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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoxamine
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Accession:CHEBI:6839 term browser browse the term
Definition:An amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine .
Synonyms:related_synonym: Formula=C11H17NO3;   InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3;   InChIKey=WJAJPNHVVFWKKL-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C(O)C(C)N)OC)OC;   methoxamedrine;   methoxamin
 xref: CAS:390-28-3;   KEGG:C07513;   KEGG:D08201;   LINCS:LSM-4423
 xref_mesh: MESH:D008729
 xref: PMID:24282936;   PMID:26914134;   PMID:28166217;   PMID:28599629


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methoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D affects binding ISO Methoxamine binds to ADRA1D protein CTD PMID:15493479 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein] CTD PMID:7816204 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of PTGS2 protein CTD PMID:12500202 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein CTD PMID:12500202 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      application 19464
        pharmaceutical 19337
          drug 19337
            cardiovascular drug 7656
              antihypotensive agent 4
                methoxamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    main group molecular entity 19730
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18743
                            inorganic hydride 17482
                              pnictogen hydride 17455
                                nitrogen hydride 17300
                                  azane 17019
                                    ammonia 17018
                                      organic amino compound 17017
                                        amine 7783
                                          amphetamines 5715
                                            methoxamine 4
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