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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(Z)-ligustilide
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Accession:CHEBI:68232 term browser browse the term
Definition:A butenolide that has formula C12H14O2.
Synonyms:related_synonym: 1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-;   Formula=C12H14O2;   InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3/b11-8-;   InChIKey=IQVQXVFMNOFTMU-FLIBITNWSA-N;   SMILES=CCC\\C=C1OC(=O)C2=C/1CCC=C2
 xref: CAS:4431-01-0;   KEGG:C16987
 xref_mesh: MESH:C027820
 xref: PMID:20879744


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(Z)-ligustilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions
ISO ligustilide results in increased activity of AHR protein
[butylidenephthalide co-treated with ligustilide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of AKT1 protein CTD PMID:23973442 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO ligustilide results in decreased expression of APP protein CTD PMID:23973442 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ligustilide results in increased expression of BAX mRNA; ligustilide results in increased expression of BAX protein CTD PMID:31765699 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO ligustilide results in decreased expression of BCL2 mRNA; ligustilide results in decreased expression of BCL2 protein CTD PMID:31765699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO ligustilide results in increased activity of CASP3 protein
ligustilide results in increased cleavage of CASP3 protein
CTD PMID:30243965 PMID:31765699 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage ISO ligustilide results in increased cleavage of CASP9 protein CTD PMID:31765699 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO ligustilide results in increased expression of and results in increased activity of CAT protein CTD PMID:23973442 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO ligustilide results in increased expression of CCNB1 protein CTD PMID:31765699 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO ligustilide results in increased expression of CCND1 protein CTD PMID:31765699 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ligustilide results in increased expression of CDKN1A protein CTD PMID:31765699 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO ligustilide results in increased expression of CYCS protein CTD PMID:31765699 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO ligustilide results in increased expression of CYP1A1 mRNA
ligustilide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of FOXO1 protein CTD PMID:23973442 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO ligustilide results in increased expression of HMOX1 mRNA; ligustilide results in increased expression of HMOX1 protein CTD PMID:23441843 PMID:30243965 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization EXP ligustilide affects the localization of HSF1 protein CTD PMID:26212861 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IGF1R protein CTD PMID:23973442 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Irs1 insulin receptor substrate 1 decreases phosphorylation ISO ligustilide results in decreased phosphorylation of IRS1 protein CTD PMID:23973442 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kl Klotho increases expression ISO ligustilide results in increased expression of KL mRNA; ligustilide results in increased expression of KL protein CTD PMID:23973442 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK1 protein CTD PMID:26212861 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP ligustilide results in increased phosphorylation of MAPK3 protein CTD PMID:26212861 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapt microtubule-associated protein tau decreases phosphorylation ISO ligustilide results in decreased phosphorylation of MAPT protein CTD PMID:23973442 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases methylation
affects response to substance
increases methylation
multiple interactions
ISO ligustilide results in decreased methylation of NFE2L2 promoter
NFE2L2 protein affects the susceptibility to ligustilide
ligustilide results in increased methylation of NFE2L2 promoter
ligustilide results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:23441843 PMID:30243965 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ligustilide results in increased expression of NQO1 mRNA; ligustilide results in increased expression of NQO1 protein CTD PMID:23441843 PMID:30243965 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO ligustilide results in increased activity of NR1I2 protein
[ligustilide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO ligustilide results in increased expression of and results in increased activity of SOD2 protein CTD PMID:23973442 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO ligustilide results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31765699 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ligustilide results in increased expression of UGT1A1 protein
ligustilide results in increased expression of UGT1A1 mRNA
CTD PMID:23441843 PMID:30243965 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            (Z)-ligustilide 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic ester 14367
                                        lactone 5988
                                          gamma-lactone 1220
                                            butenolide 361
                                              (Z)-ligustilide 28
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