomyosin 2, beta decreases expression ISO diethyl maleate results in decreased expression of TPM2 mRNA CTD PMID:21161181 NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions
decreases response to substance
ISO diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]
TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD PMID:17853063 NCBI chr16:4,039,971...4,077,840
Ensembl chr16:4,039,971...4,077,827
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 decreases expression EXP diethyl maleate results in decreased expression of TRDMT1 mRNA CTD PMID:25270620 NCBI chr 2:13,504,879...13,544,797
Ensembl chr 2:13,509,014...13,544,668
JBrowse link
G Trf transferrin decreases expression ISO diethyl maleate results in decreased expression of TF protein CTD PMID:21161181 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444
JBrowse link
G Trib1 tribbles pseudokinase 1 increases expression ISO diethyl maleate results in increased expression of TRIB1 mRNA CTD PMID:33545341 NCBI chr15:59,648,654...59,657,099
Ensembl chr15:59,648,350...59,657,099
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO diethyl maleate results in increased expression of TRIB3 mRNA CTD PMID:33545341 NCBI chr 2:152,337,425...152,344,060
Ensembl chr 2:152,337,422...152,344,032
JBrowse link
G Trim6 tripartite motif-containing 6 decreases expression ISO diethyl maleate results in decreased expression of TRIM6 mRNA CTD PMID:21161181 NCBI chr 7:104,218,795...104,235,152
Ensembl chr 7:104,218,793...104,235,152
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO diethyl maleate results in increased expression of TRIP13 mRNA CTD PMID:21161181 NCBI chr13:73,912,450...73,937,795
Ensembl chr13:73,911,347...73,937,784
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP
ISO
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD PMID:22003191 PMID:27982581 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO diethyl maleate results in decreased expression of TSC22D1 mRNA CTD PMID:21161181 NCBI chr14:76,414,961...76,507,765
Ensembl chr14:76,414,961...76,507,765
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO diethyl maleate results in decreased expression of TSPAN8 mRNA CTD PMID:21161181 NCBI chr10:115,816,817...115,849,893
Ensembl chr10:115,816,832...115,849,893
JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 decreases expression EXP diethyl maleate results in decreased expression of TSTD1 mRNA CTD PMID:25270620 NCBI chr 1:171,419,033...171,420,352
Ensembl chr 1:171,418,872...171,420,352
JBrowse link
G Txn1 thioredoxin 1 decreases activity ISO diethyl maleate results in decreased activity of TXN protein CTD PMID:15388247 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO diethyl maleate results in increased expression of TXNIP mRNA CTD PMID:21161181 NCBI chr 3:96,557,957...96,561,857
Ensembl chr 3:96,557,957...96,561,883
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO diethyl maleate results in increased expression of TXNRD1 mRNA CTD PMID:15521073 PMID:33545341 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
G Ubd ubiquitin D decreases expression ISO diethyl maleate results in decreased expression of UBD mRNA CTD PMID:21161181 NCBI chr17:37,193,892...37,196,101
Ensembl chr17:37,193,892...37,196,095
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases expression EXP diethyl maleate results in increased expression of UGT2B35 mRNA CTD PMID:25270620 NCBI chr 5:87,000,860...87,013,274
Ensembl chr 5:87,000,860...87,013,275
JBrowse link
G Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 increases expression ISO diethyl maleate results in increased expression of UHRF1 mRNA CTD PMID:21161181 NCBI chr17:56,303,337...56,323,486
Ensembl chr17:56,303,321...56,323,486
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO diethyl maleate results in decreased expression of USP18 mRNA CTD PMID:21161181 NCBI chr 6:121,245,906...121,270,917
Ensembl chr 6:121,245,906...121,270,917
JBrowse link
G Usp2 ubiquitin specific peptidase 2 decreases expression ISO diethyl maleate results in decreased expression of USP2 mRNA CTD PMID:21161181 NCBI chr 9:44,067,021...44,095,627
Ensembl chr 9:44,067,021...44,095,627
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO diethyl maleate results in increased expression of VEGFA mRNA CTD PMID:33545341 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression EXP diethyl maleate results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 4:62,448,653...62,470,999
Ensembl chr 4:62,448,653...62,470,896
JBrowse link
G Wdr6 WD repeat domain 6 decreases expression ISO diethyl maleate results in decreased expression of WDR6 mRNA CTD PMID:21161181 NCBI chr 9:108,572,311...108,578,713
Ensembl chr 9:108,572,311...108,578,739
JBrowse link
G Ypel5 yippee like 5 increases expression EXP diethyl maleate results in increased expression of YPEL5 mRNA CTD PMID:25270620 NCBI chr17:72,836,628...72,850,444
Ensembl chr17:72,836,453...72,851,195
JBrowse link
G Zfand2a zinc finger, AN1-type domain 2A increases expression ISO diethyl maleate results in increased expression of ZFAND2A mRNA CTD PMID:33545341 NCBI chr 5:139,471,216...139,484,491
Ensembl chr 5:139,471,211...139,484,549
JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO diethyl maleate results in increased expression of ZFP36 protein CTD PMID:21969073 NCBI chr 7:28,376,784...28,379,228
Ensembl chr 7:28,376,784...28,380,253
JBrowse link
G Zfp367 zinc finger protein 367 increases expression ISO diethyl maleate results in increased expression of ZNF367 mRNA CTD PMID:21161181 NCBI chr13:64,133,022...64,153,199
Ensembl chr13:64,133,018...64,153,202
JBrowse link
G Zfp37 zinc finger protein 37 decreases expression ISO diethyl maleate results in decreased expression of ZFP37 mRNA CTD PMID:21161181 NCBI chr 4:62,189,537...62,209,129
Ensembl chr 4:62,189,540...62,231,047
JBrowse link
G Zfp493 zinc finger protein 493 decreases reduction EXP diethyl maleate results in decreased reduction of ZFP493 protein CTD PMID:19843705 NCBI chr13:67,779,693...67,789,082
Ensembl chr13:67,779,693...67,792,512
JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression EXP diethyl maleate results in decreased expression of ZNRD2 mRNA CTD PMID:25270620 NCBI chr19:5,730,306...5,731,732
Ensembl chr19:5,728,088...5,731,713
Ensembl chr19:5,728,088...5,731,713
JBrowse link

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  CHEBI ontology 21788
    role 21767
      biological role 21765
        glutathione depleting agent 389
          diethyl maleate 389
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