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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methacholine
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Accession:CHEBI:6804 term browser browse the term
Definition:A quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis.
Synonyms:exact_synonym: 2-acetyloxy-N,N,N-trimethylpropan-1-aminium
 related_synonym: Acetyl-beta-methylcholine;   Acetylmethylcholine;   Formula=C8H18NO2;   InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1;   InChIKey=NZWOPGCLSHLLPA-UHFFFAOYSA-N;   MCh;   SMILES=CC(C[N+](C)(C)C)OC(C)=O
 xref: Beilstein:1769932;   CAS:55-92-5;   DrugBank:DB06709;   Drug_Central:1726;   KEGG:C07471;   LINCS:LSM-6405;   PMID:12128066;   PMID:15275856;   PMID:15694846;   PMID:16477439;   PMID:18775882;   PMID:19589828;   PMID:22826043;   PMID:22981792;   PMID:23429803;   PMID:8124805;   PMID:8420242;   Wikipedia:Methacholine



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methacholine chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases response to substance
ISO Cyclosporine inhibits the reaction [[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride]
[AHR protein results in increased susceptibility to Antigens] which results in increased susceptibility to Methacholine Chloride; AHR protein results in increased susceptibility to Methacholine Chloride
CTD PMID:27869817 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions ISO BMPR2 protein affects the susceptibility to [Methacholine Chloride co-treated with Antigens, Dermatophagoides] CTD PMID:22427841 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
JBrowse link
G C3 complement C3 multiple interactions ISO C3 protein affects the susceptibility to [Ozone co-treated with Methacholine Chloride] CTD PMID:14701711 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Atropine inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Calcium inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]; Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]; Ro 31-8425 inhibits the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides]]; Methacholine Chloride promotes the reaction [CFTR protein results in increased export of Chlorides] CTD PMID:20675434 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cpe carboxypeptidase E increases response to substance ISO CPE gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:16002559 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 multiple interactions ISO Ozone promotes the reaction [CXCR2 protein affects the susceptibility to Methacholine Chloride] CTD PMID:15361358 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Fcer2 Fc epsilon receptor II increases expression ISO Methacholine Chloride results in increased expression of FCER2 protein CTD PMID:15801332 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects response to substance ISO GRK3 mutant form affects the susceptibility to Methacholine Chloride CTD PMID:10198406 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO IL1RN protein results in decreased susceptibility to [Ozone co-treated with Methacholine Chloride]
Methacholine Chloride results in increased expression of IL1RN protein
CTD PMID:14754758 PMID:15801332 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Lep leptin increases response to substance ISO LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein affects the reaction [2-chloroethyl ethyl sulfide affects the susceptibility to Methacholine Chloride] CTD PMID:22446026 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases response to substance
ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [NOS3 gene mutant form results in decreased susceptibility to Methacholine Chloride] CTD PMID:22421449 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the susceptibility to [5-alpha-Dihydroprogesterone co-treated with Methacholine Chloride] CTD PMID:17159084 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride] CTD PMID:22414385 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases response to substance ISO TNFRSF1A protein results in increased susceptibility to Methacholine Chloride CTD PMID:21070800 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 increases activity ISO Methacholine Chloride results in increased activity of TRPC3 protein CTD PMID:16522635 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      biological role 20000
        epitope 6999
          methacholine 17
            methacholine chloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      carboxylic acid 18556
                                        monocarboxylic acid 17740
                                          acetic acid 10872
                                            acetate ester 3889
                                              methacholine 17
                                                methacholine chloride 17
paths to the root