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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Chikusetsusaponin-V
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Accession:CHEBI:67981 term browser browse the term
Definition:A triterpenoid saponin that has formula C48H76O19.
Synonyms:related_synonym: Formula=C48H76O19;   Ginsenoside Ro;   InChI=1S/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23+,24+,25-,26+,27-,28+,29+,30-,31-,32-,33-,34+,35+,36-,37+,39-,40-,41+,45-,46+,47+,48-/m0/s1;   InChIKey=NFZYDZXHKFHPGA-QQHDHSITSA-N;   SMILES=[H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)O[C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@]1([H])O[C@H]1CC[C@@]2(C)[C@@]([H])(CC[C@]3(C)[C@]2([H])CC=C2[C@]4([H])CC(C)(C)CC[C@@]4(CC[C@@]32C)C(=O)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C1(C)C)C(O)=O;   beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-
 xref: CAS:34367-04-9;   KEGG:C17543
 xref_mesh: MESH:C064378
 xref: PMID:21417387


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Chikusetsusaponin-V term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:25073091 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:25073091 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp12 caspase 12 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP12 mRNA] CTD PMID:25073091 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein] CTD PMID:25073091 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Lpl lipoprotein lipase increases secretion ISO ginsenoside Ro results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] CTD PMID:25073091 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD2 mRNA] CTD PMID:25073091 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            Chikusetsusaponin-V 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          glycoside 9260
                                            saponin 421
                                              triterpenoid saponin 359
                                                Chikusetsusaponin-V 7
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