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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:farrerol
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Accession:CHEBI:67897 term browser browse the term
Definition:An organic molecular entity that has formula C17H16O5.
Synonyms:related_synonym: (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone;   Formula=C17H16O5;   InChI=1S/C17H16O5/c1-8-15(20)9(2)17-14(16(8)21)12(19)7-13(22-17)10-3-5-11(18)6-4-10/h3-6,13,18,20-21H,7H2,1-2H3/t13-/m0/s1;   InChIKey=DYHOLQACRGJEHX-ZDUSSCGKSA-N;   SMILES=Cc1c(O)c(C)c2O[C@@H](CC(=O)c2c1O)c1ccc(O)cc1
 alt_id: CHEBI:4981
 xref: CAS:24211-30-1;   KEGG:C09734;   KNApSAcK:C00008239
 xref_mesh: MESH:C015881
 xref: PMID:21443171


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farrerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP farrerol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of CYBA mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:31838053 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO farrerol results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation EXP farrerol results in increased phosphorylation of ESR1 protein CTD PMID:17323972 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:31838053 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO farrerol results in increased expression of GCLC mRNA CTD PMID:26111761 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [farrerol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
farrerol results in increased expression of HMOX1 mRNA; farrerol results in increased expression of HMOX1 protein
CTD PMID:26111761 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:31838053 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:31838053 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO farrerol results in decreased expression of KEAP1 protein CTD PMID:26111761 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
farrerol results in increased phosphorylation of MAPK1 protein
farrerol inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
CTD PMID:26111761, PMID:31838053 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
farrerol results in increased phosphorylation of MAPK3 protein
farrerol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
CTD PMID:26111761, PMID:31838053 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP farrerol inhibits the reaction [Glucose results in decreased expression of MMP2 mRNA]; farrerol inhibits the reaction [Glucose results in decreased expression of MMP2 protein] CTD PMID:31838053 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP farrerol inhibits the reaction [Glucose results in decreased expression of MMP9 mRNA]; farrerol inhibits the reaction [Glucose results in decreased expression of MMP9 protein] CTD PMID:31838053 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO farrerol affects the localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; NFE2L2 protein promotes the reaction [farrerol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; U 0126 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]
CTD PMID:26111761 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of NOX4 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of NOX4 protein] CTD PMID:31838053 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO farrerol results in increased expression of NQO1 mRNA CTD PMID:26111761 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of TGFB1 protein] CTD PMID:31838053 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of TNF mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:31838053 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            farrerol 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      p-block molecular entity 19672
                        carbon group molecular entity 19574
                          organic molecular entity 19563
                            farrerol 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.