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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:syringic acid
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Accession:CHEBI:68329 term browser browse the term
Definition:A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.
Synonyms:related_synonym: 4-Hydroxy-3,5-dimethoxybenzoic acid;   Cedar acid;   Formula=C9H10O5;   Gallic acid 3,5-dimethyl ether;   InChI=1S/C9H10O5/c1-13-6-3-5(9(11)12)4-7(14-2)8(6)10/h3-4,10H,1-2H3,(H,11,12);   InChIKey=JMSVCTWVEWCHDZ-UHFFFAOYSA-N;   SMILES=COc1cc(cc(OC)c1O)C(O)=O
 alt_id: CHEBI:9379
 xref: CAS:530-57-4;   KEGG:C10833;   KNApSAcK:C00002674;   LINCS:LSM-19009
 xref_mesh: MESH:C001945
 xref: PMID:21192716;   PMID:21261296;   Reaxys:2115262;   Wikipedia:Syringic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132111



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syringic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO syringic acid results in decreased expression of AKT1 mRNA; syringic acid results in decreased expression of AKT1 protein CTD PMID:33548266 PMID:33759321 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg3 autophagy related 3 increases expression ISO syringic acid results in increased expression of ATG3 protein CTD PMID:33548266 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO syringic acid results in increased expression of BAX mRNA CTD PMID:33759321 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO syringic acid results in decreased expression of BCL2 mRNA CTD PMID:33759321 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 increases expression ISO syringic acid results in increased expression of BECN1 protein CTD PMID:33548266 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases expression
increases secretion
multiple interactions
ISO syringic acid results in increased expression of CASP3 mRNA
syringic acid analog results in increased secretion of CASP3 protein
HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of CASP3 protein]
CTD PMID:33759321 PMID:34523043 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases expression ISO syringic acid results in increased expression of CASP8 mRNA CTD PMID:33759321 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases secretion
ISO syringic acid results in increased expression of CASP9 mRNA
aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein]; pepstatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein]
CTD PMID:33759321 PMID:34523043 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases activity
multiple interactions
increases activity
ISO
EXP
syringic acid results in decreased activity of CAT protein
syringic acid inhibits the reaction [Propylthiouracil results in decreased activity of CAT protein]
syringic acid results in increased activity of CAT protein
CTD PMID:33548266 PMID:34047416 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO syringic acid results in decreased expression of CCND1 mRNA CTD PMID:33759321 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO syringic acid results in decreased expression of CDK2 mRNA CTD PMID:33759321 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO syringic acid results in decreased expression of CDK4 mRNA CTD PMID:33759321 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO syringic acid results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Fadd Fas associated via death domain increases secretion
multiple interactions
ISO syringic acid analog results in increased secretion of FADD protein
HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of FADD protein]
CTD PMID:34523043 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 multiple interactions ISO syringic acid analog results in increased expression of and affects the localization of G3BP1 protein CTD PMID:34523043 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases secretion
ISO aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein]; HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein]; pepstatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] CTD PMID:34523043 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP syringic acid inhibits the reaction [Propylthiouracil results in increased expression of GPT protein] CTD PMID:34047416 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO syringic acid inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased phosphorylation of GSK3B protein] CTD PMID:31586550 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO syringic acid results in decreased activity of GSR protein CTD PMID:33548266 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of CASP3 protein]; HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of FADD protein]; HSPA1A protein inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] CTD PMID:34523043 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Il10 interleukin 10 decreases secretion ISO syringic acid results in decreased secretion of IL10 protein CTD PMID:33759321 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 decreases secretion ISO syringic acid results in decreased secretion of IL2 protein CTD PMID:33759321 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
ISO
EXP
syringic acid results in decreased secretion of IL6 protein
syringic acid inhibits the reaction [Propylthiouracil results in increased expression of IL6 protein]
CTD PMID:33759321 PMID:34047416 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO syringic acid results in decreased expression of MAPK1 protein CTD PMID:33548266 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO syringic acid results in decreased expression of MAPK14 mRNA CTD PMID:33759321 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO syringic acid results in decreased expression of MAPK3 protein CTD PMID:33548266 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression ISO syringic acid results in decreased expression of MAPK8 mRNA CTD PMID:33759321 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mpo myeloperoxidase decreases activity ISO syringic acid results in decreased activity of MPO protein CTD PMID:24060682 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 decreases expression ISO syringic acid results in decreased expression of PIN1 mRNA CTD PMID:33759321 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO syringic acid results in decreased expression of RELA mRNA CTD PMID:33759321 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO syringic acid analog results in increased expression of SQSTM1 protein CTD PMID:34523043 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO syringic acid results in decreased expression of STAT3 mRNA CTD PMID:33759321 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
syringic acid results in decreased secretion of TNF protein
syringic acid inhibits the reaction [Propylthiouracil results in increased expression of TNF protein]
CTD PMID:33759321 PMID:34047416 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO syringic acid results in increased expression of TP53 protein CTD PMID:33548266 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases expression
EXP syringic acid inhibits the reaction [Propylthiouracil results in increased expression of TSHB protein]
syringic acid results in decreased expression of TSHB protein
CTD PMID:34047416 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      chemical role 19356
        antioxidant 15686
          gallic acid 2668
            syringic acid 35
              methyl syringate 0
              syringic acid acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic acid 18518
                                        aromatic carboxylic acid 11801
                                          benzoic acids 11775
                                            benzoic acid 4340
                                              hydroxybenzoic acid 3750
                                                trihydroxybenzoic acid 2683
                                                  gallic acid 2668
                                                    syringic acid 35
                                                      methyl syringate 0
                                                      syringic acid acetate 0
paths to the root