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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apoptosis inducer
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Accession:CHEBI:68495 term browser browse the term
Definition:Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Synonyms:related_synonym: Type I cell-death inducer;   Type I cell-death inducers;   Type I programmed cell-death inducer;   Type I programmed cell-death inducers;   apoptosis inducers


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(-)-epigallocatechin 3-gallate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578 PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression		 EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
epigallocatechin gallate results in decreased expression of CCL2 mRNA		 CTD PMID:20580034 PMID:22521609 PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
decreases expression		 EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
epigallocatechin gallate results in decreased activity of CYP1A1 protein
epigallocatechin gallate results in decreased expression of CYP1A1 mRNA		 CTD PMID:12970578 PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions
increases expression		 EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA] CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP epigallocatechin gallate results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA]		 CTD PMID:22521609 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression		 EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
epigallocatechin gallate results in decreased expression of VCAM1 mRNA		 CTD PMID:22521609 PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
(25R)-cholest-5-ene-3beta,26-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,343,123...74,372,621 		JBrowse link
4-hydroxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF4 protein] CTD PMID:36754226 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of ATF6 protein] CTD PMID:36754226 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein] CTD PMID:36754226 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CLDN1 claudin 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein] CTD PMID:36754226 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657 		JBrowse link
G CLDN3 claudin 3 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of CLDN3 protein] CTD PMID:36754226 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of DDIT3 protein] CTD PMID:36754226 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of ERN1 protein] CTD PMID:36754226 NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 protein] CTD PMID:36754226 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G OCLN occludin multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of OCLN protein] CTD PMID:36754226 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions EXP 4-phenylbutyric acid promotes the reaction [Benzo(a)pyrene results in decreased expression of TJP1 protein] CTD PMID:36754226 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
bafilomycin A1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein] CTD PMID:36754226 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,556,710...98,623,940 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases lipidation
multiple interactions		 EXP bafilomycin A1 results in increased lipidation of MAP1LC3B protein
bafilomycin A1 inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]		 CTD PMID:36754226 NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069 		JBrowse link
cisplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 multiple interactions EXP Cisplatin inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306] CTD PMID:24800945 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects response to substance EXP AIFM1 protein affects the susceptibility to Cisplatin CTD PMID:15983031 NCBI chr  X:106,676,596...106,708,290
Ensembl chr  X:106,670,520...106,708,317 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization		 EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP2 caspase 2 increases expression EXP Cisplatin results in increased expression of CASP2 CTD PMID:12712633 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,941,937...6,966,061 		JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
increases activity		 EXP Cisplatin results in increased expression of CASP3
[Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein; Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:12712633 PMID:16316343 PMID:20435919 PMID:21497595 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP8 caspase 8 increases activity
increases expression
multiple interactions		 EXP Cisplatin results in increased activity of CASP8 protein
Cisplatin results in increased expression of CASP8
Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]		 CTD PMID:12712633 PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CASP9 caspase 9 increases expression
increases activity		 EXP Cisplatin results in increased expression of CASP9
Cisplatin results in increased activity of CASP9 protein		 CTD PMID:12712633 PMID:20435919 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions		 EXP Cisplatin affects the localization of CYCS protein
Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein]		 CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G EPO erythropoietin multiple interactions EXP [Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein CTD PMID:21497595 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP Cisplatin results in increased expression of FAS mRNA CTD PMID:20435919 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FASLG Fas ligand multiple interactions
affects localization		 EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein] CTD PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:20732396 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity
multiple interactions		 EXP Cisplatin results in increased activity of PARP1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in increased activity of PARP1 protein]		 CTD PMID:25806124 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases activity
multiple interactions		 EXP Cisplatin results in decreased activity of PPARA protein
[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified; Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein]		 CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Cisplatin results in increased expression of TNF mRNA CTD PMID:20435919 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP Cisplatin results in increased expression of TP53
mangostin inhibits the reaction [Cisplatin results in increased expression of TP53]		 CTD PMID:12712633 PMID:20603111 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
disulfiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]; Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Disulfiram inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] CTD PMID:10975995 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552 		JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116 		JBrowse link
hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 decreases activity
multiple interactions		 EXP Hydrogen Peroxide results in decreased activity of ALDH7A1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]; Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]; NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]		 CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] CTD PMID:15191356 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CAT catalase decreases response to substance
multiple interactions		 EXP CAT results in decreased susceptibility to Hydrogen Peroxide
CAT protein inhibits the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]		 CTD PMID:11039594 PMID:18086661 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Hydrogen Peroxide results in increased expression of CXCL8 mRNA CTD PMID:22083491 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Hydrogen Peroxide results in increased expression of FOS mRNA CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP Hydrogen Peroxide results in increased expression of HSPA5 protein
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]; nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]		 CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:11325585 PMID:21798251 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11325585 PMID:21798251 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein CTD PMID:11325585 PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein CTD PMID:11325585 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [sodium arsenite results in increased activity of SOD1 protein] which results in increased abundance of Hydrogen Peroxide CTD PMID:12530527 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Hydrogen Peroxide results in increased expression of TNF mRNA CTD PMID:22083491 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
laminarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21948611 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 decreases response to substance EXP IL4 protein results in decreased susceptibility to Melitten CTD PMID:20017192 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G PLA2G1B phospholipase A2 group IB increases activity EXP Melitten results in increased activity of PLA2G1B protein CTD PMID:9092818 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G SELE selectin E increases expression EXP Melitten results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] CTD PMID:10617950 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] CTD PMID:14519784 PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]		 CTD PMID:18845708 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA] CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein
caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]		 CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SELE selectin E multiple interactions
increases expression		 EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA] CTD PMID:18845708 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G TNF tumor necrosis factor multiple interactions
increases activity		 EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
notoginsenoside R1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 decreases expression EXP notoginsenoside R1 results in decreased expression of IL10 protein CTD PMID:25721049 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL4 interleukin 4 decreases expression EXP notoginsenoside R1 results in decreased expression of IL4 protein CTD PMID:25721049 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
phenylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUOX2 dual oxidase 2 affects folding EXP oxophenylarsine affects the folding of DUOX2 protein CTD PMID:10601291 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP oxophenylarsine results in increased expression of HIF1A protein CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G INS insulin multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid] CTD PMID:1928324 PMID:8048502 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G NOS3 nitric oxide synthase 3 decreases phosphorylation
affects localization		 EXP oxophenylarsine results in decreased phosphorylation of NOS3 protein
oxophenylarsine affects the localization of NOS3 protein		 CTD PMID:9546377 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of CXCL8 protein CTD PMID:15912099 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G EDN1 endothelin 1 multiple interactions
increases expression		 EXP Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein CTD PMID:11325585 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein CTD PMID:11325585 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein CTD PMID:11325585 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 EXP Tetradecanoylphorbol Acetate results in decreased expression of PPARA; Tetradecanoylphorbol Acetate results in decreased expression of PPARA protein
calphostin C promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]		 CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239 		JBrowse link
G PRKCB protein kinase C beta decreases phosphorylation EXP Tetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB protein CTD PMID:15089098 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264 		JBrowse link
G PRKCD protein kinase C delta increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein CTD PMID:15089098 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
G SELE selectin E increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELE protein CTD PMID:16797888 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELP protein CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of VCAM1 protein CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]
Simvastatin results in decreased expression of HMGCR mRNA		 CTD PMID:17130282 PMID:19343539 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957 		JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression		 EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]
Simvastatin results in increased expression of LDLR mRNA		 CTD PMID:17130282 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827 		JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA] CTD PMID:17130282 NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,922...50,757,649 		JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Simvastatin results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,570,010...241,611,727 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA CTD PMID:17130282 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA] CTD PMID:17130282 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671 		JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
T-2 toxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP T-2 Toxin results in increased expression of ATF4 protein CTD PMID:34637808 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression		 EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP T-2 Toxin results in increased expression of DDIT3 protein CTD PMID:34637808 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2AK3 protein CTD PMID:34637808 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2S1 protein CTD PMID:34637808 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression EXP T-2 Toxin results in decreased expression of HSPA5 protein CTD PMID:34637808 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        biochemical role 4938
          apoptosis inducer 76
            (-)-coronaridine + 0
            (-)-epigallocatechin 3-gallate + 10
            (-)-noscapine 0
            (20S)-ginsenoside Rg3 + 0
            (20S)-ginsenoside Rh2 0
            (25R)-cholest-5-ene-3beta,26-diol + 1
            (2E)-2-benzylidene-3-(cyclohexylamino)indan-1-one 0
            (2E,4E)-deca-2,4-dienal 0
            (9E,11E)-octadecadienoic acid + 0
            (E)-2-[[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]benzoic acid 0
            (E)-3-tosylacrylonitrile 0
            (E)-trans-miyabenol C 0
            (E,E)-germacrone 0
            (R)-amygdalin 0
            1,3,6,8-tetraazatricyclo[6.2.1.1(3,6)]dodecane 0
            1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine 0
            1-stearoyl-sn-glycero-3-phosphocholine 0
            10058-F4 0
            18-hydroxyoctadecanoic acid + 0
            2'-hydroxybiochanin A 0
            2,4-dihydroxy-6-methylbenzaldehyde 0
            2-acetamidophenol 0
            2-amino-3-cyano-7-(dimethylamino)-4-(2-methoxyphenyl)-4H-chromene 0
            2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene 0
            2-hydroxymelatonin 0
            2-hydroxyoleic acid 0
            3,3',5,5'-tetraiodothyroacetic acid 0
            3,3'-dimethylquercetin 0
            3,4'-dimethylkaempferol 0
            3PO 0
            4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
            4-hydroxy-TEMPO + 2
            4-hydroxycinnamaldehyde 0
            4-iodo-6-phenylpyrimidine 0
            4-methoxy-TEMPO 0
            4-phenylbutyric acid 11
            4-terpineol + 0
            5-(N,N-hexamethylene)amiloride 0
            5-(tetradecyloxy)-2-furoic acid 0
            6-diazo-5-oxo-L-norleucine 0
            ABT-737 0
            AEE788 0
            AM-251 0
            AMG-925 0
            AOH1996 0
            AS1842856 0
            ASP-3026 0
            AZD-8055 0
            AZD1080 0
            AZD3463 0
            BAR0329 0
            BAY11-7085 0
            BCI-215 0
            BDA-366 0
            BMS-214662 0
            C-1027 chromophore 0
            C646 0
            C75 0
            CAN-508 0
            CBL0137 0
            CCT-018159 0
            CD437 + 0
            CG-1521 0
            CHIR-98014 0
            CIGB-300 0
            CP-724714 0
            CX-5461 0
            Fasnall 0
            GANT61 0
            GDC-0623 0
            GI254023X 0
            GSK343 0
            HT-2 toxin + 6
            ICRF-193 0
            JM335 0
            JQ1 0
            JTE-607 dihydrochloride 0
            JTE-607 free base 0
            KP1019 0
            KP1339 0
            KRIBB11 0
            KU-55933 0
            Ki11502 0
            LB42908 0
            LCL161 0
            LDC4297 0
            LFM-A13 0
            LY-2090314 0
            LY3009120 0
            MI-63 0
            MK-8353 0
            MP-A08 0
            N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine 9
            N-(5-\{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl\}-1,3-thiazol-2-yl)piperidine-4-carboxamide 0
            N-methyl-4-phenylpyridinium 0
            N-methylparoxetine 0
            N-nitrosopiperidine 0
            N-oleoyltaurine 0
            N-succinimidyl N-methylcarbamate 0
            NNC 55-0396 (free base) + 0
            NNC 55-0396 dihydrochloride 0
            NSC 23766 + 0
            NSC 23766 trihydrochloride 0
            OSU-03012 0
            PABA/NO 0
            PB28 0
            PD-166866 + 0
            PJ34 0
            PJ34 hydrochloride 0
            Ro 41-5253 0
            S-acetylglutathione 0
            SB 415286 0
            SB-202190 0
            SC560 0
            SCH772984 0
            SKF-96365 hydrochloride 0
            SM-164 0
            SN-38 + 0
            SR9243 0
            STM2457 0
            T-2 toxin 6
            TAK-580 0
            TAK-632 0
            TDZD-8 0
            TG101209 0
            THZ531 0
            U0126 + 0
            U0126.EtOH 0
            VX-745 0
            XPO1-IN-1 0
            ZM447439 0
            acalabrutinib 0
            aclacinomycin A 0
            aclacinomycin A zwitterion 0
            actinodaphnine 0
            akebia saponin D 0
            alantolactone + 0
            allyl isothiocyanate 0
            alpha-tocopheryloxyacetic acid 0
            alsterpaullone 0
            alvocidib 0
            alvocidib hydrochloride 0
            amrubicinol 0
            anacardic acid 0
            antimony trichloride 0
            aphidicolin 0
            atromentin 0
            auraptene 0
            avenanthramide B 0
            b-AP15 0
            bafilomycin A1 2
            baicalein + 0
            beta-tocotrienol 0
            bigelovin 0
            binimetinib 0
            bis(S-citronellalthiosemicarbazonato)nickel(II) 0
            bixin + 0
            bleomycin A5 0
            borrelidin 0
            brazilin 0
            brivanib + 0
            brivanib alaninate 0
            cadiyenol 0
            cafestol 0
            calmidazolium + 0
            calmidazolium chloride 0
            cantharidic acid 0
            carminomycin + 0
            carnosic acid 0
            casticin 0
            chrysazin + 0
            cis-9-nonadecenoic acid 0
            cisplatin 18
            columbianadin 0
            copanlisib + 0
            copanlisib dihydrochloride 0
            cratoxylumxanthone C 0
            crenolanib 0
            cytotrienin A 0
            deguelin 0
            dehydrocostus lactone 0
            delanzomib 0
            delphinidin 3-O-beta-D-sambubioside 0
            delta-elemene 0
            delta-tocotrienol 0
            deoxypodophyllotoxin 0
            devazepide 0
            diallyl trisulfide 0
            dibromoacetic acid 0
            diethyl sulfate 0
            dioscin 0
            diosgenin + 0
            diosmetin + 0
            disulfiram 2
            dolastatin 10 0
            dutomycin 0
            ebselen 2
            edelfosine 0
            elesclomol + 0
            elesclomol-Cu(II) 0
            eltanexor 0
            entinostat + 0
            entrectinib 0
            epothilone B 0
            ethyl 3,4-dihydroxybenzoate 0
            eugenol + 0
            eupatorin 0
            flavokawain B 0
            fluazinam 0
            fraxetin + 0
            galactoxylomannan 0
            gallic acid + 10
            gamma-tocotrienol 0
            ghrelin 0
            gilteritinib 0
            ginsenoside F2 0
            ginsenoside Rd + 0
            ginsenoside Rf 0
            gnidilatimonoein 0
            guttiferone F 0
            harmol + 0
            helveticoside 0
            herbacetin 0
            herbimycin 0
            hexadecan-2-ol 0
            hispidulin 0
            hydrogen peroxide + 13
            hyperforin 0
            iberin 0
            icariside II 0
            idelalisib 0
            ikarugamycin + 0
            imatinib + 0
            imatinib methanesulfonate 0
            indirubin 0
            irinotecan 0
            irinotecan hydrochloride (anhydrous) + 0
            irinotecan hydrochloride hydrate 0
            isoalantolactone 0
            isorhamnetin 3-O-robinobioside 0
            isosilybin A 0
            ixazomib + 0
            ixazomib citrate 0
            jaceosidin 0
            jadomycin B 0
            jaspamide 0
            kaempferol 3,7-di-O-alpha-L-rhamnoside 0
            kahweol 0
            laminarin 1
            lancovutide 0
            laurinterol + 0
            licocoumarone 0
            lificiguat 0
            lobaplatin 0
            lupulone 0
            luteolin + 0
            mancozeb 0
            manumycin A 0
            mefuparib 0
            mefuparib hydrochloride 0
            melittin 3
            methoxyacetic acid 0
            methyl gamma-linolenate 0
            methyl isocyanate + 0
            methyl methanesulfonate 0
            mevastatin + 6
            midazolam + 0
            midazolam hydrochloride 0
            miltefosine 0
            mitoguazone 0
            mitoguazone hydrochloride + 0
            mitoguazone hydrochloride hydrate 0
            mocetinostat 0
            momelotinib 0
            motixafortide + 0
            motixafortide acetate 0
            myriocin 0
            myristoleic acid + 0
            naphthazarin 0
            natamycin 0
            navitoclax 0
            neral + 0
            niclosamide 0
            niraparib 0
            nitrosulindac 0
            nitryl chloride 0
            norsalsolinol + 0
            nortriptyline 0
            notoginsenoside R1 2
            olaparib 0
            oleocanthal 0
            oleuropein + 0
            omacetaxine mepesuccinate 0
            oncrasin-1 0
            ophiobolin C 0
            oridonin 0
            pannarin 0
            pectolinarin 0
            peonidin + 0
            peonidin chloride 0
            pevonedistat 0
            phenylarsine oxide 4
            phorbol 13-acetate 12-myristate 11
            physalin F 0
            physcion + 0
            piceatannol + 0
            pipercallosidine 0
            pipercallosine 0
            piperyline 0
            pirtobrutinib 0
            plaunotol 0
            plinabulin 0
            poziotinib 0
            pracinostat 0
            prodigiosin 0
            pterostilbene 0
            pyoluteorin 0
            rigosertib 0
            rigosertib sodium 0
            roducitabine 0
            rottlerin 0
            rotundifuran 0
            rubimaillin 0
            salvianolic acid B 0
            saracatinib 0
            scalaradial 0
            sclareol 0
            selinexor 0
            sepantronium bromide 0
            soblidotin 0
            sodium gallate 0
            sodium methoxyacetate 0
            solanine 0
            solasodine + 0
            solasodine(1+) 0
            staurosporine + 0
            sulindac + 2
            sulindac sulfide 0
            sulindac sulfone 0
            survivin suppressant + 0
            tabernaemontanine 0
            tabtoxinine beta-lactam + 0
            tafenoquine 0
            talmapimod 0
            tanespimycin 0
            tetrazolium violet 0
            thallium(I) acetate 0
            theasinensin A 0
            tideglusib 0
            tilimycin 0
            tipifarnib 0
            tirapazamine 0
            toxoflavin 0
            toyocamycin 0
            trans-rhaponticin + 0
            tributyrin 0
            trichothecin 0
            triptohypol C 0
            trisodium vanadate 0
            tyloxapol 0
            tyrphostin B42 0
            undecylprodigiosin 0
            venetoclax 0
            violacein 0
            vitetrifolin D 0
            vitexilactone 0
            vorinostat 0
            wedelolactone 0
            withaferin A + 0
            xanthohumol 0
            ziram 0
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