CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: apoptosis inhibitor
Accession: CHEBI:68494
browse the term
Definition: Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms.
Synonyms: related_synonym: Type I cell-death inhibitor; Type I cell-death inhibitors; Type I programmed cell-death inhibitor; Type I programmed cell-death inhibitors; apoptosis inhibitors
G
NR1I3
nuclear receptor subfamily 1 group I member 3
increases activity
EXP
Diethylhexyl Phthalate results in increased activity of NR1I3 protein
CTD
PMID:27732639
NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
G
ADRB2
adrenoceptor beta 2
multiple interactions
EXP
[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine
CTD
PMID:2884805
NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
G
NPPA
natriuretic peptide A
increases expression
EXP
Propranolol results in increased expression of NPPA protein
CTD
PMID:2566282
NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
G
REN
renin
multiple interactions decreases activity
EXP
Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] Propranolol results in decreased activity of REN protein
CTD
PMID:2566282 PMID:6103674
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
G
VIP
vasoactive intestinal peptide
decreases expression
EXP
Propranolol results in decreased expression of VIP protein
CTD
PMID:2566282
NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
G
CNR2
cannabinoid receptor 2
affects binding
EXP
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to CNR2 protein
CTD
PMID:21871882
NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
501
role
501
biological role
501
biochemical role
460
apoptosis inhibitor
6
(+)-schisandrin B
0
(4Z,7Z,10Z,12E,14S,16Z,19Z,21R)-dihydroxydocosahexaenoic acid
0
(E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside
0
(Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid
0
GRI977143
0
Genipin
0
HU-308
0
JWH-133
0
PR-39
0
WIN 55212-2
1
Z-DEVD-FMK
0
Z-Val-Ala-Asp(OMe)-CH2F
0
Z-Val-Phe-H
0
abyssinone I
0
aspartame
0
beauvericin
0
bis(2-ethylhexyl) phthalate
1
bis(7)-tacrine
0
bongkrekic acid
0
carboxy-PTIO
0
ferulic acid +
0
fostriecin
0
fraxetin +
0
fucoidan
0
fucoxanthin
0
gentisyl alcohol
0
ginsenoside F1
0
ginsenoside Rb1
0
isoformononetin
0
molsidomine
0
naphthalene +
4
p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
0
potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide
0
protectin D1 +
0
salvigenin
0
sodium ferulate
0
suramin
0
suramin sodium
0
tauroursodeoxycholic acid
0
tepoxalin
0
tetramethylpyrazine
0
triacsin C
0
tropisetron
0
tropisetron hydrochloride
0
zofenopril
0
zofenopril calcium
0
zofenoprilat
0
zofenoprilat arginine
0