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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Chikusetsusaponin-IV
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Accession:CHEBI:67975 term browser browse the term
Definition:A triterpenoid saponin that has formula C47H74O18.
Synonyms:related_synonym: Araloside A;   Formula=C47H74O18;   InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-33(55)30(52)28(50)23(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)31(53)35(36(64-40)37(57)58)63-38-32(54)29(51)24(20-49)60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)/t22-,23+,24-,25-,26+,27-,28+,29-,30-,31+,32+,33+,34+,35-,36-,38-,39-,40+,44-,45+,46+,47-/m0/s1;   InChIKey=KQSFNXMDCOFFGW-GNDIVNLPSA-N;   Oleanoside E;   SMILES=[H][C@]1(O[C@@H](CO)[C@H](O)[C@H]1O)O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5(CC[C@@]43C)C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C2(C)C)O[C@@H]1C(O)=O;   beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-alpha-L-arabinofuranosyl-
 xref: CAS:7518-22-1;   KEGG:C17540
 xref_mesh: MESH:C071578
 xref: PMID:21417387


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Chikusetsusaponin-IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO araloside A results in decreased expression of BCL2 protein CTD PMID:31004595 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Il1b interleukin 1 beta decreases expression
decreases secretion
ISO araloside A results in decreased expression of IL1B mRNA
araloside A results in decreased secretion of IL1B protein
CTD PMID:31004595 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
decreases secretion
ISO araloside A results in decreased expression of IL6 mRNA
araloside A results in decreased secretion of IL6 protein
CTD PMID:31004595 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO araloside A results in decreased phosphorylation of NFKBIA protein CTD PMID:31004595 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation ISO araloside A results in decreased phosphorylation of RELA protein CTD PMID:31004595 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          metabolite 19308
            Chikusetsusaponin-IV 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            heteroorganic entity 19217
                              organochalcogen compound 18922
                                organooxygen compound 18846
                                  carbohydrates and carbohydrate derivatives 12248
                                    carbohydrate 12248
                                      carbohydrate derivative 11874
                                        glycosyl compound 10927
                                          glycoside 9219
                                            saponin 374
                                              triterpenoid saponin 319
                                                Chikusetsusaponin-IV 5
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