CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: glutathione depleting agent
Accession: CHEBI:68509
browse the term
Definition: A compound which causes a reduction in the levels of glutathione in cells.
Synonyms: related_synonym: glutathione depleting agents; glutathione depletion agent; glutathione depletion agents; glutathione depletor; glutathione depletors
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ABCC2
ATP binding cassette subfamily C member 2
increases expression
ISO
diethyl maleate results in increased expression of ABCC2 mRNA
CTD
PMID:25270620
NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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ABHD4
abhydrolase domain containing 4, N-acyl phospholipase B
increases expression
ISO
diethyl maleate results in increased expression of ABHD4 mRNA
CTD
PMID:25270620
NCBI chr14:22,598,300...22,612,963
Ensembl chr14:22,598,290...22,612,963
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ACACA
acetyl-CoA carboxylase alpha
decreases expression
ISO
diethyl maleate results in decreased expression of ACACA mRNA
CTD
PMID:25270620
NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
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ACOX1
acyl-CoA oxidase 1
multiple interactions
ISO
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]
CTD
PMID:17134953
NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
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ACY3
aminoacylase 3
decreases expression
ISO
diethyl maleate results in decreased expression of ACY3 mRNA
CTD
PMID:21161181
NCBI chr11:67,642,555...67,650,730
Ensembl chr11:67,642,555...67,650,730
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ADM
adrenomedullin
increases expression
EXP
diethyl maleate results in increased expression of ADM mRNA
CTD
PMID:33545341
NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
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ADORA3
adenosine A3 receptor
decreases expression
ISO
diethyl maleate results in decreased expression of ADORA3 mRNA
CTD
PMID:21161181
NCBI chr 1:111,499,429...111,503,633
Ensembl chr 1:111,499,429...111,503,633
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AEN
apoptosis enhancing nuclease
increases expression
EXP
diethyl maleate results in increased expression of AEN mRNA
CTD
PMID:33545341
NCBI chr15:88,604,683...88,632,281
Ensembl chr15:88,621,337...88,632,281
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AFP
alpha fetoprotein
increases expression
ISO
diethyl maleate results in increased expression of AFP mRNA
CTD
PMID:25270620
NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
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AHCYL1
adenosylhomocysteinase like 1
increases expression
ISO
diethyl maleate results in increased expression of AHCYL1 mRNA
CTD
PMID:25270620
NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742
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AKR1A1
aldo-keto reductase family 1 member A1
increases expression
ISO
diethyl maleate results in increased expression of AKR1A1 protein
CTD
PMID:21161181
NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
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AKR1B10
aldo-keto reductase family 1 member B10
increases expression
EXP
diethyl maleate results in increased expression of AKR1B10 mRNA
CTD
PMID:33545341
NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412
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AKR1C2
aldo-keto reductase family 1 member C2
increases expression
EXP
diethyl maleate results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
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ALDH1A1
aldehyde dehydrogenase 1 family member A1
affects reduction
ISO
diethyl maleate affects the reduction of ALDH1A1 protein
CTD
PMID:19843705
NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
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ALDH1B1
aldehyde dehydrogenase 1 family member B1
decreases expression
ISO
diethyl maleate results in decreased expression of ALDH1B1 mRNA
CTD
PMID:21161181
NCBI chr 9:38,392,702...38,398,661
Ensembl chr 9:38,392,702...38,398,661
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ALDH2
aldehyde dehydrogenase 2 family member
decreases reduction increases expression decreases expression
ISO
diethyl maleate results in decreased reduction of ALDH2 protein diethyl maleate results in increased expression of ALDH2 protein diethyl maleate results in decreased expression of ALDH2 protein
CTD
PMID:19843705 PMID:21161181
NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
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ALDOA
aldolase, fructose-bisphosphate A
affects expression
EXP
diethyl maleate affects the expression of ALDOA mRNA
CTD
PMID:34480604
NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457
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ALDOB
aldolase, fructose-bisphosphate B
decreases expression
ISO
diethyl maleate results in decreased expression of ALDOB protein
CTD
PMID:21161181
NCBI chr 9:101,420,560...101,435,774
Ensembl chr 9:101,420,560...101,449,664
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AMIGO2
adhesion molecule with Ig like domain 2
decreases expression
ISO
diethyl maleate results in decreased expression of AMIGO2 mRNA
CTD
PMID:21161181
NCBI chr12:47,075,707...47,079,959
Ensembl chr12:47,075,707...47,079,959
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ANGPTL2
angiopoietin like 2
decreases expression
ISO
diethyl maleate results in decreased expression of ANGPTL2 mRNA
CTD
PMID:21161181
NCBI chr 9:127,087,348...127,122,635
Ensembl chr 9:127,087,348...127,122,635
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ANGPTL4
angiopoietin like 4
increases expression
EXP
diethyl maleate results in increased expression of ANGPTL4 mRNA
CTD
PMID:33545341
NCBI chr19:8,364,155...8,374,370
Ensembl chr19:8,363,289...8,374,370
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ANKRD46
ankyrin repeat domain 46
decreases expression
ISO
diethyl maleate results in decreased expression of ANKRD46 mRNA
CTD
PMID:21161181
NCBI chr 8:100,509,752...100,559,759
Ensembl chr 8:100,509,752...100,559,784
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ANLN
anillin, actin binding protein
increases expression
ISO
diethyl maleate results in increased expression of ANLN mRNA
CTD
PMID:21161181
NCBI chr 7:36,389,862...36,453,791
Ensembl chr 7:36,389,821...36,453,791
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ANXA1
annexin A1
affects expression
EXP
diethyl maleate affects the expression of ANXA1 mRNA
CTD
PMID:34480604
NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
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ANXA3
annexin A3
decreases expression
ISO
diethyl maleate results in decreased expression of ANXA3 mRNA
CTD
PMID:21161181
NCBI chr 4:78,551,770...78,610,447
Ensembl chr 4:78,551,747...78,610,451
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AP3M2
adaptor related protein complex 3 subunit mu 2
decreases expression
ISO
diethyl maleate results in decreased expression of AP3M2 mRNA
CTD
PMID:21161181
NCBI chr 8:42,153,063...42,171,183
Ensembl chr 8:42,152,946...42,171,673
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APAF1
apoptotic peptidase activating factor 1
increases expression
EXP
diethyl maleate results in increased expression of APAF1 mRNA
CTD
PMID:11875189
NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,290...98,735,433
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APLP1
amyloid beta precursor like protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of APLP1 mRNA
CTD
PMID:25270620
NCBI chr19:35,868,574...35,879,792
Ensembl chr19:35,867,899...35,879,792
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APOL4
apolipoprotein L4
decreases expression
ISO
diethyl maleate results in decreased expression of APOL9A mRNA
CTD
PMID:21161181
NCBI chr22:36,189,128...36,204,833
Ensembl chr22:36,189,124...36,204,840
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ARHGAP9
Rho GTPase activating protein 9
increases expression
EXP
diethyl maleate results in increased expression of ARHGAP9 mRNA
CTD
PMID:33545341
NCBI chr12:57,472,269...57,488,824
Ensembl chr12:57,472,264...57,488,814
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ARRDC2
arrestin domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of ARRDC2 mRNA
CTD
PMID:21161181
NCBI chr19:18,001,124...18,014,102
Ensembl chr19:18,001,132...18,014,102
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ARRDC4
arrestin domain containing 4
decreases expression
ISO
diethyl maleate results in decreased expression of ARRDC4 mRNA
CTD
PMID:25270620
NCBI chr15:97,960,703...97,973,833
Ensembl chr15:97,960,703...97,973,833
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ASF1B
anti-silencing function 1B histone chaperone
increases expression
ISO
diethyl maleate results in increased expression of ASF1B mRNA
CTD
PMID:21161181
NCBI chr19:14,119,512...14,136,589
Ensembl chr19:14,119,512...14,136,613
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ASXL1
ASXL transcriptional regulator 1
decreases expression
ISO
diethyl maleate results in decreased expression of ASXL1 mRNA
CTD
PMID:25270620
NCBI chr20:32,358,331...32,439,319
Ensembl chr20:32,358,330...32,439,319
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ATM
ATM serine/threonine kinase
increases expression
EXP
diethyl maleate results in increased expression of ATM mRNA
CTD
PMID:11875189
NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102
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ATP5F1B
ATP synthase F1 subunit beta
increases expression
ISO
diethyl maleate results in increased expression of ATP5F1B protein
CTD
PMID:21161181
NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984
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AURKA
aurora kinase A
increases expression decreases expression
ISO
diethyl maleate results in increased expression of AURKA mRNA diethyl maleate results in decreased expression of AURKA mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr20:56,369,390...56,392,215
Ensembl chr20:56,369,389...56,392,337
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BABAM2-AS1
BABAM2 antisense RNA 1
increases expression
EXP
diethyl maleate results in increased expression of BABAM2-AS1 mRNA
CTD
PMID:33545341
NCBI chr 2:27,889,456...27,891,114
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BBC3
BCL2 binding component 3
increases expression
EXP
diethyl maleate results in increased expression of BBC3 mRNA
CTD
PMID:33545341
NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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BCL2
BCL2 apoptosis regulator
multiple interactions increases expression
ISO EXP
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA diethyl maleate results in increased expression of BCL2 mRNA
CTD
PMID:22564015 PMID:33545341
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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BCL2A1
BCL2 related protein A1
decreases expression
ISO
diethyl maleate results in decreased expression of BCL2A1 mRNA
CTD
PMID:21161181
NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
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BCL3
BCL3 transcription coactivator
decreases expression
ISO
diethyl maleate results in decreased expression of BCL3 mRNA
CTD
PMID:25270620
NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044
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BCL6B
BCL6B transcription repressor
decreases expression
ISO
diethyl maleate results in decreased expression of BCL6B mRNA
CTD
PMID:21161181
NCBI chr17:7,023,050...7,029,644
Ensembl chr17:7,023,050...7,030,290
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BHLHE41
basic helix-loop-helix family member e41
decreases expression
ISO
diethyl maleate results in decreased expression of BHLHE41 mRNA
CTD
PMID:21161181
NCBI chr12:26,120,030...26,125,037
Ensembl chr12:26,120,030...26,125,037
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BHMT
betaine--homocysteine S-methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of BHMT mRNA
CTD
PMID:21161181
NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
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BIRC3
baculoviral IAP repeat containing 3
multiple interactions
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
CTD
PMID:12774022
NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403
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BLVRB
biliverdin reductase B
increases expression
ISO
diethyl maleate results in increased expression of BLVRB mRNA
CTD
PMID:25270620 PMID:34626751
NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764
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BMF
Bcl2 modifying factor
decreases expression
ISO
diethyl maleate results in decreased expression of BMF mRNA
CTD
PMID:21161181
NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
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BRIP1
BRCA1 interacting helicase 1
increases expression
ISO
diethyl maleate results in increased expression of BRIP1 mRNA
CTD
PMID:21161181
NCBI chr17:61,679,139...61,863,528
Ensembl chr17:61,679,139...61,863,559
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BTBD2
BTB domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of BTBD2 mRNA
CTD
PMID:21161181
NCBI chr19:1,985,448...2,015,714
Ensembl chr19:1,985,438...2,034,881
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BTG2
BTG anti-proliferation factor 2
increases expression decreases expression multiple interactions
ISO
diethyl maleate results in increased expression of BTG2 mRNA diethyl maleate results in decreased expression of BTG2 mRNA NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]
CTD
PMID:22003191 PMID:25270620 PMID:34626751
NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
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C6
complement C6
decreases expression
ISO
diethyl maleate results in decreased expression of C6 mRNA
CTD
PMID:21161181
NCBI chr 5:41,142,116...41,261,469
Ensembl chr 5:41,142,116...41,261,438
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CASP2
caspase 2
increases expression
EXP
diethyl maleate results in increased expression of CASP2 mRNA
CTD
PMID:11875189
NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
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CASP3
caspase 3
increases expression increases cleavage
EXP
diethyl maleate results in increased expression of CASP3 mRNA diethyl maleate results in increased cleavage of CASP3 protein
CTD
PMID:11875189 PMID:21105742
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP9
caspase 9
increases expression
EXP
diethyl maleate results in increased expression of CASP9 mRNA
CTD
PMID:11875189
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CAT
catalase
decreases expression
ISO
diethyl maleate results in decreased expression of CAT protein
CTD
PMID:21161181
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CBR1
carbonyl reductase 1
increases expression
ISO
diethyl maleate results in increased expression of CBR1 mRNA
CTD
PMID:25270620
NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
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CBR3
carbonyl reductase 3
increases expression multiple interactions
EXP ISO
diethyl maleate results in increased expression of CBR3 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD
PMID:20806931 PMID:25270620
NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562
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CBX4
chromobox 4
increases expression
EXP
diethyl maleate results in increased expression of CBX4 mRNA
CTD
PMID:33545341
NCBI chr17:79,833,156...79,839,440
Ensembl chr17:79,833,156...79,839,440
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CCDC50
coiled-coil domain containing 50
decreases expression
ISO
diethyl maleate results in decreased expression of CCDC50 mRNA
CTD
PMID:25270620
NCBI chr 3:191,329,394...191,398,659
Ensembl chr 3:191,329,085...191,398,659
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CCNA1
cyclin A1
decreases expression
EXP
diethyl maleate results in decreased expression of CCNA1 mRNA
CTD
PMID:11875189
NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870
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CCNA2
cyclin A2
increases expression
ISO
diethyl maleate results in increased expression of CCNA2 mRNA
CTD
PMID:21161181
NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
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CCND1
cyclin D1
decreases expression increases expression
EXP ISO
diethyl maleate results in decreased expression of CCND1 mRNA diethyl maleate results in increased expression of CCND1 mRNA
CTD
PMID:11875189 PMID:21161181 PMID:25270620
NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
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CCNE2
cyclin E2
increases expression
ISO
diethyl maleate results in increased expression of CCNE2 mRNA
CTD
PMID:21161181
NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678
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CCNK
cyclin K
decreases expression
EXP
diethyl maleate results in decreased expression of CCNK mRNA
CTD
PMID:11875189
NCBI chr14:99,481,409...99,512,440
Ensembl chr14:99,481,169...99,535,044
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CD80
CD80 molecule
multiple interactions increases expression
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein diethyl maleate results in increased expression of CD80 protein
CTD
PMID:31958493
NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
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CD86
CD86 molecule
multiple interactions increases expression
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]
CTD
PMID:24136171 PMID:31958493
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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CDC25A
cell division cycle 25A
increases expression
ISO
diethyl maleate results in increased expression of CDC25A mRNA
CTD
PMID:21161181
NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
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CDCA2
cell division cycle associated 2
increases expression
ISO
diethyl maleate results in increased expression of CDCA2 mRNA
CTD
PMID:21161181
NCBI chr 8:25,458,931...25,507,917
Ensembl chr 8:25,459,199...25,507,911
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CDCA3
cell division cycle associated 3
increases expression
ISO
diethyl maleate results in increased expression of CDCA3 mRNA
CTD
PMID:21161181
NCBI chr12:6,844,798...6,851,286
Ensembl chr12:6,844,793...6,851,292
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CDCA8
cell division cycle associated 8
increases expression
ISO
diethyl maleate results in increased expression of CDCA8 mRNA
CTD
PMID:21161181
NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719
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CDH11
cadherin 11
decreases expression
ISO
diethyl maleate results in decreased expression of CDH11 mRNA
CTD
PMID:21161181
NCBI chr16:64,943,753...65,123,744
Ensembl chr16:64,943,753...65,126,112
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CDKN1A
cyclin dependent kinase inhibitor 1A
increases expression multiple interactions
EXP
diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD
PMID:11875189 PMID:27982581
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
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CDS2
CDP-diacylglycerol synthase 2
increases expression
ISO
diethyl maleate results in increased expression of CDS2 mRNA
CTD
PMID:25270620
NCBI chr20:5,127,008...5,197,887
Ensembl chr20:5,126,879...5,197,887
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CES1
carboxylesterase 1
increases reduction decreases expression
ISO
diethyl maleate results in increased reduction of CES1D protein diethyl maleate results in decreased expression of CES1D protein
CTD
PMID:19843705 PMID:21161181
NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
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CFLAR
CASP8 and FADD like apoptosis regulator
decreases expression
ISO
diethyl maleate results in decreased expression of CFLAR mRNA
CTD
PMID:21161181
NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
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CHRNA4
cholinergic receptor nicotinic alpha 4 subunit
increases expression
EXP
diethyl maleate results in increased expression of CHRNA4 mRNA
CTD
PMID:33545341
NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401
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CIDEC
cell death inducing DFFA like effector c
decreases expression
ISO
diethyl maleate results in decreased expression of CIDEC mRNA
CTD
PMID:21161181
NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255
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CITED2
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
decreases expression
ISO
diethyl maleate results in decreased expression of CITED2 mRNA
CTD
PMID:21161181
NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
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CITED4
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
decreases expression
ISO
diethyl maleate results in decreased expression of CITED4 mRNA
CTD
PMID:21161181
NCBI chr 1:40,861,054...40,862,363
Ensembl chr 1:40,861,054...40,862,363
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CKB
creatine kinase B
decreases reduction
ISO
diethyl maleate results in decreased reduction of CKB protein
CTD
PMID:19843705
NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833
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CKS2
CDC28 protein kinase regulatory subunit 2
increases expression
EXP
diethyl maleate results in increased expression of CKS2 mRNA
CTD
PMID:33545341
NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703
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CLK1
CDC like kinase 1
increases expression
EXP
diethyl maleate results in increased expression of CLK1 mRNA
CTD
PMID:33545341
NCBI chr 2:200,853,009...200,864,658
Ensembl chr 2:200,853,009...200,864,691
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CMPK2
cytidine/uridine monophosphate kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of CMPK2 mRNA
CTD
PMID:21161181
NCBI chr 2:6,840,553...6,866,635
Ensembl chr 2:6,840,570...6,866,635
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CNTN1
contactin 1
increases expression
EXP
diethyl maleate results in increased expression of CNTN1 mRNA
CTD
PMID:33545341
NCBI chr12:40,692,439...41,072,415
Ensembl chr12:40,692,439...41,072,415
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COL1A1
collagen type I alpha 1 chain
decreases expression
ISO
diethyl maleate results in decreased expression of COL1A1 mRNA
CTD
PMID:21161181
NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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COL3A1
collagen type III alpha 1 chain
decreases expression
ISO
diethyl maleate results in decreased expression of COL3A1 mRNA
CTD
PMID:25270620
NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
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COMMD3
COMM domain containing 3
increases expression
ISO
diethyl maleate results in increased expression of COMMD3 mRNA
CTD
PMID:25270620
NCBI chr10:22,316,388...22,320,306
Ensembl chr10:22,316,386...22,320,306
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COMT
catechol-O-methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of COMT mRNA
CTD
PMID:21161181
NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975
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CP
ceruloplasmin
decreases expression
ISO
diethyl maleate results in decreased expression of CP mRNA
CTD
PMID:25270620
NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
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CPSF4L
cleavage and polyadenylation specific factor 4 like
increases expression
EXP
diethyl maleate results in increased expression of CPSF4L mRNA
CTD
PMID:33545341
NCBI chr17:73,242,101...73,263,778
Ensembl chr17:73,248,449...73,262,352
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CRYM
crystallin mu
decreases expression
ISO
diethyl maleate results in decreased expression of CRYM mRNA
CTD
PMID:21161181
NCBI chr16:21,258,521...21,303,062
Ensembl chr16:21,238,874...21,303,083
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CSRP1
cysteine and glycine rich protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of CSRP1 mRNA
CTD
PMID:21161181
NCBI chr 1:201,483,530...201,507,123
Ensembl chr 1:201,483,530...201,509,456
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CSRP3
cysteine and glycine rich protein 3
decreases reduction
ISO
diethyl maleate results in decreased reduction of CSRP3 protein
CTD
PMID:19843705
NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
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CXCL10
C-X-C motif chemokine ligand 10
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL10 mRNA
CTD
PMID:21161181
NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
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CXCL12
C-X-C motif chemokine ligand 12
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL12 mRNA
CTD
PMID:21161181
NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
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CXCL8
C-X-C motif chemokine ligand 8
increases expression multiple interactions increases secretion increases stability
EXP
diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein] diethyl maleate results in increased secretion of CXCL8 protein diethyl maleate results in increased stability of CXCL8 mRNA
CTD
PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 PMID:31958493 More...
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CXCL9
C-X-C motif chemokine ligand 9
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL9 mRNA
CTD
PMID:21161181
NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
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CYB5A
cytochrome b5 type A
increases expression
ISO
diethyl maleate results in increased expression of CYB5A mRNA
CTD
PMID:25270620
NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973
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CYP26B1
cytochrome P450 family 26 subfamily B member 1
decreases expression
ISO
diethyl maleate results in decreased expression of CYP26B1 mRNA
CTD
PMID:21161181
NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862
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DBP
D-box binding PAR bZIP transcription factor
decreases expression
ISO
diethyl maleate results in decreased expression of DBP mRNA
CTD
PMID:21161181
NCBI chr19:48,630,030...48,637,379
Ensembl chr19:48,630,030...48,637,379
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DDIT3
DNA damage inducible transcript 3
increases expression
EXP
diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein
CTD
PMID:33545341 PMID:35724838
NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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DDIT4
DNA damage inducible transcript 4
increases expression
EXP
diethyl maleate results in increased expression of DDIT4 mRNA
CTD
PMID:33545341
NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
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DDIT4L
DNA damage inducible transcript 4 like
increases expression
ISO
diethyl maleate results in increased expression of DDIT4L mRNA
CTD
PMID:25270620
NCBI chr 4:100,185,870...100,190,468
Ensembl chr 4:100,185,870...100,190,782
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DDX60
DExD/H-box helicase 60
decreases expression
ISO
diethyl maleate results in decreased expression of DDX60 mRNA
CTD
PMID:21161181
NCBI chr 4:168,216,294...168,325,979
Ensembl chr 4:168,216,291...168,318,883
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DHX58
DExH-box helicase 58
decreases expression
ISO
diethyl maleate results in decreased expression of DHX58 mRNA
CTD
PMID:21161181
NCBI chr17:42,101,411...42,112,714
Ensembl chr17:42,101,404...42,112,714
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DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
EXP
diethyl maleate results in increased expression of DNAJB1 mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,514,769...14,560,391
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DNAJB4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
EXP
diethyl maleate results in increased expression of DNAJB4 mRNA
CTD
PMID:33545341
NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964
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DNMBP
dynamin binding protein
decreases expression
ISO
diethyl maleate results in decreased expression of DNMBP mRNA
CTD
PMID:21161181
NCBI chr10:99,875,571...100,009,947
Ensembl chr10:99,875,577...100,009,947
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DPYSL2
dihydropyrimidinase like 2
decreases reduction
ISO
diethyl maleate results in decreased reduction of DPYSL2 protein
CTD
PMID:19843705
NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
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DTX3L
deltex E3 ubiquitin ligase 3L
decreases expression
ISO
diethyl maleate results in decreased expression of DTX3L mRNA
CTD
PMID:21161181
NCBI chr 3:122,564,338...122,575,203
Ensembl chr 3:122,564,338...122,575,203
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DUS3L
dihydrouridine synthase 3 like
decreases expression
ISO
diethyl maleate results in decreased expression of DUS3L mRNA
CTD
PMID:25270620
NCBI chr19:5,785,140...5,791,163
Ensembl chr19:5,784,832...5,791,225
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DUSP6
dual specificity phosphatase 6
increases expression
EXP
diethyl maleate results in increased expression of DUSP6 mRNA
CTD
PMID:33545341
NCBI chr12:89,347,235...89,352,501
Ensembl chr12:89,347,235...89,352,501
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EEF2K
eukaryotic elongation factor 2 kinase
decreases expression
ISO
diethyl maleate results in decreased expression of EEF2K mRNA
CTD
PMID:21161181
NCBI chr16:22,206,278...22,288,738
Ensembl chr16:22,206,278...22,288,738
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EGLN3
egl-9 family hypoxia inducible factor 3
increases expression
EXP
diethyl maleate results in increased expression of EGLN3 mRNA
CTD
PMID:34480604
NCBI chr14:33,924,227...33,951,074
Ensembl chr14:33,924,227...34,462,774
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EIF2AK2
eukaryotic translation initiation factor 2 alpha kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of EIF2AK2 mRNA
CTD
PMID:21161181
NCBI chr 2:37,099,210...37,156,980
Ensembl chr 2:37,099,210...37,157,522
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ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
increases expression
ISO
diethyl maleate results in increased expression of ENTPD5 mRNA
CTD
PMID:25270620
NCBI chr14:73,955,329...74,019,288
Ensembl chr14:73,958,010...74,019,399
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ERAS
ES cell expressed Ras
decreases expression
ISO
diethyl maleate results in decreased expression of ERAS mRNA
CTD
PMID:25270620
NCBI chr X:48,826,513...48,829,869
Ensembl chr X:48,826,513...48,830,138
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ERCC6L
ERCC excision repair 6 like, spindle assembly checkpoint helicase
increases expression
ISO
diethyl maleate results in increased expression of ERCC6L mRNA
CTD
PMID:21161181
NCBI chr X:72,204,665...72,239,027
Ensembl chr X:72,204,657...72,239,027
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EXO1
exonuclease 1
increases expression
ISO
diethyl maleate results in increased expression of EXO1 mRNA
CTD
PMID:21161181
NCBI chr 1:241,847,986...241,889,939
Ensembl chr 1:241,847,967...241,895,148
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FABP1
fatty acid binding protein 1
increases expression
ISO
diethyl maleate results in increased expression of FABP1 protein
CTD
PMID:21161181
NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
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FABP7
fatty acid binding protein 7
decreases expression
ISO
diethyl maleate results in decreased expression of FABP7 mRNA
CTD
PMID:21161181
NCBI chr 6:122,749,201...122,784,074
Ensembl chr 6:122,779,716...122,784,074
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FAH
fumarylacetoacetate hydrolase
affects expression
EXP
diethyl maleate affects the expression of FAH mRNA
CTD
PMID:34480604
NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946
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FAM83D
family with sequence similarity 83 member D
increases expression
EXP
diethyl maleate results in increased expression of FAM83D mRNA
CTD
PMID:33545341
NCBI chr20:38,926,417...38,953,106
Ensembl chr20:38,926,312...38,953,106
G
FASN
fatty acid synthase
decreases expression
ISO
diethyl maleate results in decreased expression of FASN mRNA
CTD
PMID:21161181
NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
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FBN1
fibrillin 1
decreases expression
ISO
diethyl maleate results in decreased expression of FBN1 mRNA
CTD
PMID:21161181
NCBI chr15:48,408,313...48,645,709
Ensembl chr15:48,408,313...48,645,721
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FBP1
fructose-bisphosphatase 1
decreases expression
ISO
diethyl maleate results in decreased expression of FBP1 protein
CTD
PMID:21161181
NCBI chr 9:94,603,133...94,640,263
Ensembl chr 9:94,603,133...94,640,249
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FGF17
fibroblast growth factor 17
decreases expression
ISO
diethyl maleate results in decreased expression of FGF17 mRNA
CTD
PMID:25270620
NCBI chr 8:22,039,672...22,048,809
Ensembl chr 8:22,042,398...22,048,809
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FGG
fibrinogen gamma chain
decreases expression
ISO
diethyl maleate results in decreased expression of FGG mRNA
CTD
PMID:25270620
NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
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FGR
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
diethyl maleate results in decreased expression of FGR mRNA
CTD
PMID:21161181
NCBI chr 1:27,612,064...27,635,185
Ensembl chr 1:27,612,064...27,635,185
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FNDC3B
fibronectin type III domain containing 3B
decreases expression
ISO
diethyl maleate results in decreased expression of FNDC3B mRNA
CTD
PMID:25270620
NCBI chr 3:172,039,578...172,401,669
Ensembl chr 3:172,039,578...172,401,669
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO EXP
diethyl maleate results in increased expression of FOS mRNA
CTD
PMID:10915739 PMID:33545341
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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FOXO1
forkhead box O1
multiple interactions
EXP
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]
CTD
PMID:30261343
NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
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FOXO3
forkhead box O3
increases expression
EXP
diethyl maleate results in increased expression of FOXO3 mRNA
CTD
PMID:33545341
NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
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FSTL3
follistatin like 3
increases expression
EXP
diethyl maleate results in increased expression of FSTL3 mRNA
CTD
PMID:33545341
NCBI chr19:676,392...683,385
Ensembl chr19:676,392...683,392
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G6PC1
glucose-6-phosphatase catalytic subunit 1
decreases expression
EXP ISO
diethyl maleate results in decreased expression of G6PC1 mRNA
CTD
PMID:25270620 PMID:30261343
NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
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G6PD
glucose-6-phosphate dehydrogenase
increases activity increases expression
ISO EXP
diethyl maleate results in increased activity of G6PD protein diethyl maleate results in increased expression of G6PD mRNA
CTD
PMID:3099627 PMID:30261343 PMID:33545341
NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572
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GAB1
GRB2 associated binding protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of GAB1 mRNA
CTD
PMID:25270620
NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,876...143,474,565
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GADD45A
growth arrest and DNA damage inducible alpha
increases expression
EXP
diethyl maleate results in increased expression of GADD45A mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
G
GADD45G
growth arrest and DNA damage inducible gamma
increases expression
EXP
diethyl maleate results in increased expression of GADD45G mRNA
CTD
PMID:33545341
NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555
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GAPDH
glyceraldehyde-3-phosphate dehydrogenase
increases reduction
ISO
diethyl maleate results in increased reduction of GAPDH protein
CTD
PMID:19843705
NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
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GBA2
glucosylceramidase beta 2
decreases expression
ISO
diethyl maleate results in decreased expression of GBA2 mRNA
CTD
PMID:25270620
NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,866...35,749,228
G
GBP2
guanylate binding protein 2
decreases expression
ISO
diethyl maleate results in decreased expression of GBP2 mRNA
CTD
PMID:21161181
NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456
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GCLC
glutamate-cysteine ligase catalytic subunit
increases activity increases expression
ISO EXP
diethyl maleate results in increased activity of GCLC protein diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD
PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34021431 PMID:34480604 More...
NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
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GCLM
glutamate-cysteine ligase modifier subunit
increases expression
ISO EXP
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein
CTD
PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34480604 More...
NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
G
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
EXP
diethyl maleate results in increased expression of GCNT3 mRNA
CTD
PMID:33545341
NCBI chr15:59,549,039...59,622,723
Ensembl chr15:59,594,875...59,640,239
G
GDF15
growth differentiation factor 15
increases expression
EXP
diethyl maleate results in increased expression of GDF15 mRNA
CTD
PMID:33545341
NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
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GDF9
growth differentiation factor 9
increases expression
EXP
diethyl maleate results in increased expression of GDF9 mRNA
CTD
PMID:33545341
NCBI chr 5:132,861,185...132,866,651
Ensembl chr 5:132,861,181...132,866,884
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GFOD1
Gfo/Idh/MocA-like oxidoreductase domain containing 1
increases expression
EXP
diethyl maleate results in increased expression of GFOD1 mRNA
CTD
PMID:33545341
NCBI chr 6:13,357,830...13,487,600
Ensembl chr 6:13,357,830...13,487,662
G
GLUL
glutamate-ammonia ligase
decreases expression
ISO
diethyl maleate results in decreased expression of GLUL mRNA
CTD
PMID:25270620
NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
G
GOT2
glutamic-oxaloacetic transaminase 2
decreases expression
ISO
diethyl maleate results in decreased expression of GOT2 protein
CTD
PMID:21161181
NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
G
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of GPIHBP1 mRNA
CTD
PMID:25270620
NCBI chr 8:143,213,218...143,217,170
Ensembl chr 8:143,213,218...143,217,170
G
GPX2
glutathione peroxidase 2
affects expression
EXP
diethyl maleate affects the expression of GPX2 mRNA
CTD
PMID:34480604
NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
G
GRIA3
glutamate ionotropic receptor AMPA type subunit 3
decreases expression
ISO
diethyl maleate results in decreased expression of GRIA3 mRNA
CTD
PMID:21161181
NCBI chr X:123,184,278...123,490,915
Ensembl chr X:123,184,153...123,490,915
G
GSN
gelsolin
decreases reduction
ISO
diethyl maleate results in decreased reduction of GSN protein
CTD
PMID:19843705
NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843
G
GSR
glutathione-disulfide reductase
increases expression
ISO
diethyl maleate results in increased expression of GSR mRNA
CTD
PMID:25270620
NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
G
GSS
glutathione synthetase
increases expression
ISO
diethyl maleate results in increased expression of GSS mRNA
CTD
PMID:10978506
NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
G
GSTA1
glutathione S-transferase alpha 1
affects expression
EXP
diethyl maleate affects the expression of GSTA1 mRNA
CTD
PMID:34480604
NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
G
GSTA5
glutathione S-transferase alpha 5
increases expression
ISO
diethyl maleate results in increased expression of GSTA5 protein
CTD
PMID:9794803
NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843
G
GSTK1
glutathione S-transferase kappa 1
multiple interactions
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA
CTD
PMID:22564015
NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
G
GSTM1
glutathione S-transferase mu 1
decreases expression
ISO
diethyl maleate results in decreased expression of GSTM1 protein
CTD
PMID:21161181
NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
G
GSTO1
glutathione S-transferase omega 1
increases expression
ISO
diethyl maleate results in increased expression of GSTO1 mRNA
CTD
PMID:25270620
NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
G
GSTP1
glutathione S-transferase pi 1
increases expression
ISO
diethyl maleate results in increased expression of GSTP1 protein
CTD
PMID:9794803
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
G
GSTT1
glutathione S-transferase theta 1
increases expression
ISO
diethyl maleate results in increased expression of GSTT1 protein
CTD
PMID:9794803
G
GTSE1
G2 and S-phase expressed 1
increases expression
ISO
diethyl maleate results in increased expression of GTSE1 mRNA
CTD
PMID:21161181
NCBI chr22:46,296,870...46,330,810
Ensembl chr22:46,296,870...46,330,810
G
H2AZ2
H2A.Z variant histone 2
increases expression
EXP
diethyl maleate results in increased expression of H2AZ2 mRNA
CTD
PMID:33545341
NCBI chr 7:44,826,889...44,848,126
Ensembl chr 7:44,826,791...44,848,087
G
H6PD
hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
increases expression
ISO
diethyl maleate results in increased expression of H6PD mRNA
CTD
PMID:25270620
NCBI chr 1:9,234,774...9,271,337
Ensembl chr 1:9,234,774...9,271,337
G
HAMP
hepcidin antimicrobial peptide
increases expression
EXP
diethyl maleate results in increased expression of HAMP mRNA
CTD
PMID:33545341
NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
G
HELB
DNA helicase B
decreases expression
ISO
diethyl maleate results in decreased expression of HELB mRNA
CTD
PMID:25270620
NCBI chr12:66,302,493...66,343,643
Ensembl chr12:66,302,493...66,343,643
G
HES6
hes family bHLH transcription factor 6
decreases expression
ISO
diethyl maleate results in decreased expression of HES6 mRNA
CTD
PMID:21161181
NCBI chr 2:238,238,267...238,240,038
Ensembl chr 2:238,238,267...238,240,662
G
HJURP
Holliday junction recognition protein
increases expression
ISO
diethyl maleate results in increased expression of HJURP mRNA
CTD
PMID:21161181
NCBI chr 2:233,836,702...233,854,535
Ensembl chr 2:233,833,416...233,854,566
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HMOX1
heme oxygenase 1
increases expression
EXP ISO
diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein
CTD
PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 PMID:35724838 More...
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
decreases reduction
ISO
diethyl maleate results in decreased reduction of HNRNPH1 protein
CTD
PMID:19843705
NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
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HSD17B10
hydroxysteroid 17-beta dehydrogenase 10
increases expression
EXP
diethyl maleate results in increased expression of HSD17B10 mRNA
CTD
PMID:33545341
NCBI chr X:53,431,258...53,434,376
Ensembl chr X:53,431,258...53,434,370
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HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
decreases expression
ISO
diethyl maleate results in decreased expression of HSD17B2 mRNA
CTD
PMID:21161181
NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534
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HSPA1B
heat shock protein family A (Hsp70) member 1B
increases expression
EXP
diethyl maleate results in increased expression of HSPA1B mRNA
CTD
PMID:33545341
NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
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HSPA1L
heat shock protein family A (Hsp70) member 1 like
increases expression
EXP
diethyl maleate results in increased expression of HSPA1L mRNA
CTD
PMID:33545341
NCBI chr 6:31,809,619...31,815,283
Ensembl chr 6:31,809,619...31,815,283
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HSPA5
heat shock protein family A (Hsp70) member 5
decreases reduction
ISO
diethyl maleate results in decreased reduction of HSPA5 protein
CTD
PMID:19843705
NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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HSPA6
heat shock protein family A (Hsp70) member 6
increases expression
EXP
diethyl maleate results in increased expression of HSPA6 mRNA
CTD
PMID:33545341
NCBI chr 1:161,524,540...161,526,894
Ensembl chr 1:161,524,540...161,526,894
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HSPA8
heat shock protein family A (Hsp70) member 8
increases reduction
ISO
diethyl maleate results in increased reduction of HSPA8 protein
CTD
PMID:19843705
NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230
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HTATIP2
HIV-1 Tat interactive protein 2
increases expression
ISO
diethyl maleate results in increased expression of HTATIP2 mRNA
CTD
PMID:25270620
NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,782
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HYCC2
hyccin PI4KA lipid kinase complex subunit 2
decreases expression
ISO
diethyl maleate results in decreased expression of HYCC2 mRNA
CTD
PMID:21161181
NCBI chr 2:200,973,718...201,071,671
Ensembl chr 2:200,973,718...201,071,671
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ICAM1
intercellular adhesion molecule 1
decreases expression multiple interactions
ISO EXP
diethyl maleate results in decreased expression of ICAM1 mRNA diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
CTD
PMID:25270620 PMID:35724838
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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ID3
inhibitor of DNA binding 3
decreases expression
ISO
diethyl maleate results in decreased expression of ID3 mRNA
CTD
PMID:25270620
NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
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ID4
inhibitor of DNA binding 4
decreases expression
ISO
diethyl maleate results in decreased expression of ID4 mRNA
CTD
PMID:25270620
NCBI chr 6:19,837,370...19,842,197
Ensembl chr 6:19,837,370...19,842,197
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IFIT3
interferon induced protein with tetratricopeptide repeats 3
decreases expression
ISO
diethyl maleate results in decreased expression of IFIT3 mRNA
CTD
PMID:21161181
NCBI chr10:89,327,997...89,340,968
Ensembl chr10:89,327,307...89,377,473
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IFRD1
interferon related developmental regulator 1
increases expression
EXP
diethyl maleate results in increased expression of IFRD1 mRNA
CTD
PMID:33545341
NCBI chr 7:112,423,174...112,477,203
Ensembl chr 7:112,422,887...112,481,017
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IKBKE
inhibitor of nuclear factor kappa B kinase subunit epsilon
decreases expression
ISO
diethyl maleate results in decreased expression of IKBKE mRNA
CTD
PMID:25270620
NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889
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IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
increases expression
ISO
diethyl maleate results in increased expression of IKBKG mRNA
CTD
PMID:25270620
NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046
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IL10
interleukin 10
increases secretion
EXP
diethyl maleate results in increased secretion of IL10 protein
CTD
PMID:31958493
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL18
interleukin 18
increases expression
EXP
diethyl maleate results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096
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IL1A
interleukin 1 alpha
multiple interactions
EXP
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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IL1B
interleukin 1 beta
multiple interactions
EXP
diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]
CTD
PMID:35724838
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1R1
interleukin 1 receptor type 1
affects expression
EXP
diethyl maleate affects the expression of IL1R1 mRNA
CTD
PMID:34480604
NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
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IL4
interleukin 4
multiple interactions
EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD
PMID:31958493
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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INHBB
inhibin subunit beta B
decreases expression
ISO
diethyl maleate results in decreased expression of INHBB mRNA
CTD
PMID:25270620
NCBI chr 2:120,346,136...120,351,803
Ensembl chr 2:120,346,136...120,351,803
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INMT
indolethylamine N-methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of INMT mRNA
CTD
PMID:21161181
NCBI chr 7:30,752,135...30,757,602
Ensembl chr 7:30,697,985...30,757,602
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INS
insulin
multiple interactions
EXP
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]
CTD
PMID:30261343
NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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INTS7
integrator complex subunit 7
decreases expression
ISO
diethyl maleate results in decreased expression of INTS7 mRNA
CTD
PMID:25270620
NCBI chr 1:211,940,403...212,035,557
Ensembl chr 1:211,940,399...212,035,557
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IRF7
interferon regulatory factor 7
decreases expression
ISO
diethyl maleate results in decreased expression of IRF7 mRNA
CTD
PMID:21161181
NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983
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IRF9
interferon regulatory factor 9
decreases expression
ISO
diethyl maleate results in decreased expression of IRF9 mRNA
CTD
PMID:21161181
NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,234...24,168,043
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IRGM
immunity related GTPase M
decreases expression
ISO
diethyl maleate results in decreased expression of IRGM mRNA
CTD
PMID:21161181
NCBI chr 5:150,846,521...150,902,402
Ensembl chr 5:150,846,521...150,900,736
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ITGAL
integrin subunit alpha L
decreases expression
ISO
diethyl maleate results in decreased expression of ITGAL mRNA
CTD
PMID:21161181
NCBI chr16:30,472,742...30,523,185
Ensembl chr16:30,472,658...30,523,567
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ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
decreases expression
ISO
diethyl maleate results in decreased expression of ITIH3 mRNA
CTD
PMID:25270620
NCBI chr 3:52,794,796...52,808,797
Ensembl chr 3:52,794,768...52,808,799
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ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
decreases expression
ISO
diethyl maleate results in decreased expression of ITIH4 mRNA
CTD
PMID:25270620
NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688
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JAM3
junctional adhesion molecule 3
decreases expression
ISO
diethyl maleate results in decreased expression of JAM3 mRNA
CTD
PMID:21161181
NCBI chr11:134,069,072...134,152,001
Ensembl chr11:134,069,071...134,152,001
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JUN
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression increases phosphorylation
ISO EXP
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein] diethyl maleate results in increased expression of JUN protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form] diethyl maleate results in increased expression of JUN mRNA
CTD
PMID:10915739 PMID:12774022 PMID:30261343
NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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KCNE3
potassium voltage-gated channel subfamily E regulatory subunit 3
decreases expression
ISO
diethyl maleate results in decreased expression of KCNE3 mRNA
CTD
PMID:25270620
NCBI chr11:74,454,841...74,467,549
Ensembl chr11:74,454,841...74,467,729
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KEAP1
kelch like ECH associated protein 1
increases expression
EXP
diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein
CTD
PMID:27358234 PMID:33545341 PMID:34480604
NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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KHDRBS3
KH RNA binding domain containing, signal transduction associated 3
increases expression
EXP
diethyl maleate results in increased expression of KHDRBS3 mRNA
CTD
PMID:33545341
NCBI chr 8:135,457,456...135,656,516
Ensembl chr 8:135,457,456...135,656,722
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KIFC1
kinesin family member C1
increases expression
ISO
diethyl maleate results in increased expression of KIFC1 mRNA
CTD
PMID:21161181
NCBI chr 6:33,391,461...33,409,896
Ensembl chr 6:33,391,823...33,409,896
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KLF10
KLF transcription factor 10
decreases expression
ISO
diethyl maleate results in decreased expression of KLF10 mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 8:102,648,784...102,655,725
Ensembl chr 8:102,648,784...102,655,725
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KRT75
keratin 75
increases reduction
ISO
diethyl maleate results in increased reduction of KRT75 protein
CTD
PMID:19843705
NCBI chr12:52,424,070...52,434,371
Ensembl chr12:52,424,070...52,434,371
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LAMA1
laminin subunit alpha 1
decreases expression
ISO
diethyl maleate results in decreased expression of LAMA1 mRNA
CTD
PMID:25270620
NCBI chr18:6,941,742...7,117,797
Ensembl chr18:6,941,742...7,117,797
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LANCL2
LanC like glutathione S-transferase 2
decreases expression
ISO
diethyl maleate results in decreased expression of LANCL2 mRNA
CTD
PMID:25270620
NCBI chr 7:55,365,337...55,433,737
Ensembl chr 7:55,365,337...55,433,737
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LDLR
low density lipoprotein receptor
decreases expression
ISO
diethyl maleate results in decreased expression of LDLR mRNA
CTD
PMID:21161181
NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
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LEPR
leptin receptor
decreases expression
ISO
diethyl maleate results in decreased expression of LEPR mRNA
CTD
PMID:21161181
NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
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LGALS3BP
galectin 3 binding protein
decreases expression
ISO
diethyl maleate results in decreased expression of LGALS3BP mRNA
CTD
PMID:21161181
NCBI chr17:78,971,255...78,979,923
Ensembl chr17:78,971,238...78,979,947
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LMNB1
lamin B1
increases expression
ISO
diethyl maleate results in increased expression of LMNB1 mRNA
CTD
PMID:21161181
NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020
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LMO7
LIM domain 7
decreases expression
ISO
diethyl maleate results in decreased expression of LMO7 mRNA
CTD
PMID:21161181
NCBI chr13:75,620,434...75,859,870
Ensembl chr13:75,620,434...75,859,870
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LRIG3
leucine rich repeats and immunoglobulin like domains 3
decreases expression
ISO
diethyl maleate results in decreased expression of LRIG3 mRNA
CTD
PMID:21161181
NCBI chr12:58,872,155...58,920,504
Ensembl chr12:58,872,149...58,920,504
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LRRN4
leucine rich repeat neuronal 4
increases expression
ISO
diethyl maleate results in increased expression of LRRN4 mRNA
CTD
PMID:21161181
NCBI chr20:6,040,546...6,054,060
Ensembl chr20:6,040,546...6,054,060
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LRTM2
leucine rich repeats and transmembrane domains 2
decreases expression
ISO
diethyl maleate results in decreased expression of LRTM2 mRNA
CTD
PMID:21161181
NCBI chr12:1,820,565...1,836,753
Ensembl chr12:1,820,267...1,836,753
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LTC4S
leukotriene C4 synthase
decreases expression
ISO
diethyl maleate results in decreased expression of LTC4S mRNA
CTD
PMID:21161181
NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647
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LUM
lumican
decreases expression
ISO
diethyl maleate results in decreased expression of LUM mRNA
CTD
PMID:21161181
NCBI chr12:91,102,629...91,111,494
Ensembl chr12:91,102,629...91,111,494
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MAFF
MAF bZIP transcription factor F
increases expression
EXP
diethyl maleate results in increased expression of MAFF mRNA
CTD
PMID:20491607 PMID:33545341
NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507
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MAFG
MAF bZIP transcription factor G
increases expression
EXP
diethyl maleate results in increased expression of MAFG mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735
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MAOA
monoamine oxidase A
increases expression
ISO
diethyl maleate results in increased expression of MAOA mRNA
CTD
PMID:25270620
NCBI chr X:43,655,006...43,746,817
Ensembl chr X:43,654,907...43,746,817
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MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1 like
increases expression
EXP
diethyl maleate results in increased expression of MAPK1IP1L mRNA
CTD
PMID:33545341
NCBI chr14:55,051,647...55,070,194
Ensembl chr14:55,051,647...55,070,194
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MAPK8
mitogen-activated protein kinase 8
multiple interactions increases expression
EXP
pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]
CTD
PMID:30261343
NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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MAPK9
mitogen-activated protein kinase 9
increases expression multiple interactions
EXP
diethyl maleate results in increased expression of MAPK9 protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]
CTD
PMID:30261343
NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
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MARVELD1
MARVEL domain containing 1
decreases expression
ISO
diethyl maleate results in decreased expression of MARVELD1 mRNA
CTD
PMID:21161181
NCBI chr10:97,713,730...97,718,150
Ensembl chr10:97,713,173...97,718,150
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MBOAT7
membrane bound O-acyltransferase domain containing 7
increases expression
EXP
diethyl maleate results in increased expression of MBOAT7 mRNA
CTD
PMID:33545341
NCBI chr19:54,173,415...54,189,580
Ensembl chr19:54,173,412...54,189,882
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MCM10
minichromosome maintenance 10 replication initiation factor
increases expression
ISO
diethyl maleate results in increased expression of MCM10 mRNA
CTD
PMID:21161181
NCBI chr10:13,161,558...13,211,110
Ensembl chr10:13,161,558...13,211,110
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MCM4
minichromosome maintenance complex component 4
increases expression
ISO
diethyl maleate results in increased expression of MCM4 mRNA
CTD
PMID:21161181
NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
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ME1
malic enzyme 1
increases expression
ISO
diethyl maleate results in increased expression of ME1 mRNA
CTD
PMID:25270620
NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051
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MFAP4
microfibril associated protein 4
decreases expression
ISO
diethyl maleate results in decreased expression of MFAP4 mRNA
CTD
PMID:21161181
NCBI chr17:19,383,445...19,387,190
Ensembl chr17:19,383,442...19,387,190
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MGMT
O-6-methylguanine-DNA methyltransferase
decreases activity
EXP
diethyl maleate results in decreased activity of MGMT protein
CTD
PMID:16950796
NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
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MKI67
marker of proliferation Ki-67
increases expression
ISO
diethyl maleate results in increased expression of MKI67 mRNA
CTD
PMID:21161181
NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
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MKNK2
MAPK interacting serine/threonine kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of MKNK2 mRNA
CTD
PMID:21161181
NCBI chr19:2,037,471...2,051,244
Ensembl chr19:2,037,465...2,051,244
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MMP1
matrix metallopeptidase 1
increases expression
EXP
diethyl maleate results in increased expression of MMP1 mRNA
CTD
PMID:33545341
NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
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MMP12
matrix metallopeptidase 12
increases expression
ISO
diethyl maleate results in increased expression of MMP12 mRNA
CTD
PMID:10216232
NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
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MMP2
matrix metallopeptidase 2
decreases expression
ISO
diethyl maleate results in decreased expression of MMP2 mRNA
CTD
PMID:21161181
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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MMP3
matrix metallopeptidase 3
increases expression
EXP
diethyl maleate results in increased expression of MMP3 mRNA
CTD
PMID:33545341
NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
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MPZL1
myelin protein zero like 1
decreases expression
EXP
diethyl maleate results in decreased expression of MPZL1 mRNA
CTD
PMID:34480604
NCBI chr 1:167,721,982...167,791,919
Ensembl chr 1:167,721,192...167,791,919
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MSN
moesin
increases reduction
ISO
diethyl maleate results in increased reduction of MSN protein
CTD
PMID:19843705
NCBI chr X:65,588,377...65,741,931
Ensembl chr X:65,588,377...65,741,931
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MT1A
metallothionein 1A
increases expression
EXP
diethyl maleate results in increased expression of MT1A mRNA
CTD
PMID:20491607
NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
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MT2A
metallothionein 2A
increases expression
EXP
diethyl maleate results in increased expression of MT2A mRNA
CTD
PMID:20491607
NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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MX1
MX dynamin like GTPase 1
decreases expression
ISO
diethyl maleate results in decreased expression of MX1 mRNA
CTD
PMID:21161181
NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071
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MX2
MX dynamin like GTPase 2
decreases expression
ISO
diethyl maleate results in decreased expression of MX2 mRNA
CTD
PMID:21161181
NCBI chr21:41,362,027...41,409,393
Ensembl chr21:41,361,999...41,409,393
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MYBL2
MYB proto-oncogene like 2
increases expression
ISO
diethyl maleate results in increased expression of MYBL2 mRNA
CTD
PMID:21161181
NCBI chr20:43,667,114...43,716,482
Ensembl chr20:43,667,019...43,716,495
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MYCN
MYCN proto-oncogene, bHLH transcription factor
decreases expression
ISO
diethyl maleate results in decreased expression of MYCN mRNA
CTD
PMID:25270620
NCBI chr 2:15,940,550...15,947,004
Ensembl chr 2:15,940,550...15,947,007
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NAT8
N-acetyltransferase 8 (putative)
decreases expression
ISO
diethyl maleate results in decreased expression of NAT8 mRNA
CTD
PMID:21161181
NCBI chr 2:73,640,723...73,642,422
Ensembl chr 2:73,640,723...73,642,422
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NCAPH
non-SMC condensin I complex subunit H
increases expression
ISO
diethyl maleate results in increased expression of NCAPH mRNA
CTD
PMID:21161181
NCBI chr 2:96,335,766...96,377,091
Ensembl chr 2:96,335,766...96,377,091
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NDRG1
N-myc downstream regulated 1
increases expression
EXP
diethyl maleate results in increased expression of NDRG1 mRNA
CTD
PMID:33545341
NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
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NFE2L2
NFE2 like bZIP transcription factor 2
affects localization increases activity increases expression multiple interactions decreases response to substance
ISO EXP
diethyl maleate affects the localization of NFE2L2 protein diethyl maleate results in increased activity of NFE2L2 protein diethyl maleate results in increased expression of NFE2L2 protein [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] NFE2L2 results in decreased susceptibility to diethyl maleate NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]
CTD
PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726 PMID:27358234 PMID:27982581 PMID:30114225 PMID:34021431 PMID:35724838 More...
NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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NFKBIA
NFKB inhibitor alpha
multiple interactions
ISO EXP
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]
CTD
PMID:12774022 PMID:35724838
NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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NHERF1
NHERF family PDZ scaffold protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of NHERF1 mRNA
CTD
PMID:21161181
NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
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NOS2
nitric oxide synthase 2
multiple interactions
ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein] Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD
PMID:7532384 PMID:9918918 PMID:12774022
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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NOTCH1
notch receptor 1
increases expression
EXP
diethyl maleate results in increased expression of NOTCH1 mRNA
CTD
PMID:33545341
NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
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NQO1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP ISO
diethyl maleate results in increased expression of NQO1 mRNA
CTD
PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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NR0B2
nuclear receptor subfamily 0 group B member 2
decreases expression
ISO
diethyl maleate results in decreased expression of NR0B2 mRNA
CTD
PMID:21161181
NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
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NR1D1
nuclear receptor subfamily 1 group D member 1
decreases expression
ISO
diethyl maleate results in decreased expression of NR1D1 mRNA
CTD
PMID:21161181
NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589
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NREP
neuronal regeneration related protein
decreases expression
ISO
diethyl maleate results in decreased expression of NREP mRNA
CTD
PMID:21161181
NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
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NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor
decreases expression
ISO
diethyl maleate results in decreased expression of NSMF mRNA
CTD
PMID:25270620
NCBI chr 9:137,447,570...137,459,334
Ensembl chr 9:137,447,570...137,459,334
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NTF3
neurotrophin 3
decreases expression
ISO
diethyl maleate results in decreased expression of NTF3 mRNA
CTD
PMID:21161181
NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536
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NUP153
nucleoporin 153
multiple interactions affects localization
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein
CTD
PMID:20041180
NCBI chr 6:17,615,037...17,706,925
Ensembl chr 6:17,615,035...17,706,925
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NUP88
nucleoporin 88
multiple interactions affects localization
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein
CTD
PMID:20041180
NCBI chr17:5,384,833...5,419,662
Ensembl chr17:5,359,668...5,420,164
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OAF
out at first homolog
decreases expression
ISO
diethyl maleate results in decreased expression of OAF mRNA
CTD
PMID:21161181
NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334
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OGG1
8-oxoguanine DNA glycosylase
multiple interactions
ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA
CTD
PMID:22564015
NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219
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ORC1
origin recognition complex subunit 1
increases expression
ISO
diethyl maleate results in increased expression of ORC1 mRNA
CTD
PMID:21161181
NCBI chr 1:52,372,829...52,409,503
Ensembl chr 1:52,372,829...52,404,423
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OSGIN1
oxidative stress induced growth inhibitor 1
increases expression
EXP
diethyl maleate results in increased expression of OSGIN1 mRNA
CTD
PMID:33545341
NCBI chr16:83,953,240...83,966,332
Ensembl chr16:83,931,311...83,966,332
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P2RX7
purinergic receptor P2X 7
decreases expression
ISO
diethyl maleate results in decreased expression of P2RX7 mRNA
CTD
PMID:21161181
NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032
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PARP1
poly(ADP-ribose) polymerase 1
increases cleavage
EXP
diethyl maleate results in increased cleavage of PARP1 protein
CTD
PMID:21105742
NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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PBLD
phenazine biosynthesis like protein domain containing
decreases expression
ISO
diethyl maleate results in decreased expression of PBLD protein
CTD
PMID:21161181
NCBI chr10:68,282,660...68,332,928
Ensembl chr10:68,282,660...68,333,049
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PCNA
proliferating cell nuclear antigen
decreases expression
EXP
diethyl maleate results in decreased expression of PCNA mRNA
CTD
PMID:11875189
NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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PDLIM2
PDZ and LIM domain 2
decreases expression
ISO
diethyl maleate results in decreased expression of PDLIM2 mRNA
CTD
PMID:21161181
NCBI chr 8:22,578,741...22,598,026
Ensembl chr 8:22,578,279...22,598,025
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PDRG1
p53 and DNA damage regulated 1
increases expression
ISO
diethyl maleate results in increased expression of PDRG1 mRNA
CTD
PMID:25270620
NCBI chr20:31,944,337...31,952,046
Ensembl chr20:31,944,337...31,952,046
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PER2
period circadian regulator 2
decreases expression
ISO
diethyl maleate results in decreased expression of PER2 mRNA
CTD
PMID:21161181
NCBI chr 2:238,244,044...238,300,065
Ensembl chr 2:238,244,044...238,290,102
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PER3
period circadian regulator 3
decreases expression
ISO
diethyl maleate results in decreased expression of PER3 mRNA
CTD
PMID:21161181
NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177
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PGD
phosphogluconate dehydrogenase
increases activity
ISO
diethyl maleate results in increased activity of PGD protein
CTD
PMID:3099627
NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
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PGRMC1
progesterone receptor membrane component 1
increases expression
ISO
diethyl maleate results in increased expression of PGRMC1 mRNA
CTD
PMID:25270620
NCBI chr X:119,236,285...119,244,466
Ensembl chr X:119,236,245...119,244,466
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PIR
pirin
increases expression
ISO
diethyl maleate results in increased expression of PIR mRNA
CTD
PMID:25270620
NCBI chr X:15,384,799...15,493,333
Ensembl chr X:15,384,799...15,493,564
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PKLR
pyruvate kinase L/R
decreases expression
ISO
diethyl maleate results in decreased expression of PKLR mRNA
CTD
PMID:21161181
NCBI chr 1:155,289,293...155,308,654
Ensembl chr 1:155,289,293...155,301,438
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PLAT
plasminogen activator, tissue type
increases expression decreases expression
ISO
diethyl maleate results in increased expression of PLAT mRNA diethyl maleate results in decreased expression of PLAT mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709
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PLEK
pleckstrin
decreases expression
ISO
diethyl maleate results in decreased expression of PLEK mRNA
CTD
PMID:21161181
NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453
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PLEKHM1
pleckstrin homology and RUN domain containing M1
increases expression
EXP
diethyl maleate results in increased expression of PLEKHM1 mRNA
CTD
PMID:33545341
NCBI chr17:45,434,209...45,490,721
Ensembl chr17:45,435,900...45,490,758
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PLIN2
perilipin 2
increases expression
EXP
diethyl maleate results in increased expression of PLIN2 mRNA
CTD
PMID:33545341
NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290
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PLK1
polo like kinase 1
increases expression
EXP
diethyl maleate results in increased expression of PLK1 mRNA
CTD
PMID:33545341
NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
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PLK3
polo like kinase 3
increases expression
EXP
diethyl maleate results in increased expression of PLK3 mRNA
CTD
PMID:33545341
NCBI chr 1:44,800,377...44,805,990
Ensembl chr 1:44,800,377...44,805,990
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POU5F1
POU class 5 homeobox 1
increases expression
EXP
diethyl maleate results in increased expression of POU5F1 mRNA
CTD
PMID:33545341
NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
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PPARA
peroxisome proliferator activated receptor alpha
multiple interactions decreases activity
ISO
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein]
CTD
PMID:17134953
NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
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PPARGC1B
PPARG coactivator 1 beta
decreases expression
ISO
diethyl maleate results in decreased expression of PPARGC1B mRNA
CTD
PMID:21161181
NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
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PPP1R3B
protein phosphatase 1 regulatory subunit 3B
decreases expression
ISO
diethyl maleate results in decreased expression of PPP1R3B mRNA
CTD
PMID:21161181
NCBI chr 8:9,136,255...9,151,539
Ensembl chr 8:9,136,255...9,151,574
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PPP1R3C
protein phosphatase 1 regulatory subunit 3C
decreases expression
ISO
diethyl maleate results in decreased expression of PPP1R3C mRNA
CTD
PMID:21161181
NCBI chr10:91,628,442...91,633,071
Ensembl chr10:91,628,442...91,633,071
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PRDM14
PR/SET domain 14
decreases expression
ISO
diethyl maleate results in decreased expression of PRDM14 mRNA
CTD
PMID:25270620
NCBI chr 8:70,051,651...70,071,252
Ensembl chr 8:70,051,651...70,071,693
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PRDX1
peroxiredoxin 1
increases expression
ISO EXP
diethyl maleate results in increased expression of PRDX1 mRNA
CTD
PMID:9506838
NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
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PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
decreases expression
ISO
diethyl maleate results in decreased expression of PRKAB1 mRNA
CTD
PMID:25270620
NCBI chr12:119,667,952...119,681,619
Ensembl chr12:119,667,864...119,681,624
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PRKAG2
protein kinase AMP-activated non-catalytic subunit gamma 2
increases expression
EXP
diethyl maleate results in increased expression of PRKAG2 mRNA
CTD
PMID:33545341
NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214
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PRKCB
protein kinase C beta
affects expression
EXP
diethyl maleate affects the expression of PRKCB protein
CTD
PMID:31958493
NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
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PRKCD
protein kinase C delta
multiple interactions
ISO
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein
CTD
PMID:11118818
NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
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PRKCE
protein kinase C epsilon
multiple interactions
ISO
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein
CTD
PMID:11118818
NCBI chr 2:45,651,279...46,187,990
Ensembl chr 2:45,651,345...46,187,990
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PRSS8
serine protease 8
decreases expression
ISO
diethyl maleate results in decreased expression of PRSS8 mRNA
CTD
PMID:21161181
NCBI chr16:31,131,433...31,135,727
Ensembl chr16:31,131,433...31,135,727
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PTGR1
prostaglandin reductase 1
increases expression
ISO
diethyl maleate results in increased expression of PTGR1 mRNA
CTD
PMID:25270620
NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893
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PTPN14
protein tyrosine phosphatase non-receptor type 14
increases expression
ISO
diethyl maleate results in increased expression of PTPN14 mRNA
CTD
PMID:25270620
NCBI chr 1:214,348,700...214,551,602
Ensembl chr 1:214,348,700...214,552,449
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PUS1
pseudouridine synthase 1
decreases expression
ISO
diethyl maleate results in decreased expression of PUS1 mRNA
CTD
PMID:25270620
NCBI chr12:131,929,276...131,945,896
Ensembl chr12:131,929,200...131,945,896
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PXN
paxillin
increases expression
EXP
diethyl maleate results in increased expression of PXN mRNA
CTD
PMID:33545341
NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771
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RAB27A
RAB27A, member RAS oncogene family
decreases expression
ISO
diethyl maleate results in decreased expression of RAB27A mRNA
CTD
PMID:21161181
NCBI chr15:55,202,966...55,289,813
Ensembl chr15:55,202,966...55,319,113
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RELA
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:20116392 PMID:35724838
NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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RHO
rhodopsin
increases expression
EXP
diethyl maleate results in increased expression of RHO mRNA
CTD
PMID:33545341
NCBI chr 3:129,528,639...129,535,344
Ensembl chr 3:129,528,639...129,535,344
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RNF114
ring finger protein 114
decreases expression
ISO
diethyl maleate results in decreased expression of RNF114 mRNA
CTD
PMID:25270620
NCBI chr20:49,936,397...49,953,885
Ensembl chr20:49,936,336...49,953,885
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RNF14
ring finger protein 14
increases expression
ISO
diethyl maleate results in increased expression of RNF14 mRNA
CTD
PMID:25270620
NCBI chr 5:141,949,337...141,990,292
Ensembl chr 5:141,958,328...141,990,292
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RRM2
ribonucleotide reductase regulatory subunit M2
increases expression
ISO EXP
diethyl maleate results in increased expression of RRM2 mRNA
CTD
PMID:21161181 PMID:33545341
NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725
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RSAD2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of RSAD2 mRNA
CTD
PMID:21161181
NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239
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S100A9
S100 calcium binding protein A9
decreases expression
ISO
diethyl maleate results in decreased expression of S100A9 mRNA
CTD
PMID:21161181
NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
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SASH3
SAM and SH3 domain containing 3
decreases expression
ISO
diethyl maleate results in decreased expression of SASH3 mRNA
CTD
PMID:21161181
NCBI chr X:129,779,949...129,795,201
Ensembl chr X:129,779,949...129,795,201
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SCARB1
scavenger receptor class B member 1
decreases expression
EXP
diethyl maleate results in decreased expression of SCARB1 mRNA
CTD
PMID:34480604
NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
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SCD
stearoyl-CoA desaturase
decreases expression
ISO
diethyl maleate results in decreased expression of SCD1 mRNA
CTD
PMID:21161181
NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
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SDS
serine dehydratase
decreases expression
ISO
diethyl maleate results in decreased expression of SDS mRNA
CTD
PMID:21161181
NCBI chr12:113,392,445...113,403,887
Ensembl chr12:113,392,445...113,426,301
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SELENOP
selenoprotein P
decreases expression
EXP
diethyl maleate results in decreased expression of SELENOP mRNA
CTD
PMID:30261343
NCBI chr 5:42,799,880...42,811,892
Ensembl chr 5:42,799,880...42,887,392
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SERPIND1
serpin family D member 1
decreases expression
ISO
diethyl maleate results in decreased expression of SERPIND1 mRNA
CTD
PMID:25270620
NCBI chr22:20,774,113...20,787,720
Ensembl chr22:20,774,113...20,787,720
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SERTAD1
SERTA domain containing 1
increases expression
EXP
diethyl maleate results in increased expression of SERTAD1 mRNA
CTD
PMID:33545341
NCBI chr19:40,421,589...40,425,992
Ensembl chr19:40,421,589...40,425,992
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SEZ6
seizure related 6 homolog
decreases expression
ISO
diethyl maleate results in decreased expression of SEZ6 mRNA
CTD
PMID:21161181
NCBI chr17:28,954,905...29,006,440
Ensembl chr17:28,954,901...29,006,440
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SFXN1
sideroflexin 1
decreases expression
ISO
diethyl maleate results in decreased expression of SFXN1 mRNA
CTD
PMID:25270620
NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742
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SH3BP5
SH3 domain binding protein 5
increases expression affects expression
EXP
diethyl maleate results in increased expression of SH3BP5 mRNA diethyl maleate affects the expression of SH3BP5 mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 3:15,254,353...15,341,380
Ensembl chr 3:15,254,353...15,341,368
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SIX4
SIX homeobox 4
increases expression
ISO
diethyl maleate results in increased expression of SIX4 mRNA
CTD
PMID:25270620
NCBI chr14:60,709,539...60,724,351
Ensembl chr14:60,709,539...60,724,351
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SLC16A6
solute carrier family 16 member 6
decreases expression
ISO
diethyl maleate results in decreased expression of SLC16A6 mRNA
CTD
PMID:25270620
NCBI chr17:68,267,026...68,291,479
Ensembl chr17:68,267,026...68,291,267
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SLC1A4
solute carrier family 1 member 4
increases expression
ISO
diethyl maleate results in increased expression of SLC1A4 mRNA
CTD
PMID:25270620
NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865
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SLC2A2
solute carrier family 2 member 2
decreases expression
ISO
diethyl maleate results in decreased expression of SLC2A2 mRNA
CTD
PMID:21161181
NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743
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SLC2A5
solute carrier family 2 member 5
decreases expression
ISO
diethyl maleate results in decreased expression of SLC2A5 mRNA
CTD
PMID:21161181
NCBI chr 1:9,035,106...9,094,195
Ensembl chr 1:9,035,106...9,088,478
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SLC39A14
solute carrier family 39 member 14
decreases expression
ISO
diethyl maleate results in decreased expression of SLC39A14 mRNA
CTD
PMID:25270620
NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,278...22,434,129
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SLC3A2
solute carrier family 3 member 2
increases expression
EXP
diethyl maleate results in increased expression of SLC3A2 mRNA
CTD
PMID:33545341
NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880
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SLC40A1
solute carrier family 40 member 1
multiple interactions
EXP
diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]
CTD
PMID:21303654
NCBI chr 2:189,560,590...189,580,786
Ensembl chr 2:189,560,590...189,583,758
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SLC44A4
solute carrier family 44 member 4
decreases expression
ISO
diethyl maleate results in decreased expression of SLC44A4 mRNA
CTD
PMID:21161181
NCBI chr 6:31,863,192...31,878,997
Ensembl chr 6:31,863,192...31,879,046
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SLC7A11
solute carrier family 7 member 11
multiple interactions increases expression
ISO EXP
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]
CTD
PMID:12235164 PMID:33545341
NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
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SLCO2A1
solute carrier organic anion transporter family member 2A1
decreases expression
ISO
diethyl maleate results in decreased expression of SLCO2A1 mRNA
CTD
PMID:21161181
NCBI chr 3:133,932,701...134,029,925
Ensembl chr 3:133,932,701...134,052,184
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SMC4
structural maintenance of chromosomes 4
increases expression
ISO
diethyl maleate results in increased expression of SMC4 mRNA
CTD
PMID:21161181
NCBI chr 3:160,399,650...160,434,953
Ensembl chr 3:160,399,274...160,434,954
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SMPD1
sphingomyelin phosphodiesterase 1
increases expression multiple interactions increases activity
EXP
diethyl maleate results in increased expression of SMPD1 mRNA Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA] diethyl maleate results in increased activity of SMPD1 protein
CTD
PMID:25762726
NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,440...6,394,998
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SMTN
smoothelin
increases expression
ISO
diethyl maleate results in increased expression of SMTN mRNA
CTD
PMID:21161181
NCBI chr22:31,064,118...31,104,624
Ensembl chr22:31,064,105...31,104,757
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SOCS3
suppressor of cytokine signaling 3
decreases expression
ISO
diethyl maleate results in decreased expression of SOCS3 mRNA
CTD
PMID:25270620
NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
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SOD2
superoxide dismutase 2
multiple interactions
EXP
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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SORL1
sortilin related receptor 1
decreases expression
ISO
diethyl maleate results in decreased expression of SORL1 mRNA
CTD
PMID:21161181
NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763
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SOX9
SRY-box transcription factor 9
increases expression
ISO
diethyl maleate results in increased expression of SOX9 mRNA
CTD
PMID:21161181
NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
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SP5
Sp5 transcription factor
decreases expression
ISO
diethyl maleate results in decreased expression of SP5 mRNA
CTD
PMID:25270620
NCBI chr 2:170,715,337...170,718,078
Ensembl chr 2:170,715,337...170,718,078
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SPC25
SPC25 component of NDC80 kinetochore complex
increases expression
ISO
diethyl maleate results in increased expression of SPC25 mRNA
CTD
PMID:21161181
NCBI chr 2:168,861,521...168,890,430
Ensembl chr 2:168,834,132...168,913,371
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SPTA1
spectrin alpha, erythrocytic 1
increases expression
ISO
diethyl maleate results in increased expression of SPTA1 mRNA
CTD
PMID:25270620
NCBI chr 1:158,610,704...158,686,715
Ensembl chr 1:158,610,704...158,686,715
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SPTAN1
spectrin alpha, non-erythrocytic 1
increases cleavage
EXP
diethyl maleate results in increased cleavage of SPTAN1 protein
CTD
PMID:21105742
NCBI chr 9:128,552,587...128,633,662
Ensembl chr 9:128,552,558...128,633,662
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SPTBN4
spectrin beta, non-erythrocytic 4
increases expression
ISO
diethyl maleate results in increased expression of SPTBN4 mRNA
CTD
PMID:25270620
NCBI chr19:40,467,001...40,576,464
Ensembl chr19:40,466,241...40,576,464
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SPTLC1
serine palmitoyltransferase long chain base subunit 1
increases expression
EXP
diethyl maleate results in increased expression of SPTLC1 mRNA
CTD
PMID:33545341
NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,413
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SQSTM1
sequestosome 1
increases expression
ISO EXP
diethyl maleate results in increased expression of SQSTM1 mRNA
CTD
PMID:25270620 PMID:33545341 PMID:34480604
NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
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SREBF1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
diethyl maleate results in decreased expression of SREBF1 mRNA
CTD
PMID:21161181
NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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SRXN1
sulfiredoxin 1
multiple interactions decreases expression increases expression
ISO EXP
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] diethyl maleate results in decreased expression of SRXN1 mRNA diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 PMID:34480604 PMID:34626751 PMID:35724838 More...
NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200
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STAT1
signal transducer and activator of transcription 1
decreases expression
ISO
diethyl maleate results in decreased expression of STAT1 mRNA
CTD
PMID:21161181
NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
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STEAP4
STEAP4 metalloreductase
decreases expression
ISO
diethyl maleate results in decreased expression of STEAP4 mRNA
CTD
PMID:25270620
NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894
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SULF2
sulfatase 2
decreases expression
ISO
diethyl maleate results in decreased expression of SULF2 mRNA
CTD
PMID:21161181
NCBI chr20:47,657,406...47,786,627
Ensembl chr20:47,656,197...47,786,616
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SULT1A1
sulfotransferase family 1A member 1
decreases expression
ISO
diethyl maleate results in decreased expression of SULT1A1 protein
CTD
PMID:21161181
NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044
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TAGLN
transgelin
decreases expression
ISO
diethyl maleate results in decreased expression of TAGLN mRNA
CTD
PMID:21161181
NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
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TATDN2
TatD DNase domain containing 2
increases expression
EXP
diethyl maleate results in increased expression of TATDN2 mRNA
CTD
PMID:33545341
NCBI chr 3:10,248,459...10,281,218
Ensembl chr 3:10,248,023...10,281,218
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TBCEL
tubulin folding cofactor E like
increases expression
ISO
diethyl maleate results in increased expression of TBCEL mRNA
CTD
PMID:25270620
NCBI chr11:121,024,102...121,090,776
Ensembl chr11:121,024,072...121,090,776
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TENT4A
terminal nucleotidyltransferase 4A
increases expression
EXP
diethyl maleate results in increased expression of TENT4A mRNA
CTD
PMID:33545341
NCBI chr 5:6,713,432...6,757,044
Ensembl chr 5:6,713,432...6,757,044
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TENT5A
terminal nucleotidyltransferase 5A
decreases expression
ISO
diethyl maleate results in decreased expression of TENT5A mRNA
CTD
PMID:21161181
NCBI chr 6:81,745,730...81,752,681
Ensembl chr 6:81,491,439...81,752,774
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TESMIN
testis expressed metallothionein like protein
affects localization
ISO
diethyl maleate affects the localization of TESMIN protein
CTD
PMID:12606435
NCBI chr11:68,704,796...68,751,520
Ensembl chr11:68,707,440...68,751,520
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TF
transferrin
decreases expression
ISO
diethyl maleate results in decreased expression of TF protein
CTD
PMID:21161181
NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
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TFEB
transcription factor EB
decreases expression
ISO
diethyl maleate results in decreased expression of TFEB mRNA
CTD
PMID:25270620
NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259
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TGM2
transglutaminase 2
increases expression
ISO
diethyl maleate results in increased expression of TGM2 mRNA
CTD
PMID:21161181
NCBI chr20:38,127,385...38,168,475
Ensembl chr20:38,127,385...38,166,578
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THBS1
thrombospondin 1
increases expression
ISO
diethyl maleate results in increased expression of THBS1 mRNA
CTD
PMID:21161181
NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466
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THRSP
thyroid hormone responsive
decreases expression
ISO
diethyl maleate results in decreased expression of THRSP mRNA
CTD
PMID:21161181
NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
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TM4SF1
transmembrane 4 L six family member 1
increases expression
ISO
diethyl maleate results in increased expression of TM4SF1 mRNA
CTD
PMID:21161181
NCBI chr 3:149,369,022...149,377,649
Ensembl chr 3:149,369,022...149,377,692
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TMEM209
transmembrane protein 209
increases expression
ISO
diethyl maleate results in increased expression of TMEM209 mRNA
CTD
PMID:25270620
NCBI chr 7:130,164,713...130,205,406
Ensembl chr 7:130,164,713...130,207,770
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TNF
tumor necrosis factor
multiple interactions
EXP ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate] diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]
CTD
PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 PMID:35724838 More...
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFAIP3
TNF alpha induced protein 3
multiple interactions
EXP
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
CTD
PMID:35724838
NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314
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TNFRSF14
TNF receptor superfamily member 14
decreases expression
ISO
diethyl maleate results in decreased expression of TNFRSF14 mRNA
CTD
PMID:21161181
NCBI chr 1:2,554,234...2,563,829
Ensembl chr 1:2,555,639...2,565,382
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TP53
tumor protein p53
multiple interactions
ISO EXP
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA] TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:22003191 PMID:27982581
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
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TPM2
tropomyosin 2
decreases expression
ISO
diethyl maleate results in decreased expression of TPM2 mRNA
CTD
PMID:21161181
NCBI chr 9:35,681,993...35,690,056
Ensembl chr 9:35,681,992...35,690,056
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TRAP1
TNF receptor associated protein 1
multiple interactions decreases response to substance
EXP
diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein] TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD
PMID:17853063
NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553
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TRDMT1
tRNA aspartic acid methyltransferase 1
decreases expression
ISO
diethyl maleate results in decreased expression of TRDMT1 mRNA
CTD
PMID:25270620
NCBI chr10:17,137,336...17,201,672
Ensembl chr10:17,137,336...17,202,054
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TRIB1
tribbles pseudokinase 1
increases expression
EXP
diethyl maleate results in increased expression of TRIB1 mRNA
CTD
PMID:33545341
NCBI chr 8:125,430,358...125,438,403
Ensembl chr 8:125,430,358...125,438,403
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TRIB3
tribbles pseudokinase 3
increases expression
EXP
diethyl maleate results in increased expression of TRIB3 mRNA
CTD
PMID:33545341
NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
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TRIM6
tripartite motif containing 6
decreases expression
ISO
diethyl maleate results in decreased expression of TRIM6 mRNA
CTD
PMID:21161181
NCBI chr11:5,596,111...5,612,952
Ensembl chr11:5,596,109...5,612,958
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TRIP13
thyroid hormone receptor interactor 13
increases expression
ISO
diethyl maleate results in increased expression of TRIP13 mRNA
CTD
PMID:21161181
NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357
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TSC22D1
TSC22 domain family member 1
decreases expression
ISO
diethyl maleate results in decreased expression of TSC22D1 mRNA
CTD
PMID:21161181
NCBI chr13:44,432,143...44,577,344
Ensembl chr13:44,432,143...44,577,147
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TSPAN8
tetraspanin 8
decreases expression
ISO
diethyl maleate results in decreased expression of TSPAN8 mRNA
CTD
PMID:21161181
NCBI chr12:71,125,096...71,157,999
Ensembl chr12:71,125,085...71,441,898
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TSTD1
thiosulfate sulfurtransferase like domain containing 1
decreases expression
ISO
diethyl maleate results in decreased expression of TSTD1 mRNA
CTD
PMID:25270620
NCBI chr 1:161,037,631...161,038,964
Ensembl chr 1:161,037,631...161,038,977
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TXN
thioredoxin
decreases activity
EXP
diethyl maleate results in decreased activity of TXN protein
CTD
PMID:15388247
NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
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TXNIP
thioredoxin interacting protein
increases expression
ISO
diethyl maleate results in increased expression of TXNIP mRNA
CTD
PMID:21161181
NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579
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TXNRD1
thioredoxin reductase 1
increases expression
EXP
diethyl maleate results in increased expression of TXNRD1 mRNA
CTD
PMID:15521073 PMID:33545341 PMID:34480604
NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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UBD
ubiquitin D
decreases expression
ISO
diethyl maleate results in decreased expression of UBD mRNA
CTD
PMID:21161181
NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
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UHRF1
ubiquitin like with PHD and ring finger domains 1
increases expression
ISO
diethyl maleate results in increased expression of UHRF1 mRNA
CTD
PMID:21161181
NCBI chr19:4,903,080...4,962,154
Ensembl chr19:4,903,080...4,962,154
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USP18
ubiquitin specific peptidase 18
decreases expression
ISO
diethyl maleate results in decreased expression of USP18 mRNA
CTD
PMID:21161181
NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,150,118...18,177,397
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USP2
ubiquitin specific peptidase 2
decreases expression
ISO
diethyl maleate results in decreased expression of USP2 mRNA
CTD
PMID:21161181
NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711
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VEGFA
vascular endothelial growth factor A
increases expression
EXP
diethyl maleate results in increased expression of VEGFA mRNA
CTD
PMID:33545341
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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WDR31
WD repeat domain 31
decreases expression
ISO
diethyl maleate results in decreased expression of WDR31 mRNA
CTD
PMID:25270620
NCBI chr 9:113,313,222...113,340,275
Ensembl chr 9:113,313,222...113,340,298
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WDR6
WD repeat domain 6
decreases expression
ISO
diethyl maleate results in decreased expression of WDR6 mRNA
CTD
PMID:21161181
NCBI chr 3:49,007,391...49,015,951
Ensembl chr 3:49,007,062...49,015,953
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YPEL5
yippee like 5
increases expression
ISO
diethyl maleate results in increased expression of YPEL5 mRNA
CTD
PMID:25270620
NCBI chr 2:30,147,007...30,160,533
Ensembl chr 2:30,146,941...30,160,533
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ZFAND2A
zinc finger AN1-type containing 2A
increases expression
EXP
diethyl maleate results in increased expression of ZFAND2A mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 7:1,148,850...1,160,196
Ensembl chr 7:1,152,071...1,160,759
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ZFP36
ZFP36 ring finger protein
increases expression
EXP
diethyl maleate results in increased expression of ZFP36 protein
CTD
PMID:21969073
NCBI chr19:39,406,847...39,409,407
Ensembl chr19:39,406,847...39,409,412
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ZFP37
ZFP37 zinc finger protein
decreases expression
ISO
diethyl maleate results in decreased expression of ZFP37 mRNA
CTD
PMID:21161181
NCBI chr 9:113,038,377...113,056,724
Ensembl chr 9:113,038,377...113,056,759
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ZNF367
zinc finger protein 367
increases expression
ISO
diethyl maleate results in increased expression of ZNF367 mRNA
CTD
PMID:21161181
NCBI chr 9:96,385,941...96,418,370
Ensembl chr 9:96,385,941...96,418,370
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ZNRD2
zinc ribbon domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of ZNRD2 mRNA
CTD
PMID:25270620
NCBI chr11:65,570,477...65,571,888
Ensembl chr11:65,570,460...65,573,942
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