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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:68443 term browser browse the term
Definition:A monomethylxanthine having the methyl group located at the 1-position. It is a metabolite of caffeine in humans.
Synonyms:related_synonym: 1-methylxanthines

show annotations for term's descendants           Sort by:
1-methyl-7H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO 1-methylxanthine results in decreased activity of CYP1A2 protein
[CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1-methylxanthine
CTD PMID:11465391, PMID:19215233 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases metabolic processing
ISO [XDH protein alternative form results in increased metabolism of 1-methylxanthine] which results in increased chemical synthesis of 1-methyluric acid CTD PMID:19215233 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            xenobiotic metabolite 14043
              human xenobiotic metabolite 13294
                1-methylxanthine 2
                  1-methyl-7H-xanthine + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      imidazopyrimidine 5439
                                        purines 5437
                                          aminopurine 4394
                                            2-aminopurines 4007
                                              guanine 3971
                                                xanthine 3889
                                                  methylxanthine 1138
                                                    monomethylxanthine 2
                                                      1-methylxanthine 2
                                                        1-methyl-7H-xanthine + 2
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.