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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:farrerol
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Accession:CHEBI:67897 term browser browse the term
Definition:An organic molecular entity that has formula C17H16O5.
Synonyms:related_synonym: (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone;   Formula=C17H16O5;   InChI=1S/C17H16O5/c1-8-15(20)9(2)17-14(16(8)21)12(19)7-13(22-17)10-3-5-11(18)6-4-10/h3-6,13,18,20-21H,7H2,1-2H3/t13-/m0/s1;   InChIKey=DYHOLQACRGJEHX-ZDUSSCGKSA-N;   SMILES=Cc1c(O)c(C)c2O[C@@H](CC(=O)c2c1O)c1ccc(O)cc1
 alt_id: CHEBI:4981
 xref: CAS:24211-30-1;   KEGG:C09734;   KNApSAcK:C00008239
 xref_mesh: MESH:C015881
 xref: PMID:21443171


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farrerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP farrerol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of CYBA mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:31838053 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO farrerol results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO farrerol results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation EXP farrerol results in increased phosphorylation of ESR1 protein CTD PMID:17323972 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of FN1 protein] CTD PMID:31838053 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO farrerol results in increased expression of GCLC mRNA CTD PMID:26111761 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Mercaptoethanol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [farrerol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [farrerol results in increased expression of HMOX1 protein]
farrerol results in increased expression of HMOX1 mRNA; farrerol results in increased expression of HMOX1 protein
CTD PMID:26111761 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:31838053 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:31838053 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO farrerol results in decreased expression of KEAP1 protein CTD PMID:26111761 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
farrerol results in increased phosphorylation of MAPK1 protein
farrerol inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
CTD PMID:26111761 PMID:31838053 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
farrerol results in increased phosphorylation of MAPK3 protein
farrerol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
CTD PMID:26111761 PMID:31838053 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP farrerol inhibits the reaction [Glucose results in decreased expression of MMP2 mRNA]; farrerol inhibits the reaction [Glucose results in decreased expression of MMP2 protein] CTD PMID:31838053 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP farrerol inhibits the reaction [Glucose results in decreased expression of MMP9 mRNA]; farrerol inhibits the reaction [Glucose results in decreased expression of MMP9 protein] CTD PMID:31838053 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO farrerol affects the localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; NFE2L2 protein promotes the reaction [farrerol results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; U 0126 inhibits the reaction [farrerol affects the localization of NFE2L2 protein]
CTD PMID:26111761 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of NOX4 mRNA]; farrerol inhibits the reaction [Glucose results in increased expression of NOX4 protein] CTD PMID:31838053 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO farrerol results in increased expression of NQO1 mRNA CTD PMID:26111761 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of TGFB1 protein] CTD PMID:31838053 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP farrerol inhibits the reaction [Glucose results in increased expression of TNF mRNA]; farrerol inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:31838053 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            farrerol 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      p-block molecular entity 19716
                        carbon group molecular entity 19640
                          organic molecular entity 19630
                            farrerol 22
paths to the root