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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrimidine deoxyribonucleoside
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Accession:CHEBI:68472 term browser browse the term
Definition:A deoxyribonucleoside containing a pyrimidine base.
Synonyms:related_synonym: pyrimidine deoxyribonucleosides
 xref: MetaCyc:Pyrimidine-Deoxyribonucleosides


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2'-deoxycytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556, PMID:9403342 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Dck deoxycytidine kinase affects binding ISO Deoxycytidine binds to DCK protein CTD PMID:17530837 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Slc28a1 solute carrier family 28 member 1 increases transport ISO SLC28A1 protein results in increased transport of Deoxycytidine CTD PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
5-bromo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of ARHGEF26 mRNA CTD PMID:24910943 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 decreases expression ISO Bromodeoxyuridine results in decreased expression of ATOH8 mRNA CTD PMID:24910943 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of BAX mRNA CTD PMID:24910943 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of BIRC5 mRNA CTD PMID:24910943 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of CDKN1A mRNA CTD PMID:24910943 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces2c carboxylesterase 2C multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of CES2C mRNA CTD PMID:24910943 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Dnase1 deoxyribonuclease 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of DNASE1 mRNA CTD PMID:24910943 NCBI chr10:11,757,681...11,760,672
Ensembl chr10:11,757,682...11,760,620
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP6 mRNA CTD PMID:24910943 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP8 mRNA CTD PMID:24910943 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 increases expression ISO Bromodeoxyuridine results in increased expression of ELOVL6 mRNA CTD PMID:24910943 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Fam47e family with sequence similarity 47, member E increases expression ISO Bromodeoxyuridine results in increased expression of FAM47E mRNA CTD PMID:24910943 NCBI chr14:16,991,496...17,027,563 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GCLC mRNA CTD PMID:24910943 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GDF15 mRNA CTD PMID:24910943 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA CTD PMID:24910943 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta6 glutathione S-transferase alpha 6 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA CTD PMID:24910943 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO [Bromodeoxyuridine co-treated with furan] affects the expression of HMGCR mRNA
Bromodeoxyuridine results in increased expression of HMGCR mRNA
CTD PMID:24910943 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 affects abundance
multiple interactions
ISO HMOX1 protein affects the abundance of Bromodeoxyuridine
[Bromodeoxyuridine co-treated with furan] results in increased expression of HMOX1 mRNA
CTD PMID:17401437, PMID:24910943 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Bromodeoxyuridine CTD PMID:16960656 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Itga5 integrin subunit alpha 5 increases expression ISO Bromodeoxyuridine results in increased expression of ITGA5 mRNA; Bromodeoxyuridine results in increased expression of ITGA5 protein CTD PMID:7519154 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of JUN mRNA CTD PMID:24910943 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mogat2 monoacylglycerol O-acyltransferase 2 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of MOGAT2 mRNA CTD PMID:24910943 NCBI chr 1:164,181,762...164,205,222
Ensembl chr 1:164,181,764...164,205,222
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Bromodeoxyuridine results in increased expression of MSMO1 mRNA CTD PMID:24910943 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of MYC mRNA CTD PMID:24910943 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TNFRSF10B mRNA CTD PMID:24910943 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 increases expression ISO Bromodeoxyuridine results in increased expression of NMRK1 mRNA CTD PMID:24910943 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of NQO1 mRNA CTD PMID:24910943 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G P2ry1 purinergic receptor P2Y1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of P2RY1 mRNA CTD PMID:24910943 NCBI chr 2:151,314,818...151,320,312
Ensembl chr 2:151,314,818...151,320,319
JBrowse link
G Pax3 paired box 3 increases response to substance ISO PAX3 gene polymorphism results in increased susceptibility to Bromodeoxyuridine CTD PMID:3902948 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
JBrowse link
G Scgb1c1 secretoglobin, family 1C, member 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of SCGB1C1 mRNA CTD PMID:24910943 NCBI chr 1:213,595,240...213,596,459
Ensembl chr 1:213,595,240...213,596,459
JBrowse link
G Slc17a8 solute carrier family 17 member 8 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] affects the expression of SLC17A8 mRNA CTD PMID:24910943 NCBI chr 7:30,215,231...30,274,993
Ensembl chr 7:30,216,104...30,274,984
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Bromodeoxyuridine results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sqle squalene epoxidase increases expression ISO Bromodeoxyuridine results in increased expression of SQLE mRNA CTD PMID:24910943 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of SRXN1 mRNA CTD PMID:24910943 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stmn1 stathmin 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of STMN1 mRNA CTD PMID:24910943 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TNFRSF12A mRNA CTD PMID:24910943 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Trib3 tribbles pseudokinase 3 decreases expression ISO Bromodeoxyuridine results in decreased expression of TRIB3 mRNA CTD PMID:24910943 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tubb2a tubulin, beta 2A class IIa multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TUBB2A mRNA CTD PMID:24910943 NCBI chr17:31,493,145...31,496,827
Ensembl chr17:31,493,107...31,498,651
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Bromodeoxyuridine co-treated with furan] results in increased expression of TXNRD1 mRNA CTD PMID:24910943 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vsnl1 visinin-like 1 decreases response to substance ISO VSNL1 protein results in decreased susceptibility to Bromodeoxyuridine CTD PMID:20419170 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
5-iodo-2'-deoxyuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects response to substance ISO MBD4 protein affects the susceptibility to Idoxuridine CTD PMID:16885370 NCBI chr 4:147,744,673...147,756,462
Ensembl chr 4:147,746,186...147,756,294
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Idoxuridine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions EXP Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:8713072 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Tyms thymidylate synthetase affects uptake ISO TYMS protein affects the uptake of Idoxuridine CTD PMID:15001691 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
doxifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Anxa8 annexin A8 decreases response to substance ISO ANXA8 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Dapk1 death associated protein kinase 1 increases response to substance ISO DAPK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression
affects response to substance
decreases response to substance
multiple interactions
ISO doxifluridine affects the expression of DPYD mRNA
DPYD protein affects the susceptibility to doxifluridine
DPYD protein results in decreased susceptibility to doxifluridine
[Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA
CTD PMID:16646564, PMID:16734730, PMID:18630517 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Elf3 E74 like ETS transcription factor 3 increases response to substance ISO ELF3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Etnk1 ethanolamine kinase 1 increases response to substance ISO ETNK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:177,402,904...177,447,047
Ensembl chr 4:177,402,904...177,447,028
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:46,955,460...46,969,468
Ensembl chr10:46,955,487...46,969,406
JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 5:154,269,296...154,286,545
Ensembl chr 5:154,269,118...154,286,544
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance ISO HIF1A protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine CTD PMID:15301717 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:87,019,598...87,027,720
Ensembl chr 1:87,019,975...87,027,691
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nme7 NME/NM23 family member 7 decreases response to substance ISO NME7 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
G Osmr oncostatin M receptor decreases response to substance ISO OSMR protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases response to substance ISO PLOD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:110,557,798...110,585,424
Ensembl chr10:110,557,729...110,585,376
JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:178,940,515...179,010,257
Ensembl chr 1:178,940,516...179,010,257
JBrowse link
G Sinhcaf SIN3-HDAC complex associated factor increases response to substance ISO SINHCAF protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:183,401,314...183,426,439
Ensembl chr 4:183,401,318...183,426,439
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine
CTD PMID:16397116, PMID:17988526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases metabolic processing
increases response to substance
affects expression
ISO
EXP
[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] which results in decreased susceptibility to doxifluridine; [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine; [Paclitaxel co-treated with doxifluridine] affects the expression of TYMP mRNA; [TYMP protein results in increased expression of IFNA1 mRNA] which results in increased susceptibility to doxifluridine; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine; doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
TYMP protein results in increased metabolism of doxifluridine
TYMP protein results in increased susceptibility to doxifluridine
doxifluridine affects the expression of TYMP mRNA
CTD PMID:15301717, PMID:15864645, PMID:16457948, PMID:17988526, PMID:18630517, PMID:21804305 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase affects expression
multiple interactions
decreases response to substance
ISO doxifluridine affects the expression of TYMS mRNA
[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to doxifluridine
CTD PMID:16734730, PMID:18630517 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions ISO 5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine CTD PMID:16397116 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
dTDP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gale UDP-galactose-4-epimerase affects binding ISO thymidine 5'-diphosphate binds to GALE protein CTD PMID:25526675 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [thymidine 5'-diphosphate co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 9:11,165,006...11,240,329
Ensembl chr 9:11,164,715...11,339,790
JBrowse link
dTMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO [Fluorouracil results in decreased activity of TYMS protein] which results in decreased abundance of Thymidine Monophosphate CTD PMID:29258758 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
floxuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance
ISO APEX1 protein mutant form results in increased susceptibility to Floxuridine
APEX1 protein results in decreased susceptibility to Floxuridine
CTD PMID:19470598, PMID:22194930 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR protein results in decreased susceptibility to Floxuridine CTD PMID:21613406, PMID:22194930 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Floxuridine CTD PMID:25354864 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406, PMID:22194930 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases activity
ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein
Floxuridine results in increased activity of CHEK2 protein
CTD PMID:21613406, PMID:22194930 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
decreases response to substance
ISO olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Msh2 mutS homolog 2 multiple interactions
decreases response to substance
ISO olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Floxuridine CTD PMID:18202788 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases response to substance ISO PARP1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance
decreases response to substance
ISO TIMP3 protein affects the susceptibility to Floxuridine
TIMP3 gene modified form results in decreased susceptibility to Floxuridine
CTD PMID:18202788 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Floxuridine results in increased expression of TK1 protein CTD PMID:16951200 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Floxuridine results in increased expression of TP53 protein CTD PMID:19015155 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tyms thymidylate synthetase affects response to substance
increases response to substance
decreases response to substance
ISO TYMS protein affects the susceptibility to Floxuridine
TYMS results in increased susceptibility to Floxuridine
TYMS protein results in decreased susceptibility to Floxuridine
CTD PMID:2537495, PMID:10482907, PMID:15040806, PMID:17018589 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ung uracil-DNA glycosylase affects expression
increases response to substance
affects stability
ISO Floxuridine affects the expression of UNG mRNA; Floxuridine affects the expression of UNG protein
UNG protein results in increased susceptibility to Floxuridine
Floxuridine affects the stability of UNG protein alternative form
CTD PMID:16951200 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases response to substance ISO XRCC1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406, PMID:22194930 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Floxuridine CTD PMID:21785230 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
gemcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO gemcitabine results in increased expression of A2M protein CTD PMID:20531411 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Acp3 acid phosphatase 3 decreases expression ISO gemcitabine results in decreased expression of ACP3 protein CTD PMID:20531411 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein] CTD PMID:20726858 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO gemcitabine results in increased expression of ADIPOQ protein CTD PMID:20531411 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO gemcitabine results in decreased expression of AFP protein CTD PMID:20531411 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 decreases expression ISO gemcitabine results in decreased expression of AGPAT2 mRNA CTD PMID:17039268 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO AKT1 protein affects the susceptibility to gemcitabine
[gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with gemcitabine] results in decreased phosphorylation of AKT1 protein
CTD PMID:15867245, PMID:29782821 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of ALDH1A1 protein
sulforafan promotes the reaction [gemcitabine results in decreased expression of ALDH1A1 protein]
CTD PMID:20940707 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO gemcitabine results in increased expression of ALDH1A3 mRNA CTD PMID:17039268 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO gemcitabine results in increased expression of ALDH6A1 mRNA CTD PMID:17039268 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 increases expression ISO gemcitabine results in increased expression of ANAPC1 mRNA CTD PMID:17039268 NCBI chr 3:121,147,484...121,226,125
Ensembl chr 3:121,147,547...121,226,125
JBrowse link
G Ank3 ankyrin 3 increases expression ISO gemcitabine results in increased expression of ANK3 mRNA CTD PMID:17039268 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO gemcitabine results in increased expression of ANKRD1 mRNA CTD PMID:17039268 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 affects expression ISO gemcitabine affects the expression of ANTXR1 mRNA CTD PMID:17039268 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO gemcitabine results in decreased expression of APCS protein CTD PMID:20531411 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575
JBrowse link
G Apoh apolipoprotein H increases expression ISO gemcitabine results in increased expression of APOH protein CTD PMID:20531411 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G Ar androgen receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
increases cleavage
decreases response to substance
ISO ADAM17 protein promotes the reaction [gemcitabine results in increased cleavage of AREG protein]
gemcitabine results in increased expression of AREG protein
AREG protein results in decreased susceptibility to gemcitabine
CTD PMID:20726858 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arf1 ADP-ribosylation factor 1 decreases expression ISO gemcitabine results in decreased expression of ARF1 mRNA CTD PMID:17039268 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases expression ISO gemcitabine results in increased expression of ARNT mRNA CTD PMID:20103597 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO gemcitabine results in increased expression of ATF3 mRNA CTD PMID:17039268 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Axin2 axin 2 affects expression ISO gemcitabine affects the expression of AXIN2 mRNA CTD PMID:20103597 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Axl Axl receptor tyrosine kinase multiple interactions ISO AXL protein promotes the reaction [Warfarin results in increased susceptibility to gemcitabine] CTD PMID:26206560 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [alvocidib co-treated with gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein CTD PMID:15770523, PMID:17671697, PMID:20523344, PMID:21570961 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of BCL2 protein
[alvocidib co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with gemcitabine] results in decreased expression of BCL2 protein; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [gemcitabine results in decreased expression of BCL2 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein
CTD PMID:15476743, PMID:15645133, PMID:15770523, PMID:16929163, PMID:17440100, PMID:20523344, PMID:21570961 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
gemcitabine results in decreased expression of BCL2L1 protein
CTD PMID:15476743, PMID:16929163, PMID:17440100 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO gemcitabine results in increased expression of BCL2L11 mRNA CTD PMID:17039268 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO gemcitabine results in increased expression of BCL6 mRNA CTD PMID:17039268 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO gemcitabine results in decreased expression of BDNF protein CTD PMID:20531411 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO gemcitabine results in increased cleavage of BID protein CTD PMID:14750167 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO gemcitabine results in increased expression of BIRC2 mRNA CTD PMID:17039268 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects expression
multiple interactions
ISO gemcitabine affects the expression of BIRC3 mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
CTD PMID:17039268, PMID:17440100 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16929163, PMID:17440100 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO gemcitabine results in increased expression of BNIP3L mRNA CTD PMID:17039268 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO gemcitabine results in decreased expression of BRAF mRNA CTD PMID:20103597 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression
decreases response to substance
ISO gemcitabine results in increased expression of BRCA1 mRNA
BRCA1 results in decreased susceptibility to gemcitabine
CTD PMID:20103597, PMID:21771338 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
increases cleavage
ISO gemcitabine results in increased activity of CASP3 protein
gemcitabine results in increased expression of CASP3 protein modified form
[10-propargyl-10-deazaaminopterin co-treated with gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein
gemcitabine results in increased cleavage of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with gemcitabine] results in increased expression of CASP3 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [vorinostat co-treated with gemcitabine] results in increased activity of CASP3 protein; gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:15770523, PMID:16153448, PMID:16467107, PMID:17159604, PMID:17440100, PMID:18089714, PMID:20299819, PMID:20699664, PMID:20798217, PMID:21418860, PMID:26050647, PMID:29782821 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP6 protein CTD PMID:20699664 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP8 protein; [gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein; gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
gemcitabine results in increased cleavage of CASP8 protein
gemcitabine results in increased activity of CASP8 protein
CTD PMID:12479703, PMID:14750167, PMID:17159604, PMID:17671697, PMID:18089714, PMID:20699664, PMID:26894857 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
ISO [Calcitriol co-treated with gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein
gemcitabine results in increased cleavage of CASP9 protein
CTD PMID:12479703, PMID:15476743, PMID:15726400, PMID:17159604, PMID:17440100, PMID:20699664, PMID:21418860, PMID:26050647 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO gemcitabine results in decreased expression of CCL2 protein CTD PMID:20531411 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO gemcitabine results in increased expression of CCL20 mRNA CTD PMID:17039268 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CCL3 protein CTD PMID:20531411 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO gemcitabine results in decreased expression of CCNB1 mRNA
gemcitabine results in increased expression of CCNB1 protein
CTD PMID:11504793, PMID:20103597 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [gemcitabine results in decreased expression of CCND1 protein]
gemcitabine results in decreased expression of CCND1 mRNA; gemcitabine results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
CTD PMID:16060994, PMID:17039268, PMID:17440100 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO gemcitabine results in increased expression of CCNG2 mRNA CTD PMID:17039268 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd40 CD40 molecule decreases expression ISO gemcitabine results in decreased expression of CD40 mRNA; gemcitabine results in decreased expression of CD40 protein CTD PMID:17039268, PMID:20531411 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO gemcitabine results in decreased expression of CD40LG protein CTD PMID:20531411 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cda cytidine deaminase affects response to substance
multiple interactions
ISO CDA protein affects the susceptibility to gemcitabine
[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine; CDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]
CTD PMID:18728667, PMID:22973962 NCBI chr 5:156,703,579...156,734,541
Ensembl chr 5:156,703,579...156,734,541
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein CTD PMID:20103597 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 increases expression ISO gemcitabine results in increased expression of CDH1 mRNA CTD PMID:17039268 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [alvocidib co-treated with gemcitabine] results in increased expression of CDKN1A protein; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [gemcitabine results in increased expression of CDKN1A protein]
gemcitabine results in increased expression of CDKN1A mRNA; gemcitabine results in increased expression of CDKN1A protein
CTD PMID:15476743, PMID:15770523, PMID:16601104, PMID:17039268, PMID:25189999 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases response to substance ISO CDKN1B results in decreased susceptibility to gemcitabine CTD PMID:21652059 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO gemcitabine results in increased expression of CEBPB mRNA CTD PMID:17039268 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrdl2 chordin-like 2 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein CTD PMID:24979617 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435
JBrowse link
G Ckb creatine kinase B decreases expression ISO gemcitabine results in decreased expression of CKB mRNA CTD PMID:17039268 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clic4 chloride intracellular channel 4 increases expression ISO gemcitabine results in increased expression of CLIC4 mRNA CTD PMID:17039268 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869
JBrowse link
G Clu clusterin affects response to substance
increases expression
ISO CLU protein affects the susceptibility to gemcitabine
gemcitabine results in increased expression of CLU protein
CTD PMID:19007378 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions
increases expression
ISO BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO gemcitabine results in decreased expression of CSF2 protein CTD PMID:20531411 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression ISO gemcitabine results in decreased expression of CSF3 protein CTD PMID:20531411 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression ISO gemcitabine results in increased expression of CSRP2 mRNA CTD PMID:17039268 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression ISO gemcitabine results in increased expression of CTHRC1 mRNA CTD PMID:17039268 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO gemcitabine results in increased expression of CTNNB1 mRNA CTD PMID:25605917 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO gemcitabine results in increased expression of CXCL2 mRNA CTD PMID:17039268 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO gemcitabine results in increased expression of CXCL1 mRNA CTD PMID:17039268 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 affects expression ISO gemcitabine affects the expression of CXCR4 mRNA CTD PMID:20103597 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression ISO gemcitabine results in decreased expression of CYP24A1 mRNA CTD PMID:17039268 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects expression ISO gemcitabine affects the expression of DDIT4 mRNA CTD PMID:17039268 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dhx9 DExH-box helicase 9 decreases expression ISO gemcitabine results in decreased expression of DHX9 mRNA CTD PMID:17039268 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO gemcitabine results in increased expression of DLG2 mRNA CTD PMID:17039268 NCBI chr 1:154,916,274...157,274,077
Ensembl chr 1:156,552,328...157,269,747
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; DNMT1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein CTD PMID:25189999 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO [TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine CTD PMID:18728667 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO gemcitabine results in decreased expression of DYNC1H1 mRNA CTD PMID:17039268 NCBI chr 6:134,958,854...135,085,769
Ensembl chr 6:134,958,854...135,085,769
JBrowse link
G Edn1 endothelin 1 decreases expression ISO gemcitabine results in decreased expression of EDN1 protein CTD PMID:20531411 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 decreases expression ISO gemcitabine results in decreased expression of EDN2 mRNA CTD PMID:17039268 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Egf epidermal growth factor multiple interactions
decreases expression
ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
gemcitabine results in decreased expression of EGF protein
CTD PMID:20531411, PMID:21613822 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
increases expression
decreases expression
increases degradation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
gemcitabine results in increased phosphorylation of EGFR protein
gemcitabine results in increased expression of EGFR mRNA
gemcitabine results in decreased expression of EGFR mRNA; gemcitabine results in decreased expression of EGFR protein
gemcitabine results in increased degradation of EGFR protein
CTD PMID:17146438, PMID:20103597, PMID:20726858, PMID:21541241 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 increases expression ISO gemcitabine results in increased expression of EGR1 mRNA CTD PMID:17039268 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO gemcitabine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO gemcitabine results in increased expression of ETV1 mRNA CTD PMID:17039268 NCBI chr 6:58,467,215...58,558,640
Ensembl chr 6:58,467,254...58,558,631
JBrowse link
G Evi2b ecotropic viral integration site 2B decreases expression ISO gemcitabine results in decreased expression of EVI2B mRNA CTD PMID:17039268 NCBI chr10:66,856,980...66,858,598
Ensembl chr10:66,856,980...66,858,598
JBrowse link
G F7 coagulation factor VII decreases expression ISO gemcitabine results in decreased expression of F7 protein CTD PMID:20531411 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO gemcitabine results in increased expression of FAS mRNA; gemcitabine results in increased expression of FAS protein CTD PMID:11138460, PMID:17159604 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbxo25 F-box protein 25 increases expression ISO gemcitabine results in increased expression of FBXO25 mRNA CTD PMID:17039268 NCBI chr16:80,770,788...80,806,661
Ensembl chr16:80,771,596...80,798,041
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
ISO [gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein
gemcitabine results in increased expression of FGF2 protein
CTD PMID:12738744, PMID:20531411 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO gemcitabine affects the expression of FGG mRNA CTD PMID:17039268 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit decreases expression ISO gemcitabine results in decreased expression of FOSL2 mRNA CTD PMID:17039268 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 increases expression ISO gemcitabine results in increased expression of FXYD3 mRNA CTD PMID:17039268 NCBI chr 1:89,502,561...89,510,146
Ensembl chr 1:89,502,562...89,509,343
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 decreases expression ISO gemcitabine results in decreased expression of GAL3ST1 mRNA CTD PMID:17039268 NCBI chr14:84,231,473...84,247,371
Ensembl chr14:84,231,639...84,247,369
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO gemcitabine results in decreased expression of GAS1 mRNA CTD PMID:17039268 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gask1b golgi associated kinase 1B decreases expression ISO gemcitabine results in decreased expression of GASK1B mRNA CTD PMID:17039268 NCBI chr 2:178,678,946...178,751,459
Ensembl chr 2:178,679,041...178,750,668
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein CTD PMID:24979617 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 affects response to substance ISO GIPC1 affects the susceptibility to gemcitabine CTD PMID:25469510 NCBI chr19:24,786,604...24,798,231
Ensembl chr19:24,786,628...24,798,233
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO gemcitabine affects the expression of GLI2 mRNA CTD PMID:20103597 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Glrx glutaredoxin increases expression ISO gemcitabine results in increased expression of GLRX mRNA CTD PMID:17039268 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gpc3 glypican 3 increases expression ISO gemcitabine results in increased expression of GPC3 mRNA CTD PMID:17039268 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO gemcitabine results in increased phosphorylation of GSK3B protein CTD PMID:16570353 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 affects expression ISO gemcitabine affects the expression of GTF2A1 mRNA CTD PMID:17039268 NCBI chr 6:115,321,110...115,352,659
Ensembl chr 6:115,320,467...115,352,681
JBrowse link
G Hdac9 histone deacetylase 9 increases expression ISO gemcitabine results in increased expression of HDAC9 mRNA CTD PMID:17039268 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects response to substance ISO HIF1A protein affects the susceptibility to gemcitabine CTD PMID:16628086 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO gemcitabine results in decreased expression of H4C2 mRNA CTD PMID:17039268 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
JBrowse link
G Hoxb2 homeobox B2 increases expression ISO gemcitabine results in increased expression of HOXB2 mRNA CTD PMID:17039268 NCBI chr10:84,200,859...84,203,065
Ensembl chr10:84,200,880...84,202,688
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO gemcitabine results in decreased expression of HSPA1L mRNA CTD PMID:17039268 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO gemcitabine results in increased expression of HSPA5 mRNA CTD PMID:17039268 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO [Curcumin co-treated with gemcitabine] results in decreased expression of ICAM1 protein
gemcitabine results in decreased expression of ICAM1 protein
CTD PMID:17440100, PMID:20531411 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma decreases expression ISO gemcitabine results in decreased expression of IFNG protein CTD PMID:20531411 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO gemcitabine results in decreased expression of IGF1R mRNA CTD PMID:20103597 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression ISO gemcitabine affects the expression of IGFBP3 mRNA CTD PMID:20103597 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 decreases expression ISO gemcitabine results in decreased expression of IL10 protein CTD PMID:20531411 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 increases expression ISO gemcitabine results in increased expression of IL13 protein CTD PMID:20531411 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15 interleukin 15 decreases expression ISO gemcitabine results in decreased expression of IL15 protein CTD PMID:20531411 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il16 interleukin 16 increases expression ISO gemcitabine results in increased expression of IL16 protein CTD PMID:20531411 NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO gemcitabine results in decreased expression of IL1A protein CTD PMID:20531411 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO gemcitabine results in decreased expression of IL1B protein CTD PMID:20531411 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 decreases expression ISO gemcitabine results in decreased expression of IL4 protein CTD PMID:20531411 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 decreases expression
increases secretion
increases expression
ISO gemcitabine results in decreased expression of IL6 protein
gemcitabine results in increased secretion of IL6 protein
gemcitabine results in increased expression of IL6 mRNA
CTD PMID:17039268, PMID:20531411, PMID:28007550 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ilk integrin-linked kinase affects response to substance ISO ILK protein affects the susceptibility to gemcitabine CTD PMID:15867245 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Ins2 insulin 2 increases expression ISO gemcitabine results in increased expression of INS protein CTD PMID:20531411 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO gemcitabine results in increased expression of INSIG1 mRNA CTD PMID:17039268 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 increases expression ISO gemcitabine results in increased expression of IQGAP1 mRNA CTD PMID:17039268 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO gemcitabine results in increased expression of IRAK2 mRNA CTD PMID:17039268 NCBI chr 4:145,594,575...145,651,066
Ensembl chr 4:145,594,575...145,651,053
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO gemcitabine results in decreased expression of IRF3 mRNA CTD PMID:17039268 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itgav integrin subunit alpha V multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions ISO [ITGB6 co-treated with ITGAV] affects the susceptibility to gemcitabine CTD PMID:20150628 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itsn2 intersectin 2 increases expression ISO gemcitabine results in increased expression of ITSN2 mRNA CTD PMID:17039268 NCBI chr 6:30,098,378...30,208,694
Ensembl chr 6:30,098,380...30,187,337
JBrowse link
G Jam3 junctional adhesion molecule 3 decreases expression ISO gemcitabine results in decreased expression of JAM3 mRNA CTD PMID:17039268 NCBI chr 8:28,147,110...28,208,466
Ensembl chr 8:28,147,111...28,208,466
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein CTD PMID:23033007 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO gemcitabine results in decreased expression of KCTD12 mRNA CTD PMID:17039268 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kitlg KIT ligand decreases expression
multiple interactions
ISO gemcitabine results in decreased expression of KITLG protein
[gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
CTD PMID:20531411, PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klf8 Kruppel-like factor 8 increases expression ISO gemcitabine results in increased expression of KLF8 mRNA CTD PMID:17039268 NCBI chr  X:18,836,902...19,032,012
Ensembl chr  X:18,835,827...18,890,090
JBrowse link
G Krt8 keratin 8 decreases expression ISO gemcitabine results in decreased expression of KRT8 mRNA CTD PMID:17039268 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Larp4b La ribonucleoprotein 4B increases expression ISO gemcitabine results in increased expression of LARP4B mRNA CTD PMID:17039268 NCBI chr17:63,236,007...63,317,298
Ensembl chr17:63,265,407...63,314,019
JBrowse link
G Lep leptin decreases expression ISO gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO gemcitabine results in increased expression of LIFR mRNA CTD PMID:17039268 NCBI chr 2:56,424,910...56,489,346
Ensembl chr 2:56,426,367...56,489,415
JBrowse link
G LOC100360841 ribosomal protein L37-like increases expression ISO gemcitabine results in increased expression of RPL37 mRNA CTD PMID:17039268 NCBI chr 9:69,790,829...69,791,199
Ensembl chr 9:69,790,831...69,791,196
JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 decreases expression ISO gemcitabine results in decreased expression of LPAR6 mRNA CTD PMID:17039268 NCBI chr15:55,126,953...55,128,762
Ensembl chr15:55,126,953...55,128,761
JBrowse link
G Lrrc28 leucine rich repeat containing 28 increases expression ISO gemcitabine results in increased expression of LRRC28 mRNA CTD PMID:17039268 NCBI chr 1:128,486,164...128,604,190
Ensembl chr 1:128,486,166...128,604,188
JBrowse link
G Lta lymphotoxin alpha increases expression ISO gemcitabine results in increased expression of LTA protein CTD PMID:20531411 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO gemcitabine results in decreased expression of LYZ mRNA CTD PMID:17039268 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO gemcitabine results in increased expression of MAF mRNA CTD PMID:17039268 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Magea10 MAGE family member A10 decreases expression ISO gemcitabine results in decreased expression of MAGEA10 mRNA CTD PMID:17039268 NCBI chr  X:152,365,785...152,371,961
Ensembl chr  X:152,366,893...152,367,861
JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO gemcitabine results in increased expression of MAGI1 mRNA CTD PMID:17039268 NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K3 protein CTD PMID:15003513 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases phosphorylation ISO gemcitabine results in increased phosphorylation of MAP2K6 protein CTD PMID:15003513 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK1 protein
gemcitabine results in increased phosphorylation of MAPK1 protein
CTD PMID:15476743, PMID:23033007 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with gemcitabine] results in increased phosphorylation of MAPK3 protein
CTD PMID:15476743, PMID:23033007 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression
increases phosphorylation
ISO gemcitabine results in increased expression of MARCKS mRNA
gemcitabine results in increased phosphorylation of MARCKS protein
CTD PMID:9523737, PMID:17039268 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO gemcitabine results in increased expression of MARS1 mRNA CTD PMID:17039268 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression
increases expression
ISO gemcitabine results in decreased expression of MDM2 mRNA
gemcitabine results in increased expression of MDM2 mRNA
CTD PMID:17039268, PMID:20103597 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO gemcitabine results in decreased expression of MGMT mRNA CTD PMID:17039268 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions ISO MIR24-2 mRNA affects the susceptibility to [betulinic acid co-treated with gemcitabine] CTD PMID:25841339 NCBI chr19:25,318,863...25,318,970
Ensembl chr19:25,318,863...25,318,970
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MKI67 protein CTD PMID:17440100 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO gemcitabine results in decreased expression of MMP3 protein CTD PMID:20531411 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of MMP9 protein
[gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
CTD PMID:12738744, PMID:17440100 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase increases expression ISO gemcitabine results in increased expression of MPO protein CTD PMID:20531411 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msln mesothelin multiple interactions EXP gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form CTD PMID:25347530 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases response to substance
multiple interactions
ISO COX3 protein results in decreased susceptibility to gemcitabine
Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to gemcitabine]
CTD PMID:17428446 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein increases expression ISO gemcitabine results in increased expression of MXI1 mRNA CTD PMID:17039268 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO gemcitabine results in increased expression of MYB mRNA CTD PMID:17039268 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects response to substance
multiple interactions
ISO MYC affects the susceptibility to gemcitabine
[Curcumin co-treated with gemcitabine] results in decreased expression of MYC protein
[Oligonucleotides binds to MYC gene] which results in increased susceptibility to gemcitabine
CTD PMID:17440100, PMID:23681918 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nanog Nanog homeobox decreases expression ISO gemcitabine results in decreased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncbp1 nuclear cap binding protein subunit 1 increases expression ISO gemcitabine results in increased expression of NCBP1 mRNA CTD PMID:17039268 NCBI chr 5:61,734,118...61,767,098
Ensembl chr 5:61,734,118...61,766,481
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO gemcitabine results in increased expression of NEDD9 mRNA CTD PMID:17039268 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO gemcitabine results in increased expression of NEU1 mRNA CTD PMID:17039268 NCBI chr20:4,610,995...4,615,258
Ensembl chr20:4,610,995...4,615,247
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to gemcitabine CTD PMID:21489257 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 affects expression ISO gemcitabine affects the expression of NFKB2 mRNA CTD PMID:17039268 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Mastic Resin co-treated with gemcitabine] results in increased expression of NFKBIA protein CTD PMID:20523344 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbie NFKB inhibitor epsilon affects expression ISO gemcitabine affects the expression of NFKBIE mRNA CTD PMID:17039268 NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression ISO gemcitabine results in increased expression of NNMT mRNA CTD PMID:17039268 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Notch1 notch receptor 1 increases expression
multiple interactions
ISO gemcitabine results in increased expression of NOTCH1 protein
sulforafan inhibits the reaction [gemcitabine results in increased expression of NOTCH1 protein]
CTD PMID:20940707 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npepps aminopeptidase puromycin sensitive decreases expression ISO gemcitabine results in decreased expression of NPEPPS mRNA CTD PMID:17039268 NCBI chr10:85,140,368...85,222,861
Ensembl chr10:85,140,370...85,222,861
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to gemcitabine CTD PMID:24736981 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO gemcitabine results in increased expression of NR4A3 mRNA CTD PMID:17039268 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO gemcitabine results in increased expression of NRG1 mRNA CTD PMID:17039268 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nrp1 neuropilin 1 decreases response to substance ISO NRP1 protein results in decreased susceptibility to gemcitabine CTD PMID:15956974 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression
affects response to substance
ISO gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to gemcitabine
CTD PMID:16397047 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Olr325 olfactory receptor 325 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to gemcitabine CTD PMID:26378035 NCBI chr 1:228,545,913...228,546,857
Ensembl chr 1:228,545,913...228,546,857
JBrowse link
G Osm oncostatin M multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pappa1 pappalysin 1 decreases expression ISO gemcitabine results in decreased expression of PAPPA protein CTD PMID:20531411 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 increases expression ISO gemcitabine results in increased expression of PAQR8 mRNA CTD PMID:17039268 NCBI chr 9:27,005,270...27,054,591
Ensembl chr 9:27,034,022...27,051,002
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [alvocidib co-treated with gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein] CTD PMID:15770523, PMID:17146438, PMID:26894857 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases response to substance ISO PARP2 protein results in decreased susceptibility to gemcitabine CTD PMID:20798217 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO gemcitabine results in increased expression of PCSK9 mRNA CTD PMID:17039268 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases response to substance ISO PDPK1 protein modified form results in decreased susceptibility to gemcitabine CTD PMID:16782806 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdzk1ip1 PDZK1 interacting protein 1 increases expression ISO gemcitabine results in increased expression of PDZK1IP1 mRNA CTD PMID:17039268 NCBI chr 5:133,895,849...133,900,720
Ensembl chr 5:133,896,141...133,900,726
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] CTD PMID:17440100 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pgr progesterone receptor multiple interactions ISO gemcitabine binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 increases expression ISO gemcitabine results in increased expression of PJA2 mRNA CTD PMID:17039268 NCBI chr 9:111,998,204...112,048,847
Ensembl chr 9:111,998,203...112,027,240
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO gemcitabine results in increased expression of PLAU mRNA CTD PMID:17039268 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plk1 polo-like kinase 1 decreases expression
affects response to substance
multiple interactions
ISO gemcitabine results in decreased expression of PLK1; gemcitabine results in decreased expression of PLK1 mRNA
PLK1 protein affects the susceptibility to gemcitabine
[gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to gemcitabine]
CTD PMID:20103597 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression ISO gemcitabine affects the expression of PPARA mRNA CTD PMID:19427843 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects expression ISO gemcitabine affects the expression of PPARD mRNA CTD PMID:19427843 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO gemcitabine affects the expression of PPARG mRNA CTD PMID:19427843 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO gemcitabine results in increased expression of PPFIA4 mRNA CTD PMID:17039268 NCBI chr13:51,134,831...51,183,321
Ensembl chr13:51,134,525...51,183,269
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO gemcitabine results in increased expression of PPP1R15A mRNA CTD PMID:17039268 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO gemcitabine results in increased expression of PSAT1 mRNA CTD PMID:17039268 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptch1 patched 1 affects expression ISO gemcitabine affects the expression of PTCH1 mRNA CTD PMID:20103597 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Pten phosphatase and tensin homolog affects expression ISO gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO gemcitabine results in decreased expression of PTGS1 mRNA CTD PMID:17039268 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Curcumin co-treated with gemcitabine] results in decreased expression of PTGS2 protein CTD PMID:17440100 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases response to substance ISO PTK2 protein results in decreased susceptibility to gemcitabine CTD PMID:14623342 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 affects expression ISO gemcitabine affects the expression of PTPN11 mRNA CTD PMID:17039268 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO gemcitabine results in decreased expression of RAB8A mRNA CTD PMID:17039268 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to gemcitabine CTD PMID:16061639 NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO gemcitabine results in decreased expression of REG3A mRNA CTD PMID:16570353 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
decreases expression
ISO sulforafan promotes the reaction [gemcitabine results in decreased expression of REL protein] CTD PMID:20940707 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
ISO [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [gemcitabine results in increased expression of RELA protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of RELA protein
CTD PMID:17039268, PMID:17440100, PMID:20523344, PMID:29782821 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO gemcitabine results in increased expression of RGS2 mRNA CTD PMID:17039268 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rnf149 ring finger protein 149 increases expression ISO gemcitabine results in increased expression of RNF149 mRNA CTD PMID:17039268 NCBI chr 9:46,285,546...46,309,692
Ensembl chr 9:46,286,657...46,309,451
JBrowse link
G Rragd Ras-related GTP binding D increases expression ISO gemcitabine results in increased expression of RRAGD mRNA CTD PMID:17039268 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 multiple interactions
affects response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM1 protein
RRM1 protein affects the susceptibility to gemcitabine
CTD PMID:25189999, PMID:26894857 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
affects response to substance
decreases response to substance
ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to gemcitabine
RRM2 protein results in decreased susceptibility to gemcitabine
CTD PMID:14661056, PMID:25189999, PMID:26894857 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 increases expression ISO gemcitabine results in increased expression of RSL24D1 mRNA CTD PMID:17039268 NCBI chr 8:79,792,587...79,801,592
Ensembl chr 8:79,792,587...79,801,594
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO gemcitabine results in increased expression of SAT1 mRNA CTD PMID:17039268 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO gemcitabine results in increased expression of SCD mRNA CTD PMID:17039268 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sfn stratifin multiple interactions
affects response to substance
decreases response to substance
increases methylation
ISO [DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; [gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased methylation of SFN gene; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN mRNA; [gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; SFN protein inhibits the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
SFN protein affects the susceptibility to gemcitabine
gemcitabine results in increased methylation of SFN gene
CTD PMID:25189999, PMID:26894857 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO gemcitabine results in decreased expression of SHH mRNA CTD PMID:20103597 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression ISO gemcitabine results in increased expression of SLC25A29 mRNA CTD PMID:17039268 NCBI chr 6:132,736,964...132,747,912
Ensembl chr 6:132,735,883...132,747,828
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO
EXP
gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]
gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
CTD PMID:8713072, PMID:10772724 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases response to substance
decreases response to substance
increases uptake
affects response to substance
multiple interactions
ISO SLC29A1 mRNA results in increased susceptibility to gemcitabine; SLC29A1 protein results in increased susceptibility to gemcitabine
SLC29A1 protein results in decreased susceptibility to gemcitabine
SLC29A1 protein results in increased uptake of gemcitabine
SLC29A1 protein affects the susceptibility to gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of gemcitabine]
CTD PMID:15501974, PMID:16868479, PMID:17695509, PMID:18383843, PMID:18452103, PMID:18490900, PMID:18728667, PMID:18992248, PMID:26894857 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of gemcitabine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO gemcitabine results in increased expression of SLC2A3 mRNA CTD PMID:17039268 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO gemcitabine results in decreased expression of SLC43A3 mRNA CTD PMID:17039268 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slitrk2 SLIT and NTRK-like family, member 2 increases expression ISO gemcitabine results in increased expression of SLITRK2 mRNA CTD PMID:17039268 NCBI chr  X:151,099,388...151,111,816
Ensembl chr  X:151,103,576...151,107,016
JBrowse link
G Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase multiple interactions
decreases response to substance
ISO SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [gemcitabine results in increased activity of CASP9 protein]
SMG1 protein results in decreased susceptibility to gemcitabine
CTD PMID:21418860 NCBI chr 1:187,781,577...187,882,833
Ensembl chr 1:187,784,270...187,883,157
JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO gemcitabine results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO gemcitabine results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO gemcitabine results in increased expression of SPP1 mRNA CTD PMID:17039268 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
decreases response to substance
affects response to substance
ISO [AG 1879 co-treated with SRC] results in increased susceptibility to gemcitabine
SRC protein modified form results in decreased susceptibility to gemcitabine; SRC protein results in decreased susceptibility to gemcitabine
SRC protein affects the susceptibility to gemcitabine
CTD PMID:15073106, PMID:15194078 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases activity ISO gemcitabine results in decreased activity of STAT3 protein CTD PMID:22348037 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO gemcitabine results in decreased expression of SYNCRIP mRNA CTD PMID:17039268 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
JBrowse link
G Szrd1 SUZ RNA binding domain containing 1 decreases expression ISO gemcitabine results in decreased expression of SZRD1 mRNA CTD PMID:17039268 NCBI chr 5:159,638,259...159,662,790
Ensembl chr 5:159,638,259...159,662,754
JBrowse link
G Tceal9 transcription elongation factor A like 9 increases expression ISO gemcitabine results in increased expression of TCEAL9 mRNA CTD PMID:17039268 NCBI chr  X:106,791,333...106,794,667
Ensembl chr  X:106,791,333...106,794,657
JBrowse link
G Tcof1 treacle ribosome biogenesis factor 1 decreases expression ISO gemcitabine results in decreased expression of TCOF1 mRNA CTD PMID:17039268 NCBI chr18:56,081,863...56,115,719
Ensembl chr18:56,082,195...56,115,593
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions
decreases activity
ISO [Fluorouracil co-treated with gemcitabine] results in decreased activity of TERT protein
gemcitabine results in decreased activity of TERT protein
CTD PMID:16929163 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions
increases response to substance
ISO [TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine
TFAP2A protein results in increased susceptibility to gemcitabine
CTD PMID:21489314 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases response to substance
multiple interactions
ISO TGFB1 results in decreased susceptibility to gemcitabine
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]]
CTD PMID:21613822 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO gemcitabine results in increased expression of TGFB2 mRNA CTD PMID:17039268 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thpo thrombopoietin increases expression ISO gemcitabine results in increased expression of THPO protein CTD PMID:20531411 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tnf tumor necrosis factor increases expression
affects expression
ISO gemcitabine results in increased expression of TNF protein
gemcitabine affects the expression of TNF mRNA
CTD PMID:17039268, PMID:20531411 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO gemcitabine results in increased expression of TNFAIP3 mRNA CTD PMID:17039268 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO gemcitabine results in increased expression of TNFRSF11B mRNA CTD PMID:17039268 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [TNFSF10 co-treated with gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with gemcitabine] results in increased activity of CASP8 protein CTD PMID:17671697 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf8 TNF superfamily member 8 multiple interactions ISO [gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein CTD PMID:24979617 NCBI chr 5:79,664,779...79,691,547
Ensembl chr 5:79,664,765...79,691,258
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO gemcitabine results in increased expression of TP53 protein
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to gemcitabine; Nicotine inhibits the reaction [gemcitabine results in increased expression of TP53 protein]
CTD PMID:12082016, PMID:16601104, PMID:17671697, PMID:21489314 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO gemcitabine results in increased expression of TP53BP1 mRNA CTD PMID:17039268 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO gemcitabine results in increased expression of TP53INP1 mRNA CTD PMID:16570353, PMID:17039268 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Traf1 TNF receptor-associated factor 1 affects expression ISO gemcitabine affects the expression of TRAF1 mRNA CTD PMID:17039268 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Tube1 tubulin, epsilon 1 increases expression ISO gemcitabine results in increased expression of TUBE1 mRNA CTD PMID:17039268 NCBI chr20:44,220,823...44,238,830
Ensembl chr20:44,220,840...44,238,830
JBrowse link
G Tymp thymidine phosphorylase affects response to substance
multiple interactions
ISO TYMP protein affects the susceptibility to gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to gemcitabine; TYMP protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]
CTD PMID:18728667 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyrp1 tyrosinase-related protein 1 affects expression ISO gemcitabine affects the expression of TYRP1 mRNA CTD PMID:17039268 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO gemcitabine results in decreased expression of UBE2C mRNA CTD PMID:17039268 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO gemcitabine results in increased expression of UGGT2 mRNA CTD PMID:17039268 NCBI chr15:104,235,678...104,405,308 JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 multiple interactions ISO [gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]; UHRF1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine] CTD PMID:25189999 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO gemcitabine results in decreased expression of VCAM1 protein CTD PMID:20531411 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with gemcitabine] results in decreased expression of VEGFA protein
CTD PMID:17039268, PMID:17440100 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO gemcitabine results in decreased expression of VGF mRNA CTD PMID:17039268 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO gemcitabine results in increased expression of VLDLR mRNA CTD PMID:17039268 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO gemcitabine results in increased expression of VMP1 CTD PMID:20299819 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Vwf von Willebrand factor decreases expression ISO gemcitabine results in decreased expression of VWF protein CTD PMID:20531411 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO gemcitabine results in decreased expression of WNT5A mRNA CTD PMID:17039268 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; gemcitabine promotes the reaction [rimonabant results in increased expression of XBP1 mRNA] CTD PMID:21525939 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis affects response to substance ISO XIAP affects the susceptibility to gemcitabine CTD PMID:16628085 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
affects response to substance
ISO SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]]; YAP1 protein affects the reaction [gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to gemcitabine]
YAP1 protein affects the susceptibility to gemcitabine
CTD PMID:26894857 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO gemcitabine results in increased expression of ZNF274 mRNA CTD PMID:17039268 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528
JBrowse link
G Zfp449 zinc finger protein 449 increases expression ISO gemcitabine results in increased expression of ZNF449 mRNA CTD PMID:17039268 NCBI chr  X:73,390,885...73,413,939
Ensembl chr  X:73,390,903...73,413,931
JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO gemcitabine results in decreased expression of ZNF521 mRNA CTD PMID:17039268 NCBI chr18:5,022,042...5,315,242
Ensembl chr18:5,032,029...5,314,585
JBrowse link
thymidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
ISO Thymidine results in increased expression of ACTA2 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Thymidine results in increased expression of ACTA2 mRNA]
CTD PMID:31170432 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions ISO Thymidine promotes the reaction [Methotrexate results in increased activity of ALPI protein] CTD PMID:16598758 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein] CTD PMID:11570579 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein]
Thymidine results in increased activity of CASP3 protein
CTD PMID:11570579, PMID:16419169 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein] CTD PMID:11570579 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Csf1 colony stimulating factor 1 increases uptake ISO CSF1 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 increases uptake ISO CSF2 protein results in increased uptake of Thymidine CTD PMID:8193360 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Edn1 endothelin 1 increases uptake ISO EDN1 protein results in increased uptake of Thymidine CTD PMID:10100047 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Faslg Fas ligand increases expression ISO Thymidine results in increased expression of FASLG protein CTD PMID:16419169 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein CTD PMID:15841086 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein] CTD PMID:11103787, PMID:15841086 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 decreases uptake
multiple interactions
ISO IGF1 protein results in decreased uptake of Thymidine
[Tetrachlorodibenzodioxin co-treated with Estradiol] inhibits the reaction [IGF1 protein results in increased uptake of Thymidine]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in decreased uptake of Thymidine]
CTD PMID:1332906 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein] CTD PMID:11103787 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO [Thymidine co-treated with Hypoxanthine co-treated with 5,6,7,8-tetrahydrofolic acid] inhibits the reaction [Methotrexate results in decreased expression of MTR protein]; [Thymidine co-treated with Hypoxanthine] inhibits the reaction [Methotrexate results in decreased expression of MTR protein] CTD PMID:16598758 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein] CTD PMID:9808420 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions ISO Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] CTD PMID:9124315 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP
Thymidine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301, PMID:11085929 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Thymidine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:220,306,622...220,314,631
Ensembl chr 1:220,400,855...220,407,189
Ensembl chr 1:220,400,855...220,407,189
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases phosphorylation
ISO [Thymidine co-treated with TYMP co-treated with Oxygen deficiency] results in increased expression of HIF1A protein; [Thymidine co-treated with TYMP protein] results in increased expression of HMOX1 protein; [Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein; [Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein; [TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased expression of MMP1 protein]; Thymine inhibits the reaction [[Thymidine co-treated with TYMP protein] results in increased secretion of CXCL8 protein]; Thymine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]
TYMP protein results in increased phosphorylation of Thymidine
CTD PMID:11103787, PMID:15841086 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO Thymidine inhibits the reaction [Fluorouracil results in decreased expression of TYMS] CTD PMID:9050858 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
trifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19816940 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Trifluridine results in increased cleavage of CASP8 protein CTD PMID:19816940 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Trifluridine results in increased cleavage of CASP9 protein CTD PMID:19816940 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ctsb cathepsin B increases cleavage
multiple interactions
ISO Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]
CTD PMID:19816940 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Trifluridine results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Trifluridine results in increased cleavage of PARP1 protein CTD PMID:19816940 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
zalcitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Zalcitabine affects the phosphorylation of AKT1 protein CTD PMID:19781600 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Zalcitabine binds to ALB protein CTD PMID:15814459 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Ano3 anoctamin 3 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ANO3 mRNA CTD PMID:18606552 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Zalcitabine CTD PMID:17259346 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA CTD PMID:18606552 NCBI chr 1:146,399,217...146,556,437
Ensembl chr 1:146,399,217...146,556,171
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNA CTD PMID:18606552 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Bptf bromodomain PHD finger transcription factor multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA CTD PMID:18606552 NCBI chr10:95,248,573...95,350,162
Ensembl chr10:95,250,294...95,349,789
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Zalcitabine results in increased expression of CCL2 protein CTD PMID:17761732 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Zalcitabine results in increased expression of CXCL12 mRNA CTD PMID:17292584 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression EXP Zalcitabine results in increased expression of CXCR4 mRNA CTD PMID:17292584 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Dck deoxycytidine kinase affects response to substance ISO DCK protein affects the susceptibility to Zalcitabine CTD PMID:11952160 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Depdc1b DEP domain containing 1B multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of DEPDC1B mRNA CTD PMID:18606552 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975
JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA CTD PMID:18606552 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA CTD PMID:18606552 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fam81a family with sequence similarity 81, member A multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA CTD PMID:18606552 NCBI chr 8:76,521,662...76,579,387
Ensembl chr 8:76,521,657...76,579,387
JBrowse link
G Fpgt fucose-1-phosphate guanylyltransferase multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FPGT mRNA CTD PMID:18606552 NCBI chr 2:261,382,015...261,402,950
Ensembl chr 2:261,382,060...261,402,903
JBrowse link
G Gla galactosidase, alpha multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of GLA mRNA CTD PMID:18606552 NCBI chr  X:105,405,915...105,417,331
Ensembl chr  X:105,406,792...105,417,323
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
increases expression
multiple interactions
ISO
EXP
HTR2A gene results in increased susceptibility to Zalcitabine
Zalcitabine results in increased expression of HTR2A protein
[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine
CTD PMID:17888573 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression
multiple interactions
ISO Zalcitabine results in decreased expression of IL2RA mRNA; Zalcitabine results in decreased expression of IL2RA protein
Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]
CTD PMID:7606800 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA CTD PMID:18606552 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Kif5a kinesin family member 5A multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA CTD PMID:18606552 NCBI chr 7:70,515,832...70,552,897
Ensembl chr 7:70,513,343...70,556,827
JBrowse link
G Lama5 laminin subunit alpha 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA CTD PMID:18606552 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127
JBrowse link
G Luzp2 leucine zipper protein 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA CTD PMID:18606552 NCBI chr 1:111,849,494...112,067,502
NCBI chr 1:113,419,707...113,531,330
Ensembl chr 1:111,849,998...113,527,735
JBrowse link
G Midn midnolin multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA CTD PMID:18606552 NCBI chr 7:12,414,303...12,426,712
Ensembl chr 7:12,414,733...12,424,367
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions
ISO Zalcitabine results in decreased expression of COX1 protein
Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]
CTD PMID:17187420, PMID:18823003, PMID:20032772 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression EXP Zalcitabine results in decreased expression of COX2 mRNA CTD PMID:19781600 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression ISO Zalcitabine results in decreased expression of COX3 protein CTD PMID:17508937 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions ISO Zalcitabine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein] CTD PMID:17904600 NCBI chr  X:1,787,266...1,789,524
Ensembl chr  X:1,787,266...1,789,524
JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NECAB1 mRNA CTD PMID:18606552 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of NKIRAS1 mRNA CTD PMID:18606552 NCBI chr15:8,179,090...8,188,656
Ensembl chr15:8,179,102...8,183,682
JBrowse link
G Notch1 notch receptor 1 increases mutagenesis ISO Zalcitabine results in increased mutagenesis of NOTCH1 gene CTD PMID:18798262 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NPY mRNA CTD PMID:18606552 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of NTRK2 mRNA alternative form CTD PMID:18606552 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Per2 period circadian regulator 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of PER2 mRNA CTD PMID:18606552 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RAB27B mRNA CTD PMID:18606552 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B mRNA; [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of REG3B protein CTD PMID:18606552 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G RGD1305110 similar to KIAA1841 protein multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RGD1305110 mRNA CTD PMID:18606552 NCBI chr14:108,305,343...108,376,618
Ensembl chr14:108,305,418...108,372,157
JBrowse link
G RGD1310429 similar to Protein Njmu-R1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of RGD1310429 mRNA CTD PMID:18606552 NCBI chr10:67,738,131...67,751,049
Ensembl chr10:67,739,103...67,751,002
JBrowse link
G Robo2 roundabout guidance receptor 2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ROBO2 mRNA CTD PMID:18606552 NCBI chr11:11,062,866...12,618,793
Ensembl chr11:11,062,790...11,585,765
JBrowse link
G Scube1 signal peptide, CUB domain and EGF like domain containing 1 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SCUBE1 mRNA CTD PMID:18606552 NCBI chr 7:124,501,988...124,620,755
Ensembl chr 7:124,501,988...124,620,703
JBrowse link
G Senp5 SUMO specific peptidase 5 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SENP5 mRNA CTD PMID:18606552 NCBI chr11:72,883,892...72,918,759
Ensembl chr11:72,892,448...72,915,230
JBrowse link
G Slc28a1 solute carrier family 28 member 1 multiple interactions
increases uptake
EXP Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
SLC28A1 protein results in increased uptake of Zalcitabine
CTD PMID:8027026, PMID:8700147, PMID:8713072 NCBI chr 1:142,948,942...142,992,410
Ensembl chr 1:142,950,540...142,992,615
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Zalcitabine CTD PMID:19164483 NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
JBrowse link
G Slc35g2 solute carrier family 35, member G2 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SLC35G2 mRNA CTD PMID:18606552 NCBI chr 8:108,854,134...108,881,519
Ensembl chr 8:108,854,146...108,880,879
JBrowse link
G Slc4a8 solute carrier family 4 member 8 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of SLC4A8 mRNA CTD PMID:18606552 NCBI chr 7:142,397,352...142,467,398
Ensembl chr 7:142,397,371...142,464,158
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ST8SIA3 mRNA CTD PMID:18606552 NCBI chr18:59,748,766...59,755,257
Ensembl chr18:59,748,444...59,755,226
JBrowse link
G Sv2b synaptic vesicle glycoprotein 2b multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of SV2B mRNA CTD PMID:18606552 NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
JBrowse link
G Tfam transcription factor A, mitochondrial affects expression ISO Zalcitabine affects the expression of TFAM protein CTD PMID:7849699 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO Zalcitabine results in decreased expression of TK1 mRNA; Zalcitabine results in decreased expression of TK1 protein CTD PMID:14659972 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tk2 thymidine kinase 2 decreases expression ISO Zalcitabine results in decreased expression of TK2 mRNA CTD PMID:14659972 NCBI chr19:917,203...939,236
Ensembl chr19:917,203...939,221
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases response to substance EXP TRPV4 protein results in increased susceptibility to Zalcitabine CTD PMID:18234883 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Tymp thymidine phosphorylase increases expression ISO Zalcitabine results in increased expression of TYMP protein CTD PMID:16457948 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vgf VGF nerve growth factor inducible multiple interactions EXP [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of VGF mRNA CTD PMID:18606552 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
zidovudine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 increases expression ISO Zidovudine results in increased expression of ABCA3 mRNA CTD PMID:24292225 NCBI chr10:13,723,365...13,780,558
Ensembl chr10:13,723,405...13,779,963
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 decreases expression
increases expression
ISO Zidovudine results in decreased expression of ABCA7 mRNA
Zidovudine results in increased expression of ABCA7 mRNA
CTD PMID:24292225 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Zidovudine results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Zidovudine results in increased expression of ABCB1 mRNA; Zidovudine results in increased expression of ABCB1 protein CTD PMID:9148857, PMID:15456083, PMID:18310046, PMID:24292225 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO Zidovudine results in increased expression of ABCB9 mRNA CTD PMID:24292225 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Zidovudine results in increased expression of ABCC1 mRNA CTD PMID:24292225 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 increases expression ISO Zidovudine results in increased expression of ABCC10 mRNA CTD PMID:24292225 NCBI chr 9:17,041,351...17,061,263
Ensembl chr 9:17,041,389...17,063,780
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
ISO
EXP
Zidovudine results in increased expression of ABCC3 mRNA
Zidovudine results in decreased expression of ABCC3 mRNA
CTD PMID:24292225, PMID:27765674 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects abundance
increases expression
increases export
ISO ABCC4 protein affects the abundance of Zidovudine
Zidovudine results in increased expression of ABCC4 mRNA
ABCC4 protein results in increased export of Zidovudine
CTD PMID:15456083, PMID:18364470, PMID:18535159 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 increases export
increases expression
ISO ABCC5 protein results in increased export of Zidovudine
Zidovudine results in increased expression of ABCC5 mRNA
CTD PMID:15456083, PMID:18535159, PMID:24292225 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 increases expression ISO Zidovudine results in increased expression of ABCC6 mRNA CTD PMID:24292225 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcd1 ATP binding cassette subfamily D member 1 increases expression ISO Zidovudine results in increased expression of ABCD1 mRNA CTD PMID:24292225 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274
JBrowse link
G Abcf2 ATP binding cassette subfamily F member 2 increases expression ISO Zidovudine results in increased expression of ABCF2 mRNA CTD PMID:24292225 NCBI chr 4:7,122,850...7,135,607
Ensembl chr 4:7,122,890...7,135,669
JBrowse link
G Abcf3 ATP binding cassette subfamily F member 3 increases expression ISO Zidovudine results in increased expression of ABCF3 mRNA CTD PMID:24292225 NCBI chr11:84,026,206...84,037,938
Ensembl chr11:84,026,207...84,037,938
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
decreases expression
increases export
decreases export
ISO
EXP
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]
Zidovudine results in increased expression of ABCG2 protein
Zidovudine results in decreased expression of ABCG2 mRNA
Zidovudine results in increased expression of ABCG2 mRNA
CTD PMID:17437964, PMID:19056916, PMID:24292225, PMID:27765674, PMID:28705594 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Zidovudine results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression ISO Zidovudine affects the expression of ACACA mRNA CTD PMID:20032539 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta affects expression ISO Zidovudine affects the expression of ACACB mRNA CTD PMID:20032539 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA CTD PMID:18313992 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA CTD PMID:18313992 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Ada adenosine deaminase increases expression ISO Zidovudine results in increased expression of ADA protein CTD PMID:2261134 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
ISO Zidovudine results in decreased expression of ADIPOQ protein
Zidovudine results in decreased expression of ADIPOQ mRNA; Zidovudine results in decreased expression of ADIPOQ protein
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA
CTD PMID:15865214, PMID:16931933, PMID:17503663, PMID:17668557 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Aebp1 AE binding protein 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA CTD PMID:16931933 NCBI chr14:86,101,253...86,111,323
Ensembl chr14:86,101,277...86,111,306
JBrowse link
G Afap1 actin filament associated protein 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA CTD PMID:15784690 NCBI chr14:79,923,132...80,035,096
Ensembl chr14:79,919,717...79,988,110
JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 multiple interactions
increases expression
EXP [Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]
Zidovudine results in increased expression of AGPAT3 mRNA
CTD PMID:28619387 NCBI chr20:11,060,584...11,144,806
Ensembl chr20:11,114,164...11,144,806
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Zidovudine results in increased phosphorylation of AKT1 protein CTD PMID:29594326 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO Zidovudine binds to ALB protein CTD PMID:15814459, PMID:16336266 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA CTD PMID:16931933 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression
multiple interactions
EXP Zidovudine results in decreased expression of APOA5 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]
CTD PMID:28619387 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Aprt adenine phosphoribosyl transferase increases mutagenesis ISO Zidovudine results in increased mutagenesis of APRT gene CTD PMID:10970446 NCBI chr19:55,387,288...55,389,256
Ensembl chr19:55,387,288...55,389,256
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA
CTD PMID:18313992, PMID:20370541 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA CTD PMID:16931933 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507
JBrowse link
G Asic2 acid sensing ion channel subunit 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA CTD PMID:16931933 NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
JBrowse link
G Asl argininosuccinate lyase multiple interactions
increases activity
EXP [Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]
Zidovudine results in increased activity of ASL protein
CTD PMID:28619387 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA CTD PMID:15784690 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA CTD PMID:15784690 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA CTD PMID:15784690 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA CTD PMID:11706060 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5C1 mRNA CTD PMID:18313992 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta decreases expression ISO Zidovudine results in decreased expression of ATP5F1D mRNA CTD PMID:16894629 NCBI chr 7:12,426,807...12,432,120
Ensembl chr 7:12,426,809...12,432,130
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 increases expression
multiple interactions
ISO Zidovudine results in increased expression of ATP5MC3 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5G3 mRNA
CTD PMID:16894629, PMID:18313992 NCBI chr 3:60,811,218...60,813,903
Ensembl chr 3:60,811,210...60,813,869
JBrowse link
G Atp5me ATP synthase membrane subunit e increases expression ISO Zidovudine results in increased expression of ATP5ME mRNA CTD PMID:16894629 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5J2 mRNA CTD PMID:18313992 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Atp5mg ATP synthase membrane subunit g increases expression ISO Zidovudine results in increased expression of ATP5MG mRNA CTD PMID:16894629 NCBI chr 8:49,220,441...49,227,273
Ensembl chr 8:49,220,443...49,227,273
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b increases expression ISO Zidovudine results in increased expression of ATP5PB mRNA CTD PMID:16894629 NCBI chr 2:208,566,385...208,577,147
Ensembl chr 2:208,566,385...208,577,146
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ATP5H mRNA CTD PMID:18313992 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 increases expression
multiple interactions
ISO Zidovudine results in increased expression of ATP5PF mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5J mRNA
CTD PMID:16894629, PMID:18313992 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions
increases expression
ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5O mRNA
Zidovudine results in increased expression of ATP5PO mRNA
CTD PMID:16894629, PMID:18313992 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 decreases expression ISO Zidovudine results in decreased expression of ATP8B1 mRNA CTD PMID:16894629 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
increases expression
multiple interactions
decreases expression
ISO
EXP
BCL2 protein affects the susceptibility to Zidovudine
Zidovudine results in increased expression of BCL2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA
Drugs, Chinese Herbal promotes the reaction [Zidovudine results in decreased expression of BCL2 mRNA]
CTD PMID:9850737, PMID:17696246, PMID:18313992, PMID:29594326 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Zidovudine results in increased expression of BNIP3L protein CTD PMID:23640862 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA CTD PMID:20370541 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Zidovudine results in increased expression of BTG2 mRNA CTD PMID:23675285 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G C1r complement C1r multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA CTD PMID:16931933 NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829
JBrowse link
G C3ar1 complement C3a receptor 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA
CTD PMID:16931933, PMID:20370541 NCBI chr 4:155,681,767...155,691,240
Ensembl chr 4:155,684,029...155,690,869
JBrowse link
G Cars cysteinyl-tRNA synthetase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA CTD PMID:15784690 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO [Acrolein co-treated with Zidovudine] results in increased cleavage of CASP3 protein; Drugs, Chinese Herbal promotes the reaction [Zidovudine results in increased expression of CASP3 mRNA]
Zidovudine results in increased cleavage of CASP3 protein
Zidovudine results in increased expression of CASP3 protein
Zidovudine results in increased activity of CASP3 protein
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]
CTD PMID:16601281, PMID:17696246, PMID:17943461, PMID:18801031, PMID:27238871 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Zidovudine results in increased cleavage of CASP8 protein
Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]; Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]
CTD PMID:27238871 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase decreases response to substance ISO CAT protein results in decreased susceptibility to Zidovudine CTD PMID:19398959 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Zidovudine results in increased expression of CCL2 protein CTD PMID:17668557 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA
Zidovudine results in decreased expression of CCNA2 mRNA
CTD PMID:15784690, PMID:20370541 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA CTD PMID:20370541 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnc cyclin C multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA CTD PMID:15784690 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA
Zidovudine results in increased expression of CCND1 mRNA
CTD PMID:15784690 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA
Zidovudine results in decreased expression of CCND2 mRNA
CTD PMID:15784690 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions
ISO Zidovudine results in decreased expression of CCNE2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA
CTD PMID:15784690 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA CTD PMID:20370541 NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA CTD PMID:20370541 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA CTD PMID:16931933 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA CTD PMID:15784690 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd83 CD83 molecule multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA CTD PMID:15784690 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA CTD PMID:20370541 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdca8 cell division cycle associated 8 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA CTD PMID:20370541 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA CTD PMID:20370541 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA CTD PMID:20370541 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA CTD PMID:20370541 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA CTD PMID:15784690 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects expression
decreases expression
ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA
Zidovudine affects the expression of CDKN1A protein
Zidovudine results in decreased expression of CDKN1A mRNA
CTD PMID:15784690, PMID:18389896 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA CTD PMID:15784690 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA CTD PMID:15784690 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects expression
increases expression
ISO Zidovudine affects the expression of CDKN2A protein
Zidovudine results in increased expression of CDKN2A mRNA; Zidovudine results in increased expression of CDKN2A protein
CTD PMID:16797627, PMID:18389896 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA CTD PMID:15784690 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Zidovudine results in decreased expression of CEBPA protein CTD PMID:15722030 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cfd complement factor D multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA CTD PMID:16931933 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
decreases expression
ISO Zidovudine results in increased phosphorylation of CHEK1 protein
Zidovudine results in decreased expression of CHEK1 protein
CTD PMID:19541796 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression
increases phosphorylation
ISO Zidovudine results in decreased expression of CHEK2 protein
Zidovudine results in increased phosphorylation of CHEK2 protein
CTD PMID:19541796 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chn1 chimerin 1 decreases expression ISO Zidovudine results in decreased expression of CHN1 mRNA CTD PMID:16894629 NCBI chr 3:60,512,360...60,668,413
Ensembl chr 3:60,513,077...60,611,924
JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA CTD PMID:16931933 NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
JBrowse link
G Clcn3 chloride voltage-gated channel 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA CTD PMID:16931933 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA CTD PMID:15784690 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 decreases expression ISO Zidovudine results in decreased expression of COX11 mRNA CTD PMID:16894629 NCBI chr10:78,168,691...78,173,845
NCBI chr10:78,102,620...78,174,584
Ensembl chr10:78,111,050...78,174,584
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 decreases expression ISO Zidovudine results in decreased expression of COX15 mRNA CTD PMID:16894629 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A decreases expression
multiple interactions
ISO Zidovudine results in decreased expression of COX5A protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA
CTD PMID:7807166, PMID:18313992 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions
decreases expression
ISO [Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA
Zidovudine results in decreased expression of COX5B protein
CTD PMID:7807166, PMID:18313992 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA CTD PMID:18313992 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C decreases expression
multiple interactions
ISO Zidovudine results in decreased expression of COX6C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA
CTD PMID:7807166, PMID:18313992 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 decreases expression ISO Zidovudine results in decreased expression of COX7A1 protein CTD PMID:7807166 NCBI chr 1:88,619,619...88,650,672
Ensembl chr 1:91,071,493...91,074,294
Ensembl chr 1:91,071,493...91,074,294
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 increases expression ISO Zidovudine results in increased expression of COX7A2 mRNA CTD PMID:16894629 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B increases expression
decreases expression
ISO Zidovudine results in increased expression of COX7B mRNA
Zidovudine results in decreased expression of COX7B protein
CTD PMID:7807166, PMID:16894629 NCBI chr  X:77,065,427...77,071,676
Ensembl chr  X:77,065,397...77,071,676
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C decreases expression
multiple interactions
ISO Zidovudine results in decreased expression of COX7C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA
CTD PMID:7807166, PMID:18313992 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
JBrowse link
G Cpne5 copine 5 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA CTD PMID:20370541 NCBI chr20:6,419,033...6,500,843
Ensembl chr20:6,419,033...6,500,523
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression
ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA
Zidovudine results in increased expression of CPT1A mRNA
CTD PMID:14576092, PMID:18313992 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crat carnitine O-acetyltransferase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA CTD PMID:18313992 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Cs citrate synthase affects expression
decreases expression
ISO Zidovudine affects the expression of CS mRNA
Zidovudine results in decreased expression of CS protein
CTD PMID:1892364, PMID:20032539 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA] CTD PMID:12084393 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha multiple interactions
decreases expression
ISO [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA] CTD PMID:12084393 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA CTD PMID:20370541 NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
JBrowse link
G Cul7 cullin 7 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA CTD PMID:18313992 NCBI chr 9:16,629,491...16,643,527
Ensembl chr 9:16,629,401...16,643,182
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
decreases expression
ISO
EXP
[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA
Zidovudine results in decreased expression of CYB5A mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]
CTD PMID:18313992, PMID:28619387 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA CTD PMID:18313992 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA CTD PMID:20370541 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine CTD PMID:19501153 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dcn decorin multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA CTD PMID:16931933 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA
Zidovudine results in increased expression of DDIT3 mRNA
CTD PMID:15784690 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA CTD PMID:20370541 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA CTD PMID:15784690 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA CTD PMID:18313992 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA CTD PMID:18313992 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Dmd dystrophin affects localization ISO Zidovudine affects the localization of DMD protein CTD PMID:17943461 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA CTD PMID:18313992 NCBI chr10:11,059,701...11,085,186
Ensembl chr10:11,060,313...11,085,210
JBrowse link
G Dnm1l dynamin 1-like multiple interactions
affects localization
ISO
EXP
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein
Zidovudine affects the localization of DNM1L protein
CTD PMID:28683400 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA CTD PMID:20370541 NCBI chr11:67,758,093...67,767,623
NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
JBrowse link
G Dtymk deoxythymidylate kinase multiple interactions
affects response to substance
ISO [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein; DTYMK gene mutant form results in increased phosphorylation of and results in increased susceptibility to Zidovudine CTD PMID:17375075, PMID:28683400 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dusp3 dual specificity phosphatase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA CTD PMID:16931933 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA CTD PMID:18313992 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA CTD PMID:18313992 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases secretion
ISO coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein] CTD PMID:23640862 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Zidovudine co-treated with Arsenic Trioxide] results in increased expression of EGR1 mRNA CTD PMID:29910624 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehf ets homologous factor multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA CTD PMID:20370541 NCBI chr 3:93,176,257...93,216,484
Ensembl chr 3:93,178,163...93,216,495
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Zidovudine results in increased phosphorylation of EIF2S1 protein CTD PMID:27041070 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA CTD PMID:15784690 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA CTD PMID:16931933 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
JBrowse link
G Epo erythropoietin increases expression
multiple interactions
ISO Zidovudine results in increased expression of EPO protein
EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]; Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]
CTD PMID:1549625, PMID:1889487, PMID:3422548, PMID:7646543, PMID:9735323 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor multiple interactions
decreases expression
ISO EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]
Zidovudine results in decreased expression of EPOR mRNA; Zidovudine results in decreased expression of EPOR protein
CTD PMID:1417927, PMID:7646543 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Epsti1 epithelial stromal interaction 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA CTD PMID:20370541 NCBI chr15:60,084,966...60,190,360
Ensembl chr15:60,084,918...60,190,363
JBrowse link
G Esr1 estrogen receptor 1 affects localization EXP Zidovudine affects the localization of ESR1 protein CTD PMID:15531092 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA CTD PMID:16931933 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Etv6 ETS variant transcription factor 6 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA CTD PMID:16931933 NCBI chr 4:167,754,684...167,992,370
Ensembl chr 4:167,754,525...167,992,168
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression ISO Zidovudine affects the expression of FABP4 mRNA CTD PMID:20032539 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA CTD PMID:16931933 NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
JBrowse link
G Faim Fas apoptotic inhibitory molecule multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA CTD PMID:16931933 NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224
Ensembl chr 8:107,225,212...107,241,224
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Zidovudine results in increased expression of FAS protein CTD PMID:17943461 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression
multiple interactions
ISO
EXP
Zidovudine results in increased expression of FASLG protein
Zidovudine results in increased expression of FASLG mRNA
Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]
[Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]
CTD PMID:17943461, PMID:27238871 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
multiple interactions
ISO Zidovudine affects the expression of FASN mRNA
Zidovudine results in decreased expression of FASN protein
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA
CTD PMID:11741158, PMID:15722030, PMID:20032539 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA CTD PMID:20370541 NCBI chr 2:198,430,536...198,439,453
Ensembl chr 2:198,430,530...198,458,041
JBrowse link
G Fdxr ferredoxin reductase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA CTD PMID:18313992 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
JBrowse link
G Fgl2 fibrinogen-like 2 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA CTD PMID:20370541 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Fh fumarate hydratase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA CTD PMID:18313992 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]] CTD PMID:7646543 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA CTD PMID:23962110 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G G0s2 G0/G1switch 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA CTD PMID:16931933 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of G6PC mRNA CTD PMID:16931933 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Ganc glucosidase, alpha; neutral C multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA CTD PMID:16931933 NCBI chr 3:112,173,907...112,226,886
Ensembl chr 3:112,173,907...112,226,023
JBrowse link
G Gars glycyl-tRNA synthetase multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA CTD PMID:15784690 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gas1 growth arrest-specific 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA CTD PMID:15784690, PMID:20370541 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gata1 GATA binding protein 1 decreases activity
decreases expression
ISO Zidovudine results in decreased activity of GATA1 protein
Zidovudine results in decreased expression of GATA1 mRNA
CTD PMID:8599995, PMID:10651068 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gbp1 guanylate binding protein 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA CTD PMID:20370541 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gbp4 guanylate binding protein 4 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA CTD PMID:20370541 NCBI chr 2:248,249,232...248,263,104
Ensembl chr 2:248,249,468...248,263,168
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]] CTD PMID:28619387 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grb7 growth factor receptor bound protein 7 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA CTD PMID:20370541 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Grhl2 grainyhead-like transcription factor 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA CTD PMID:16931933 NCBI chr 7:76,058,623...76,197,360
Ensembl chr 7:76,059,386...76,197,856
JBrowse link
G Gtf2h1 general transcription factor IIH subunit 1 increases expression ISO Zidovudine results in increased expression of GTF2H1 mRNA; Zidovudine results in increased expression of GTF2H1 protein CTD PMID:21192964 NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA CTD PMID:16931933 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) affects expression ISO Zidovudine affects the expression of H6PD mRNA CTD PMID:20032539 NCBI chr 5:166,994,683...167,030,441
Ensembl chr 5:166,998,881...167,030,441
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA CTD PMID:16931933 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA CTD PMID:18313992 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA CTD PMID:15784690 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hbb hemoglobin subunit beta decreases expression ISO Zidovudine results in decreased expression of HBB mRNA CTD PMID:10651068 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA CTD PMID:16931933 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hdlbp high density lipoprotein binding protein decreases expression ISO Zidovudine results in decreased expression of HDLBP mRNA CTD PMID:16894629 NCBI chr 9:100,554,574...100,624,707
Ensembl chr 9:100,554,563...100,624,638
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA CTD PMID:20370541 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hist1h4a histone cluster 1 H4 family member A multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA CTD PMID:16931933 NCBI chr17:43,617,161...43,617,705 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA CTD PMID:18313992 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Zidovudine results in increased expression of HMOX1 mRNA CTD PMID:29594326 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO Zidovudine results in increased mutagenesis of HPRT1 exon CTD PMID:10526209 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene CTD PMID:9766437 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA CTD PMID:16931933 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects expression ISO Zidovudine affects the expression of HSD11B1 mRNA CTD PMID:20032539 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA CTD PMID:18313992
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B3 mRNA CTD PMID:18313992 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression ISO Zidovudine affects the expression of HSPD1 protein CTD PMID:27041070 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA CTD PMID:18313992 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA CTD PMID:18313992 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma multiple interactions ISO [Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA CTD PMID:18313992 NCBI chr  X:156,999,803...157,008,735
Ensembl chr  X:156,999,826...157,008,733
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA CTD PMID:20370541 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA CTD PMID:20370541 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44l interferon-induced protein 44-like multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA CTD PMID:20370541 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA CTD PMID:20370541 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 multiple interactions ISO [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA CTD PMID:20370541 NCBI chr 1:252,894,663...252,900,727
Ensembl chr 1:252,894,663...252,900,726
JBrowse link
G Ifng interferon gamma affects expression
multiple interactions
ISO Zidovudine affects the expression of IFNG protein
[Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA
CTD PMID:9612607, PMID:23962110 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 multiple interactions ISO [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA CTD PMID:16931933 NCBI chr 7:3,061,422...3,098,142
Ensembl chr 7:3,061,469...3,074,359
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein CTD PMID:23962110 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Zidovudine results in increased expression of IL1A protein CTD PMID:7979221 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Zidovudine results in increased expression of IL1B mRNA; Zidovudine results in increased expression of IL1B protein CTD PMID:9184656, PMID:17668557 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link