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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:arjunolic acid
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Accession:CHEBI:68381 term browser browse the term
Definition:A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). Isolated from Symplocos lancifolia and Juglans sinensis, it exhibits antioxidant and antimicrobial activities.
Synonyms:exact_synonym: (2alpha,3beta)-2,3,23-trihydroxyolean-12-en-28-oic acid
 related_synonym: (2alpha,3beta,4alpha)-2,3,23-trihydroxyolean-12-en-28-oic acid;   Formula=C30H48O5;   InChI=1S/C30H48O5/c1-25(2)11-13-30(24(34)35)14-12-28(5)18(19(30)15-25)7-8-22-26(3)16-20(32)23(33)27(4,17-31)21(26)9-10-29(22,28)6/h7,19-23,31-33H,8-17H2,1-6H3,(H,34,35)/t19-,20+,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1;   InChIKey=RWNHLTKFBKYDOJ-DDHMHSPCSA-N;   SMILES=[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]3([H])CC[C@@]12C)C(O)=O
 xref: CAS:465-00-9;   HMDB:HMDB0034502
 xref_mesh: MESH:C061640
 xref: PMID:21046976;   PMID:21732908;   PMID:22486656;   PMID:23402784;   Patent:CN101416970;   Patent:GB923414;   Patent:WO2013064326;   Reaxys:2712723


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arjunolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BAD protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BAD protein]
CTD PMID:19682444 PMID:21420465 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]
CTD PMID:19682444 PMID:21420465 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein] CTD PMID:19682444 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of BID protein] CTD PMID:21420465 NCBI chr 4:154,113,198...154,136,353 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
arjunolic acid inhibits the reaction [Acetaminophen results in increased cleavage of and results in increased activity of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
CTD PMID:19133311 PMID:19682444 PMID:19922764 PMID:20053369 PMID:21420465 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein] CTD PMID:21420465 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] CTD PMID:21420465 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of CAT protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:18273903 PMID:18434106 PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CHUK protein] CTD PMID:21420465 NCBI chr 1:242,959,539...242,995,066 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19682444 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of FAS protein] CTD PMID:21420465 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:19133311 PMID:19682444 NCBI chr  X:152,201,081...152,220,863 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite affects the activity of GSR protein]; arjunolic acid inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
CTD PMID:18273903 PMID:18434106 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Ifng interferon gamma multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein] CTD PMID:20053369 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IKBKB protein] CTD PMID:21420465 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il2 interleukin 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IL2 protein] CTD PMID:20053369 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:19133311 PMID:19682444 PMID:20053369 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of NFKBIA protein]
arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of NFKBIA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of NFKBIA protein]
CTD PMID:20053369 PMID:21420465 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of NOS2] CTD PMID:19922764 PMID:25130312 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP arjunolic acid increases expression of Nr1h4 mRNA in steatotic liver RGD PMID:30257410 RGD:15090799 NCBI chr 7:23,846,122...23,942,085 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO arjunolic acid inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein] CTD PMID:21420465 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCD protein] CTD PMID:19682444 NCBI chr16:5,769,226...5,807,214 JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein] CTD PMID:19682444 NCBI chr 6:7,965,048...8,451,966 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of RELA protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of RELA protein]
CTD PMID:19133311 PMID:19682444 PMID:20053369 PMID:21420465 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD1 protein] CTD PMID:20053369 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] CTD PMID:20053369 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP arjunolic acid inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; arjunolic acid inhibits the reaction [Cisplatin results in increased expression of TNF]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:19682444 PMID:19922764 PMID:20053369 PMID:25130312 NCBI chr20:3,622,011...3,624,629 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      chemical role 19254
        antioxidant 14376
          arjunolic acid 28
            2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopynoside 0
            3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]arjunolic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        hydroxy carboxylic acid 3649
                                          hydroxy monocarboxylic acid 3649
                                            arjunolic acid 28
                                              2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopynoside 0
                                              3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]arjunolic acid 0
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