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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:syringic acid
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Accession:CHEBI:68329 term browser browse the term
Definition:A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.
Synonyms:related_synonym: 4-Hydroxy-3,5-dimethoxybenzoic acid;   Cedar acid;   Formula=C9H10O5;   Gallic acid 3,5-dimethyl ether;   InChI=1S/C9H10O5/c1-13-6-3-5(9(11)12)4-7(14-2)8(6)10/h3-4,10H,1-2H3,(H,11,12);   InChIKey=JMSVCTWVEWCHDZ-UHFFFAOYSA-N;   SMILES=COc1cc(cc(OC)c1O)C(O)=O
 alt_id: CHEBI:9379
 xref: CAS:530-57-4;   KEGG:C10833;   KNApSAcK:C00002674;   LINCS:LSM-19009
 xref_mesh: MESH:C001945
 xref: PMID:21192716;   PMID:21261296;   Reaxys:2115262;   Wikipedia:Syringic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132111


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syringic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO syringic acid results in decreased expression of AKT1 mRNA; syringic acid results in decreased expression of AKT1 protein CTD PMID:33548266 PMID:33759321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg3 autophagy related 3 increases expression ISO syringic acid results in increased expression of ATG3 protein CTD PMID:33548266 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO syringic acid results in increased expression of BAX mRNA CTD PMID:33759321 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO syringic acid results in decreased expression of BCL2 mRNA CTD PMID:33759321 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 increases expression ISO syringic acid results in increased expression of BECN1 protein CTD PMID:33548266 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases expression ISO syringic acid results in increased expression of CASP3 mRNA CTD PMID:33759321 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO syringic acid results in increased expression of CASP8 mRNA CTD PMID:33759321 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression ISO syringic acid results in increased expression of CASP9 mRNA CTD PMID:33759321 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity ISO syringic acid results in decreased activity of CAT protein CTD PMID:33548266 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO syringic acid results in decreased expression of CCND1 mRNA CTD PMID:33759321 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO syringic acid results in decreased expression of CDK2 mRNA CTD PMID:33759321 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO syringic acid results in decreased expression of CDK4 mRNA CTD PMID:33759321 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO syringic acid results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO syringic acid inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein] CTD PMID:31586550 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO syringic acid results in decreased activity of GSR protein CTD PMID:33548266 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Il10 interleukin 10 decreases secretion ISO syringic acid results in decreased secretion of IL10 protein CTD PMID:33759321 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 decreases secretion ISO syringic acid results in decreased secretion of IL2 protein CTD PMID:33759321 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 decreases secretion ISO syringic acid results in decreased secretion of IL6 protein CTD PMID:33759321 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO syringic acid results in decreased expression of MAPK1 protein CTD PMID:33548266 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO syringic acid results in decreased expression of MAPK14 mRNA CTD PMID:33759321 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO syringic acid results in decreased expression of MAPK3 protein CTD PMID:33548266 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression ISO syringic acid results in decreased expression of MAPK8 mRNA CTD PMID:33759321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mpo myeloperoxidase decreases activity ISO syringic acid results in decreased activity of MPO protein CTD PMID:24060682 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO syringic acid results in decreased expression of PIN1 mRNA CTD PMID:33759321 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO syringic acid results in decreased expression of RELA mRNA CTD PMID:33759321 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO syringic acid results in decreased expression of STAT3 mRNA CTD PMID:33759321 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO syringic acid results in decreased secretion of TNF protein CTD PMID:33759321 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO syringic acid results in increased expression of TP53 protein CTD PMID:33548266 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      chemical role 19336
        antioxidant 14442
          gallic acid 2614
            syringic acid 28
              methyl syringate 0
              syringic acid acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        aromatic carboxylic acid 11708
                                          benzoic acids 11681
                                            benzoic acid 4157
                                              hydroxybenzoic acid 3562
                                                trihydroxybenzoic acid 2629
                                                  gallic acid 2614
                                                    syringic acid 28
                                                      methyl syringate 0
                                                      syringic acid acetate 0
paths to the root