CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: diethyl maleate
Accession: CHEBI:68508
browse the term
Definition: A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis.
Synonyms: exact_synonym: diethyl (2Z)-but-2-enedioate
related_synonym: 2-butenedioic acid (2Z)-, dimethyl ester; Formula=C8H12O4; InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5-; InChIKey=IEPRKVQEAMIZSS-WAYWQWQTSA-N; SMILES=CCOC(=O)\\C=C/C(=O)OCC; maleic acid, diethyl ester
xref: CAS:141-05-9
xref_mesh: MESH:C014476
xref: PMID:1471155; PMID:1609410; PMID:3341033; Reaxys:907616
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Abcc2
ATP-binding cassette, sub-family member 2
increases expression
EXP
diethyl maleate results in increased expression of ABCC2 mRNA
CTD
PMID:25270620
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abhd4
abhydrolase domain containing 4
increases expression
EXP
diethyl maleate results in increased expression of ABHD4 mRNA
CTD
PMID:25270620
NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094
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Acaca
acetyl-Coenzyme A carboxylase alpha
decreases expression
EXP
diethyl maleate results in decreased expression of ACACA mRNA
CTD
PMID:25270620
NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
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Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
multiple interactions
ISO
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]
CTD
PMID:17134953
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
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Acy3
aminoacylase 3
decreases expression
ISO
diethyl maleate results in decreased expression of ACY3 mRNA
CTD
PMID:21161181
NCBI chr19:4,036,570...4,040,007
Ensembl chr19:4,036,570...4,040,007
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Adm
adrenomedullin
increases expression
ISO
diethyl maleate results in increased expression of ADM mRNA
CTD
PMID:33545341
NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
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Adora3
adenosine A3 receptor
decreases expression
ISO
diethyl maleate results in decreased expression of ADORA3 mRNA
CTD
PMID:21161181
NCBI chr 3:105,811,737...105,816,244
Ensembl chr 3:105,778,174...105,816,242
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Aen
apoptosis enhancing nuclease
increases expression
ISO
diethyl maleate results in increased expression of AEN mRNA
CTD
PMID:33545341
NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
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Afp
alpha fetoprotein
increases expression
EXP
diethyl maleate results in increased expression of AFP mRNA
CTD
PMID:25270620
NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
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Ahcyl1
S-adenosylhomocysteine hydrolase-like 1
increases expression
EXP
diethyl maleate results in increased expression of AHCYL1 mRNA
CTD
PMID:25270620
NCBI chr 3:107,570,436...107,603,876
Ensembl chr 3:107,570,434...107,603,876
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Akr1a1
aldo-keto reductase family 1, member A1
increases expression
ISO
diethyl maleate results in increased expression of AKR1A1 protein
CTD
PMID:21161181
NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
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Akr1b10
aldo-keto reductase family 1, member B10
increases expression
ISO
diethyl maleate results in increased expression of AKR1B10 mRNA
CTD
PMID:33545341
NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
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Akr1c19
aldo-keto reductase family 1, member C19
increases expression
EXP
diethyl maleate results in increased expression of AKR1C19 mRNA
CTD
PMID:25270620
NCBI chr13:4,283,499...4,298,360
Ensembl chr13:4,278,699...4,302,842
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Akr1c21
aldo-keto reductase family 1, member C21
increases expression
ISO
diethyl maleate results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540
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Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
affects reduction
EXP
diethyl maleate affects the reduction of ALDH1A1 protein
CTD
PMID:19843705
NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Aldh1b1
aldehyde dehydrogenase 1 family, member B1
decreases expression
ISO
diethyl maleate results in decreased expression of ALDH1B1 mRNA
CTD
PMID:21161181
NCBI chr 4:45,799,022...45,804,608
Ensembl chr 4:45,799,022...45,804,604
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Aldh2
aldehyde dehydrogenase 2, mitochondrial
decreases reduction decreases expression increases expression
EXP ISO
diethyl maleate results in decreased reduction of ALDH2 protein diethyl maleate results in decreased expression of ALDH2 protein diethyl maleate results in increased expression of ALDH2 protein
CTD
PMID:19843705 PMID:21161181
NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
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Aldob
aldolase B, fructose-bisphosphate
decreases expression
ISO
diethyl maleate results in decreased expression of ALDOB protein
CTD
PMID:21161181
NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
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Amigo2
adhesion molecule with Ig like domain 2
decreases expression
ISO
diethyl maleate results in decreased expression of AMIGO2 mRNA
CTD
PMID:21161181
NCBI chr15:97,141,955...97,145,168
Ensembl chr15:97,142,006...97,145,168
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Angptl2
angiopoietin-like 2
decreases expression
ISO
diethyl maleate results in decreased expression of ANGPTL2 mRNA
CTD
PMID:21161181
NCBI chr 2:33,105,963...33,137,737
Ensembl chr 2:33,106,081...33,137,729
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Angptl4
angiopoietin-like 4
increases expression
ISO
diethyl maleate results in increased expression of ANGPTL4 mRNA
CTD
PMID:33545341
NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
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Ankrd46
ankyrin repeat domain 46
decreases expression
ISO
diethyl maleate results in decreased expression of ANKRD46 mRNA
CTD
PMID:21161181
NCBI chr15:36,477,814...36,496,937
Ensembl chr15:36,477,814...36,496,966
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Anln
anillin, actin binding protein
increases expression
ISO
diethyl maleate results in increased expression of ANLN mRNA
CTD
PMID:21161181
NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484
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Anxa1
annexin A1
affects expression
ISO
diethyl maleate affects the expression of ANXA1 mRNA
CTD
PMID:34480604
NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308
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Anxa3
annexin A3
decreases expression
ISO
diethyl maleate results in decreased expression of ANXA3 mRNA
CTD
PMID:21161181
NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
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Ap3m2
adaptor-related protein complex 3, mu 2 subunit
decreases expression
ISO
diethyl maleate results in decreased expression of AP3M2 mRNA
CTD
PMID:21161181
NCBI chr 8:23,277,370...23,297,308
Ensembl chr 8:23,277,370...23,295,638
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Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
diethyl maleate results in increased expression of APAF1 mRNA
CTD
PMID:11875189
NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
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Aplp1
amyloid beta precursor like protein 1
decreases expression
EXP
diethyl maleate results in decreased expression of APLP1 mRNA
CTD
PMID:25270620
NCBI chr 7:30,134,405...30,144,960
Ensembl chr 7:30,134,407...30,144,960
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Apol9a
apolipoprotein L 9a
decreases expression
ISO
diethyl maleate results in decreased expression of APOL9A mRNA
CTD
PMID:21161181
NCBI chr15:77,287,989...77,295,280
Ensembl chr15:77,287,989...77,295,335
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Arhgap9
Rho GTPase activating protein 9
increases expression
ISO
diethyl maleate results in increased expression of ARHGAP9 mRNA
CTD
PMID:33545341
NCBI chr10:127,157,829...127,165,816
Ensembl chr10:127,157,833...127,165,812
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Arrdc2
arrestin domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of ARRDC2 mRNA
CTD
PMID:21161181
NCBI chr 8:71,287,773...71,293,173
Ensembl chr 8:71,287,773...71,292,364
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Arrdc4
arrestin domain containing 4
decreases expression
EXP
diethyl maleate results in decreased expression of ARRDC4 mRNA
CTD
PMID:25270620
NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989
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Asf1b
anti-silencing function 1B histone chaperone
increases expression
ISO
diethyl maleate results in increased expression of ASF1B mRNA
CTD
PMID:21161181
NCBI chr 8:84,682,323...84,696,824
Ensembl chr 8:84,682,136...84,696,826
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Asxl1
ASXL transcriptional regulator 1
decreases expression
EXP
diethyl maleate results in decreased expression of ASXL1 mRNA
CTD
PMID:25270620
NCBI chr 2:153,187,750...153,245,927
Ensembl chr 2:153,187,749...153,245,927
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Atm
ataxia telangiectasia mutated
increases expression
ISO
diethyl maleate results in increased expression of ATM mRNA
CTD
PMID:11875189
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
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Atp5f1b
ATP synthase F1 subunit beta
increases expression
ISO
diethyl maleate results in increased expression of ATP5F1B protein
CTD
PMID:21161181
NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
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Aurka
aurora kinase A
increases expression decreases expression
ISO EXP
diethyl maleate results in increased expression of AURKA mRNA diethyl maleate results in decreased expression of AURKA mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 2:172,198,116...172,212,825
Ensembl chr 2:172,198,110...172,212,455
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Bbc3
BCL2 binding component 3
increases expression
ISO
diethyl maleate results in increased expression of BBC3 mRNA
CTD
PMID:33545341
NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
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Bcl2
B cell leukemia/lymphoma 2
multiple interactions increases expression
EXP ISO
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA diethyl maleate results in increased expression of BCL2 mRNA
CTD
PMID:22564015 PMID:33545341
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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Bcl2a1b
B cell leukemia/lymphoma 2 related protein A1b
decreases expression
ISO
diethyl maleate results in decreased expression of BCL2A1 mRNA
CTD
PMID:21161181
NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
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Bcl3
B cell leukemia/lymphoma 3
decreases expression
EXP
diethyl maleate results in decreased expression of BCL3 mRNA
CTD
PMID:25270620
NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695
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Bcl6b
B cell CLL/lymphoma 6, member B
decreases expression
ISO
diethyl maleate results in decreased expression of BCL6B mRNA
CTD
PMID:21161181
NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624
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Bhlhe41
basic helix-loop-helix family, member e41
decreases expression
ISO
diethyl maleate results in decreased expression of BHLHE41 mRNA
CTD
PMID:21161181
NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284
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Bhmt
betaine-homocysteine methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of BHMT mRNA
CTD
PMID:21161181
NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
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Birc3
baculoviral IAP repeat-containing 3
multiple interactions
EXP
diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
CTD
PMID:12774022
NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187
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Blvrb
biliverdin reductase B
increases expression
EXP
diethyl maleate results in increased expression of BLVRB mRNA
CTD
PMID:25270620 PMID:34626751
NCBI chr 7:27,147,403...27,165,406
Ensembl chr 7:27,147,403...27,165,569
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Bmf
BCL2 modifying factor
decreases expression
ISO
diethyl maleate results in decreased expression of BMF mRNA
CTD
PMID:21161181
NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
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Brip1
BRCA1 interacting protein C-terminal helicase 1
increases expression
ISO
diethyl maleate results in increased expression of BRIP1 mRNA
CTD
PMID:21161181
NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019
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Btbd2
BTB domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of BTBD2 mRNA
CTD
PMID:21161181
NCBI chr10:80,478,457...80,492,328
Ensembl chr10:80,478,451...80,492,328
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Btg2
BTG anti-proliferation factor 2
increases expression multiple interactions decreases expression
EXP
diethyl maleate results in increased expression of BTG2 mRNA NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA] diethyl maleate results in decreased expression of BTG2 mRNA
CTD
PMID:22003191 PMID:25270620 PMID:34626751
NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858
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C6
complement component 6
decreases expression
ISO
diethyl maleate results in decreased expression of C6 mRNA
CTD
PMID:21161181
NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449
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Casp2
caspase 2
increases expression
ISO
diethyl maleate results in increased expression of CASP2 mRNA
CTD
PMID:11875189
NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
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Casp3
caspase 3
increases expression increases cleavage
ISO
diethyl maleate results in increased expression of CASP3 mRNA diethyl maleate results in increased cleavage of CASP3 protein
CTD
PMID:11875189 PMID:21105742
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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Casp9
caspase 9
increases expression
ISO
diethyl maleate results in increased expression of CASP9 mRNA
CTD
PMID:11875189
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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Cat
catalase
decreases expression
ISO
diethyl maleate results in decreased expression of CAT protein
CTD
PMID:21161181
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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Cbr1
carbonyl reductase 1
increases expression
EXP
diethyl maleate results in increased expression of CBR1 mRNA
CTD
PMID:25270620
NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393
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Cbr3
carbonyl reductase 3
increases expression multiple interactions
ISO EXP
diethyl maleate results in increased expression of CBR3 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diethyl maleate results in increased expression of CBR3 mRNA]
CTD
PMID:20806931 PMID:25270620
NCBI chr16:93,480,107...93,487,879
Ensembl chr16:93,480,103...93,487,878
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Cbx4
chromobox 4
increases expression
ISO
diethyl maleate results in increased expression of CBX4 mRNA
CTD
PMID:33545341
NCBI chr11:118,968,399...118,977,067
Ensembl chr11:118,968,399...118,977,047
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Ccdc50
coiled-coil domain containing 50
decreases expression
EXP
diethyl maleate results in decreased expression of CCDC50 mRNA
CTD
PMID:25270620
NCBI chr16:27,205,815...27,270,968
Ensembl chr16:27,207,619...27,270,968
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Ccna1
cyclin A1
decreases expression
ISO
diethyl maleate results in decreased expression of CCNA1 mRNA
CTD
PMID:11875189
NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
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Ccna2
cyclin A2
increases expression
ISO
diethyl maleate results in increased expression of CCNA2 mRNA
CTD
PMID:21161181
NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
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Ccnd1
cyclin D1
decreases expression increases expression
ISO EXP
diethyl maleate results in decreased expression of CCND1 mRNA diethyl maleate results in increased expression of CCND1 mRNA
CTD
PMID:11875189 PMID:21161181 PMID:25270620
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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Ccne2
cyclin E2
increases expression
ISO
diethyl maleate results in increased expression of CCNE2 mRNA
CTD
PMID:21161181
NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
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Ccnk
cyclin K
decreases expression
ISO
diethyl maleate results in decreased expression of CCNK mRNA
CTD
PMID:11875189
NCBI chr12:108,145,543...108,170,252
Ensembl chr12:108,145,838...108,169,618
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Cd80
CD80 antigen
multiple interactions increases expression
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein diethyl maleate results in increased expression of CD80 protein
CTD
PMID:31958493
NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697
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Cd86
CD86 antigen
multiple interactions increases expression
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]
CTD
PMID:24136171 PMID:31958493
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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Cdc25a
cell division cycle 25A
increases expression
ISO
diethyl maleate results in increased expression of CDC25A mRNA
CTD
PMID:21161181
NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963
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Cdca2
cell division cycle associated 2
increases expression
ISO
diethyl maleate results in increased expression of CDCA2 mRNA
CTD
PMID:21161181
NCBI chr14:67,910,629...67,953,290
Ensembl chr14:67,913,780...67,953,290
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Cdca3
cell division cycle associated 3
increases expression
ISO
diethyl maleate results in increased expression of CDCA3 mRNA
CTD
PMID:21161181
NCBI chr 6:124,806,533...124,810,664
Ensembl chr 6:124,806,510...124,810,664
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Cdca8
cell division cycle associated 8
increases expression
ISO
diethyl maleate results in increased expression of CDCA8 mRNA
CTD
PMID:21161181
NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104
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Cdh11
cadherin 11
decreases expression
ISO
diethyl maleate results in decreased expression of CDH11 mRNA
CTD
PMID:21161181
NCBI chr 8:103,358,727...103,512,125
Ensembl chr 8:103,358,727...103,512,274
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Cdkn1a
cyclin dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
diethyl maleate results in increased expression of CDKN1A mRNA; diethyl maleate results in increased expression of CDKN1A protein TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]
CTD
PMID:11875189 PMID:27982581
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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Cds2
CDP-diacylglycerol synthase 2
increases expression
EXP
diethyl maleate results in increased expression of CDS2 mRNA
CTD
PMID:25270620
NCBI chr 2:132,105,068...132,153,970
Ensembl chr 2:132,105,068...132,153,970
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Ces1d
carboxylesterase 1D
increases reduction decreases expression
EXP ISO
diethyl maleate results in increased reduction of CES1D protein diethyl maleate results in decreased expression of CES1D protein
CTD
PMID:19843705 PMID:21161181
NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
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Ces2a
carboxylesterase 2A
increases reduction
EXP
diethyl maleate results in increased reduction of CES2A protein
CTD
PMID:19843705
NCBI chr 8:105,460,635...105,468,266
Ensembl chr 8:105,460,635...105,468,266
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Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
ISO
diethyl maleate results in decreased expression of CFLAR mRNA
CTD
PMID:21161181
NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
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Chrna4
cholinergic receptor, nicotinic, alpha polypeptide 4
increases expression
ISO
diethyl maleate results in increased expression of CHRNA4 mRNA
CTD
PMID:33545341
NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339
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Cidec
cell death-inducing DFFA-like effector c
decreases expression
ISO
diethyl maleate results in decreased expression of CIDEC mRNA
CTD
PMID:21161181
NCBI chr 6:113,401,595...113,412,721
Ensembl chr 6:113,401,595...113,412,721
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
ISO
diethyl maleate results in decreased expression of CITED2 mRNA
CTD
PMID:21161181
NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422
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Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
decreases expression
ISO
diethyl maleate results in decreased expression of CITED4 mRNA
CTD
PMID:21161181
NCBI chr 4:120,523,760...120,525,017
Ensembl chr 4:120,523,769...120,525,017
G
Ckb
creatine kinase, brain
decreases reduction
EXP
diethyl maleate results in decreased reduction of CKB protein
CTD
PMID:19843705
NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
G
Cks2
CDC28 protein kinase regulatory subunit 2
increases expression
ISO
diethyl maleate results in increased expression of CKS2 mRNA
CTD
PMID:33545341
NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
G
Clk1
CDC-like kinase 1
increases expression
ISO
diethyl maleate results in increased expression of CLK1 mRNA
CTD
PMID:33545341
NCBI chr 1:58,451,147...58,463,247
Ensembl chr 1:58,449,348...58,463,225
G
Cmpk2
cytidine/uridine monophosphate kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of CMPK2 mRNA
CTD
PMID:21161181
NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836
G
Cntn1
contactin 1
increases expression
ISO
diethyl maleate results in increased expression of CNTN1 mRNA
CTD
PMID:33545341
NCBI chr15:91,949,034...92,239,834
Ensembl chr15:91,949,046...92,239,848
G
Col1a1
collagen, type I, alpha 1
decreases expression
ISO
diethyl maleate results in decreased expression of COL1A1 mRNA
CTD
PMID:21161181
NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
G
Col3a1
collagen, type III, alpha 1
decreases expression
EXP
diethyl maleate results in decreased expression of COL3A1 mRNA
CTD
PMID:25270620
NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866
G
Commd3
COMM domain containing 3
increases expression
EXP
diethyl maleate results in increased expression of COMMD3 mRNA
CTD
PMID:25270620
NCBI chr 2:18,677,246...18,681,042
Ensembl chr 2:18,677,234...18,681,042
G
Comt
catechol-O-methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of COMT mRNA
CTD
PMID:21161181
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
G
Cp
ceruloplasmin
decreases expression
EXP
diethyl maleate results in decreased expression of CP mRNA
CTD
PMID:25270620
NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309
G
Cpsf4l
cleavage and polyadenylation specific factor 4-like
increases expression
ISO
diethyl maleate results in increased expression of CPSF4L mRNA
CTD
PMID:33545341
NCBI chr11:113,588,997...113,601,125
Ensembl chr11:113,588,998...113,600,843
G
Crym
crystallin, mu
decreases expression
ISO
diethyl maleate results in decreased expression of CRYM mRNA
CTD
PMID:21161181
NCBI chr 7:119,785,603...119,801,212
Ensembl chr 7:119,785,603...119,801,334
G
Csrp1
cysteine and glycine-rich protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of CSRP1 mRNA
CTD
PMID:21161181
NCBI chr 1:135,614,650...135,679,970
Ensembl chr 1:135,647,799...135,679,970
G
Csrp3
cysteine and glycine-rich protein 3
decreases reduction
EXP
diethyl maleate results in decreased reduction of CSRP3 protein
CTD
PMID:19843705
NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
G
Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL10 mRNA
CTD
PMID:21161181
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
G
Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL12 mRNA
CTD
PMID:21161181
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
G
Cxcl15
C-X-C motif chemokine ligand 15
increases expression increases stability increases secretion multiple interactions
ISO
diethyl maleate results in increased expression of CXCL8 mRNA; diethyl maleate results in increased expression of CXCL8 protein diethyl maleate results in increased stability of CXCL8 mRNA diethyl maleate results in increased secretion of CXCL8 protein bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CXCL8 protein]
CTD
PMID:20491607 PMID:20541004 PMID:21920952 PMID:21969073 PMID:24136171 PMID:31958493 More...
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
G
Cxcl9
C-X-C motif chemokine ligand 9
decreases expression
ISO
diethyl maleate results in decreased expression of CXCL9 mRNA
CTD
PMID:21161181
NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
G
Cyb5a
cytochrome b5 type A (microsomal)
increases expression
EXP
diethyl maleate results in increased expression of CYB5A mRNA
CTD
PMID:25270620
NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
G
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
decreases expression
ISO
diethyl maleate results in decreased expression of CYP26B1 mRNA
CTD
PMID:21161181
NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
G
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
decreases expression
EXP
diethyl maleate results in decreased expression of D17H6S56E-5 mRNA
CTD
PMID:25270620
NCBI chr17:35,215,654...35,219,722
Ensembl chr17:35,215,654...35,219,393
G
Dbp
D site albumin promoter binding protein
decreases expression
ISO
diethyl maleate results in decreased expression of DBP mRNA
CTD
PMID:21161181
NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
diethyl maleate results in increased expression of DDIT3 mRNA; diethyl maleate results in increased expression of DDIT3 protein
CTD
PMID:33545341 PMID:35724838
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
G
Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
diethyl maleate results in increased expression of DDIT4 mRNA
CTD
PMID:33545341
NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656
G
Ddit4l
DNA-damage-inducible transcript 4-like
increases expression
EXP
diethyl maleate results in increased expression of DDIT4L mRNA
CTD
PMID:25270620
NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094
G
Ddx60
DExD/H box helicase 60
decreases expression
ISO
diethyl maleate results in decreased expression of DDX60 mRNA
CTD
PMID:21161181
NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278
G
Dhx58
DExH-box helicase 58
decreases expression
ISO
diethyl maleate results in decreased expression of DHX58 mRNA
CTD
PMID:21161181
NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097
G
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
increases expression
ISO
diethyl maleate results in increased expression of DNAJB1 mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
diethyl maleate results in increased expression of DNAJB4 mRNA
CTD
PMID:33545341
NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939
G
Dnmbp
dynamin binding protein
decreases expression
ISO
diethyl maleate results in decreased expression of DNMBP mRNA
CTD
PMID:21161181
NCBI chr19:43,835,259...43,930,930
Ensembl chr19:43,835,260...43,928,630
G
Dpysl2
dihydropyrimidinase-like 2
decreases reduction
EXP
diethyl maleate results in decreased reduction of DPYSL2 protein
CTD
PMID:19843705
NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,106,137
G
Dtx3l
deltex 3-like, E3 ubiquitin ligase
decreases expression
ISO
diethyl maleate results in decreased expression of DTX3L mRNA
CTD
PMID:21161181
NCBI chr16:35,746,885...35,759,397
Ensembl chr16:35,746,881...35,759,521
G
Dus3l
dihydrouridine synthase 3 like
decreases expression
EXP
diethyl maleate results in decreased expression of DUS3L mRNA
CTD
PMID:25270620
NCBI chr17:57,069,224...57,077,093
Ensembl chr17:57,071,757...57,077,093
G
Dusp6
dual specificity phosphatase 6
increases expression
ISO
diethyl maleate results in increased expression of DUSP6 mRNA
CTD
PMID:33545341
NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
G
Eef2k
eukaryotic elongation factor-2 kinase
decreases expression
ISO
diethyl maleate results in decreased expression of EEF2K mRNA
CTD
PMID:21161181
NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673
G
Egln3
egl-9 family hypoxia-inducible factor 3
increases expression
ISO
diethyl maleate results in increased expression of EGLN3 mRNA
CTD
PMID:34480604
NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
G
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of EIF2AK2 mRNA
CTD
PMID:21161181
NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
G
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
increases expression
EXP
diethyl maleate results in increased expression of ENTPD5 mRNA
CTD
PMID:25270620
NCBI chr12:84,420,649...84,455,803
Ensembl chr12:84,420,631...84,455,803
G
Eras
ES cell-expressed Ras
decreases expression
EXP
diethyl maleate results in decreased expression of ERAS mRNA
CTD
PMID:25270620
NCBI chr X:7,790,515...7,794,846
Ensembl chr X:7,790,515...7,794,846
G
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 like
increases expression
ISO
diethyl maleate results in increased expression of ERCC6L mRNA
CTD
PMID:21161181
NCBI chr X:101,186,426...101,200,697
Ensembl chr X:101,185,322...101,200,697
G
Exo1
exonuclease 1
increases expression
ISO
diethyl maleate results in increased expression of EXO1 mRNA
CTD
PMID:21161181
NCBI chr 1:175,708,334...175,738,962
Ensembl chr 1:175,708,147...175,741,055
G
Fabp1
fatty acid binding protein 1, liver
increases expression
ISO
diethyl maleate results in increased expression of FABP1 protein
CTD
PMID:21161181
NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007
G
Fabp7
fatty acid binding protein 7, brain
decreases expression
ISO
diethyl maleate results in decreased expression of FABP7 mRNA
CTD
PMID:21161181
NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546
G
Fah
fumarylacetoacetate hydrolase
affects expression
ISO
diethyl maleate affects the expression of FAH mRNA
CTD
PMID:34480604
NCBI chr 7:84,234,367...84,255,150
Ensembl chr 7:84,234,367...84,255,930
G
Fam83d
family with sequence similarity 83, member D
increases expression
ISO
diethyl maleate results in increased expression of FAM83D mRNA
CTD
PMID:33545341
NCBI chr 2:158,610,011...158,628,557
Ensembl chr 2:158,610,013...158,628,557
G
Fasn
fatty acid synthase
decreases expression
ISO
diethyl maleate results in decreased expression of FASN mRNA
CTD
PMID:21161181
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
G
Fbn1
fibrillin 1
decreases expression
ISO
diethyl maleate results in decreased expression of FBN1 mRNA
CTD
PMID:21161181
NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
G
Fbp1
fructose bisphosphatase 1
decreases expression
ISO
diethyl maleate results in decreased expression of FBP1 protein
CTD
PMID:21161181
NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
G
Fgf17
fibroblast growth factor 17
decreases expression
EXP
diethyl maleate results in decreased expression of FGF17 mRNA
CTD
PMID:25270620
NCBI chr14:70,873,643...70,880,064
Ensembl chr14:70,873,643...70,879,708
G
Fgg
fibrinogen gamma chain
decreases expression
EXP
diethyl maleate results in decreased expression of FGG mRNA
CTD
PMID:25270620
NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356
G
Fgr
FGR proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
diethyl maleate results in decreased expression of FGR mRNA
CTD
PMID:21161181
NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221
G
Fndc3b
fibronectin type III domain containing 3B
decreases expression
EXP
diethyl maleate results in decreased expression of FNDC3B mRNA
CTD
PMID:25270620
NCBI chr 3:27,470,284...27,765,469
Ensembl chr 3:27,470,311...27,765,456
G
Fos
FBJ osteosarcoma oncogene
increases expression
EXP ISO
diethyl maleate results in increased expression of FOS mRNA
CTD
PMID:10915739 PMID:33545341
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Foxo1
forkhead box O1
multiple interactions
ISO
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]
CTD
PMID:30261343
NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
G
Foxo3
forkhead box O3
increases expression
ISO
diethyl maleate results in increased expression of FOXO3 mRNA
CTD
PMID:33545341
NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751
G
Fstl3
follistatin-like 3
increases expression
ISO
diethyl maleate results in increased expression of FSTL3 mRNA
CTD
PMID:33545341
NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464
G
G6pc1
glucose-6-phosphatase catalytic subunit 1
decreases expression
ISO EXP
diethyl maleate results in decreased expression of G6PC1 mRNA
CTD
PMID:25270620 PMID:30261343
NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
increases activity increases expression
ISO
diethyl maleate results in increased activity of G6PD protein diethyl maleate results in increased expression of G6PD mRNA
CTD
PMID:3099627 PMID:30261343 PMID:33545341
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Gab1
growth factor receptor bound protein 2-associated protein 1
decreases expression
EXP
diethyl maleate results in decreased expression of GAB1 mRNA
CTD
PMID:25270620
NCBI chr 8:81,491,060...81,607,151
Ensembl chr 8:81,491,067...81,607,148
G
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
increases expression
ISO
diethyl maleate results in increased expression of GADD45A mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
G
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
increases expression
ISO
diethyl maleate results in increased expression of GADD45G mRNA
CTD
PMID:33545341
NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
increases reduction
EXP
diethyl maleate results in increased reduction of GAPDH protein
CTD
PMID:19843705
NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
G
Gba2
glucosidase beta 2
decreases expression
EXP
diethyl maleate results in decreased expression of GBA2 mRNA
CTD
PMID:25270620
NCBI chr 4:43,566,928...43,578,893
Ensembl chr 4:43,566,928...43,578,873
G
Gbp2
guanylate binding protein 2
decreases expression
ISO
diethyl maleate results in decreased expression of GBP2 mRNA
CTD
PMID:21161181
NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases activity increases expression
EXP ISO
diethyl maleate results in increased activity of GCLC protein diethyl maleate results in increased expression of GCLC mRNA; diethyl maleate results in increased expression of GCLC protein
CTD
PMID:10915739 PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34021431 PMID:34480604 More...
NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
G
Gclm
glutamate-cysteine ligase, modifier subunit
increases expression
ISO EXP
diethyl maleate results in increased expression of GCLM mRNA; diethyl maleate results in increased expression of GCLM protein
CTD
PMID:10978506 PMID:15115889 PMID:21465251 PMID:25270620 PMID:33545341 PMID:34480604 More...
NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
G
Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
diethyl maleate results in increased expression of GCNT3 mRNA
CTD
PMID:33545341
NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370
G
Gdf15
growth differentiation factor 15
increases expression
ISO
diethyl maleate results in increased expression of GDF15 mRNA
CTD
PMID:33545341
NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
G
Gdf9
growth differentiation factor 9
increases expression
ISO
diethyl maleate results in increased expression of GDF9 mRNA
CTD
PMID:33545341
NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731
G
Gfod1
glucose-fructose oxidoreductase domain containing 1
increases expression
ISO
diethyl maleate results in increased expression of GFOD1 mRNA
CTD
PMID:33545341
NCBI chr13:43,348,716...43,457,648
Ensembl chr13:43,348,721...43,457,648
G
Glul
glutamate-ammonia ligase
decreases expression
EXP
diethyl maleate results in decreased expression of GLUL mRNA
CTD
PMID:25270620
NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
G
Got2
glutamatic-oxaloacetic transaminase 2, mitochondrial
decreases expression
ISO
diethyl maleate results in decreased expression of GOT2 protein
CTD
PMID:21161181
NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175
G
Gpihbp1
GPI-anchored HDL-binding protein 1
decreases expression
EXP
diethyl maleate results in decreased expression of GPIHBP1 mRNA
CTD
PMID:25270620
NCBI chr15:75,468,479...75,470,062
Ensembl chr15:75,468,477...75,471,330
G
Gpx2
glutathione peroxidase 2
affects expression
ISO
diethyl maleate affects the expression of GPX2 mRNA
CTD
PMID:34480604
NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273
G
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
decreases expression
ISO
diethyl maleate results in decreased expression of GRIA3 mRNA
CTD
PMID:21161181
NCBI chr X:40,489,351...40,767,478
Ensembl chr X:40,489,731...40,767,478
G
Gsn
gelsolin
decreases reduction
EXP
diethyl maleate results in decreased reduction of GSN protein
CTD
PMID:19843705
NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
G
Gsr
glutathione reductase
increases expression
EXP
diethyl maleate results in increased expression of GSR mRNA
CTD
PMID:25270620
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
Gss
glutathione synthetase
increases expression
ISO
diethyl maleate results in increased expression of GSS mRNA
CTD
PMID:10978506
NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
G
Gsta1
glutathione S-transferase, alpha 1 (Ya)
increases expression
ISO
diethyl maleate results in increased expression of GSTA5 protein
CTD
PMID:9794803
NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
G
Gsta2
glutathione S-transferase, alpha 2 (Yc2)
increases expression
EXP
diethyl maleate results in increased expression of GSTA2 mRNA
CTD
PMID:25270620
NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
G
Gstk1
glutathione S-transferase kappa 1
multiple interactions
EXP
[diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA
CTD
PMID:22564015
NCBI chr 6:42,222,869...42,227,375
Ensembl chr 6:42,222,869...42,227,381
G
Gstm1
glutathione S-transferase, mu 1
decreases expression
ISO
diethyl maleate results in decreased expression of GSTM1 protein
CTD
PMID:21161181
NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
G
Gsto1
glutathione S-transferase omega 1
increases expression
EXP
diethyl maleate results in increased expression of GSTO1 mRNA
CTD
PMID:25270620
NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
G
Gstp1
glutathione S-transferase, pi 1
increases expression
ISO
diethyl maleate results in increased expression of GSTP1 protein
CTD
PMID:9794803
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
G
Gstt1
glutathione S-transferase, theta 1
increases expression
ISO
diethyl maleate results in increased expression of GSTT1 protein
CTD
PMID:9794803
NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
G
Gtse1
G two S phase expressed protein 1
increases expression
ISO
diethyl maleate results in increased expression of GTSE1 mRNA
CTD
PMID:21161181
NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774
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H2az2
H2A.Z histone variant 2
increases expression
ISO
diethyl maleate results in increased expression of H2AZ2 mRNA
CTD
PMID:33545341
NCBI chr11:6,377,226...6,394,511
Ensembl chr11:6,377,229...6,394,443
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H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
increases expression
EXP
diethyl maleate results in increased expression of H6PD mRNA
CTD
PMID:25270620
NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480
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Hamp
hepcidin antimicrobial peptide
increases expression
ISO
diethyl maleate results in increased expression of HAMP mRNA
CTD
PMID:33545341
NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
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Helb
helicase (DNA) B
decreases expression
EXP
diethyl maleate results in decreased expression of HELB mRNA
CTD
PMID:25270620
NCBI chr10:119,919,513...119,948,917
Ensembl chr10:119,919,513...119,948,892
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Hes6
hairy and enhancer of split 6
decreases expression
ISO
diethyl maleate results in decreased expression of HES6 mRNA
CTD
PMID:21161181
NCBI chr 1:91,339,204...91,342,901
Ensembl chr 1:91,339,205...91,341,760
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Hjurp
Holliday junction recognition protein
increases expression
ISO
diethyl maleate results in increased expression of HJURP mRNA
CTD
PMID:21161181
NCBI chr 1:88,186,578...88,205,366
Ensembl chr 1:88,190,193...88,205,355
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Hmox1
heme oxygenase 1
increases expression
ISO EXP
diethyl maleate results in increased expression of HMOX1 mRNA; diethyl maleate results in increased expression of HMOX1 protein
CTD
PMID:20491607 PMID:25270620 PMID:30261343 PMID:33545341 PMID:34480604 PMID:35724838 More...
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
decreases reduction
EXP
diethyl maleate results in decreased reduction of HNRNPH1 protein
CTD
PMID:19843705
NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
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Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
increases expression
ISO
diethyl maleate results in increased expression of HSD17B10 mRNA
CTD
PMID:33545341
NCBI chr X:150,784,892...150,787,438
Ensembl chr X:150,784,841...150,787,438
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression
ISO
diethyl maleate results in decreased expression of HSD17B2 mRNA
CTD
PMID:21161181
NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
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Hspa1b
heat shock protein 1B
increases expression
ISO
diethyl maleate results in increased expression of HSPA1B mRNA
CTD
PMID:33545341
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
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Hspa1l
heat shock protein 1-like
increases expression
ISO
diethyl maleate results in increased expression of HSPA1L mRNA
CTD
PMID:33545341
NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261
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Hspa5
heat shock protein 5
decreases reduction
EXP
diethyl maleate results in decreased reduction of HSPA5 protein
CTD
PMID:19843705
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
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Hspa8
heat shock protein 8
increases reduction
EXP
diethyl maleate results in increased reduction of HSPA8 protein
CTD
PMID:19843705
NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383
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Htatip2
HIV-1 Tat interactive protein 2
increases expression
EXP
diethyl maleate results in increased expression of HTATIP2 mRNA
CTD
PMID:25270620
NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723
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Hycc2
hyccin PI4KA lipid kinase complex subunit 2
decreases expression
ISO
diethyl maleate results in decreased expression of HYCC2 mRNA
CTD
PMID:21161181
NCBI chr 1:58,561,965...58,625,492
Ensembl chr 1:58,561,965...58,625,482
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Icam1
intercellular adhesion molecule 1
decreases expression multiple interactions
EXP ISO
diethyl maleate results in decreased expression of ICAM1 mRNA diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
CTD
PMID:25270620 PMID:35724838
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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Id3
inhibitor of DNA binding 3
decreases expression
EXP
diethyl maleate results in decreased expression of ID3 mRNA
CTD
PMID:25270620
NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066
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Id4
inhibitor of DNA binding 4
decreases expression
EXP
diethyl maleate results in decreased expression of ID4 mRNA
CTD
PMID:25270620
NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
decreases expression
ISO
diethyl maleate results in decreased expression of IFIT3 mRNA
CTD
PMID:21161181
NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131
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Ifrd1
interferon-related developmental regulator 1
increases expression
ISO
diethyl maleate results in increased expression of IFRD1 mRNA
CTD
PMID:33545341
NCBI chr12:40,253,128...40,273,184
Ensembl chr12:40,251,566...40,298,503
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Ikbke
inhibitor of kappaB kinase epsilon
decreases expression
EXP
diethyl maleate results in decreased expression of IKBKE mRNA
CTD
PMID:25270620
NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344
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Ikbkg
inhibitor of kappaB kinase gamma
increases expression
EXP
diethyl maleate results in increased expression of IKBKG mRNA
CTD
PMID:25270620
NCBI chr X:73,436,883...73,498,013
Ensembl chr X:73,436,896...73,497,460
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Il10
interleukin 10
increases secretion
ISO
diethyl maleate results in increased secretion of IL10 protein
CTD
PMID:31958493
NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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Il18
interleukin 18
increases expression
ISO
diethyl maleate results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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Il1a
interleukin 1 alpha
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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Il1b
interleukin 1 beta
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]
CTD
PMID:35724838
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Il1r1
interleukin 1 receptor, type I
affects expression
ISO
diethyl maleate affects the expression of IL1R1 mRNA
CTD
PMID:34480604
NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
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Il4
interleukin 4
multiple interactions
ISO
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD
PMID:31958493
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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Inhbb
inhibin beta-B
decreases expression
EXP
diethyl maleate results in decreased expression of INHBB mRNA
CTD
PMID:25270620
NCBI chr 1:119,343,193...119,349,978
Ensembl chr 1:119,343,195...119,349,978
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Inmt
indolethylamine N-methyltransferase
decreases expression
ISO
diethyl maleate results in decreased expression of INMT mRNA
CTD
PMID:21161181
NCBI chr 6:55,147,612...55,151,975
Ensembl chr 6:55,147,611...55,152,028
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Ins2
insulin II
multiple interactions
ISO
diethyl maleate inhibits the reaction [INS protein affects the localization of and results in increased phosphorylation of FOXO1 protein]
CTD
PMID:30261343
NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
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Ints7
integrator complex subunit 7
decreases expression
EXP
diethyl maleate results in decreased expression of INTS7 mRNA
CTD
PMID:25270620
NCBI chr 1:191,307,652...191,355,802
Ensembl chr 1:191,307,748...191,355,800
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Irf7
interferon regulatory factor 7
decreases expression
ISO
diethyl maleate results in decreased expression of IRF7 mRNA
CTD
PMID:21161181
NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394
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Irf9
interferon regulatory factor 9
decreases expression
ISO
diethyl maleate results in decreased expression of IRF9 mRNA
CTD
PMID:21161181
NCBI chr14:55,841,442...55,847,487
Ensembl chr14:55,841,028...55,847,487
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Irgm1
immunity-related GTPase family M member 1
decreases expression
ISO
diethyl maleate results in decreased expression of IRGM mRNA
CTD
PMID:21161181
NCBI chr11:48,756,072...48,762,247
Ensembl chr11:48,752,795...48,762,510
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Itgal
integrin alpha L
decreases expression
ISO
diethyl maleate results in decreased expression of ITGAL mRNA
CTD
PMID:21161181
NCBI chr 7:126,895,404...126,934,309
Ensembl chr 7:126,895,432...126,934,310
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Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
EXP
diethyl maleate results in decreased expression of ITIH3 mRNA
CTD
PMID:25270620
NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717
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Itih4
inter alpha-trypsin inhibitor, heavy chain 4
decreases expression
EXP
diethyl maleate results in decreased expression of ITIH4 mRNA
CTD
PMID:25270620
NCBI chr14:30,608,433...30,623,943
Ensembl chr14:30,608,433...30,624,310
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Jam3
junction adhesion molecule 3
decreases expression
ISO
diethyl maleate results in decreased expression of JAM3 mRNA
CTD
PMID:21161181
NCBI chr 9:27,008,680...27,066,739
Ensembl chr 9:27,008,680...27,066,717
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Jun
jun proto-oncogene
multiple interactions increases phosphorylation increases expression
EXP ISO
pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein] diethyl maleate results in increased expression of JUN mRNA pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of JUN protein modified form]
CTD
PMID:10915739 PMID:12774022 PMID:30261343
NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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Kcne3
potassium voltage-gated channel, Isk-related subfamily, gene 3
decreases expression
EXP
diethyl maleate results in decreased expression of KCNE3 mRNA
CTD
PMID:25270620
NCBI chr 7:99,825,714...99,834,076
Ensembl chr 7:99,825,709...99,834,076
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Keap1
kelch-like ECH-associated protein 1
increases expression
ISO
diethyl maleate results in increased expression of KEAP1 mRNA; diethyl maleate results in increased expression of KEAP1 protein
CTD
PMID:27358234 PMID:33545341 PMID:34480604
NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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Khdrbs3
KH domain containing, RNA binding, signal transduction associated 3
increases expression
ISO
diethyl maleate results in increased expression of KHDRBS3 mRNA
CTD
PMID:33545341
NCBI chr15:68,800,155...68,973,064
Ensembl chr15:68,800,269...68,973,060
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Kifc1
kinesin family member C1
increases expression
ISO
diethyl maleate results in increased expression of KIFC1 mRNA
CTD
PMID:21161181
NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635
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Klf10
Kruppel-like transcription factor 10
decreases expression
ISO EXP
diethyl maleate results in decreased expression of KLF10 mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
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Krt75
keratin 75
increases reduction
EXP
diethyl maleate results in increased reduction of KRT75 protein
CTD
PMID:19843705
NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339
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Lama1
laminin, alpha 1
decreases expression
EXP
diethyl maleate results in decreased expression of LAMA1 mRNA
CTD
PMID:25270620
NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642
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Lancl2
LanC (bacterial lantibiotic synthetase component C)-like 2
decreases expression
EXP
diethyl maleate results in decreased expression of LANCL2 mRNA
CTD
PMID:25270620
NCBI chr 6:57,679,440...57,716,434
Ensembl chr 6:57,679,525...57,716,424
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Ldlr
low density lipoprotein receptor
decreases expression
ISO
diethyl maleate results in decreased expression of LDLR mRNA
CTD
PMID:21161181
NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
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Lepr
leptin receptor
decreases expression
ISO
diethyl maleate results in decreased expression of LEPR mRNA
CTD
PMID:21161181
NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
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Lgals3bp
lectin, galactoside-binding, soluble, 3 binding protein
decreases expression
ISO
diethyl maleate results in decreased expression of LGALS3BP mRNA
CTD
PMID:21161181
NCBI chr11:118,283,573...118,292,787
Ensembl chr11:118,283,577...118,292,918
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Lmnb1
lamin B1
increases expression
ISO
diethyl maleate results in increased expression of LMNB1 mRNA
CTD
PMID:21161181
NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496
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Lmo7
LIM domain only 7
decreases expression
ISO
diethyl maleate results in decreased expression of LMO7 mRNA
CTD
PMID:21161181
NCBI chr14:101,967,353...102,172,144
Ensembl chr14:101,967,393...102,172,146
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Lrig3
leucine-rich repeats and immunoglobulin-like domains 3
decreases expression
ISO
diethyl maleate results in decreased expression of LRIG3 mRNA
CTD
PMID:21161181
NCBI chr10:125,802,088...125,851,228
Ensembl chr10:125,802,037...125,851,228
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Lrrn4
leucine rich repeat neuronal 4
increases expression
ISO
diethyl maleate results in increased expression of LRRN4 mRNA
CTD
PMID:21161181
NCBI chr 2:132,710,436...132,735,930
Ensembl chr 2:132,710,225...132,722,811
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Lrtm2
leucine-rich repeats and transmembrane domains 2
decreases expression
ISO
diethyl maleate results in decreased expression of LRTM2 mRNA
CTD
PMID:21161181
NCBI chr 6:119,292,094...119,315,009
Ensembl chr 6:119,292,094...119,307,727
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Ltc4s
leukotriene C4 synthase
decreases expression
ISO
diethyl maleate results in decreased expression of LTC4S mRNA
CTD
PMID:21161181
NCBI chr11:50,127,288...50,129,378
Ensembl chr11:50,127,288...50,129,443
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Lum
lumican
decreases expression
ISO
diethyl maleate results in decreased expression of LUM mRNA
CTD
PMID:21161181
NCBI chr10:97,401,363...97,408,565
Ensembl chr10:97,400,990...97,408,565
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Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
increases expression
ISO
diethyl maleate results in increased expression of MAFF mRNA
CTD
PMID:20491607 PMID:33545341
NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
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Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
increases expression
ISO
diethyl maleate results in increased expression of MAFG mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
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Maoa
monoamine oxidase A
increases expression
EXP
diethyl maleate results in increased expression of MAOA mRNA
CTD
PMID:25270620
NCBI chr X:16,485,937...16,554,051
Ensembl chr X:16,485,937...16,554,057
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Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
increases expression
ISO
diethyl maleate results in increased expression of MAPK1IP1L mRNA
CTD
PMID:33545341
NCBI chr14:47,535,731...47,560,663
Ensembl chr14:47,535,723...47,560,661
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Mapk8
mitogen-activated protein kinase 8
increases expression multiple interactions
ISO
diethyl maleate results in increased expression of MAPK8 protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK8 protein modified form]
CTD
PMID:30261343
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mapk9
mitogen-activated protein kinase 9
increases expression multiple interactions
ISO
diethyl maleate results in increased expression of MAPK9 protein modified form pyrazolanthrone inhibits the reaction [diethyl maleate results in increased expression of MAPK9 protein modified form]
CTD
PMID:30261343
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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Marveld1
MARVEL (membrane-associating) domain containing 1
decreases expression
ISO
diethyl maleate results in decreased expression of MARVELD1 mRNA
CTD
PMID:21161181
NCBI chr19:42,135,879...42,140,137
Ensembl chr19:42,135,839...42,140,142
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Mboat7
membrane bound O-acyltransferase domain containing 7
increases expression
ISO
diethyl maleate results in increased expression of MBOAT7 mRNA
CTD
PMID:33545341
NCBI chr 7:3,680,788...3,696,188
Ensembl chr 7:3,680,788...3,696,522
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Mcm10
minichromosome maintenance 10 replication initiation factor
increases expression
ISO
diethyl maleate results in increased expression of MCM10 mRNA
CTD
PMID:21161181
NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602
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Mcm4
minichromosome maintenance complex component 4
increases expression
ISO
diethyl maleate results in increased expression of MCM4 mRNA
CTD
PMID:21161181
NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
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Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
increases expression
EXP
diethyl maleate results in increased expression of ME1 mRNA
CTD
PMID:25270620
NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006
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Mfap4
microfibrillar-associated protein 4
decreases expression
ISO
diethyl maleate results in decreased expression of MFAP4 mRNA
CTD
PMID:21161181
NCBI chr11:61,376,257...61,379,536
Ensembl chr11:61,376,257...61,379,726
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases activity
ISO
diethyl maleate results in decreased activity of MGMT protein
CTD
PMID:16950796
NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
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Mki67
antigen identified by monoclonal antibody Ki 67
increases expression
ISO
diethyl maleate results in increased expression of MKI67 mRNA
CTD
PMID:21161181
NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
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Mknk2
MAP kinase-interacting serine/threonine kinase 2
decreases expression
ISO
diethyl maleate results in decreased expression of MKNK2 mRNA
CTD
PMID:21161181
NCBI chr10:80,501,152...80,512,264
Ensembl chr10:80,501,161...80,513,946
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Mmp12
matrix metallopeptidase 12
increases expression
EXP
diethyl maleate results in increased expression of MMP12 mRNA
CTD
PMID:10216232
NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499
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Mmp1b
matrix metallopeptidase 1b (interstitial collagenase)
increases expression
ISO
diethyl maleate results in increased expression of MMP1 mRNA
CTD
PMID:33545341
NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
diethyl maleate results in decreased expression of MMP2 mRNA
CTD
PMID:21161181
NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
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Mmp3
matrix metallopeptidase 3
increases expression
ISO
diethyl maleate results in increased expression of MMP3 mRNA
CTD
PMID:33545341
NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
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Mpzl1
myelin protein zero-like 1
decreases expression
ISO
diethyl maleate results in decreased expression of MPZL1 mRNA
CTD
PMID:34480604
NCBI chr 1:165,419,745...165,462,144
Ensembl chr 1:165,419,809...165,462,107
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Msn
moesin
increases reduction
EXP
diethyl maleate results in increased reduction of MSN protein
CTD
PMID:19843705
NCBI chr X:95,139,651...95,212,159
Ensembl chr X:95,139,648...95,212,158
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Mt2
metallothionein 2
increases expression
ISO
diethyl maleate results in increased expression of MT2A mRNA
CTD
PMID:20491607
NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196
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Mx1
MX dynamin-like GTPase 1
decreases expression
ISO
diethyl maleate results in decreased expression of MX1 mRNA
CTD
PMID:21161181
NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107
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Mybl2
myeloblastosis oncogene-like 2
increases expression
ISO
diethyl maleate results in increased expression of MYBL2 mRNA
CTD
PMID:21161181
NCBI chr 2:162,896,246...162,926,608
Ensembl chr 2:162,896,607...162,926,608
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Mycn
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
decreases expression
EXP
diethyl maleate results in decreased expression of MYCN mRNA
CTD
PMID:25270620
NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
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Nat8
N-acetyltransferase 8 (GCN5-related)
decreases expression
ISO
diethyl maleate results in decreased expression of NAT8 mRNA
CTD
PMID:21161181
NCBI chr 6:85,807,369...85,813,839
Ensembl chr 6:85,807,370...85,809,064
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Ncaph
non-SMC condensin I complex, subunit H
increases expression
ISO
diethyl maleate results in increased expression of NCAPH mRNA
CTD
PMID:21161181
NCBI chr 2:126,945,729...126,975,857
Ensembl chr 2:126,945,729...126,975,874
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Ndrg1
N-myc downstream regulated gene 1
increases expression
ISO
diethyl maleate results in increased expression of NDRG1 mRNA
CTD
PMID:33545341
NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489
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Nfe2l2
nuclear factor, erythroid derived 2, like 2
affects localization multiple interactions decreases response to substance increases expression increases activity
EXP ISO
diethyl maleate affects the localization of NFE2L2 protein NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] NFE2L2 results in decreased susceptibility to diethyl maleate diethyl maleate results in increased expression of NFE2L2 protein [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; diethyl maleate binds to and results in increased activity of NFE2L2 protein; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; diethyl maleate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] diethyl maleate results in increased activity of NFE2L2 protein
CTD
PMID:12235164 PMID:20806931 PMID:21465251 PMID:22003191 PMID:25762726 PMID:27358234 PMID:27982581 PMID:30114225 PMID:34021431 PMID:35724838 More...
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
multiple interactions
EXP ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA] diethyl maleate inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]
CTD
PMID:12774022 PMID:35724838
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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Nherf1
NHERF family PDZ scaffold protein 1
decreases expression
ISO
diethyl maleate results in decreased expression of NHERF1 mRNA
CTD
PMID:21161181
NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007
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Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP ISO
diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein] Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD
PMID:7532384 PMID:9918918 PMID:12774022
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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Notch1
notch 1
increases expression
ISO
diethyl maleate results in increased expression of NOTCH1 mRNA
CTD
PMID:33545341
NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675
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Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
ISO EXP
diethyl maleate results in increased expression of NQO1 mRNA
CTD
PMID:20491607 PMID:25270620 PMID:33545341 PMID:34480604
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
ISO
diethyl maleate results in decreased expression of NR0B2 mRNA
CTD
PMID:21161181
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
decreases expression
ISO
diethyl maleate results in decreased expression of NR1D1 mRNA
CTD
PMID:21161181
NCBI chr11:98,658,758...98,666,233
Ensembl chr11:98,658,758...98,666,159
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Nrep
neuronal regeneration related protein
decreases expression
ISO
diethyl maleate results in decreased expression of NREP mRNA
CTD
PMID:21161181
NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082
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Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
decreases expression
EXP
diethyl maleate results in decreased expression of NSMF mRNA
CTD
PMID:25270620
NCBI chr 2:24,944,370...24,952,893
Ensembl chr 2:24,944,367...24,952,893
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Ntf3
neurotrophin 3
decreases expression
ISO
diethyl maleate results in decreased expression of NTF3 mRNA
CTD
PMID:21161181
NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873
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Nup153
nucleoporin 153
multiple interactions affects localization
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]; diethyl maleate results in increased phosphorylation of and results in increased O-linked glycosylation of NUP153 protein
CTD
PMID:20041180
NCBI chr13:46,833,369...46,890,682
Ensembl chr13:46,833,381...46,881,416
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Nup88
nucleoporin 88
multiple interactions affects localization
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]; diethyl maleate results in increased phosphorylation of and results in increased glycosylation of NUP88 protein
CTD
PMID:20041180
NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799
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Oaf
out at first homolog
decreases expression
ISO
diethyl maleate results in decreased expression of OAF mRNA
CTD
PMID:21161181
NCBI chr 9:43,132,575...43,151,113
Ensembl chr 9:43,132,532...43,151,208
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Ogg1
8-oxoguanine DNA-glycosylase 1
multiple interactions
EXP
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA
CTD
PMID:22564015
NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
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Orc1
origin recognition complex, subunit 1
increases expression
ISO
diethyl maleate results in increased expression of ORC1 mRNA
CTD
PMID:21161181
NCBI chr 4:108,436,651...108,472,030
Ensembl chr 4:108,436,620...108,472,030
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Osgin1
oxidative stress induced growth inhibitor 1
increases expression
ISO
diethyl maleate results in increased expression of OSGIN1 mRNA
CTD
PMID:33545341
NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995
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P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
decreases expression
ISO
diethyl maleate results in decreased expression of P2RX7 mRNA
CTD
PMID:21161181
NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495
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Parp1
poly (ADP-ribose) polymerase family, member 1
increases cleavage
ISO
diethyl maleate results in increased cleavage of PARP1 protein
CTD
PMID:21105742
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Pbld1
phenazine biosynthesis-like protein domain containing 1
decreases expression
ISO
diethyl maleate results in decreased expression of PBLD protein
CTD
PMID:21161181
NCBI chr10:62,896,404...62,913,743
Ensembl chr10:62,895,941...62,913,741
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
diethyl maleate results in decreased expression of PCNA mRNA
CTD
PMID:11875189
NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
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Pdlim2
PDZ and LIM domain 2
decreases expression
ISO
diethyl maleate results in decreased expression of PDLIM2 mRNA
CTD
PMID:21161181
NCBI chr14:70,401,667...70,415,140
Ensembl chr14:70,401,667...70,415,130
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Pdrg1
p53 and DNA damage regulated 1
increases expression
EXP
diethyl maleate results in increased expression of PDRG1 mRNA
CTD
PMID:25270620
NCBI chr 2:152,850,810...152,857,939
Ensembl chr 2:152,850,810...152,857,347
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Per2
period circadian clock 2
decreases expression
ISO
diethyl maleate results in decreased expression of PER2 mRNA
CTD
PMID:21161181
NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
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Per3
period circadian clock 3
decreases expression
ISO
diethyl maleate results in decreased expression of PER3 mRNA
CTD
PMID:21161181
NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122
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Pgd
phosphogluconate dehydrogenase
increases activity
ISO
diethyl maleate results in increased activity of PGD protein
CTD
PMID:3099627
NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228
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Pgrmc1
progesterone receptor membrane component 1
increases expression
EXP
diethyl maleate results in increased expression of PGRMC1 mRNA
CTD
PMID:25270620
NCBI chr X:35,861,846...35,869,732
Ensembl chr X:35,861,859...35,869,732
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Pir
pirin
increases expression
EXP
diethyl maleate results in increased expression of PIR mRNA
CTD
PMID:25270620
NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007
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Pklr
pyruvate kinase liver and red blood cell
decreases expression
ISO
diethyl maleate results in decreased expression of PKLR mRNA
CTD
PMID:21161181
NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091
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Plat
plasminogen activator, tissue
increases expression decreases expression
ISO EXP
diethyl maleate results in increased expression of PLAT mRNA diethyl maleate results in decreased expression of PLAT mRNA
CTD
PMID:21161181 PMID:25270620
NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860
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Plek
pleckstrin
decreases expression
ISO
diethyl maleate results in decreased expression of PLEK mRNA
CTD
PMID:21161181
NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381
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Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
increases expression
ISO
diethyl maleate results in increased expression of PLEKHM1 mRNA
CTD
PMID:33545341
NCBI chr11:103,255,101...103,303,531
Ensembl chr11:103,255,101...103,303,513
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Plin2
perilipin 2
increases expression
ISO
diethyl maleate results in increased expression of PLIN2 mRNA
CTD
PMID:33545341
NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297
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Plk1
polo like kinase 1
increases expression
ISO
diethyl maleate results in increased expression of PLK1 mRNA
CTD
PMID:33545341
NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096
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Plk3
polo like kinase 3
increases expression
ISO
diethyl maleate results in increased expression of PLK3 mRNA
CTD
PMID:33545341
NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160
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Pou5f1
POU domain, class 5, transcription factor 1
increases expression
ISO
diethyl maleate results in increased expression of POU5F1 mRNA
CTD
PMID:33545341
NCBI chr17:35,816,929...35,821,674
Ensembl chr17:35,816,915...35,821,669
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions decreases activity
ISO
diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]; resveratrol inhibits the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol inhibits the reaction [diethyl maleate results in decreased activity of PPARA protein]; resveratrol promotes the reaction [diethyl maleate inhibits the reaction [PPARA protein binds to ACOX1 promoter]]; resveratrol promotes the reaction [diethyl maleate results in decreased activity of PPARA protein]
CTD
PMID:17134953
NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
decreases expression
ISO
diethyl maleate results in decreased expression of PPARGC1B mRNA
CTD
PMID:21161181
NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
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Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
ISO
diethyl maleate results in decreased expression of PPP1R3B mRNA
CTD
PMID:21161181
NCBI chr 8:35,842,847...35,855,293
Ensembl chr 8:35,842,893...35,855,293
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Ppp1r3c
protein phosphatase 1, regulatory subunit 3C
decreases expression
ISO
diethyl maleate results in decreased expression of PPP1R3C mRNA
CTD
PMID:21161181
NCBI chr19:36,709,131...36,714,004
Ensembl chr19:36,709,131...36,714,053
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Prdm14
PR domain containing 14
decreases expression
EXP
diethyl maleate results in decreased expression of PRDM14 mRNA
CTD
PMID:25270620
NCBI chr 1:13,183,649...13,197,467
Ensembl chr 1:13,183,681...13,197,387
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Prdx1
peroxiredoxin 1
increases expression
EXP ISO
diethyl maleate results in increased expression of PRDX1 mRNA
CTD
PMID:9506838
NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
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Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
decreases expression
EXP
diethyl maleate results in decreased expression of PRKAB1 mRNA
CTD
PMID:25270620
NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567
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Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
increases expression
ISO
diethyl maleate results in increased expression of PRKAG2 mRNA
CTD
PMID:33545341
NCBI chr 5:25,067,733...25,311,576
Ensembl chr 5:25,067,742...25,305,640
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Prkcb
protein kinase C, beta
affects expression
ISO
diethyl maleate affects the expression of PRKCB protein
CTD
PMID:31958493
NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625
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Prkcd
protein kinase C, delta
multiple interactions
ISO
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCD protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCD protein
CTD
PMID:11118818
NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167
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Prkce
protein kinase C, epsilon
multiple interactions
ISO
Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]; diethyl maleate results in increased expression of and results in increased activity of PRKCE protein
CTD
PMID:11118818
NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347
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Prss8
serine protease 8 (prostasin)
decreases expression
ISO
diethyl maleate results in decreased expression of PRSS8 mRNA
CTD
PMID:21161181
NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276
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Ptgr1
prostaglandin reductase 1
increases expression
EXP
diethyl maleate results in increased expression of PTGR1 mRNA
CTD
PMID:25270620
NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
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Ptpn14
protein tyrosine phosphatase, non-receptor type 14
increases expression
EXP
diethyl maleate results in increased expression of PTPN14 mRNA
CTD
PMID:25270620
NCBI chr 1:189,460,417...189,608,892
Ensembl chr 1:189,460,465...189,608,892
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Pus1
pseudouridine synthase 1
decreases expression
EXP
diethyl maleate results in decreased expression of PUS1 mRNA
CTD
PMID:25270620
NCBI chr 5:110,921,533...110,928,523
Ensembl chr 5:110,921,533...110,928,525
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Pxn
paxillin
increases expression
ISO
diethyl maleate results in increased expression of PXN mRNA
CTD
PMID:33545341
NCBI chr 5:115,630,035...115,694,046
Ensembl chr 5:115,644,735...115,694,046
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Rab27a
RAB27A, member RAS oncogene family
decreases expression
ISO
diethyl maleate results in decreased expression of RAB27A mRNA
CTD
PMID:21161181
NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911
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Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
multiple interactions
ISO
diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [IL1B protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein inhibits the reaction [diethyl maleate results in increased expression of NFE2L2 protein]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:20116392 PMID:35724838
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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Rho
rhodopsin
increases expression
ISO
diethyl maleate results in increased expression of RHO mRNA
CTD
PMID:33545341
NCBI chr 6:115,903,741...115,916,999
Ensembl chr 6:115,908,709...115,916,997
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Rnf114
ring finger protein 114
decreases expression
EXP
diethyl maleate results in decreased expression of RNF114 mRNA
CTD
PMID:25270620
NCBI chr 2:167,334,565...167,358,093
Ensembl chr 2:167,334,565...167,358,093
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Rnf14
ring finger protein 14
increases expression
EXP
diethyl maleate results in increased expression of RNF14 mRNA
CTD
PMID:25270620
NCBI chr18:38,410,513...38,450,905
Ensembl chr18:38,417,590...38,450,902
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Rrm2
ribonucleotide reductase M2
increases expression
ISO
diethyl maleate results in increased expression of RRM2 mRNA
CTD
PMID:21161181 PMID:33545341
NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
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Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
diethyl maleate results in decreased expression of RSAD2 mRNA
CTD
PMID:21161181
NCBI chr12:26,492,742...26,506,451
Ensembl chr12:26,492,745...26,506,451
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S100a9
S100 calcium binding protein A9 (calgranulin B)
decreases expression
ISO
diethyl maleate results in decreased expression of S100A9 mRNA
CTD
PMID:21161181
NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
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Sash3
SAM and SH3 domain containing 3
decreases expression
ISO
diethyl maleate results in decreased expression of SASH3 mRNA
CTD
PMID:21161181
NCBI chr X:47,235,313...47,250,442
Ensembl chr X:47,235,313...47,250,442
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Scarb1
scavenger receptor class B, member 1
decreases expression
ISO
diethyl maleate results in decreased expression of SCARB1 mRNA
CTD
PMID:34480604
NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
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Scd1
stearoyl-Coenzyme A desaturase 1
decreases expression
ISO
diethyl maleate results in decreased expression of SCD1 mRNA
CTD
PMID:21161181
NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
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Sds
serine dehydratase
decreases expression
ISO
diethyl maleate results in decreased expression of SDS mRNA
CTD
PMID:21161181
NCBI chr 5:120,614,612...120,621,997
Ensembl chr 5:120,614,591...120,621,997
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Selenop
selenoprotein P
decreases expression
ISO
diethyl maleate results in decreased expression of SELENOP mRNA
CTD
PMID:30261343
NCBI chr15:3,300,249...3,309,992
Ensembl chr15:3,298,029...3,309,990
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Serpinb6b
serine (or cysteine) peptidase inhibitor, clade B, member 6b
decreases expression
EXP
diethyl maleate results in decreased expression of SERPINB6B mRNA
CTD
PMID:25270620
NCBI chr13:33,140,797...33,163,050
Ensembl chr13:33,149,192...33,163,050
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Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
decreases expression
EXP
diethyl maleate results in decreased expression of SERPIND1 mRNA
CTD
PMID:25270620
NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439
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Sertad1
SERTA domain containing 1
increases expression
ISO
diethyl maleate results in increased expression of SERTAD1 mRNA
CTD
PMID:33545341
NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741
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Sez6
seizure related gene 6
decreases expression
ISO
diethyl maleate results in decreased expression of SEZ6 mRNA
CTD
PMID:21161181
NCBI chr11:77,821,403...77,869,874
Ensembl chr11:77,821,626...77,869,874
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Sfxn1
sideroflexin 1
decreases expression
EXP
diethyl maleate results in decreased expression of SFXN1 mRNA
CTD
PMID:25270620
NCBI chr13:54,225,675...54,262,365
Ensembl chr13:54,225,888...54,262,361
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Sh3bp5
SH3-domain binding protein 5 (BTK-associated)
increases expression affects expression
ISO
diethyl maleate results in increased expression of SH3BP5 mRNA diethyl maleate affects the expression of SH3BP5 mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr14:31,094,571...31,158,056
Ensembl chr14:31,081,837...31,158,035
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Six4
sine oculis-related homeobox 4
increases expression
EXP
diethyl maleate results in increased expression of SIX4 mRNA
CTD
PMID:25270620
NCBI chr12:73,146,383...73,160,201
Ensembl chr12:73,146,383...73,160,230
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Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
decreases expression
EXP
diethyl maleate results in decreased expression of SLC16A6 mRNA
CTD
PMID:25270620
NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424
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Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
increases expression
EXP
diethyl maleate results in increased expression of SLC1A4 mRNA
CTD
PMID:25270620
NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713
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Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
decreases expression
ISO
diethyl maleate results in decreased expression of SLC2A2 mRNA
CTD
PMID:21161181
NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508
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Slc2a5
solute carrier family 2 (facilitated glucose transporter), member 5
decreases expression
ISO
diethyl maleate results in decreased expression of SLC2A5 mRNA
CTD
PMID:21161181
NCBI chr 4:150,203,801...150,228,625
Ensembl chr 4:150,203,740...150,228,626
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Slc39a14
solute carrier family 39 (zinc transporter), member 14
decreases expression
EXP
diethyl maleate results in decreased expression of SLC39A14 mRNA
CTD
PMID:25270620
NCBI chr14:70,540,916...70,588,873
Ensembl chr14:70,540,918...70,588,874
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Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
increases expression
ISO
diethyl maleate results in increased expression of SLC3A2 mRNA
CTD
PMID:33545341
NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
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Slc40a1
solute carrier family 40 (iron-regulated transporter), member 1
multiple interactions
ISO
diethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]
CTD
PMID:21303654
NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683
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Slc44a4
solute carrier family 44, member 4
decreases expression
ISO
diethyl maleate results in decreased expression of SLC44A4 mRNA
CTD
PMID:21161181
NCBI chr17:35,133,200...35,149,412
Ensembl chr17:35,133,442...35,149,412
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Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
multiple interactions increases expression
EXP ISO
NFE2L2 gene mutant form inhibits the reaction [diethyl maleate results in increased expression of SLC7A11 mRNA]
CTD
PMID:12235164 PMID:33545341
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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Slco2a1
solute carrier organic anion transporter family, member 2a1
decreases expression
ISO
diethyl maleate results in decreased expression of SLCO2A1 mRNA
CTD
PMID:21161181
NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201
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Slfn3
schlafen 3
decreases expression
ISO
diethyl maleate results in decreased expression of SLFN3 mRNA
CTD
PMID:21161181
NCBI chr11:83,082,156...83,105,980
Ensembl chr11:83,082,156...83,105,980
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Smc4
structural maintenance of chromosomes 4
increases expression
ISO
diethyl maleate results in increased expression of SMC4 mRNA
CTD
PMID:21161181
NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956
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Smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
increases expression increases activity multiple interactions
ISO
diethyl maleate results in increased expression of SMPD1 mRNA diethyl maleate results in increased activity of SMPD1 protein Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]; diethyl maleate promotes the reaction [NFE2L2 protein binds to SMPD1 promoter]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SMPD1 mRNA]
CTD
PMID:25762726
NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596
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Smtn
smoothelin
increases expression
ISO
diethyl maleate results in increased expression of SMTN mRNA
CTD
PMID:21161181
NCBI chr11:3,467,522...3,489,337
Ensembl chr11:3,467,523...3,490,612
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Socs3
suppressor of cytokine signaling 3
decreases expression
EXP
diethyl maleate results in decreased expression of SOCS3 mRNA
CTD
PMID:25270620
NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873
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Sod2
superoxide dismutase 2, mitochondrial
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]
CTD
PMID:7476933
NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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Sorl1
sortilin-related receptor, LDLR class A repeats-containing
decreases expression
ISO
diethyl maleate results in decreased expression of SORL1 mRNA
CTD
PMID:21161181
NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593
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Sox9
SRY (sex determining region Y)-box 9
increases expression
ISO
diethyl maleate results in increased expression of SOX9 mRNA
CTD
PMID:21161181
NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586
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Sp5
trans-acting transcription factor 5
decreases expression
EXP
diethyl maleate results in decreased expression of SP5 mRNA
CTD
PMID:25270620
NCBI chr 2:70,305,267...70,308,070
Ensembl chr 2:70,305,267...70,308,073
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Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
increases expression
ISO
diethyl maleate results in increased expression of SPC25 mRNA
CTD
PMID:21161181
NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538
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Spta1
spectrin alpha, erythrocytic 1
increases expression
EXP
diethyl maleate results in increased expression of SPTA1 mRNA
CTD
PMID:25270620
NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016
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Sptan1
spectrin alpha, non-erythrocytic 1
increases cleavage
ISO
diethyl maleate results in increased cleavage of SPTAN1 protein
CTD
PMID:21105742
NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463
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Sptbn4
spectrin beta, non-erythrocytic 4
increases expression
EXP
diethyl maleate results in increased expression of SPTBN4 mRNA
CTD
PMID:25270620
NCBI chr 7:27,055,808...27,147,128
Ensembl chr 7:27,055,808...27,147,111
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Sptlc1
serine palmitoyltransferase, long chain base subunit 1
increases expression
ISO
diethyl maleate results in increased expression of SPTLC1 mRNA
CTD
PMID:33545341
NCBI chr13:53,486,784...53,531,401
Ensembl chr13:53,486,784...53,531,433
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Sqstm1
sequestosome 1
increases expression
EXP ISO
diethyl maleate results in increased expression of SQSTM1 mRNA
CTD
PMID:25270620 PMID:33545341 PMID:34480604
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
diethyl maleate results in decreased expression of SREBF1 mRNA
CTD
PMID:21161181
NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
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Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
multiple interactions increases expression decreases expression
EXP ISO
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 mRNA] diethyl maleate results in increased expression of SRXN1 mRNA; diethyl maleate results in increased expression of SRXN1 protein [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; NFE2L2 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein promotes the reaction [diethyl maleate results in increased expression of SRXN1 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein] diethyl maleate results in decreased expression of SRXN1 mRNA
CTD
PMID:22003191 PMID:25270620 PMID:27358234 PMID:27982581 PMID:33545341 PMID:34480604 PMID:34626751 PMID:35724838 More...
NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
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Stat1
signal transducer and activator of transcription 1
decreases expression
ISO
diethyl maleate results in decreased expression of STAT1 mRNA
CTD
PMID:21161181
NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024
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Steap4
STEAP family member 4
decreases expression
EXP
diethyl maleate results in decreased expression of STEAP4 mRNA
CTD
PMID:25270620
NCBI chr 5:8,010,472...8,032,213
Ensembl chr 5:8,010,457...8,032,213
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Sulf2
sulfatase 2
decreases expression
ISO
diethyl maleate results in decreased expression of SULF2 mRNA
CTD
PMID:21161181
NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583
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Tagln
transgelin
decreases expression
ISO
diethyl maleate results in decreased expression of TAGLN mRNA
CTD
PMID:21161181
NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356
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Tatdn2
TatD DNase domain containing 2
increases expression
ISO
diethyl maleate results in increased expression of TATDN2 mRNA
CTD
PMID:33545341
NCBI chr 6:113,674,090...113,688,030
Ensembl chr 6:113,674,011...113,688,030
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Tbcel
tubulin folding cofactor E-like
increases expression
EXP
diethyl maleate results in increased expression of TBCEL mRNA
CTD
PMID:25270620
NCBI chr 9:42,323,612...42,383,534
Ensembl chr 9:42,323,612...42,419,105
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Tent4a
terminal nucleotidyltransferase 4A
increases expression
ISO
diethyl maleate results in increased expression of TENT4A mRNA
CTD
PMID:33545341
NCBI chr13:69,646,071...69,682,710
Ensembl chr13:69,646,078...69,682,736
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Tent5a
terminal nucleotidyltransferase 5A
decreases expression
ISO
diethyl maleate results in decreased expression of TENT5A mRNA
CTD
PMID:21161181
NCBI chr 9:85,202,492...85,209,203
Ensembl chr 9:85,202,492...85,209,401
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Tesmin
testis expressed metallothionein like
affects localization
EXP
diethyl maleate affects the localization of TESMIN protein
CTD
PMID:12606435
NCBI chr19:3,438,857...3,457,823
Ensembl chr19:3,438,857...3,457,823
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Tfeb
transcription factor EB
decreases expression
EXP
diethyl maleate results in decreased expression of TFEB mRNA
CTD
PMID:25270620
NCBI chr17:48,047,962...48,103,341
Ensembl chr17:48,047,955...48,103,344
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Tgm2
transglutaminase 2, C polypeptide
increases expression
ISO
diethyl maleate results in increased expression of TGM2 mRNA
CTD
PMID:21161181
NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356
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Thbs1
thrombospondin 1
increases expression
ISO
diethyl maleate results in increased expression of THBS1 mRNA
CTD
PMID:21161181
NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614
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Thrsp
thyroid hormone responsive
decreases expression
ISO
diethyl maleate results in decreased expression of THRSP mRNA
CTD
PMID:21161181
NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937
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Tm4sf1
transmembrane 4 superfamily member 1
increases expression
ISO
diethyl maleate results in increased expression of TM4SF1 mRNA
CTD
PMID:21161181
NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409 Ensembl chr 3:57,193,032...57,209,409
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Tmem209
transmembrane protein 209
increases expression
EXP
diethyl maleate results in increased expression of TMEM209 mRNA
CTD
PMID:25270620
NCBI chr 6:30,480,806...30,509,786
Ensembl chr 6:30,479,052...30,509,782
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
[diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [diethyl maleate co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein; [diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; diethyl maleate inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; diethyl maleate inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; NFE2L2 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; NFE2L2 protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; RELA protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein] diethyl maleate inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein]]; TNF protein promotes the reaction [diethyl maleate results in increased phosphorylation of JUN protein] diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]
CTD
PMID:7476933 PMID:7532384 PMID:12774022 PMID:20116392 PMID:31958493 PMID:35724838 More...
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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Tnfaip3
tumor necrosis factor, alpha-induced protein 3
multiple interactions
ISO
diethyl maleate inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; RELA protein inhibits the reaction [diethyl maleate inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]]; TNFAIP3 protein inhibits the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of SRXN1 protein]; TNFAIP3 protein promotes the reaction [[diethyl maleate co-treated with TNF protein] results in decreased expression of NFE2L2 protein]
CTD
PMID:35724838
NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405
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Tnfrsf14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
decreases expression
ISO
diethyl maleate results in decreased expression of TNFRSF14 mRNA
CTD
PMID:21161181
NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020
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Tpm2
tropomyosin 2, beta
decreases expression
ISO
diethyl maleate results in decreased expression of TPM2 mRNA
CTD
PMID:21161181
NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765
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Trap1
TNF receptor-associated protein 1
multiple interactions decreases response to substance
ISO
diethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein] TRAP1 protein results in decreased susceptibility to diethyl maleate
CTD
PMID:17853063
NCBI chr16:3,857,835...3,895,704
Ensembl chr16:3,857,835...3,895,691
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Trdmt1
tRNA aspartic acid methyltransferase 1
decreases expression
EXP
diethyl maleate results in decreased expression of TRDMT1 mRNA
CTD
PMID:25270620
NCBI chr 2:13,509,690...13,549,475
Ensembl chr 2:13,513,825...13,549,479
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Trf
transferrin
decreases expression
ISO
diethyl maleate results in decreased expression of TF protein
CTD
PMID:21161181
NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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Trib1
tribbles pseudokinase 1
increases expression
ISO
diethyl maleate results in increased expression of TRIB1 mRNA
CTD
PMID:33545341
NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948
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Trib3
tribbles pseudokinase 3
increases expression
ISO
diethyl maleate results in increased expression of TRIB3 mRNA
CTD
PMID:33545341
NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
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Trim6
tripartite motif-containing 6
decreases expression
ISO
diethyl maleate results in decreased expression of TRIM6 mRNA
CTD
PMID:21161181
NCBI chr 7:103,868,002...103,884,359
Ensembl chr 7:103,868,000...103,884,359
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Trip13
thyroid hormone receptor interactor 13
increases expression
ISO
diethyl maleate results in increased expression of TRIP13 mRNA
CTD
PMID:21161181
NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903
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Trp53
transformation related protein 53
multiple interactions
EXP ISO
TRP53 protein affects the reaction [diethyl maleate results in increased expression of BTG2 mRNA] TP53 protein affects the reaction [diethyl maleate results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [diethyl maleate results in increased expression of SRXN1 protein]
CTD
PMID:22003191 PMID:27982581
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Tsc22d1
TSC22 domain family, member 1
decreases expression
ISO
diethyl maleate results in decreased expression of TSC22D1 mRNA
CTD
PMID:21161181
NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205
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Tspan8
tetraspanin 8
decreases expression
ISO
diethyl maleate results in decreased expression of TSPAN8 mRNA
CTD
PMID:21161181
NCBI chr10:115,652,722...115,685,798
Ensembl chr10:115,652,737...115,685,798
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Tstd1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
decreases expression
EXP
diethyl maleate results in decreased expression of TSTD1 mRNA
CTD
PMID:25270620
NCBI chr 1:171,246,601...171,247,920
Ensembl chr 1:171,246,440...171,247,920
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Txn1
thioredoxin 1
decreases activity
ISO
diethyl maleate results in decreased activity of TXN protein
CTD
PMID:15388247
NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
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Txnip
thioredoxin interacting protein
increases expression
ISO
diethyl maleate results in increased expression of TXNIP mRNA
CTD
PMID:21161181
NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
diethyl maleate results in increased expression of TXNRD1 mRNA
CTD
PMID:15521073 PMID:33545341 PMID:34480604
NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
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Ubd
ubiquitin D
decreases expression
ISO
diethyl maleate results in decreased expression of UBD mRNA
CTD
PMID:21161181
NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986
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Ugt2b35
UDP glucuronosyltransferase 2 family, polypeptide B35
increases expression
EXP
diethyl maleate results in increased expression of UGT2B35 mRNA
CTD
PMID:25270620
NCBI chr 5:87,148,719...87,161,133
Ensembl chr 5:87,148,719...87,161,134
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Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
increases expression
ISO
diethyl maleate results in increased expression of UHRF1 mRNA
CTD
PMID:21161181
NCBI chr17:56,610,405...56,630,486
Ensembl chr17:56,610,321...56,630,486
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Usp18
ubiquitin specific peptidase 18
decreases expression
ISO
diethyl maleate results in decreased expression of USP18 mRNA
CTD
PMID:21161181
NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876
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Usp2
ubiquitin specific peptidase 2
decreases expression
ISO
diethyl maleate results in decreased expression of USP2 mRNA
CTD
PMID:21161181
NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
diethyl maleate results in increased expression of VEGFA mRNA
CTD
PMID:33545341
NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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Wdr31
WD repeat domain 31
decreases expression
EXP
diethyl maleate results in decreased expression of WDR31 mRNA
CTD
PMID:25270620
NCBI chr 4:62,366,890...62,389,236
Ensembl chr 4:62,366,890...62,389,133
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Wdr6
WD repeat domain 6
decreases expression
ISO
diethyl maleate results in decreased expression of WDR6 mRNA
CTD
PMID:21161181
NCBI chr 9:108,449,510...108,455,862
Ensembl chr 9:108,449,510...108,455,938
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Ypel5
yippee like 5
increases expression
EXP
diethyl maleate results in increased expression of YPEL5 mRNA
CTD
PMID:25270620
NCBI chr17:73,143,623...73,157,439
Ensembl chr17:73,143,448...73,158,190
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Zfand2a
zinc finger, AN1-type domain 2A
increases expression
ISO
diethyl maleate results in increased expression of ZFAND2A mRNA
CTD
PMID:33545341 PMID:34480604
NCBI chr 5:139,456,971...139,470,246
Ensembl chr 5:139,456,966...139,470,304
G
Zfp36
zinc finger protein 36
increases expression
ISO
diethyl maleate results in increased expression of ZFP36 protein
CTD
PMID:21969073
NCBI chr 7:28,076,208...28,078,680
Ensembl chr 7:28,076,209...28,079,678
G
Zfp367
zinc finger protein 367
increases expression
ISO
diethyl maleate results in increased expression of ZNF367 mRNA
CTD
PMID:21161181
NCBI chr13:64,280,836...64,301,013
Ensembl chr13:64,280,832...64,301,016
G
Zfp37
zinc finger protein 37
decreases expression
ISO
diethyl maleate results in decreased expression of ZFP37 mRNA
CTD
PMID:21161181
NCBI chr 4:62,107,777...62,126,685
Ensembl chr 4:62,107,777...62,149,284
G
Zfp493
zinc finger protein 493
decreases reduction
EXP
diethyl maleate results in decreased reduction of ZFP493 protein
CTD
PMID:19843705
NCBI chr13:67,927,812...67,937,201
Ensembl chr13:67,927,812...67,940,631
G
Znrd2
zinc ribbon domain containing 2
decreases expression
EXP
diethyl maleate results in decreased expression of ZNRD2 mRNA
CTD
PMID:25270620
NCBI chr19:5,780,334...5,781,760
Ensembl chr19:5,780,331...5,781,760 Ensembl chr19:5,780,331...5,781,760
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